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Volumn 305, Issue 9, 2013, Pages

Renal anemia: From incurable to curable

Author keywords

Erythropoietin; Hypoxia inducible factors; Myofibroblast; Neural crest; Renal anemia

Indexed keywords

ANTIANEMIC AGENT; DEXAMETHASONE; GLUCOCORTICOID; HEMOGLOBIN; NEUROTROPHIN; PEGINESATIDE; RALOXIFENE; RECOMBINANT ERYTHROPOIETIN; TAMOXIFEN;

EID: 84886997570     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00233.2013     Document Type: Review
Times cited : (49)

References (128)
  • 1
    • 0014346833 scopus 로고
    • The erythropoietin-hematocrit relationship in normal and polycythemic man: Implications of marrow regulation
    • Adamson JW. The erythropoietin-hematocrit relationship in normal and polycythemic man: implications of marrow regulation. Blood 32: 597-609, 1968.
    • (1968) Blood , vol.32 , pp. 597-609
    • Adamson, J.W.1
  • 2
    • 36048948342 scopus 로고    scopus 로고
    • Serum erythropoietin concentrations and responses to anaemia in patients with or without chronic kidney disease
    • Artunc F, Risler T. Serum erythropoietin concentrations and responses to anaemia in patients with or without chronic kidney disease. Nephrol Dial Transplant 22: 2900-2908, 2007.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 2900-2908
    • Artunc, F.1    Risler, T.2
  • 4
    • 0037166636 scopus 로고    scopus 로고
    • Association of kidney function with anemia: The Third National Health and Nutrition Examination Survey (1988-1994)
    • Astor BC, Muntner P, Levin A, Eustace JA, Coresh J. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 162: 1401-1408, 2002.
    • (2002) Arch Intern Med , vol.162 , pp. 1401-1408
    • Astor, B.C.1    Muntner, P.2    Levin, A.3    Eustace, J.A.4    Coresh, J.5
  • 5
    • 84857094157 scopus 로고    scopus 로고
    • Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease
    • Bamgbola OF. Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease. Kidney Int 80: 464-474, 2011.
    • (2011) Kidney Int , vol.80 , pp. 464-474
    • Bamgbola, O.F.1
  • 6
    • 0028053857 scopus 로고
    • Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor
    • Baylis C. Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest 94: 1823-1829, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 1823-1829
    • Baylis, C.1
  • 8
    • 57049181965 scopus 로고    scopus 로고
    • Erythropoietin expands a stromal cell population that can mediate renoprotection
    • Bi B, Guo J, Marlier A, Lin SR, Cantley LG. Erythropoietin expands a stromal cell population that can mediate renoprotection. Am J Physiol Renal Physiol 295: F1017-F1022, 2008.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Bi, B.1    Guo, J.2    Marlier, A.3    Lin, S.R.4    Cantley, L.G.5
  • 9
    • 0015594961 scopus 로고
    • Effect of altitude on erythropoiesis and oxygen affinity in anaemic patients on maintenance dialysis
    • Blumberg A, Keller H, Marti HR. Effect of altitude on erythropoiesis and oxygen affinity in anaemic patients on maintenance dialysis. Eur J Clin Invest 3: 93-97, 1973.
    • (1973) Eur J Clin Invest , vol.3 , pp. 93-97
    • Blumberg, A.1    Keller, H.2    Marti, H.R.3
  • 10
    • 33746137372 scopus 로고    scopus 로고
    • Discovering erythropoietin's extra-hematopoietic functions: Biology and clinical promise
    • Brines M, Cerami A. Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise. Kidney Int 70: 246-250, 2006.
    • (2006) Kidney Int , vol.70 , pp. 246-250
    • Brines, M.1    Cerami, A.2
  • 12
    • 0023752757 scopus 로고
    • Cell lineage analysis reveals multipotency of some avian neural crest cells
    • Bronner-Fraser M, Fraser SE. Cell lineage analysis reveals multipotency of some avian neural crest cells. Nature 335: 161-164, 1988.
