Knockout of α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells

Gastroenterology

Volumn 115, Issue 2, 1998, Pages 433-442

  Carloni, V ^a   Romanelli, R G ^a   Mercurio, A M ^a   Pinzani, M ^a   Laffi, G ^a   Cotrozzi, G ^a   Gentilini, P ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LAMININ RECEPTOR; PROTEIN SUBUNIT; BETA4 INTEGRIN; LEUKOCYTE ANTIGEN; PEPTIDE FRAGMENT; VERY LATE ACTIVATION ANTIGEN 6;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL STRAIN HEPG2; DELETION MUTANT; GENE OVEREXPRESSION; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; CANCER INVASION; CELL CULTURE; CELL DIVISION; CELL MOTION; CELL TRANSFORMATION; GENE DELETION; GENETIC TRANSFECTION; GENETICS; HUMAN; LIVER TUMOR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY;

ANTIGENS, CD; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; GENE DELETION; HUMANS; INTEGRIN ALPHA6BETA1; INTEGRIN BETA4; INTEGRINS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; PEPTIDE FRAGMENTS; PHENOTYPE; RECEPTORS, LAMININ; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0031595213     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70210-0     Document Type: Article

References (37)

1. N Munoz FX. Bosch Epidemiology of hepatocellular carcinoma K Okuda KG Ishak Neoplasms of the liver. 1987 Springer-Verlag Tokyo 3 19
2. C Tiribelli M Malato LS Croce L Giarelli K Okuda K. Ohnishi Prevalence of hepatocellular carcinoma and relation to cirrhosis Hepatology 10 1989 798 805
3. P Gentilini L Melani D Riccardi V Casini Raggi RG. Romanelli Hepatocellular carcinoma and viral cirrhosis Hepatology 20 1994 764 765
4. NLR Bucher GS Robinson SR. Farmer Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and their repair of liver injury Semin Liver Dis 10 1992 11 19
5. RO. Hynes Integrins: versatility, modulation, and signaling in cell adhesion Cell 69 1992 11 25
6. A Sonnenberg CJT Linders JH Daams SJ. Kennel The α6β1 (VLA-6) and α6β4 protein complexes: tissue distributions and biochemical properties J Cell Sci 96 1990 207 217
7. EC Lee MM Lotz GD Steele AM. Mercurio The integrin α6β4 is a laminin receptor J Cell Biol 117 1992 671 678
8. AM. Mercurio Laminin receptors: achieving specificity through cooperation Trends Cell Biol 5 1995 419 423
9. R Volpes JJ van den Oord VJ. Desmet Distribution of the VLA family of integrins in normal and pathological human liver tissue Gastroenterology 101 1991 200 206
10. R Volpes JJ van den Oord VJ. Desmet Integrins as differential cell lineage markers in primary liver tumors Am J Pathol 142 1993 1483 1492
11. A Couvelard JY Scoazec G. Feldmann Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver Am J Pathol 143 1993 738 752
12. NA Begum M Mori T Matsumata K Takenaka K Sugimachi GF. Barnard Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma Hepatology 22 1995 1447 1455
13. BB Knowles CC Howe DP. Aden Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen Science 209 1980 497 499
14. LM Shaw C Chao UM Wewer AM. Mercurio Function of the integrin α6β1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor Cancer Res 56 1996 959 963
15. AS Clarke MM Lotz C Chao AM. Mercurio Activation of the p21 pathway of growth arrest and apoptosis by the β4 integrin cytoplasmic domain J Biol Chem 270 1995 22673 22676
16. V Carloni RG Romanelli M Pinzani G Laffi P. Gentilini Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells Gastroenterology 110 1996 1127 1136
17. V Carloni RG Romanelli M Pinzani G Laffi P. Gentilini Focal adhesion kinase and phospholipase Cγ involvement in adhesion and migration of human hepatic stellate cells Gastroenterology 112 1997 522 531
