-
1
-
-
38849096990
-
Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer
-
(doi:10.1093/annonc/mdm429)
-
Andre F, Nahta R, Conforti R, Boulet T, Aziz M, Yuan LX, Meslin F, Spielmann M, Tomasic G, Pusztai L et al. 2008 Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer. Annals of Oncology 19 315-320. (doi:10.1093/annonc/mdm429)
-
(2008)
Annals of Oncology
, vol.19
, pp. 315-320
-
-
Andre, F.1
Nahta, R.2
Conforti, R.3
Boulet, T.4
Aziz, M.5
Yuan, L.X.6
Meslin, F.7
Spielmann, M.8
Tomasic, G.9
Pusztai, L.10
-
3
-
-
77952465463
-
Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen consensus statement for early breast cancer
-
(doi:10.1186/1471-2407-10-228)
-
Bauer K, Parise C & Caggiano V 2010 Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen consensus statement for early breast cancer. BMC Cancer 10 228. (doi:10.1186/1471-2407-10-228)
-
(2010)
BMC Cancer
, vol.10
, pp. 228
-
-
Bauer, K.1
Parise, C.2
Caggiano, V.3
-
4
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
(doi:10.1016/j.ccr.2007.08.030)
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M et al. 2007 A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12 395-402. (doi:10.1016/j.ccr.2007.08.030)
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
-
5
-
-
79952192520
-
Semiquantitative hormone receptor level influences response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancer
-
(doi:10.1038/modpathol.2010.209)
-
Bhargava R, Dabbs DJ, Beriwal S, Yildiz IA, Badve P, Soran A, Johnson RR, Brufsky AM, Lembersky BC, McGuire KP et al. 2011 Semiquantitative hormone receptor level influences response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancer. Modern Pathology 24 367-374. (doi:10.1038/modpathol.2010.209)
-
(2011)
Modern Pathology
, vol.24
, pp. 367-374
-
-
Bhargava, R.1
Dabbs, D.J.2
Beriwal, S.3
Yildiz, I.A.4
Badve, P.5
Soran, A.6
Johnson, R.R.7
Brufsky, A.M.8
Lembersky, B.C.9
McGuire, K.P.10
-
6
-
-
84874565337
-
Progesterone receptor loss identifies luminal B breast cancer subgroups at higher risk of relapse
-
(doi:10.1093/ annonc/mds430)
-
Cancello G, Maisonneuve P, Rotmensz N, Viale G, Mastropasqua MG, Pruneri G, Montagna E, Iorfida M, Mazza M, Balduzzi A et al. 2012 Progesterone receptor loss identifies luminal B breast cancer subgroups at higher risk of relapse. Annals of Oncology 24 661-668. (doi:10.1093/ annonc/mds430)
-
(2012)
Annals of Oncology
, vol.24
, pp. 661-668
-
-
Cancello, G.1
Maisonneuve, P.2
Rotmensz, N.3
Viale, G.4
Mastropasqua, M.G.5
Pruneri, G.6
Montagna, E.7
Iorfida, M.8
Mazza, M.9
Balduzzi, A.10
-
7
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
(doi:10.1073/pnas.89.10.4285)
-
Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, Rowland AM, Kotts C, CarverME & Shepard HM1992 Humanization of an anti-p185HER2 antibody for human cancer therapy. PNAS 89 4285-4289. (doi:10.1073/pnas.89.10. 4285)
-
(1992)
PNAS
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
Ridgway, J.B.4
Henner, D.5
Wong, W.L.6
Rowland, A.M.7
Kotts, C.8
Carver, M.E.9
Shepard, H.M.10
-
8
-
-
70149087281
-
Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance
-
(doi:10.1111/j.1349-7006.2009.01217.x)
-
Chen YY, Wang ZX, Chang PA, Li JJ, Pan F, Yang L, Bian ZH, Zou L, He JM & Liang HJ 2009 Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance. Cancer Science 100 1708-1713. (doi:10.1111/j.1349- 7006.2009.01217.x)
