Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway

Toxicology Letters

Volumn 199, Issue 3, 2010, Pages 341-346

  Chinen, Takumi ^a   Nagumo, Yoko ^a   Watanabe, Tsubasa ^b   Imaizumi, Takamichi ^b   Shibuya, Masatoshi ^b   Kataoka, Takao ^c   Kanoh, Naoki ^b   Iwabuchi, Yoshiharu ^b   Usui, Takeo ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Apoptosis; Caspase 8; Irciniastatin A; JNK; Ribotoxic stress

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 8; IRCINIASTATIN A; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; PROTEIN BCL XL; PROTEIN SYNTHESIS INHIBITOR; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DRUG MECHANISM; ENANTIOSELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 8; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; PYRONES; REACTIVE OXYGEN SPECIES;

EID: 78650511655     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.09.017     Document Type: Article

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