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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 8, 2002, Pages 1225-1227

A practical synthesis of (S) 3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1- acetic acid methyl ester as a conformationally restricted dipeptido-mimetic for caspase-1 (ICE) inhibitors

(2) Lauffer, David J a Mullican, Michael D a

a VERTEX PHARMACEUTICALS (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 TERT BUTOXYCARBONYLAMINO 2 OXO 2,3,4,5 TETRAHYDRO 1,5 BENZODIAZEPIN 1 ACETIC ACID METHYL ESTER; AMINE; CASPASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; NITROGEN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BENZODIAZEPINES; CASPASE 1; CYSTEINE PROTEINASE INHIBITORS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY;

EID: 0037156352 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00107-5 Document Type: Article

Times cited : (53)

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