    • (1988) Nature , vol.335 , pp. 161-164
    • Bronner-Fraser, M.1    Fraser, S.E.2
  • 16
    • 0024213759 scopus 로고
    • Relation of serum erythropoietin levels to renal excretory function: Evidence for lowered set point for erythropoietin production in chronic renal failure
    • Chandra M, Clemons GK, McVicar MI. Relation of serum erythropoietin levels to renal excretory function: evidence for lowered set point for erythropoietin production in chronic renal failure. J Pediatr 113: 1015-1021, 1988.
    • (1988) J Pediatr , vol.113 , pp. 1015-1021
    • Chandra, M.1    Clemons, G.K.2    McVicar, M.I.3
  • 17
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4: 299-309, 2003.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 20
    • 0020043548 scopus 로고
    • Immunoreactive erythropoietin in serum. I. Evidence for the validity of the assay method and the physiological relevance of estimates
    • Cotes PM. Immunoreactive erythropoietin in serum. I. Evidence for the validity of the assay method and the physiological relevance of estimates. Br J Haematol 50: 427-438, 1982.
    • (1982) Br J Haematol , vol.50 , pp. 427-438
    • Cotes, P.M.1
  • 22
    • 0024450891 scopus 로고
    • Improvements in quality of life following treatment with r-HuEPO in anemic hemodialysis patients
    • Delano BG. Improvements in quality of life following treatment with r-HuEPO in anemic hemodialysis patients. Am J Kidney Dis 14: 14-18, 1989.
    • (1989) Am J Kidney Dis , vol.14 , pp. 14-18
    • Delano, B.G.1
  • 23
    • 34247178424 scopus 로고    scopus 로고
    • Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy
    • Dixon A, Wells CC, Singh S, Babayan R, Maric C. Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy. Am J Nephrol 27: 120-128, 2007.
    • (2007) Am J Nephrol , vol.27 , pp. 120-128
    • Dixon, A.1    Wells, C.C.2    Singh, S.3    Babayan, R.4    Maric, C.5
  • 24
    • 0034899022 scopus 로고    scopus 로고
    • Why is erythropoietin made in the kidney? The kidney functions as a critmeter
    • Donnelly S. Why is erythropoietin made in the kidney? The kidney functions as a critmeter. Am J Kidney Dis 38: 415-425, 2001.
    • (2001) Am J Kidney Dis , vol.38 , pp. 415-425
    • Donnelly, S.1
  • 26
    • 0033568576 scopus 로고    scopus 로고
    • Regulation of the erythropoietin gene
    • Ebert BL, Bunn HF. Regulation of the erythropoietin gene. Blood 94: 1864-1877, 1999.
    • (1999) Blood , vol.94 , pp. 1864-1877
    • Ebert, B.L.1    Bunn, H.F.2
  • 27
    • 0026575755 scopus 로고
    • Age-dependent expression of the erythropoietin gene in rat liver and kidneys
    • Eckardt KU, Ratcliffe PJ, Tan CC, Bauer C, Kurtz A. Age-dependent expression of the erythropoietin gene in rat liver and kidneys. J Clin Invest 89: 753-760, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 753-760
    • Eckardt, K.U.1    Ratcliffe, P.J.2    Tan, C.C.3    Bauer, C.4    Kurtz, A.5
  • 28
    • 0023120533 scopus 로고
    • Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial
    • Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 316: 73-78, 1987.
    • (1987) N Engl J Med , vol.316 , pp. 73-78
    • Eschbach, J.W.1    Egrie, J.C.2    Downing, M.R.3    Browne, J.K.4    Adamson, J.W.5
  • 29
    • 2442693041 scopus 로고    scopus 로고
    • Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
    • Fandrey J. Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. Am J Physiol Regul Integr Comp Physiol 286: R977-R988, 2004.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Fandrey, J.1
  • 30
    • 4344575935 scopus 로고    scopus 로고
    • Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia
    • Fehr T, Ammann P, Garzoni D, Korte W, Fierz W, Rickli H, Wuthrich RP. Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia. Kidney Int 66: 1206-1211, 2004.
    • (2004) Kidney Int , vol.66 , pp. 1206-1211
    • Fehr, T.1    Ammann, P.2    Garzoni, D.3    Korte, W.4    Fierz, W.5    Rickli, H.6    Wuthrich, R.P.7
  • 31
    • 79955963946 scopus 로고    scopus 로고
    • Oxygenregulated expression of the erythropoietin gene in the human renal cell line REPC
    • Frede S, Freitag P, Geuting L, Konietzny R, Fandrey J. Oxygenregulated expression of the erythropoietin gene in the human renal cell line REPC. Blood 117: 4905-4914, 2011.
