Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 7788-7803

  Kester, Robert F ^a   Donnell, Andrew F ^a   Lou, Yan ^a   Remiszewski, Stacy W ^a   Lombardo, Louis J ^a   Chen, Shaoqing ^a   Le, Nam T ^a   Lo, Jennifer ^a   Moliterni, John A ^a   Han, Xiaochun ^a   Heather Hogg, J ^a   Liang, Weiling ^a   Michoud, Christophe ^a   Rupert, Kenneth C ^a   Mischke, Steven ^a   Le, Kang ^a   Weisel, Martin ^a   Janson, Cheryl A ^a   Lukacs, Christine M ^a   Fretland, Adrian J ^b   Hong, Kyoungja ^c   Polonskaia, Ann ^c   Gao, Lin ^a   Li, Shirley ^a   Solis, Dave S ^a   Aguilar, Doug ^a   Tardell, Christine ^c   Dvorozniak, Mark ^c   Tannu, Shahid ^c   Lee, Edmund C ^c   Schutt, Andy D ^c   Goggin, Barry ^c   more..

^a Early ADME ^*  (United States)

^b Janssen R D   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACULOVIRUS IAP REPEAT 2; BACULOVIRUS IAP REPEAT 3; BENZODIAZEPINE DERIVATIVE; CASPASE 3; CASPASE 7; CONATUMUMAB; LCL 16; LCL 161; N [5 ACETYL 7 CYANO 1 ((2 METHOXYNAPHTHALEN 1 YL)METHYL) 4 METHYL 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4] DIAZEPIN 3 YL] 2 (METHYLAMINO)PROPANAMIDE; N [7 CYANO 1 ((2 METHOXYNAPHTHALEN 1 YL)METHYL) 4METHYL 5 (2 (METHYLSULFONYL)ACETYL) 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4]DIAZEPIN 3 YL] 2 (METHYLAMINO PROPANAMIDE; TERT BUTYL 1 [8 CYANO 2 METHYL 1 (2 (METHYLSULFONYL)ACETYL) 4 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4]DIAZEPIN 3 YLAMINO] 1 OXOPROPAN 2 YL(METHYL)CARBAMATE; TERT BUTYL 5 ACETYL 7 CYANO 1 [(2 METHOXYNAPHTHALEN 1YL)METHYL] 4 METHYL 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4] DIAZEPINE 3 YLCARBAMATE; TERT BUTYL 5 ACETYL 7 CYANO 4 METHYL 1 [(2 METHYLNAPHTHALEN 1 YL)METHYL] 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4]DIAZEPIN 3 YLCARBAMATE; TERT BUTYL 7 CYANO 1 [(2 METHOXYNAPHTHALEN 1 YL)METHYL] 4 METHYL 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4] DIAZEPIN 3 YLCARBAMATE; TERT BUTYL 7 CYANO 4 METHYL 1 [(2 METHYLNAPHTHALEN 1YL)METHYL] 2 OXO 2,3,4,5 TETRAHYDRO 1H[B][1,4]DIAZEPIN 3 YLCARBAMATE; TERT BUTYL 7 CYANO 4 METHYL 2 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4]DIAZEPIN 3 YLCARBAMATE; TERT BUTYL 8 CYANO 2 METHYL 1 [2 (METHYLSULFONYL)ACETYL] 4 OXO 2,3,4,5 TETRAHYDRO 1H BENZO[B][1,4]DIAZEPIN 3 YLCARBAMATE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; MOUSE; NONHUMAN;

ALANINE; ANIMALS; APOPTOSIS; BENZODIAZEPINONES; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; FEMALE; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, NUDE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886470433     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400732v     Document Type: Article

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