-
(2009)
Cancer Science
, vol.100
, pp. 1708-1713
-
-
Chen, Y.Y.1
Wang, Z.X.2
Chang, P.A.3
Li, J.J.4
Pan, F.5
Yang, L.6
Zh, B.7
Zou, L.8
He, J.M.9
Liang, H.J.10
-
9
-
-
36549031307
-
TGFb-induced EMT requires focal adhesion kinase (FAK) signaling
-
(doi:10.1016/j.yexcr.2007.09.005)
-
Cicchini C, Laudadio I, Citarella F, Corazzari M, Steindler C, Conigliaro A, Fantoni A, Amicone L & Tripodi M 2008 TGFb-induced EMT requires focal adhesion kinase (FAK) signaling. Experimental Cell Research 314 143-152. (doi:10.1016/j.yexcr.2007.09.005)
-
(2008)
Experimental Cell Research
, vol.314
, pp. 143-152
-
-
Cicchini, C.1
Laudadio, I.2
Citarella, F.3
Corazzari, M.4
Steindler, C.5
Conigliaro, A.6
Fantoni, A.7
Amicone, L.8
Tripodi, M.9
-
10
-
-
79960341728
-
Dual targeting of EGFR and focal adhesion kinase in 3D grown HNSCC cell cultures
-
(doi:10.1016/j.radonc.2011.06.006)
-
Eke I & Cordes N 2011 Dual targeting of EGFR and focal adhesion kinase in 3D grown HNSCC cell cultures. Radiotherapy and Oncology 99 279-286. (doi:10.1016/j.radonc.2011.06.006)
-
(2011)
Radiotherapy and Oncology
, vol.99
, pp. 279-286
-
-
Eke, I.1
Cordes, N.2
-
11
-
-
79952233837
-
Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers
-
(doi:10.1158/0008- 5472.CAN-10-1872)
-
Ghosh R, Narasanna A, Wang SE, Liu S, Chakrabarty A, Balko JM, Gonzalez-Angulo AM, Mills GB, Penuel E, Winslow J et al. 2011 Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Research 71 1871-1882. (doi:10.1158/0008- 5472.CAN-10-1872)
-
(2011)
Cancer Research
, vol.71
, pp. 1871-1882
-
-
Ghosh, R.1
Narasanna, A.2
Wang, S.E.3
Liu, S.4
Chakrabarty, A.5
Balko, J.M.6
Gonzalez-Angulo, A.M.7
Mills, G.B.8
Penuel, E.9
Winslow, J.10
-
12
-
-
78649661917
-
A Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer
-
(doi:10.1186/ bcr2493)
-
Gijsen M, King P, Perera T, Parker P, Larijani B, Harris A & Kong A 2010a Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer. Breast Cancer Research 12 (Suppl 1) O2. (doi:10.1186/ bcr2493)
-
(2010)
Breast Cancer Research
, vol.12
, Issue.SUPPL. 1
-
-
Gijsen, M.1
King, P.2
Perera, T.3
Parker, P.4
Larijani, B.5
Harris, A.6
Kong, A.7
-
13
-
-
78650487946
-
B HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer
-
(doi:10.1371/journal.pbio.1000563)
-
Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B & Kong A 2010b HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biology 8 e1000563. (doi:10.1371/journal.pbio.1000563)
-
(2010)
PLoS Biology
, vol.8
-
-
Gijsen, M.1
King, P.2
Perera, T.3
Parker, P.J.4
Harris, A.L.5
Larijani, B.6
Kong, A.7
-
14
-
-
0037064030
-
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells
-
(doi:10.1074/jbc.M205002200)
-
Golubovskaya V, Beviglia L, Xu LH, Earp HS III, Craven R & CanceW2002 Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. Journal of Biological Chemistry 277 38978-38987. (doi:10.1074/jbc.M205002200)
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 38978-38987
-
-
Golubovskaya, V.1
Beviglia, L.2
Xu, L.H.3
Earp III, H.S.4
Craven, R.5
Cance, W.6
-
15
-
-
84869811250
-
Molecular subclasses of breast cancer: How do we define them? The IMPAKT 2012 working group statement
-
(doi: 10.1093/annonc/mds586)
-