18. A Albini Y Iwamoto HK Kleinman GR Martin SA Aaronson JM Kozlowski RN. Mc Ewan A rapid in vitro assay for quantitating the invasive potential of tumor cells Cancer Res 47 1987 3239 3245
19. A Casini M Pinzani S Milani C Grappone G Galli AM Jezequel D Schuppan CM Rotella C. Surrenti Regulation of transforming growth factor β1 in human fat-storing cells Gastroenterology 105 1993 245 253
20. M Pinzani L Gesualdo GM Sabbah HE. Abboud Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth in cultured rat liver fat-storing cells J Clin Invest 84 1989 1786 1793
21. ME Hemler C Crouse A. Sonnenberg Association of the VLA-6 subunit with a novel protein J Biol Chem 264 1989 6529 6535
22. L Spinardi S Einheber T Cullen TA Milner FG. Giancotti A recombinant tailless integrin β4 subunit disrupts hemidesmosomes, but does not suppress α6β4-mediated cell adhesion to laminins J Cell Biol 129 1995 473 487
23. WF Grigioni S Garbisa A D'Errico P Baccarini WG Stetler-Stevenson LA Liotta AM. Mancini Evaluation of hepatocellular carcinoma aggressiveness by a panel of extracellular matrix antigens Am J Pathol 138 1991 647 654
24. T Torimura T Ueno M Kin S Inuzuka M Sata K. Tanikawa Increased expression of laminin-binding integrins in hepatocellular carcinoma (abstr) Hepatology 20 1994 276A
25. MJ Ignatius LF. Reichardt Identification of a neuronal laminin receptor: an Mr 200/120 kD integrin heterodimer that binds laminin in a divalent cation-dependent manner Neuron 1 1988 713 725
26. P Vandenberg A Kern A Ries L Luckenbill-Edds K Mann K. Kuhn Characterization of a type IV collagen major cell binding site with affinity to the α1β1 and the α2β1 integrins J Cell Biol 113 1991 1475 1483
27. MJ Elices ME. Hemler The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others Proc Natl Acad Sci USA 86 1989 9906 9910
28. D Kirchhofer LR Languino E Ruoslathi MD. Pierschbacher α2β1 integrins from different cell types show different binding specificities J Biol Chem 265 1990 615 618
29. M Lotz C Korzelius AM. Mercurio Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of α2β1 and α6β4 integrins Cell Regul 1 1990 249 257
30. A Sonnenberg CJT Linders PW Modderman CH Damsky M Aumailley R. Timpl Integrin recognition of the different cell-binding fragments of laminin (P1, E3, E8) and evidence that α6β1 but not α6β4 functions as a major receptor for fragment E8 J Cell Biol 110 1990 2145 2155
31. GO Delwel F Hogervorst I Kuikman M Paulsson R Timpl A. Sonnenberg Expression and function of the cytoplasmic variants of the integrin α6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin J Biol Chem 268 1993 25865 25875
32. I Rabinovitz RB Nagle AE. Cress Integrin α6 expression in human prostate carcinoma cells is associated with migratory and invasive phenotype in vitro and in vivo Clin Exp Metastasis 13 1995 481 491
33. K Friedrichs P Ruiz F Franke I Gille H-J Terpe AB. Imhof High expression level of α6 integrin in human breast carcinoma is correlated with reduced survival Cancer Res 55 1995 901 906
34. MG Jasiulionis R Chammas AM Ventura LR Travassos RR. Brentani α6β1-Integrin, a major cell surface carrier of β1-6-branched oligosaccharides, mediates migration of EJ-ras-transformed fibroblast on laminin-1 independently of its glycosylation state Cancer Res 56 1996 1682 1689
35. UM Wewer LM Shaw R Albrechtsen AM. Mercurio The integrin α6β1 promotes the survival of metastatic human breast carcinoma cells in mice Am J Pathol 151 1997 1191 1198
36. SL. Friedman The cellular basis of hepatic fibrosis: mechanisms and treatment strategies N Engl J Med 328 1993 1828 1835
37. M. Pinzani Novel insights into the biology and physiology of the Ito cell Pharmacol Ther 66 1995 386 412