Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells

Liver International

Volumn 30, Issue 1, 2010, Pages 31-41

  Sancho Bru, Pau ^a   Juez, Elena ^a   Moreno, Montserrat ^a   Khurdayan, Valeria ^a   Morales Ruiz, Manuel ^a   Colmenero, Jordi ^a   Arroyo, Vicente ^a   Brenner, David A ^b   Ginès, Pere ^a   Bataller, Ramón ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carcinoma; Hepatic stellate cells; Hepatocellular; Liver fibrosis; Liver inflammation; Replicon

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CARCINOMA CELL; CELL ACTIVATION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; FIBROGENESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PARACRINE SIGNALING; SIGNAL TRANSDUCTION; STELLATE CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL MARKERS; CALCIUM; CALCIUM SIGNALING; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; LIVER NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR CROSS-TALK;

EID: 73349108444     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02161.x     Document Type: Article

References (46)

1. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-50.
2. Bataller R, Brenner D.A. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001; 21: 437-51.
3. Bataller R, Brenner D.A. Liver fibrosis. J Clin Invest 2005; 115: 209-18.
4. Ooi LP, Crawford DH, Gotley DC, et al. Evidence that "myofibroblast-like" cells are the cellular source of capsular collagen in hepatocellular carcinoma. J Hepatol 1997; 26: 798-807.
5. Park YN, Yang CP, Cubukcu O, Thung SN, Theise N.D. Hepatic stellate cell activation in dysplastic nodules: evidence for an alternate hypothesis concerning human hepatocarcinogenesis. Liver 1997; 17: 271-4.
6. Faouzi S, Lepreux S, Bedin C, et al. Activation of cultured rat hepatic stellate cells by tumoral hepatocytes. Lab Invest 1999; 79: 485-93.
7. Olaso E, Salado C, Egilegor E, et al. Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis. Hepatology 2003; 37: 674-85.
8. Wang YQ, Luk JM, Ikeda K, et al. Regulatory role of vHL/ HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Biochem Biophys Res Commun 2004; 317: 358-62.
9. Corpechot C, Barbu V, Wendum D, et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 2002; 35: 1010-21.
10. Torimura T, Sata M, Ueno T, et al. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol 1998; 29: 986-91.
11. Lauer GM,Walker B.D. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52.
12. Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
13. Poynard T, Yuen MF, Ratziu V, Lai C.L. Viral hepatitis C. Lancet 2003; 362: 2095-100.
14. Levrero M. Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene 2006; 25: 3834-47.
15. Okuda M, Li K, Beard MR, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122: 366-75.
16. Lerat H, Honda M, Beard MR, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002; 122: 352-65.
17. Park KJ, Choi SH, Lee SY, Hwang SB, Lai M.M. Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation. J Biol Chem 2002; 277: 13122-8.
18. Sato Y, Kato J, Takimoto R, et al. Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor a expression via activation of nuclear factor-kB. Gut 2006; 55: 1801-8.
19. Sun BS, Pan J, Clayton MM, et al. Hepatitis C virus replication in stably transfected HepG2 cells promotes hepatocellular growth and tumorigenesis. J Cell Physiol 2004; 201: 447-58.
20. Bartenschlager R. The hepatitis C virus replicon system: from basic research to clinical application. J Hepatol 2005; 43: 210-6.
21. Guo JT, Sohn JA, Zhu Q, Seeger C. Mechanism of the interferon alpha response against hepatitis C virus replicons. Virology 2004; 325: 71-81.
22. Schulze-Krebs A, Preimel D, Popov Y, et al. Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. Gastroenterology 2005; 129: 246-58.
23. Zhu Q, Guo JT, Seeger C. Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells. J Virol 2003; 77: 9204-10.
24. Sancho-Bru P, Bataller R, Gasull X, et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005; 43: 272-82.
25. Bataller R, Nicolas JM, Gines P, et al. Arginine vasopressin induces contraction and stimulates growth of cultured human hepatic stellate cells. Gastroenterology 1997; 113: 615-24.
26. Paik YH, Schwabe RF, Bataller R, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003; 37: 1043-55.
27. Morales-Ruiz M, Lee MJ, Zollner S, et al. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J Biol Chem 2001; 276: 19672-7.
28. Bonacchi A, Romagnani P, Romanelli RG, et al. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem 2001; 276: 9945-54.
29. Aleffi S, Petrai I, Bertolani C, et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 2005; 42: 1339-48.
30. Yoshiji H, Kuriyama S, Yoshii J, et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut 2003; 52: 1347-54.
31. Mikula M, Proell V, Fischer AN, Mikulits W. Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 2006; 209: 560-7.
32. Torimura T, Sata M, Ueno T, et al. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol 1998; 29: 986-91.
33. Musso O, Theret N, Campion JP, et al. In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. J Hepatol 1997; 26: 593-605.
34. Torimura T, Ueno T, Kin M, et al. Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. J Hepatol 2004; 40: 799-807.
35. Reif S, Lang A, Lindquist JN, et al. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 2003; 278: 8083-90.
36. Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia S.V. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 2005; 24: 7482-92.
37. Morales-Ruiz M, Fulton D, Sowa G, et al. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 2000; 86: 892-6.
38. Guo JT, Bichko VV, Seeger C. Effect of alpha interferon on the hepatitis C virus replicon. J Virol 2001; 75: 8516-23.
39. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner D.A. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004; 126: 529-40.
40. Llovet JM, Ricci S, SHARP Investigators Study Group. et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
41. Zalatnai A. Molecular aspects of stromal-parenchymal interactions in malignant neoplasms. Curr Mol Med 2006; 6: 685-93.
42. Cat B, Stuhlmann D, Steinbrenner H, et al. Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J Cell Sci 2006; 119: 2727-38.
43. Galie M, Sorrentino C, Montani M, et al. Mammary carcinoma provides highly tumourigenic and invasive reactive stromal cells. Carcinogenesis 2005; 26: 1868-78.
44. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 429-47.
45. Beljaars L, Molema G, Schuppan D, et al. Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem 2000; 275: 12743-51.
46. Beljaars L, Molema G, Weert B, et al. Albumin modified with mannose 6-phosphate: a potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells. Hepatology 1999; 29: 1486-93.