Guiu S, Michiels S, Andre F, Cortes J, Denkert C, Di Leo A, Hennessy BT, Sorlie T, Sotiriou C, Turner N et al. 2012 Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement Annals of Oncology 23 2997-3006. (doi:10.1093/annonc/mds586)
-
(2012)
Annals of Oncology
, vol.23
, pp. 2997-3006
-
-
Guiu, S.1
Michiels, S.2
Andre, F.3
Cortes, J.4
Denkert, C.5
Di Leo, A.6
Hennessy, B.T.7
Sorlie, T.8
Sotiriou, C.9
Turner, N.10
-
16
-
-
36348933509
-
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma
-
(doi:10.1158/0008-5472.CAN-07-2667)
-
Halder J, Lin YG, MerrittWM, Spannuth WA, Nick AM, Honda T, Kamat AA, Han LY, Kim TJ, Lu C et al. 2007 Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Research 67 10976-10983. (doi:10.1158/0008-5472.CAN-07-2667)
-
(2007)
Cancer Research
, vol.67
, pp. 10976-10983
-
-
Halder, J.1
Lin, Y.G.2
Merritt, W.M.3
Spannuth, W.A.4
Nick, A.M.5
Honda, T.6
Kamat, A.A.7
Han, L.Y.8
Kim, T.J.9
Lu, C.10
-
17
-
-
14944377114
-
Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs
-
Han EK, McGonigal T, Wang J, Giranda VL & Luo Y 2004 Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs. Anticancer Research 24 3899-3905.
-
(2004)
Anticancer Research
, vol.24
, pp. 3899-3905
-
-
Han, E.K.1
McGonigal, T.2
Wang, J.3
Giranda, V.L.4
Luo, Y.5
-
18
-
-
84867322865
-
Impact of breast cancer subtypes and treatment on survival: An analysis spanning two decades
-
(doi:10.1158/ 1055-9965.EPI-12-0474)
-
Haque R, Ahmed SA, Inzhakova G, Shi J, Avila C, Polikoff J, Bernstein L, Enger SM & Press MF 2012 Impact of breast cancer subtypes and treatment on survival: an analysis spanning two decades. Cancer Epidemiology, Biomarkers & Prevention 21 1848-1855. (doi:10.1158/ 1055-9965.EPI-12-0474)
-
(2012)
Cancer Epidemiology, Biomarkers & Prevention
, vol.21
, pp. 1848-1855
-
-
Haque, R.1
Ahmed, S.A.2
Inzhakova, G.3
Shi, J.4
Avila, C.5
Polikoff, J.6
Bernstein, L.7
Enger, S.M.8
Press, M.F.9
-
19
-
-
84863620267
-
Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling
-
(doi:10.1016/j.ijrobp.2012.01.065)
-
Hehlgans S, Eke I&CordesN2012 Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling. International Journal of Radiation Oncology, Biology, Physics 83 e669-e676. (doi:10.1016/j.ijrobp.2012.01.065)
-
(2012)
International Journal of Radiation Oncology, Biology, Physics
, vol.83
-
-
Hehlgans, S.1
Eke, I.2
Cordes, N.3
-
20
-
-
79151480076
-
Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells
-
(doi:10.1007/s10549-010-0857-4)
-
Hiscox S, Barnfather P, Hayes E, Bramble P, Christensen J, Nicholson RI & Barrett-Lee P 2011 Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells. Breast Cancer Research and Treatment 125 659-669. (doi:10.1007/s10549-010-0857-4)
-
(2011)
Breast Cancer Research and Treatment
, vol.125
, pp. 659-669
-
-
Hiscox, S.1
Barnfather, P.2
Hayes, E.3
Bramble, P.4
Christensen, J.5
Nicholson, R.I.6
Barrett-Lee, P.7
-
21
-
-
0024516756
-
Overexpression of the c-erbB-2 protein in human breast tumor cell lines
-
(doi:10.1002/jcb.240390208)
-
Hynes NE, Gerber HA, Saurer S & Groner B 1989 Overexpression of the c-erbB-2 protein in human breast tumor cell lines. Journal of Cellular Biochemistry 39 167-173. (doi:10.1002/jcb.240390208)
-
(1989)
Journal of Cellular Biochemistry
, vol.39
, pp. 167-173
-
-
Hynes, N.E.1
Gerber, H.A.2
Saurer, S.3
Groner, B.4