    • (2011) Blood , vol.117 , pp. 4905-4914
    • Frede, S.1    Freitag, P.2    Geuting, L.3    Konietzny, R.4    Fandrey, J.5
  • 32
    • 0015426654 scopus 로고
    • The liver as a source of extrarenal erythropoietin production
    • Fried W. The liver as a source of extrarenal erythropoietin production. Blood 40: 671-677, 1972.
    • (1972) Blood , vol.40 , pp. 671-677
    • Fried, W.1
  • 35
    • 4444257379 scopus 로고    scopus 로고
    • The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease
    • Giaccia AJ, Simon MC, Johnson R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev 18: 2183-2194, 2004.
    • (2004) Genes Dev , vol.18 , pp. 2183-2194
    • Giaccia, A.J.1    Simon, M.C.2    Johnson, R.3
  • 36
    • 21444452438 scopus 로고    scopus 로고
    • Of birds and mice: Hematopoietic stem cell development
    • Godin I, Cumano A. Of birds and mice: hematopoietic stem cell development. Int J Dev Biol 49: 251-257, 2005.
    • (2005) Int J Dev Biol , vol.49 , pp. 251-257
    • Godin, I.1    Cumano, A.2
  • 39
    • 84857111725 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • Grgic I, Duffield JS, Humphreys BD. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 27: 183-193, 2012.
    • (2012) Pediatr Nephrol , vol.27 , pp. 183-193
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 40
    • 33644867127 scopus 로고    scopus 로고
    • Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP)
    • Gross AW, Lodish HF. Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem 281: 2024-2032, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 2024-2032
    • Gross, A.W.1    Lodish, H.F.2
  • 42
    • 77953854244 scopus 로고    scopus 로고
    • Hypoxic regulation of erythropoiesis and iron metabolism
    • Haase VH. Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299: F1-F13, 2010.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Haase, V.H.1
  • 43
    • 84872134149 scopus 로고    scopus 로고
    • Regulation of erythropoiesis by hypoxia-inducible factors
    • Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev 27: 41-53, 2013.
    • (2013) Blood Rev , vol.27 , pp. 41-53
    • Haase, V.H.1
  • 44
    • 0142244847 scopus 로고    scopus 로고
    • Risk factors for chronic kidney disease: A prospective study of 23,534 men and women in Washington County, Maryland
    • Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol 14: 2934-2941, 2003.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2934-2941
    • Haroun, M.K.1    Jaar, B.G.2    Hoffman, S.C.3    Comstock, G.W.4    Klag, M.J.5    Coresh, J.6
  • 47
    • 0035134102 scopus 로고    scopus 로고
    • Relationship between hematocrit and renal function in men and women
    • Hsu CY, Bates DW, Kuperman GJ, Curhan GC. Relationship between hematocrit and renal function in men and women. Kidney Int 59: 725-731, 2001.
    • (2001) Kidney Int , vol.59 , pp. 725-731
    • Hsu, C.Y.1    Bates, D.W.2    Kuperman, G.J.3    Curhan, G.C.4
  • 48
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1+ (HIF-1+) and HIF-2+ in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1+ (HIF-1+) and HIF-2+ in hypoxic gene regulation. Mol Cell Biol 23: 9361-9374, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 50
    • 0031043063 scopus 로고    scopus 로고
    • Negative regulation of the erythropoietin gene expression by the GATA transcription factors
    • Imagawa S, Yamamoto M, Miura Y. Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood 89: 1430-1439, 1997.
    • (1997) Blood , vol.89 , pp. 1430-1439
    • Imagawa, S.1    Yamamoto, M.2    Miura, Y.3
  • 51
    • 33646696626 scopus 로고    scopus 로고
    • Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure
    • Johnson DW, Pat B, Vesey DA, Guan Z, Endre Z, Gobe GC. Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure. Kidney Int 69: 1806-1813, 2006.
