메뉴 건너뛰기




Volumn 6, Issue 1, 2013, Pages

The fibrotic microenvironment as a heterogeneity facet of hepatocellular carcinoma

Author keywords

Activated hepatic stellate cells (HSC); Integrins; Intra tumor heterogeneity; Liver cancer; Tetraspanin enriched microdomains

Indexed keywords

ADAM PROTEIN; CD151 ANTIGEN; CD81 ANTIGEN; DISINTEGRIN; MEMBRANE PROTEIN; PROTEOME; TETRASPANIN;

EID: 84886928809     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-6-17     Document Type: Review
Times cited : (21)

References (57)
  • 1
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • 10.1056/NEJMra1001683, 21992124
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011, 365:1118-1127. 10.1056/NEJMra1001683, 21992124.
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • 10.1038/nrc1934, 16929323
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006, 6:674-687. 10.1038/nrc1934, 16929323.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 5
    • 77958014613 scopus 로고    scopus 로고
    • How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
    • 10.1038/sj.bjc.6605912, 2967073, 20877357
    • Gerlinger M, Swanton C. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br J Cancer 2010, 103:1139-1143. 10.1038/sj.bjc.6605912, 2967073, 20877357.
    • (2010) Br J Cancer , vol.103 , pp. 1139-1143
    • Gerlinger, M.1    Swanton, C.2
  • 6
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • 10.1016/j.cell.2009.02.024, 2894612, 19269363
    • Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009, 136:823-837. 10.1016/j.cell.2009.02.024, 2894612, 19269363.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 7
    • 67349284051 scopus 로고    scopus 로고
    • Non-genetic heterogeneity a mutation-independent driving force for the somatic evolution of tumours
    • 10.1038/nrg2556, 19337290
    • Brock A, Chang H, Huang S. Non-genetic heterogeneity a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet 2009, 10:336-342. 10.1038/nrg2556, 19337290.
    • (2009) Nat Rev Genet , vol.10 , pp. 336-342
    • Brock, A.1    Chang, H.2    Huang, S.3
  • 8
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: a looking glass for cancer?
    • Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer?. Nat Rev Cancer 2012, 12:323-334.
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 11
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: complex tissues that interface with the entire organism
    • 10.1016/j.devcel.2010.05.012, 2905377, 20627072
    • Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 2010, 18:884-901. 10.1016/j.devcel.2010.05.012, 2905377, 20627072.
    • (2010) Dev Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 12
    • 33746417036 scopus 로고    scopus 로고
    • Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes
    • 10.1101/sqb.2005.70.013, 3004779, 16869771
    • Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol 2005, 70:343-356. 10.1101/sqb.2005.70.013, 3004779, 16869771.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 343-356
    • Bissell, M.J.1    Kenny, P.A.2    Radisky, D.C.3
  • 13
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • 10.1146/annurev.pathol.1.110304.100224, 18039110
    • Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006, 1:119-150. 10.1146/annurev.pathol.1.110304.100224, 18039110.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 15
    • 84857652096 scopus 로고    scopus 로고
    • Role of the microenvironment in hepatocellular carcinoma development and progression
    • 10.1016/j.ctrv.2011.06.010, 21763074
    • Wu SD, Ma YS, Fang Y, Liu LL, Fu D, Shen XZ. Role of the microenvironment in hepatocellular carcinoma development and progression. Cancer Treat Rev 2012, 38:218-225. 10.1016/j.ctrv.2011.06.010, 21763074.
    • (2012) Cancer Treat Rev , vol.38 , pp. 218-225
    • Wu, S.D.1    Ma, Y.S.2    Fang, Y.3    Liu, L.L.4    Fu, D.5    Shen, X.Z.6
  • 16
    • 33749252188 scopus 로고    scopus 로고
    • Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion
    • 10.1002/jcp.20772, 2900580, 16883581
    • Mikula M, Proell V, Fischer AN, Mikulits W. Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 2006, 209:560-567. 10.1002/jcp.20772, 2900580, 16883581.
    • (2006) J Cell Physiol , vol.209 , pp. 560-567
    • Mikula, M.1    Proell, V.2    Fischer, A.N.3    Mikulits, W.4
  • 17
    • 84861147161 scopus 로고    scopus 로고
    • Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma
    • 10.1158/0008-5472.CAN-11-3317, 3498759, 22419664
    • Coulouarn C, Corlu A, Glaise D, Guénon I, Thorgeirsson SS, Clément B. Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Res 2012, 72:2533-2542. 10.1158/0008-5472.CAN-11-3317, 3498759, 22419664.