-
22
-
-
84862990976
-
Safety, pharmacokinetic, and pharmacodynamic phase i dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors
-
(doi:10.1200/ JCO.2011.38.9346)
-
Infante JR, Camidge DR, Mileshkin LR, Chen EX, Hicks RJ, Rischin D, Fingert H, Pierce KJ, Xu H, Roberts WG et al. 2012 Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. Journal of Clinical Oncology 30 1527-1533. (doi:10.1200/ JCO.2011.38.9346)
-
(2012)
Journal of Clinical Oncology
, vol.30
, pp. 1527-1533
-
-
Infante, J.R.1
Camidge, D.R.2
Mileshkin, L.R.3
Chen, E.X.4
Hicks, R.J.5
Rischin, D.6
Fingert, H.7
Pierce, K.J.8
Xu, H.9
Roberts, W.G.10
-
23
-
-
84878232748
-
Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence
-
(doi:10.1245/s10434-012-2825-1)
-
Ishitobi M,OkumuraY,ArimaN, Yoshida A, Nakatsukasa K, IwaseT, Shien T, Masuda N, Tanaka S, Tanabe M et al. 2013 Breast cancer subtype and distant recurrence after ipsilateral breast tumor recurrence. Annals of Surgical Oncology 20 1886-1892. (doi:10.1245/s10434-012-2825-1)
-
(2013)
Annals of Surgical Oncology
, vol.20
, pp. 1886-1892
-
-
Ishitobi, M.1
Okumura, Y.2
Arima, N.3
Yoshida, A.4
Nakatsukasa, K.5
Iwase, T.6
Shien, T.7
Masuda, N.8
Tanaka, S.9
Tanabe, M.10
-
24
-
-
1942534181
-
Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma
-
(doi:10.1158/1078-0432.CCR-1046-03)
-
Itoh S, Maeda T, Shimada M, Aishima S, Shirabe K, Tanaka S & Maehara Y 2004 Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clinical Cancer Research 10 2812-2817. (doi:10.1158/1078-0432.CCR-1046-03)
-
(2004)
Clinical Cancer Research
, vol.10
, pp. 2812-2817
-
-
Itoh, S.1
Maeda, T.2
Shimada, M.3
Aishima, S.4
Shirabe, K.5
Tanaka, S.6
Maehara, Y.7
-
25
-
-
65349101151
-
Ligand-independent HER2/HER3/ PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
(doi:10.1016/ j.ccr.2009.03.020)
-
Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D & Sliwkowski MX 2009 Ligand-independent HER2/HER3/ PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 15 429-440. (doi:10.1016/ j.ccr.2009.03.020)
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
Fields, C.4
Lewis Phillips, G.D.5
Friedman, L.S.6
Sampath, D.7
Sliwkowski, M.X.8
-
26
-
-
2942531163
-
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
-
(doi:10.1128/MCB.24.10.4361-4371.2004)
-
Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Liu ZG & CanceWG2004 Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Molecular and Cellular Biology 24 4361-4371. (doi:10.1128/MCB.24.10.4361-4371.2004)
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 4361-4371
-
-
Kurenova, E.1
Xu, L.H.2
Yang, X.3
Baldwin Jr., A.S.4
Craven, R.J.5
Hanks, S.K.6
Liu, Z.G.7
Cance, W.G.8
-
27
-
-
24944531575
-
High focal adhesion kinase expression in invasive breast carcinomas is associatedwith an aggressive phenotype
-
(doi:10.1038/modpathol. 3800424)
-
Lark AL, Livasy CA,Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ et al. 2005 High focal adhesion kinase expression in invasive breast carcinomas is associatedwith an aggressive phenotype. Modern Pathology 18 1289-1294. (doi:10.1038/modpathol. 3800424)
-
(2005)
Modern Pathology
, vol.18
, pp. 1289-1294
-
-
Lark, A.L.1
Livasy, C.A.2
Dressler, L.3
Moore, D.T.4
Millikan, R.C.5
Geradts, J.6
Iacocca, M.7
Cowan, D.8
Little, D.9
Craven, R.J.10
-
28