    • (2006) Kidney Int , vol.69 , pp. 1806-1813
    • Johnson, D.W.1    Pat, B.2    Vesey, D.A.3    Guan, Z.4    Endre, Z.5    Gobe, G.C.6
  • 53
    • 0028875438 scopus 로고
    • Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney
    • Karavanov A, Sainio K, Palgi J, Saarma M, Saxen L, Sariola H. Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney. Proc Natl Acad Sci USA 92: 11279-11283, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11279-11283
    • Karavanov, A.1    Sainio, K.2    Palgi, J.3    Saarma, M.4    Saxen, L.5    Sariola, H.6
  • 55
    • 76249113245 scopus 로고    scopus 로고
    • Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese
    • Kohagura K, Tomiyama N, Kinjo K, Takishita S, Iseki K. Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese. Clin Exp Nephrol 13: 614-620, 2009.
    • (2009) Clin Exp Nephrol , vol.13 , pp. 614-620
    • Kohagura, K.1    Tomiyama, N.2    Kinjo, K.3    Takishita, S.4    Iseki, K.5
  • 57
    • 0023738939 scopus 로고
    • Erythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta
    • Koury MJ, Bondurant MC, Graber SE, Sawyer ST. Erythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta. J Clin Invest 82: 154-159, 1988.
    • (1988) J Clin Invest , vol.82 , pp. 154-159
    • Koury, M.J.1    Bondurant, M.C.2    Graber, S.E.3    Sawyer, S.T.4
  • 58
    • 0023868741 scopus 로고
    • Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
    • Koury ST, Bondurant MC, Koury MJ. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524-527, 1988.
    • (1988) Blood , vol.71 , pp. 524-527
    • Koury, S.T.1    Bondurant, M.C.2    Koury, M.J.3
  • 59
    • 0024322837 scopus 로고
    • Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: Correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration
    • Koury ST, Koury MJ, Bondurant MC, Caro J, Graber SE. Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood 74: 645-651, 1989.
    • (1989) Blood , vol.74 , pp. 645-651
    • Koury, S.T.1    Koury, M.J.2    Bondurant, M.C.3    Caro, J.4    Graber, S.E.5
  • 60
    • 66849138375 scopus 로고    scopus 로고
    • Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA)
    • Krapf R, Hulter HN. Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA). Clin J Am Soc Nephrol 4: 470-480, 2009.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 470-480
    • Krapf, R.1    Hulter, H.N.2
  • 61
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: Fact or fantasy?
    • Kriz W, Kaissling B, Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 121: 468-474, 2011.
    • (2011) J Clin Invest , vol.121 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 63
    • 0008060451 scopus 로고
    • Renal mesangial cell cultures as a model for study of erythropoietin production
    • Kurtz A, Jelkmann W, Sinowatz F, Bauer C. Renal mesangial cell cultures as a model for study of erythropoietin production. Proc Natl Acad Sci USA 80: 4008-4011, 1983.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4008-4011
    • Kurtz, A.1    Jelkmann, W.2    Sinowatz, F.3    Bauer, C.4
  • 66
    • 3543137674 scopus 로고    scopus 로고
    • The avian embryo as a model to study the development of the neural crest: A long and still ongoing story
    • Le Douarin NM. The avian embryo as a model to study the development of the neural crest: a long and still ongoing story. Mech Dev 121: 1089-1102, 2004.
    • (2004) Mech Dev , vol.121 , pp. 1089-1102
    • Le Douarin, N.M.1
  • 67
    • 0016162921 scopus 로고
    • Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique
    • Le Douarin NM, Teillet MA. Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique. Dev Biol 41: 162-184, 1974.
    • (1974) Dev Biol , vol.41 , pp. 162-184
    • Le Douarin, N.M.1    Teillet, M.A.2
  • 68
    • 0035308590 scopus 로고    scopus 로고
    • A highly efficient Escherichia colibased chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA
    • Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG. A highly efficient Escherichia colibased chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73: 56-65, 2001.
    • (2001) Genomics , vol.73 , pp. 56-65
    • Lee, E.C.1    Yu, D.2    Martinez de Velasco, J.3    Tessarollo, L.4    Swing, D.A.5    Court, D.L.6    Jenkins, N.A.7    Copeland, N.G.8
  • 69
    • 70450223507 scopus 로고    scopus 로고
    • Generating specificity and diversity in the transcriptional response to hypoxia
    • Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet 10: 821-832, 2009.
