Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis

Cancer Research

Volumn 59, Issue 15, 1999, Pages 3812-3820

  Testa, Jacqueline E ^a,b   Brooks, Peter C ^a,c   Lin, Jian Min ^a,d   Quigley, James P ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d Matrix Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD151 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 50 6; PETA3 ANTIGEN; TETRASPANIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CANCER IMMUNOTHERAPY; CELL MIGRATION; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; INHIBITION KINETICS; METASTASIS POTENTIAL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, CD; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL MOVEMENT; CERCOPITHECUS AETHIOPS; CHICK EMBRYO; CLONING, MOLECULAR; COS CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSARCOMA; HELA CELLS; HUMANS; MOLECULAR WEIGHT; NEOPLASM METASTASIS; TRANSFECTION;

EID: 0033179240     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Ahmad, A., and Hart, I. R. Mechanisms of metastasis. Crit. Rev. Oncol./Hematol., 26: 163-173, 1997.
2. Woodhouse, E. C., Chuaqui, R. F., and Liotta, L. A. General mechanisms of metastasis. Cancer (Phila.), 80: 1529-1537, 1997.
3. Boyd, D. Invasion and metastasis. Cancer Metastasis Rev., 15: 77-89, 1996.
4. Zetter, B. Angiogenesis and tumor metastasis. Annu. Rev. Med., 49: 407-424, 1998.
5. DeClerck, Y. A., Imren, S., Montgomery, A. M., Mueller, B. M., Reisfeld, R. A., and Laug, W. E. Proteases and protease inhibitors in tumor progression. Adv. Exp. Med. Biol., 425: 89-97, 1997.
6. Denhardt, D. T. Oncogene-initiated aberrant signaling engenders the metastatic phenotype: synergistic transcription factor interactions are targets for cancer therapy. Crit. Rev. Oncogenesis, 7: 261-291, 1996.
7. Kim, J., Yu, W., Kovalski, K., and Ossowski, L. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell, 94: 353-362, 1998.
8. Ossowski, L., and Reich, E. Experimental model for quantitative study of metastasis. Cancer Res., 40: 2300-2309, 1980.
9. Ossowski, L., and Reich, E. Loss of malignancy during serial passage of human carcinoma in culture and discordance between malignancy and transformation parameters. Cancer Res., 40: 2310-2315, 1980.
10. Testa, J. E. Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2. Cancer Res., 52: 5597-5603, 1992.
11. Brooks, P. C., Lin, J. M., French, D. L., and Quigley, J. P. Subtractive immunization yields monoclonal antibodies that specifically inhibit metastasis. J. Cell Biol., 122: 1351-1359, 1993.
12. Gordon, J. R., and Quigley, J. P. Early spontaneous metastasis in the human epidermoid carcinoma HEp3-chick embryo model: contribution of incidental colonization. Int. J. Cancer, 38: 437-444, 1986.
13. Ossowski, L., Russo, H., Gartner, M., and Wilson, E. L. Growth of a human carcinoma (HEp3) in nude mice: rapid and efficient metastasis. J. Cell. Physiol., 133: 288-296, 1987.
14. Ossowski, L., Russo-Payne, H., and Wilson, E. L. Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse. Cancer Res., 51: 274-281, 1991.
15. Seed, B., and Aruffo, A. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Natl. Acad. Sci. USA, 84: 3365-3369, 1998.
16. Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlab, G., and Chasin, L. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc. Natl. Acad. Sci. USA, 76: 1373-1376, 1979.
17. Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., and Yancopoulos, G. D. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [see comments]. Cell, 87: 1161-1169, 1996.
18. Berditchevski, F., Bazzoni, G., and Hemler, M. E. Specific association of CD63 with the VLA-3 and VLA-6 integrins. J. Biol. Chem., 270: 17784-17790, 1995.
19. Deng, G., Curriden, S. A., Wang, S., Rosenberg, S., and Loskutoff, D. J. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J. Cell Biol., 134: 1563-1571, 1996.
20. Ossowski, L., and Reich, E. Antibodies to plasminogen activator inhibit human tumor metastasis. Cell, 35: 611-619, 1983.
21. Fitter, S., Tetaz, T. J., Berndt, M. C., and Ashman, L. K. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. Blood, 86: 1348-1355, 1995.
22. Hemler, M. E., Mannion, B. A., and Berditchevski, F. Association of TM4SF proteins with integrins: relevance to cancer. Biochim. Biophys. Acta, 1287: 67-71, 1996.
23. Maecker, H. T., Todd, S. C., and Levy, S. The tetraspanin superfamily: molecular facilitators. FASEB J., 11: 428-442, 1997.
24. Wright, M. D., and Tomlinson, M. G. The ins and outs of the transmembrane 4 superfamily. Immunol. Today, 15: 588-594, 1994.
