Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system

Biomaterials

Volumn 35, Issue 1, 2014, Pages 489-499

  Godinho, Bruno M D C ^a   McCarthy, David J ^a   Torres Fuentes, Cristina ^a   Beltrán, Caroll J ^b,c   McCarthy, Joanna ^a   Quinlan, Aoife ^a   Ogier, Julien R ^d   Darcy, Raphael ^d   O'Driscoll, Caitriona M ^a   Cryan, John F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cyclodextrins; Cytokines; High content analysis; SiRNA; Stereotaxic; Toll like receptors

Indexed keywords

CYTOKINES; HIGH CONTENT ANALYSIS; SIRNA; STEREOTAXIC; TOLL-LIKE RECEPTORS;

CELL MEMBRANES; CYCLODEXTRINS; CYTOTOXICITY; GENE EXPRESSION; INTERFERONS; NANOPARTICLES; NEUROPHYSIOLOGY; RNA;

VECTORS;

BETA CYCLODEXTRIN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; NANOCARRIER; POLYAMIDOAMINE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CYTOKINE RELEASE; CYTOKINE RESPONSE; CYTOTOXICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNE RESPONSE; IN VITRO STUDY; MALE; MICROGLIA; MOUSE; NANOTOXICOLOGY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; STEREOTAXIC SURGERY; WEIGHT REDUCTION;

MURINAE; RATTUS;

CYCLODEXTRINS; CYTOKINES; HIGH CONTENT ANALYSIS; SIRNA; STEREOTAXIC; TOLL-LIKE RECEPTORS;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CORPUS STRIATUM; GENETIC VECTORS; HUMANS; INFLAMMATION; MICE; MICROGLIA; NANOPARTICLES; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84887020372     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.068     Document Type: Article

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