    • (2009) Nat Rev Genet , vol.10 , pp. 821-832
    • Lendahl, U.1    Lee, K.L.2    Yang, H.3    Poellinger, L.4
  • 70
    • 77950565076 scopus 로고    scopus 로고
    • Autophagy is a component of epithelial cell fate in obstructive uropathy
    • Li L, Zepeda-Orozco D, Black R, Lin F. Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778, 2010.
    • (2010) Am J Pathol , vol.176 , pp. 1767-1778
    • Li, L.1    Zepeda-Orozco, D.2    Black, R.3    Lin, F.4
  • 71
    • 0030050404 scopus 로고    scopus 로고
    • Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
    • Lin CS, Lim SK, D'Agati V, Costantini F. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev 10: 154-164, 1996.
    • (1996) Genes Dev , vol.10 , pp. 154-164
    • Lin, C.S.1    Lim, S.K.2    D'Agati, V.3    Costantini, F.4
  • 73
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173: 1617-1627, 2008.
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 74
    • 2942635909 scopus 로고    scopus 로고
    • Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action
    • Liu Y. Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol 287: F7-F16, 2004.
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Liu, Y.1
  • 75
    • 0027935351 scopus 로고
    • Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the reporter in proximal convoluted tubule cells after hypoxia
    • Loya F, Yang Y, Lin H, Goldwasser E, Albitar M. Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the reporter in proximal convoluted tubule cells after hypoxia. Blood 84: 1831-1836, 1994.
    • (1994) Blood , vol.84 , pp. 1831-1836
    • Loya, F.1    Yang, Y.2    Lin, H.3    Goldwasser, E.4    Albitar, M.5
  • 76
    • 38749115086 scopus 로고    scopus 로고
    • Novel erythropoiesis-stimulating agents: A new era in anemia management
    • Macdougall IC. Novel erythropoiesis-stimulating agents: a new era in anemia management. Clin J Am Soc Nephrol 3: 200-207, 2008.
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. 200-207
    • Macdougall, I.C.1
  • 77
    • 60149095565 scopus 로고    scopus 로고
    • Current and upcoming erythropoiesisstimulating agents, iron products, and other novel anemia medications
    • Macdougall IC, Ashenden M. Current and upcoming erythropoiesisstimulating agents, iron products, and other novel anemia medications. Adv Chronic Kidney Dis 16: 117-130, 2009.
    • (2009) Adv Chronic Kidney Dis , vol.16 , pp. 117-130
    • Macdougall, I.C.1    Ashenden, M.2
  • 79
    • 0029002253 scopus 로고
    • Regulated basal, inducible, and tissue-specific human erythropoietin gene expression in transgenic mice requires multiple cis DNA sequences
    • Madan A, Lin C, Hatch SL, 2nd, Curtin PT. Regulated basal, inducible, and tissue-specific human erythropoietin gene expression in transgenic mice requires multiple cis DNA sequences. Blood 85: 2735-2741, 1995.
    • (1995) Blood , vol.85 , pp. 2735-2741
    • Madan, A.1    Lin, C.2    Hatch II, S.L.3    Curtin, P.T.4
  • 82
    • 0142182781 scopus 로고    scopus 로고
    • HIF-1: An oxygen response system with special relevance to the kidney
    • Maxwell P. HIF-1: an oxygen response system with special relevance to the kidney. J Am Soc Nephrol 14: 2712-2722, 2003.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2712-2722
    • Maxwell, P.1
  • 83
    • 0021347557 scopus 로고
    • Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency
    • McGonigle RJ, Wallin JD, Shadduck RK, Fisher JW. Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. Kidney Int 25: 437-444, 1984.
    • (1984) Kidney Int , vol.25 , pp. 437-444
    • McGonigle, R.J.1    Wallin, J.D.2    Shadduck, R.K.3    Fisher, J.W.4
  • 85
    • 0028891971 scopus 로고
    • Role of antennary structure of N-linked sugar chains in renal handling of recombinant human erythropoietin
    • Misaizu T, Matsuki S, Strickland TW, Takeuchi M, Kobata A, Takasaki S. Role of antennary structure of N-linked sugar chains in renal handling of recombinant human erythropoietin. Blood 86: 4097-4104, 1995.