    • (2012) Cancer Res , vol.72 , pp. 2533-2542
    • Coulouarn, C.1    Corlu, A.2    Glaise, D.3    Guénon, I.4    Thorgeirsson, S.S.5    Clément, B.6
  • 18
    • 79960701998 scopus 로고    scopus 로고
    • Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice
    • 10.1002/ijc.25920, 21213212
    • Zhao W, Zhang L, Yin Z, Su W, Ren G, Zhou C, You J, Fan J, Wang X. Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice. Int J Cancer 2011, 129:2651-2661. 10.1002/ijc.25920, 21213212.
    • (2011) Int J Cancer , vol.129 , pp. 2651-2661
    • Zhao, W.1    Zhang, L.2    Yin, Z.3    Su, W.4    Ren, G.5    Zhou, C.6    You, J.7    Fan, J.8    Wang, X.9
  • 19
    • 73349108444 scopus 로고    scopus 로고
    • Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells
    • 10.1111/j.1478-3231.2009.02161.x, 19929904
    • Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès P, Bataller R. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver Int 2010, 30:31-41. 10.1111/j.1478-3231.2009.02161.x, 19929904.
    • (2010) Liver Int , vol.30 , pp. 31-41
    • Sancho-Bru, P.1    Juez, E.2    Moreno, M.3    Khurdayan, V.4    Morales-Ruiz, M.5    Colmenero, J.6    Arroyo, V.7    Brenner, D.A.8    Ginès, P.9    Bataller, R.10
  • 21
    • 74049086775 scopus 로고    scopus 로고
    • Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum
    • 10.1007/s00432-009-0666-5, 19727817
    • Xia Y, Chen R, Song Z, Ye S, Sun R, Xue Q, Zhang Z. Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum. J Cancer Res Clin Oncol 2010, 136:309-321. 10.1007/s00432-009-0666-5, 19727817.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 309-321
    • Xia, Y.1    Chen, R.2    Song, Z.3    Ye, S.4    Sun, R.5    Xue, Q.6    Zhang, Z.7
  • 25
    • 84879808762 scopus 로고
    • Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis
    • Nevzorova YA, Hu W, Cubero FJ, Haas U, Freimuth J, Tacke F, Trautwein C, Liedtke C. Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Biochim Biophys Acta 1832, 2013:1765-1775.
    • (1832) Biochim Biophys Acta , vol.2013 , pp. 1765-1775
    • Nevzorova, Y.A.1    Hu, W.2    Cubero, F.J.3    Haas, U.4    Freimuth, J.5    Tacke, F.6    Trautwein, C.7    Liedtke, C.8
  • 26
    • 70449636444 scopus 로고    scopus 로고
    • Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
    • 10.1038/onc.2009.253, 2900602, 19718050
    • van Zijl F, Mair M, Csiszar A, Schneller D, Zulehner G, Huber H, Eferl R, Beug H, Dolznig H, Mikulits W. Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 2009, 28:4022-4033. 10.1038/onc.2009.253, 2900602, 19718050.
    • (2009) Oncogene , vol.28 , pp. 4022-4033
    • van Zijl, F.1    Mair, M.2    Csiszar, A.3    Schneller, D.4    Zulehner, G.5    Huber, H.6    Eferl, R.7    Beug, H.8    Dolznig, H.9    Mikulits, W.10
  • 28
    • 36048986396 scopus 로고    scopus 로고
    • Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis
    • 10.1111/j.1432-0436.2007.00235.x, 17999742
    • Campbell JS, Johnson MM, Bauer RL, Hudkins KL, Gilbertson DG, Riehle KJ, Yeh MM, Alpers CE, Fausto N. Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis. Differentiation 2007, 75:843-852. 10.1111/j.1432-0436.2007.00235.x, 17999742.
