LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 9, 2013, Pages

  Stump, Matthew R ^a   Gong, Qiuming ^a   Zhou, Zhengfeng ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Human ether a go go related gene; Long QT syndrome; Per Arnt Sim domain; Potassium channels; Protein trafficking

Indexed keywords

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LONG QT SYNDROME 2; NONSENSE MEDIATED MRNA DECAY; NONSENSE MUTATION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY; START CODON;

HUMAN ETHER-A-GO-GO-RELATED GENE; LONG QT SYNDROME; PER-ARNT-SIM DOMAIN; POTASSIUM CHANNELS; PROTEIN TRAFFICKING;

CODON, NONSENSE; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; LONG QT SYNDROME; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEOLYSIS; TIME FACTORS; TRANSFECTION;

EID: 84887012801     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00304.2013     Document Type: Article

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