25. Yáñez-Mó, M., Alfranca, A., Cabanas, C., Marazuela, M., Tejedor, R., Ursa, M. A., Ashman, L. K., de Landazuri, M. O., and Sanchez-Madrid, F. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/ PETA-3 with α3β1 integrin localized at endothelial lateral junctions. J. Cell Biol., 141: 791-804, 1998.
26. Yauch, R. L., Berditchevski, F., Harler, M. B., Reichner, J., and Hemler, M. E. Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol. Biol. Cell, 9: 2751-2765, 1998.
27. Hasegawa, H., Utsunomiya, Y., Kishimoto, K., Yanagisawa, K., and Fujita, S. SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily [published erratum appears in J. Virol., 71: 1737, 1997]. J. Virol., 70: 3258-3263, 1996.
28. Sincock, P. M., Mayrhofer, G., and Ashman, L. K. Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and α5β1 integrin. J. Histochem. Cytochem., 45: 515-525, 1997.
29. Bell, G. M., Seaman, W. E., Niemi, E. C., and Imboden, J. B. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J. Exp. Med., 175: 527-536, 1992.
30. Nojima, Y., Hirose, T., Tachibana, K., Tanaka, T., Shi, L., Doshen, J., Freeman, G. J., Schlossman, S. F., and Morimoto, C. The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion. Cell. Immunol., 152: 249-260, 1993.
31. Lebel-Binay, S., Lagaudriere, C., Fradelizi, D., and Conjeaud, H. CD82, member of the tetra-span-transmembrane protein family, is a costimulatory protein for T cell activation. J. Immunol., 155: 101-110, 1995.
32. Claas, C., Seiter, S., Claas, A., Savelyeva, M., and Schwab, M. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule, and consumptive coagulopathy. J. Cell Biol., 141: 267-280, 1998.
33. Ikeyama, S., Koyama, M., Yamaoko, M., Sasada, R., and Miyake, M. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J. Exp. Med., 177: 1231-1237, 1993.
34. Radford, K. J., Mallesch, J., and Hersey, P. Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). Int. J. Cancer, 62: 631-635, 1995.
35. Hotta, H., Hara, I., Miyamoto, H., and Homma, M. Overexpression of the human melanoma-associated antigen ME491 partially suppresses in vivo malignant phenotypes of H-ras-transformed NIH3T3 cells in athymic nude mice. Melanoma Res., 1: 125-132, 1991.
36. Cheng, H. C., Abdel-Ghany, M., Elble, R. C., and Pauli, B. U. Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin. J. Biol. Chem., 273: 24207-24215, 1998.
37. Koop, S., MacDonald, I. C., Luzzi, K., Schmidt, E. E., Morris, V. L., Grattan, M., Khokha, R., Chambers, A. F., and Groom, A. C. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res., 55: 2520-2523, 1995.
38. Hangan, D., Uniyal, S., Morris, V. L., MacDonald, I. C., von Ballestrem, C., Chau, T., Schmidt, E. E., Chambers, A. F., Groom, A. C., and Chan, B. M. Integrin VLA-2 (α2β1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. Cancer Res., 56: 3142-3149, 1996.
39. Luzzi, K. J., MacDonald, I. C., Schmidt, E. E., Kerkvliet, N., Morris, V. L., Chambers, A. F., and Groom, A. C. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am. J. Pathol., 153: 865-873, 1998.
40. Domanico, S. Z., Pelletier, A. J., Havran, W. L., and Quaranta, V. Integrin α6A β1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate. Mol. Biol. Cell, 8: 2253-2265, 1997.
41. Radford, K. J., Thorne, R. F., and Hersey, P. Regulation of tumor cell motilily and migration by CD63 in a human melanoma cell line. J. Immunol., 158: 3353-3358, 1997.
42. Miyake, M., Koyama, M., Seno, M., and Ikeyama, S. Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. J. Exp. Med., 174: 1347-1354, 1991.
43. Shaw, A. R., Domanska, A., Mak, A., Gilchrist, A., Dobler, K., Visser, L., Poppema, S., Fliegel, L., Letarte, M., and Willett, B. J. Ectopic expression of human and feline CD9 in a human B cell line confers β1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation. J. Biol. Chem., 270: 24092-24099, 1995.
44. Takaoka, A., Hinoda, Y., Satoh, S., Adachi, Y., Itoh, F., Adachi, M., and Imai, K. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAII gene. Oncogene, 16: 1443-1453, 1998.
45. Dong, J. T., Lamb, P. W., Rinker-Schaeffer, C. W., Vukanovic, J., Ichikawa, T., Isaacs, J., and Barrett, J. C. KAII, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2 [see comments]. Science (Washington DC), 268: 884-886, 1995.
46. Takaoka, A., Hinoda, Y., Sato, S., Itoh, F., Adachi, M., Hareyama, M., and Imai, K. Reduced invasive and metastatic potentials of KAII-transfected melanoma cells. Jpn. J. Cancer Res., 89: 397-404, 1998.