    • (1995) Blood , vol.86 , pp. 4097-4104
    • Misaizu, T.1    Matsuki, S.2    Strickland, T.W.3    Takeuchi, M.4    Kobata, A.5    Takasaki, S.6
  • 86
    • 0017755573 scopus 로고
    • Purification of human erythropoietin
    • Miyake T, Kung CK, Goldwasser E. Purification of human erythropoietin. J Biol Chem 252: 5558-5564, 1977.
    • (1977) J Biol Chem , vol.252 , pp. 5558-5564
    • Miyake, T.1    Kung, C.K.2    Goldwasser, E.3
  • 87
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1+ and HIF-2+ DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J, Ratcliffe PJ. Genome-wide association of hypoxia-inducible factor (HIF)-1+ and HIF-2+ DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284: 16767-16775, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3    Pollard, P.J.4    Gleadle, J.M.5    Ragoussis, J.6    Ratcliffe, P.J.7
  • 91
    • 36849049298 scopus 로고    scopus 로고
    • Hypoxia and the HIF system in kidney disease
    • Nangaku M, Eckardt KU. Hypoxia and the HIF system in kidney disease. J Mol Med (Berl) 85: 1325-1330, 2007.
    • (2007) J Mol Med (Berl) , vol.85 , pp. 1325-1330
    • Nangaku, M.1    Eckardt, K.U.2
  • 92
    • 33750895555 scopus 로고    scopus 로고
    • Pathogenesis of renal anemia
    • Nangaku M, Eckardt KU. Pathogenesis of renal anemia. Semin Nephrol 26: 261-268, 2006.
    • (2006) Semin Nephrol , vol.26 , pp. 261-268
    • Nangaku, M.1    Eckardt, K.U.2
  • 93
    • 46749127450 scopus 로고    scopus 로고
    • Repression via the GATA box is essential for tissue-specific erythropoietin gene expression
    • Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood 111: 5223-5232, 2008.
    • (2008) Blood , vol.111 , pp. 5223-5232
    • Obara, N.1    Suzuki, N.2    Kim, K.3    Nagasawa, T.4    Imagawa, S.5    Yamamoto, M.6
  • 94
    • 75749150800 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2+-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization
    • Paliege A, Rosenberger C, Bondke A, Sciesielski L, Shina A, Heyman SN, Flippin LA, Arend M, Klaus SJ, Bachmann S. Hypoxia-inducible factor-2+-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Kidney Int 77: 312-318, 2010.
    • (2010) Kidney Int , vol.77 , pp. 312-318
    • Paliege, A.1    Rosenberger, C.2    Bondke, A.3    Sciesielski, L.4    Shina, A.5    Heyman, S.N.6    Flippin, L.A.7    Arend, M.8    Klaus, S.J.9    Bachmann, S.10
  • 95
    • 41949100415 scopus 로고    scopus 로고
    • Ontogeny of erythropoiesis
    • Palis J. Ontogeny of erythropoiesis. Curr Opin Hematol 15: 155-161, 2008.
    • (2008) Curr Opin Hematol , vol.15 , pp. 155-161
    • Palis, J.1
  • 97
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11: 272-280, 2001.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 99
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2+ plays an important role in vascular remodeling
    • Peng J, Zhang L, Drysdale L, Fong GH. The transcription factor EPAS-1/hypoxia-inducible factor 2+ plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97: 8386-8391, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 101
    • 79958779687 scopus 로고    scopus 로고
    • Scar wars: Mapping the fate of epithelialmesenchymal-myofibroblast transition
    • Quaggin SE, Kapus A. Scar wars: mapping the fate of epithelialmesenchymal-myofibroblast transition. Kidney Int 80: 41-50, 2011.
    • (2011) Kidney Int , vol.80 , pp. 41-50
    • Quaggin, S.E.1    Kapus, A.2
  • 104
    • 0037288980 scopus 로고    scopus 로고
    • Erythropoietin-producing renal cell carcinoma in chronic hemodialysis patients: A report of two cases
    • Sakamoto S, Igarashi T, Osumi N, Imamoto T, Tobe T, Kamiya M, Ito H. Erythropoietin-producing renal cell carcinoma in chronic hemodialysis patients: a report of two cases. Int J Urol 10: 49-51, 2003.
