Changes in channel trafficking and protein stability caused by lqt2 mutations in the pas domain of the herg channel

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Harley, Carol A ^a   Jesus, Catarina S H ^b,c   Carvalho, Ricardo ^a   Brito, Rui M M ^b,c   Morais Cabral, João H ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; POTASSIUM CHANNEL HERG; PROTEIN VARIANT; ERG1 POTASSIUM CHANNEL; GLYCOSIDASE;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; GENE; GENE MUTATION; IN VITRO STUDY; LONG QT SYNDROME; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPIC VARIATION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTEIN UNFOLDING; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; WESTERN BLOTTING; CELL STRAIN HEK293; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PHENOTYPE; PROTEIN DENATURATION; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; THERMODYNAMICS; ULTRAVIOLET RADIATION;

CIRCULAR DICHROISM; ETHER-A-GO-GO POTASSIUM CHANNELS; GLYCOSIDE HYDROLASES; HEK293 CELLS; HUMANS; LONG QT SYNDROME; MUTATION; PHENOTYPE; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; TEMPERATURE; THERMODYNAMICS; ULTRAVIOLET RAYS;

EID: 84857773278     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032654     Document Type: Article

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