    • (2007) Differentiation , vol.75 , pp. 843-852
    • Campbell, J.S.1    Johnson, M.M.2    Bauer, R.L.3    Hudkins, K.L.4    Gilbertson, D.G.5    Riehle, K.J.6    Yeh, M.M.7    Alpers, C.E.8    Fausto, N.9
  • 29
    • 0034304851 scopus 로고    scopus 로고
    • Lipid rafts and signal transduction
    • 10.1038/35036052, 11413487
    • Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000, 1:31-39. 10.1038/35036052, 11413487.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 31-39
    • Simons, K.1    Toomre, D.2
  • 30
    • 80052275615 scopus 로고    scopus 로고
    • PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
    • 10.1073/pnas.1019386108, 3167518, 21873248
    • Gao X, Lowry PR, Zhou X, Depry C, Wei Z, Wong GW, Zhang J. PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A 2011, 108:14509-14514. 10.1073/pnas.1019386108, 3167518, 21873248.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14509-14514
    • Gao, X.1    Lowry, P.R.2    Zhou, X.3    Depry, C.4    Wei, Z.5    Wong, G.W.6    Zhang, J.7
  • 31
    • 69549088095 scopus 로고    scopus 로고
    • Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes
    • 10.1016/j.tcb.2009.06.004, 19709882
    • Yáñez-Mó M, Barreiro O, Gordon-Alonso M, Sala-Valdés M, Sánchez-Madrid F. Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends Cell Biol 2009, 19:434-446. 10.1016/j.tcb.2009.06.004, 19709882.
    • (2009) Trends Cell Biol , vol.19 , pp. 434-446
    • Yáñez-Mó, M.1    Barreiro, O.2    Gordon-Alonso, M.3    Sala-Valdés, M.4    Sánchez-Madrid, F.5
  • 32
    • 0036708281 scopus 로고    scopus 로고
    • Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration
    • 10.1016/S0168-8278(02)00175-7, 12175627
    • Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. J Hepatol 2002, 37:322-330. 10.1016/S0168-8278(02)00175-7, 12175627.
    • (2002) J Hepatol , vol.37 , pp. 322-330
    • Mazzocca, A.1    Carloni, V.2    Sciammetta, S.3    Cordella, C.4    Pantaleo, P.5    Caldini, A.6    Gentilini, P.7    Pinzani, M.8
  • 33
    • 57749169272 scopus 로고    scopus 로고
    • Tetraspanins: push and pull in suppressing and promoting metastasis
    • 10.1038/nrc2543, 19078974
    • Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer 2009, 9:40-55. 10.1038/nrc2543, 19078974.
    • (2009) Nat Rev Cancer , vol.9 , pp. 40-55
    • Zoller, M.1
  • 34
    • 0025284826 scopus 로고
    • TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins
    • 360911, 1695320
    • Oren R, Takahashi S, Doss C, Levy R, Levy S. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol 1990, 10:4007-4015. 360911, 1695320.
    • (1990) Mol Cell Biol , vol.10 , pp. 4007-4015
    • Oren, R.1    Takahashi, S.2    Doss, C.3    Levy, R.4    Levy, S.5
  • 35
    • 1542742106 scopus 로고    scopus 로고
    • Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells
    • 10.1038/sj.onc.1207287, 14676841
    • Carloni V, Mazzocca A, Ravichandran KS. Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 2004, 23:1566-1574. 10.1038/sj.onc.1207287, 14676841.
    • (2004) Oncogene , vol.23 , pp. 1566-1574
    • Carloni, V.1    Mazzocca, A.2    Ravichandran, K.S.3
  • 36
    • 7944236082 scopus 로고    scopus 로고
    • Membrane domains
    • 10.1146/annurev.cellbio.20.010403.095451, 15473862
    • Mukherjee S, Maxfield FR. Membrane domains. Annu Rev Cell Dev Biol 2004, 20:839-866. 10.1146/annurev.cellbio.20.010403.095451, 15473862.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 839-866
    • Mukherjee, S.1    Maxfield, F.R.2
  • 37
    • 0035193768 scopus 로고    scopus 로고
    • The CD81 expression in liver in hepatocellular carcinoma
    • Inoue G, Horiike N, Onji M. The CD81 expression in liver in hepatocellular carcinoma. Int J Mol Med 2001, 7:67-71.
    • (2001) Int J Mol Med , vol.7 , pp. 67-71
    • Inoue, G.1    Horiike, N.2    Onji, M.3
  • 38
    • 14544281476 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-survival and clinical characteristics in relation to various histologic molecular markers in Western patients
    • 10.1111/j.1478-3231.2004.0997.x, 15698400
    • Schöniger-Hekele M, Hänel S, Wrba F, Müller C. Hepatocellular carcinoma-survival and clinical characteristics in relation to various histologic molecular markers in Western patients. Liver Int 2005, 25:62-69. 10.1111/j.1478-3231.2004.0997.x, 15698400.
