Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum

Journal of Cancer Research and Clinical Oncology

Volumn 136, Issue 2, 2010, Pages 309-321

  Xia, Yunhong ^a   Chen, Rongxin ^a   Song, Zhenji ^a   Ye, Shenglong ^a   Sun, Ruixia ^a   Xue, Qiong ^a   Zhang, Zhe ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

CDNA microarray; Cultured cells; Gene expression prowles; Hepatic stellate cells; Hepatocellular carcinoma

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; GELATINASE B; INTERLEUKIN 1ALPHA; INTERLEUKIN RECEPTOR; OSTEOPONTIN; RAC2 PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; VASCULAR CELL ADHESION MOLECULE 1; WNT PROTEIN; WNT6 PROTEIN;

ADAM17 GENE; ANIMAL CELL; ARTICLE; CANCER INVASION; CCL6 GENE; CELL ACTIVATION; CELL TRANSDIFFERENTIATION; CFD GENE; ENT6 GENE; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION PROFILING; GP39 GENE; IL1A GENE; ILR7 GENE; LIVER CELL CARCINOMA; LIVER INJURY; METASTASIS; MICROARRAY ANALYSIS; MMP 9 GENE; MYOFIBROBLAST; NONHUMAN; PRAP GENE; PRIORITY JOURNAL; RAC2 GENE; RAF1 GENE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; VCAM1 GENE; WESTERN BLOTTING; ANIMAL; CATTLE; CELL CULTURE; CELL SEPARATION; CULTURE TECHNIQUE; DNA MICROARRAY; FIBROBLAST; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LIVER CELL; LIVER TUMOR; METABOLISM; METHODOLOGY; PATHOLOGY; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CATTLE; CELL CULTURE TECHNIQUES; CELL SEPARATION; CELLS, CULTURED; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATIC STELLATE CELLS; HEPATOCYTES; LIVER NEOPLASMS, EXPERIMENTAL; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 74049086775     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0666-5     Document Type: Article

References (31)

1. Adegboyega PA, Ololade O, Saada J, MiZin R, Di Mari JF, Powell DW (2004) Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. Clin Cancer Res 10:5870-5879.
2. Aishima S, Nishihara Y, Iguchi T, Taguchi K, Taketomi A, Maehara Y, Tsuneyoshi M (2008) Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma. Mod Pathol 21:256-264.
3. Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209-218.
4. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF (2007) Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 132:1937-1946.
5. De Wever O, Demetter P, Mareel M, Bracke M (2008) Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 123:2229-2238.
6. Desmoulière A, Guyot C, Gabbiani G (2004) The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol 48:509-517.
7. Dimanche-Boitrel MT, Vakaet L Jr, Pujuguet P, ChauVert B, Martin MS, Hammann A, Van Roy F, Mareel M, Martin F (1994) In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts. Int J Cancer 56:512-521.
8. Enzan H, Himeno H, Iwamura S, Onishi S, Saibara T, Yamamoto Y, Hara H (1994) Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. Hepatology 19:895-903.
9. Faouzi S, Lepreux S, Bedin C, Dubuisson L, Balabaud C, Bioulac-Sage P, Desmoulière A, Rosenbaum J (1999a) Activation of cultured rat hepatic stellate cells by tumoral hepatocytes. Lab Invest 79:485-493.
10. Faouzi S, Le Bail B, Neaud V, Boussarie L, Saric J, Bioulac-Sage P, Balabaud C, Rosenbaum J (1999b) Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol 30:275-284.
11. Futakuchi M, Ogawa K, Sano M, Tamano S, Takeshita F, Shirai T (2002) Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma. Jpn J Cancer Res 93:1175-1181.
12. Guirouilh J, Castroviejo M, Balabaud C, Desmouliere A, Rosenbaum J (2000) Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts. Int J Oncol 17:777-781.
13. Honda M, Kawai H, Shirota Y, Yamashita T, Takamura T, Kaneko S (2005) cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation. J Autoimmun 25:133-140.
14. Hong S, Park KK, Magae J, Ando K, Lee TS, Kwon TK, Kwak JY, Kim CH, Chang YC (2005) Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J Biol Chem 280:25202-25209.
15. Jiang F, Parsons CJ, Stefanovic B (2006) Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45:401-409.
16. Kellermann MG, Sobral LM, daSilva SD, Zecchin KG, Graner E, Lopes MA, Nishimoto I, Kowalski LP, Coletta RD (2007) Myo-Wbroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology 51:849-853.
17. Lau DT, Luxon BA, Xiao SY, Beard MR, Lemon SM (2005) Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis. Hepatology 42:273-281.
18. Liu C, Gaça MD, Swenson ES, Vellucci VF, Reiss M, Wells RG (2003) Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 278:11721-11728.
19. Maggard M, Meng L, Ke B, Allen R, Devgan L, Imagawa DK (2001) Antisense TGF-beta2 immunotherapy for hepatocellular carcinoma: treatment in a rat tumor model. Ann Surg Oncol 8:32-37.
20. Masamune A, Kikuta K, Watanabe T, Satoh K, Hirota M, Shimosegawa T (2008) Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol 295:G709-G717.
21. Musso O, Théret N, Campion JP, Turlin B, Milani S, Grappone C, Clément B (1997) In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. J Hepatol 126:593-605.
22. Neaud V, Faouzi S, Guirouilh J, Le Bail B, Balabaud C, Bioulac-Sage P, Rosenbaum J (1997) Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor. Hepatology 26:1458-1466.
23. Nhieu JT, Brochériou I, Préaux AM, Mallat A, Cherqui D, Zafrani ES, Mavier P (1998) Myofibroblasts and hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol 29:120-128.
24. Rockey DC, Boyles JK, Gabbiani G, Friedman SL (1992) Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 24:193-203.
25. Schmitt-Gräff A, Krüger S, Bochard F, Gabbiani G, Denk H (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 138:1233-1242.
26. Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF (2006) Fatty acid amide hydrolase determines anandamideinduced cell death in the liver. J Biol Chem 281:10431-10438.
27. Surowiak P, Murawa D, Materna V, Maciejczyk A, Pudelko M, Ciesla S, Breborowicz J, Murawa P, Zabel M, Dietel M, Lage H (2007) Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor. Anticancer Res 27:2917-2924.
28. Svegliati-Baroni G, De Minicis S, Marzioni M (2008) Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition. Liver Int 28:1052-1064.
29. Terada T, Makimoto K, Terayama N, Suzuki Y, Nakanuma Y (1996) Alpha-smooth muscle actin-positive stromal cells in cholangiocarcinomas, hepatocellular carcinomas and metastatic liver carcinomas. J Hepatol 24:706-712.
30. Tsuneyama K, Kouda W, Nakanuma Y (2002) Portal and parenchymal alterations of the liver in idiopathic portal hypertension: a histological and immunochemical study. Pathol Res Pract 198:597-603.
31. Tuchweber B, Desmoulière A, Bochaton-Piallat ML, Rubbia-Brandt L, Gabbiani G (1996) Proliferation and phenotypic modulation of portal Wbroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest 74:265-278.