    • (2003) Int J Urol , vol.10 , pp. 49-51
    • Sakamoto, S.1    Igarashi, T.2    Osumi, N.3    Imamoto, T.4    Tobe, T.5    Kamiya, M.6    Ito, H.7
  • 106
  • 107
    • 0025012679 scopus 로고
    • Human erythropoietin gene expression in transgenic mice: Multiple transcription initiation sites and cis-acting regulatory elements
    • Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol 10: 930-938, 1990.
    • (1990) Mol Cell Biol , vol.10 , pp. 930-938
    • Semenza, G.L.1    Dureza, R.C.2    Traystman, M.D.3    Gearhart, J.D.4    Antonarakis, S.E.5
  • 108
    • 0026072341 scopus 로고
    • Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
    • Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 88: 8725-8729, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8725-8729
    • Semenza, G.L.1    Koury, S.T.2    Nejfelt, M.K.3    Gearhart, J.D.4    Antonarakis, S.E.5
  • 109
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab 9: 152-164, 2009.
    • (2009) Cell Metab , vol.9 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.H.4    Gonzalez, F.J.5
  • 110
    • 0025357286 scopus 로고
    • Regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin
    • Silberberg J, Racine N, Barre P, Sniderman AD. Regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin. Can J Cardiol 6: 1-4, 1990.
    • (1990) Can J Cardiol , vol.6 , pp. 1-4
    • Silberberg, J.1    Racine, N.2    Barre, P.3    Sniderman, A.D.4
  • 113
    • 80052568370 scopus 로고    scopus 로고
    • Specific contribution of the erythropoietin gene 3= enhancer to hepatic erythropoiesis after late embryonic stages
    • Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, Yamamoto M. Specific contribution of the erythropoietin gene 3= enhancer to hepatic erythropoiesis after late embryonic stages. Mol Cell Biol 31: 3896-3905, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 3896-3905
    • Suzuki, N.1    Obara, N.2    Pan, X.3    Watanabe, M.4    Jishage, K.5    Minegishi, N.6    Yamamoto, M.7
  • 114
  • 115
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676, 2006.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 117
    • 84862783287 scopus 로고    scopus 로고
    • Recent advances and clinical application of erythropoietin and erythropoiesis-stimulating agents
    • Tanaka T, Nangaku M. Recent advances and clinical application of erythropoietin and erythropoiesis-stimulating agents. Exp Cell Res 318: 1068-1073, 2012.
    • (2012) Exp Cell Res , vol.318 , pp. 1068-1073
    • Tanaka, T.1    Nangaku, M.2
  • 118
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82, 1997.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 120
    • 57449088366 scopus 로고    scopus 로고
    • Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci 9
    • Webster NJ, Pirrung MC. Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci 9, Suppl 2: S1, 2008.
    • (2008) Suppl , vol.2
    • Webster, N.J.1    Pirrung, M.C.2
  • 121
    • 77952690589 scopus 로고    scopus 로고
    • Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells
    • Wenger RH, Hoogewijs D. Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells. Am J Physiol Renal Physiol 298: F1287-F1296, 2010.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Wenger, R.H.1    Hoogewijs, D.2
  • 122
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • Wu H, Liu X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83: 59-67, 1995.
    • (1995) Cell , vol.83 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 123
    • 51649104761 scopus 로고    scopus 로고
    • The microenvironment for erythropoiesis is regulated by HIF-2+ through VCAM-1 in endothelial cells
    • Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2+ through VCAM-1 in endothelial cells. Blood 112: 1482-1492, 2008.
    • (2008) Blood , vol.112 , pp. 1482-1492
    • Yamashita, T.1    Ohneda, O.2    Sakiyama, A.3    Iwata, F.4    Ohneda, K.5    Fujii-Kuriyama, Y.6
  • 126
    • 77955602944 scopus 로고    scopus 로고
    • Resolved: EMT produces fibroblasts in the kidney
    • Zeisberg M, Duffield JS. Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 21: 1247-1253, 2010.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1247-1253
    • Zeisberg, M.1    Duffield, J.S.2
  • 128
    • 33746255946 scopus 로고    scopus 로고
    • Nonhematologic complications of erythropoietin therapy
    • Zhu X, Perazella MA. Nonhematologic complications of erythropoietin therapy. Semin Dial 19: 279-284, 2006.
    • (2006) Semin Dial , vol.19 , pp. 279-284
    • Zhu, X.1    Perazella, M.A.2


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