    • (2005) Liver Int , vol.25 , pp. 62-69
    • Schöniger-Hekele, M.1    Hänel, S.2    Wrba, F.3    Müller, C.4
  • 39
    • 46049085204 scopus 로고    scopus 로고
    • Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma
    • 10.1053/j.gastro.2008.03.024, 18466772
    • Mazzocca A, Liotta F, Carloni V. Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma. Gastroenterology 2008, 135:244-256. 10.1053/j.gastro.2008.03.024, 18466772.
    • (2008) Gastroenterology , vol.135 , pp. 244-256
    • Mazzocca, A.1    Liotta, F.2    Carloni, V.3
  • 40
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • 10.1056/NEJMra0805239, 19109576
    • Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med 2008, 359:2814-2823. 10.1056/NEJMra0805239, 19109576.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 41
    • 0033179240 scopus 로고    scopus 로고
    • Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis
    • Testa JE, Brooks PC, Lin JM, Quigley JP. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. Cancer Res 1999, 59:3812-3820.
    • (1999) Cancer Res , vol.59 , pp. 3812-3820
    • Testa, J.E.1    Brooks, P.C.2    Lin, J.M.3    Quigley, J.P.4
  • 42
    • 79955432112 scopus 로고    scopus 로고
    • CD151 amplifies signaling by integrin α6β1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells
    • 10.1053/j.gastro.2011.02.008, 21320503
    • Ke AW, Shi GM, Zhou J, Huang XY, Shi YH, Ding ZB, Wang XY, Devbhandari RP, Fan J. CD151 amplifies signaling by integrin α6β1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells. Gastroenterology 2011, 140:1629-1641. 10.1053/j.gastro.2011.02.008, 21320503.
    • (2011) Gastroenterology , vol.140 , pp. 1629-1641
    • Ke, A.W.1    Shi, G.M.2    Zhou, J.3    Huang, X.Y.4    Shi, Y.H.5    Ding, Z.B.6    Wang, X.Y.7    Devbhandari, R.P.8    Fan, J.9
  • 43
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029
    • 10.1158/0008-5472.CAN-06-0391, 16849554
    • Gesierich S, Berezovskiy I, Ryschich E, Zoller M. Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res 2006, 66:7083-7094. 10.1158/0008-5472.CAN-06-0391, 16849554.
    • (2006) Cancer Res , vol.66 , pp. 7083-7094
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zoller, M.4
  • 44
    • 0344873270 scopus 로고    scopus 로고
    • Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells
    • 10.1046/j.1440-1746.2003.03182.x, 14535989
    • Kanetaka K, Sakamoto M, Yamamoto Y, Takamura M, Kanematsu T, Hirohashi S. Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells. J Gastroenterol Hepatol 2003, 18:1309-1314. 10.1046/j.1440-1746.2003.03182.x, 14535989.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1309-1314
    • Kanetaka, K.1    Sakamoto, M.2    Yamamoto, Y.3    Takamura, M.4    Kanematsu, T.5    Hirohashi, S.6
  • 46
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • 10.1038/nrm1490, 15459662
    • Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004, 5:816-826. 10.1038/nrm1490, 15459662.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 47
    • 0028804279 scopus 로고
    • Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma
    • Begum NA, Mori M, Matsumata T, Takenaka K, Sugimachi K, Barnard GF. Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma. Hepatology 1995, 22:1447-1455.
    • (1995) Hepatology , vol.22 , pp. 1447-1455
    • Begum, N.A.1    Mori, M.2    Matsumata, T.3    Takenaka, K.4    Sugimachi, K.5    Barnard, G.F.6
  • 48
    • 12644286609 scopus 로고    scopus 로고
    • Coordinated expression of integrin alpha6beta1 and laminin in hepatocellular carcinoma
    • 10.1016/S0046-8177(97)90250-1, 9343319
    • Torimura T, Ueno T, Kin M, Inuzuka S, Sugawara H, Tamaki S, Tsuji R, Sujaku K, Sata M, Tanikawa K. Coordinated expression of integrin alpha6beta1 and laminin in hepatocellular carcinoma. Hum Pathol 1997, 28:1131-1138. 10.1016/S0046-8177(97)90250-1, 9343319.