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
-
(doi:10.1158/0008-5472.CAN-08-0380)
-
Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP, Sliwkowski MX & Stern HM 2008 A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Research 68 5878-5887. (doi:10.1158/0008-5472.CAN-08-0380)
-
(2008)
Cancer Research
, vol.68
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
Pham, T.4
Munroe, X.5
Hoeflich, K.P.6
Sliwkowski, M.X.7
Stern, H.M.8
-
29
-
-
28644435769
-
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
-
(doi:10.1038/sj.bjc.6602862)
-
Lin HJ, Hsieh FC, Song H & Lin J 2005 Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. British Journal of Cancer 93 1372-1381. (doi:10.1038/sj.bjc.6602862)
-
(2005)
British Journal of Cancer
, vol.93
, pp. 1372-1381
-
-
Lin, H.J.1
Hsieh, F.C.2
Song, H.3
Lin, J.4
-
30
-
-
34249863300
-
Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptine) in HER2-overexpressing breast cancer cells
-
(doi:10.1186/1471-2407-7-80)
-
Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-GutierrezA&Segura-CarreteroA2007Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptine) in HER2-overexpressing breast cancer cells. BMC Cancer 7 80. (doi:10.1186/1471- 2407-7-80)
-
(2007)
BMC Cancer
, vol.7
, pp. 80
-
-
Menendez, J.A.1
Vazquez-Martin, A.2
Colomer, R.3
Brunet, J.4
Carrasco-Pancorbo, A.5
Garcia-Villalba, R.6
Fernandez-Gutierrez, A.7
Segura-Carretero, A.8
-
31
-
-
70350441646
-
Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel
-
(doi:10.1200/JCO. 2008.21.7075)
-
Millar EK, Graham PH, O'Toole SA, McNeil CM, Browne L, Morey AL, Eggleton S, Beretov J, Theocharous C, Capp A et al. 2009 Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. Journal of Clinical Oncology 27 4701-4708. (doi:10.1200/JCO. 2008.21.7075)
-
(2009)
Journal of Clinical Oncology
, vol.27
, pp. 4701-4708
-
-
Millar, E.K.1
Graham, P.H.2
O'toole, S.A.3
McNeil, C.M.4
Browne, L.5
Morey, A.L.6
Eggleton, S.7
Beretov, J.8
Theocharous, C.9
Capp, A.10
-
33
-
-
84858189073
-
Pharmacological strategies to overcome HER2 cross-talk and trastuzumab resistance
-
(doi:10.2174/092986712799320691)
-
Nahta R 2012 Pharmacological strategies to overcome HER2 cross-talk and trastuzumab resistance. Current Medicinal Chemistry 19 1065-1075. (doi:10.2174/092986712799320691)
-
(2012)
Current Medicinal Chemistry
, vol.19
, pp. 1065-1075
-
-
Nahta, R.1
-
34
-
-
44249114098
-
Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
-
(doi:10.1200/JCO. 2007.14.4287)
-
Nguyen PL, Taghian AG, Katz MS, Niemierko A, Abi Raad RF, Boon WL, Bellon JR, Wong JS, Smith BL & Harris JR 2008 Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. Journal of Clinical Oncology 26 2373-2378. (doi:10.1200/JCO. 2007.14.4287)
-
(2008)
Journal of Clinical Oncology
, vol.26
, pp. 2373-2378
-
-
Nguyen, P.L.1
Taghian, A.G.2
Katz, M.S.3
Niemierko, A.4
Abi Raad, R.F.5
Boon, W.L.6
Bellon, J.R.7
Wong, J.S.8
Smith, B.L.9
Harris, J.R.10
-
35
-
-
70449707887
-
Breast cancer subtypes as defined by the estrogen receptor (ER), progesterone receptor (PR) , and the human epidermal growth factor receptor 2 (HER2) among women with invasive breast cancer in California, 1999-2004
-
(doi:10.1111/j.1524-4741.2009.00822.x)
-