    • (1997) Hum Pathol , vol.28 , pp. 1131-1138
    • Torimura, T.1    Ueno, T.2    Kin, M.3    Inuzuka, S.4    Sugawara, H.5    Tamaki, S.6    Tsuji, R.7    Sujaku, K.8    Sata, M.9    Tanikawa, K.10
  • 49
    • 0030695152 scopus 로고    scopus 로고
    • The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice
    • 1858063, 9358743
    • Wewer UM, Shaw LM, Albrechtsen R, Mercurio AM. The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice. Am J Pathol 1997, 151:1191-1198. 1858063, 9358743.
    • (1997) Am J Pathol , vol.151 , pp. 1191-1198
    • Wewer, U.M.1    Shaw, L.M.2    Albrechtsen, R.3    Mercurio, A.M.4
  • 50
    • 0032589363 scopus 로고    scopus 로고
    • Alpha6beta1 integrin expression in hepatocarcinoma cells: regulation and role in cell adhesion and migration
    • 10.1002/(SICI)1097-0215(19991112)83:4<518::AID-IJC14>3.0.CO;2-Q, 10508489
    • Nejjari M, Hafdi Z, Dumortier J, Bringuier AF, Feldmann G, Scoazec JY. alpha6beta1 integrin expression in hepatocarcinoma cells: regulation and role in cell adhesion and migration. Int J Cancer 1999, 83:518-525. 10.1002/(SICI)1097-0215(19991112)83:4<518::AID-IJC14>3.0.CO;2-Q, 10508489.
    • (1999) Int J Cancer , vol.83 , pp. 518-525
    • Nejjari, M.1    Hafdi, Z.2    Dumortier, J.3    Bringuier, A.F.4    Feldmann, G.5    Scoazec, J.Y.6
  • 51
    • 0031595213 scopus 로고    scopus 로고
    • Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells
    • 10.1016/S0016-5085(98)70210-0, 9679049
    • Carloni V, Romanelli RG, Mercurio AM, Pinzani M, Laffi G, Cotrozzi G, Gentilini P. Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. Gastroenterology 1998, 115:433-442. 10.1016/S0016-5085(98)70210-0, 9679049.
    • (1998) Gastroenterology , vol.115 , pp. 433-442
    • Carloni, V.1    Romanelli, R.G.2    Mercurio, A.M.3    Pinzani, M.4    Laffi, G.5    Cotrozzi, G.6    Gentilini, P.7
  • 52
    • 0034743453 scopus 로고    scopus 로고
    • The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells
    • Carloni V, Mazzocca A, Pantaleo P, Cordella C, Laffi G, Gentilini P. The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells. Hepatology 2001, 34:42-49.
    • (2001) Hepatology , vol.34 , pp. 42-49
    • Carloni, V.1    Mazzocca, A.2    Pantaleo, P.3    Cordella, C.4    Laffi, G.5    Gentilini, P.6
  • 53
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • 10.1053/j.gastro.2005.09.055, 16285938
    • Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 2005, 129:1375-1383. 10.1053/j.gastro.2005.09.055, 16285938.
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 54
    • 30644467608 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced genomic instability
    • 10.1016/j.gde.2005.12.011, 2933219, 16377172
    • Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev 2006, 16:45-50. 10.1016/j.gde.2005.12.011, 2933219, 16377172.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 45-50
    • Radisky, D.C.1    Bissell, M.J.2
  • 56
    • 70350230209 scopus 로고    scopus 로고
    • Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma
    • 10.1158/0008-5472.CAN-09-0789, 19826051
    • Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res 2009, 69:8050-8057. 10.1158/0008-5472.CAN-09-0789, 19826051.
    • (2009) Cancer Res , vol.69 , pp. 8050-8057
    • Kohga, K.1    Takehara, T.2    Tatsumi, T.3    Miyagi, T.4    Ishida, H.5    Ohkawa, K.6    Kanto, T.7    Hiramatsu, N.8    Hayashi, N.9
  • 57
    • 84868099862 scopus 로고    scopus 로고
    • ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma
    • 10.1007/s13277-012-0405-4, 22581584
    • Yang CL, Jiang FQ, Xu F, Jiang GX. ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma. Tumour Biol 2012, 33:1535-1541. 10.1007/s13277-012-0405-4, 22581584.
    • (2012) Tumour Biol , vol.33 , pp. 1535-1541
    • Yang, C.L.1    Jiang, F.Q.2    Xu, F.3    Jiang, G.X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.