Parise CA, Bauer KR, Brown MM& Caggiano V 2009 Breast cancer subtypes as defined by the estrogen receptor (ER), progesterone receptor (PR) , and the human epidermal growth factor receptor 2 (HER2) among women with invasive breast cancer in California, 1999-2004. Breast Journal 15 593-602. (doi:10.1111/j.1524-4741.2009.00822.x)
-
(2009)
Breast Journal
, vol.15
, pp. 593-602
-
-
Parise, C.A.1
Bauer, K.R.2
Brown, M.M.3
Caggiano, V.4
-
36
-
-
84856358910
-
Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry
-
(doi:10.1016/j.breast.2011.07.008)
-
Park S, Koo JS, Kim MS, Park HS, Lee JS, Kim SI & Park BW 2012 Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry. Breast 21 50-57. (doi:10.1016/j.breast.2011.07.008)
-
(2012)
Breast
, vol.21
, pp. 50-57
-
-
Park, S.1
Koo, J.S.2
Kim, M.S.3
Park, H.S.4
Lee, J.S.5
Kim, S.I.6
Park, B.W.7
-
37
-
-
48349129798
-
MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells
-
(doi:10.1038/sj.bjc.6604517)
-
Ponnusamy MP, Singh AP, Jain M, Chakraborty S, Moniaux N & Batra SK 2008 MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. British Journal of Cancer 99 520-526. (doi:10.1038/sj.bjc.6604517)
-
(2008)
British Journal of Cancer
, vol.99
, pp. 520-526
-
-
Ponnusamy, M.P.1
Singh, A.P.2
Jain, M.3
Chakraborty, S.4
Moniaux, N.5
Batra, S.K.6
-
38
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
(doi:10.1056/NEJMoa052122)
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA et al. 2005 Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. New England Journal ofMedicine353 1673-1684. (doi:10.1056/NEJMoa052122)
-
(2005)
New England Journal OfMedicine
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer Jr., C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
-
39
-
-
27144539046
-
Highexpression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
-
(doi:10.1186/bcr977)
-
Schmitz KJ, Grabellus F, Callies R, Otterbach F,Wohlschlaeger J, Levkau B, Kimmig R, SchmidKW&BabaHA2005Highexpression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Research 7 R194-R203. (doi:10.1186/bcr977)
-
(2005)
Breast Cancer Research
, vol.7
-
-
Schmitz, K.J.1
Grabellus, F.2
Callies, R.3
Otterbach, F.4
Wohlschlaeger, J.5
Levkau, B.6
Kimmig, R.7
Schmid, K.W.8
Baba, H.A.9
-
40
-
-
0033772308
-
FAK integrates growth-factor and integrin signals to promote cell migration
-
(doi:10.1038/ 35010517)
-
Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH & Schlaepfer DD 2000 FAK integrates growth-factor and integrin signals to promote cell migration. Nature Cell Biology 2 249-256. (doi:10.1038/ 35010517)
-
(2000)
Nature Cell Biology
, vol.2
, pp. 249-256
-
-
Sieg, D.J.1
Hauck, C.R.2
Ilic, D.3
Klingbeil, C.K.4
Schaefer, E.5
Damsky, C.H.6
Schlaepfer, D.D.7
-
41
-
-
34447538483
-
Cellular characterization of a novel focal adhesion kinase inhibitor
-
(doi:10.1074/jbc.M606695200)
-
Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG et al. 2007 Cellular characterization of a novel focal adhesion kinase inhibitor. Journal of Biological Chemistry 282 14845-14852. (doi:10.1074/jbc.M606695200)
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 14845-14852
-
-
Slack-Davis, J.K.1
Martin, K.H.2
Tilghman, R.W.3
Iwanicki, M.4
Ung, E.J.5
Autry, C.6
Luzzio, M.J.7
Cooper, B.8
Kath, J.C.9
Roberts, W.G.10
-
42
-
-
27644545721
-
Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines
-
(doi:10.1097/ 00008390-200510000-00003)
-
Smith CS, Golubovskaya VM, Peck E, Xu LH, Monia BP, Yang X & Cance WG 2005 Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Research 15 357-362. (doi:10.1097/ 00008390-200510000-00003)
-
(2005)
Melanoma Research
, vol.15
, pp. 357-362
-
-
Smith, C.S.1
Golubovskaya, V.M.2
Peck, E.3
Xu, L.H.4
Monia, B.P.5
Yang, X.6
Cance, W.G.7
-
43
-
-
0018425119
-
Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
-
(doi:10.1016/ 0360-3016(79) 90044-0)
-
Steel GG & Peckham MJ 1979 Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. International Journal of Radiation Oncology, Biology, Physics 5 85-91. (doi:10.1016/ 0360-3016(79) 90044-0)
-
(1979)
International Journal of Radiation Oncology, Biology, Physics
, vol.5
, pp. 85-91
-
-
Steel, G.G.1
Peckham, M.J.2
-
44
-
-
77953709612
-
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
-
(doi:10.4161/cbt.9.10.11434)
-
Tanjoni I, Walsh C, Uryu S, Tomar A, Nam JO, Mielgo A, Lim ST, Liang C, Koenig M, Sun C et al. 2010 PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biology & Therapy 9 764-777. (doi:10.4161/cbt.9.10.11434)
-
(2010)
Cancer Biology & Therapy
, vol.9
, pp. 764-777
-
-
Tanjoni, I.1
Walsh, C.2
Uryu, S.3
Tomar, A.4
Nam, J.O.5
Mielgo, A.6
Lim, S.T.7
Liang, C.8
Koenig, M.9
Sun, C.10
-
45
-
-
44849117186
-
Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial
-
(doi:10.1093/annonc/mdn005)
-
Untch M, Gelber RD, Jackisch C, Procter M, Baselga J, Bell R, Cameron D, Bari M, Smith I, Leyland-Jones B et al. 2008 Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial. Annals of Oncology 19 1090-1096. (doi:10.1093/annonc/mdn005)
-
(2008)
Annals of Oncology
, vol.19
, pp. 1090-1096
-
-
Untch, M.1
Gelber, R.D.2
Jackisch, C.3
Procter, M.4
Baselga, J.5
Bell, R.6
Cameron, D.7
Bari, M.8
Smith, I.9
Leyland-Jones, B.10
-
46
-
-
0036135726
-
Differential regulation of components of the focal adhesion complex by heregulin: Role of phosphatase SHP-2
-
(doi:10.1002/jcp.10054)
-
Vadlamudi RK, Adam L, Nguyen D, Santos M & Kumar R 2002 Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. Journal of Cellular Physiology 190 189-199. (doi:10.1002/jcp.10054)
-
(2002)
Journal of Cellular Physiology
, vol.190
, pp. 189-199
-
-
Vadlamudi, R.K.1
Adam, L.2
Nguyen, D.3
Santos, M.4
Kumar, R.5
-
47
-
-
0038393116
-
Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215
-
(doi:10.1016/S0014- 5793(03) 00404-6)
-
Vadlamudi RK, Sahin AA, Adam L, Wang RA & Kumar R 2003 Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. FEBS Letters 543 76-80. (doi:10.1016/S0014- 5793(03) 00404-6)
-
(2003)
FEBS Letters
, vol.543
, pp. 76-80
-
-
Vadlamudi, R.K.1
Sahin, A.A.2
Adam, L.3
Wang, R.A.4
Kumar, R.5
-
48
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
(doi:10.1200/JCO.20.3.719)
-
Vogel CL, CobleighMA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M et al. 2002 Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. Journal of Clinical Oncology 20 719-726. (doi:10.1200/JCO.20.3.719)
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
-
49
-
-
79960150764
-
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models
-
(doi:10.4161/cbt.9.10.11433)
-
Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G et al. 2010 Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biology & Therapy 9 778-790. (doi:10.4161/cbt.9.10.11433)
-
(2010)
Cancer Biology & Therapy
, vol.9
, pp. 778-790
-
-
Walsh, C.1
Tanjoni, I.2
Uryu, S.3
Tomar, A.4
Nam, J.O.5
Luo, H.6
Phillips, A.7
Patel, N.8
Kwok, C.9
McMahon, G.10
-
50
-
-
18944382074
-
Transforming growth factor {b} (TGF-{b})-Smad target gene protein tyrosine phosphatase receptor type k is required for TGF-{b} function
-
(doi:10.1128/MCB.25.11.4703-4715.2005)
-
Wang SE, Wu FY, Shin I, Qu S & Arteaga CL 2005 Transforming growth factor {b} (TGF-{b})-Smad target gene protein tyrosine phosphatase receptor type k is required for TGF-{b} function. Molecular and Cellular Biology 25 4703-4715. (doi:10.1128/MCB.25.11.4703-4715.2005)
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 4703-4715
-
-
Wang, S.E.1
Wu, F.Y.2
Shin, I.3
Qu, S.4
Arteaga, C.L.5
-
51
-
-
58349117913
-
Transforming growth factor b induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton
-
(doi:10.1158/0008-5472. CAN-08-2649)
-
Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A & Arteaga CL 2009 Transforming growth factor b induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Research 69 475-482. (doi:10.1158/0008-5472. CAN-08-2649)
-
(2009)
Cancer Research
, vol.69
, pp. 475-482
-
-
Wang, S.E.1
Xiang, B.2
Zent, R.3
Quaranta, V.4
Pozzi, A.5
Arteaga, C.L.6
-
52
-
-
84859717313
-
ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis
-
(doi:10.1172/JCI60568)
-
Worzfeld T, Swiercz JM, LoosoM, Straub BK, Sivaraj KK & Offermanns S 2012 ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. Journal of Clinical Investigation 122 1296-1305. (doi:10.1172/JCI60568)
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 1296-1305
-
-
Worzfeld, T.1
Swiercz, J.M.2
Looso, M.3
Straub, B.K.4
Sivaraj, K.K.5
Offermanns, S.6
-
53
-
-
77950257304
-
Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists
-
(doi:10.1158/0008-5472.CAN-09-4032)
-
Yang XH, Flores LM, Li Q, Zhou P, Xu F, Krop IE & Hemler ME 2010 Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Research 70 2256-2263. (doi:10.1158/0008-5472.CAN-09-4032)
-
(2010)
Cancer Research
, vol.70
, pp. 2256-2263
-
-
Yang, X.H.1
Flores, L.M.2
Li, Q.3
Zhou, P.4
Xu, F.5
Krop, I.E.6
Hemler, M.E.7
-
54
-
-
67449168372
-
Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab
-
(doi:10.1158/1078-0432.CCR-08-2814)
-
Yao E, ZhouW,Lee-Hoeflich ST, Truong T,Haverty PM, Eastham-Anderson J, Lewin-Koh N, Gunter B, Belvin M, Murray LJ et al. 2009 Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clinical Cancer Research 15 4147-4156. (doi:10.1158/1078-0432.CCR-08-2814)
-
(2009)
Clinical Cancer Research
, vol.15
, pp. 4147-4156
-
-
Yao, E.1
Zhou, W.2
Lee-Hoeflich, S.T.3
Truong, T.4
Haverty, P.M.5
Eastham-Anderson, J.6
Lewin-Koh, N.7
Gunter, B.8
Belvin, M.9
Murray, L.J.10
-
55
-
-
75849159664
-
A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts
-
Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG & Hochwald SN 2010 A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Molecular Carcinogenesis 49 200-209.
-
(2010)
Molecular Carcinogenesis
, vol.49
, pp. 200-209
-
-
Zheng, D.1
Golubovskaya, V.2
Kurenova, E.3
Wood, C.4
Massoll, N.A.5
Ostrov, D.6
Cance, W.G.7
Hochwald, S.N.8
-
56
-
-
84868136534
-
Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo
-
Zhu Y, Zhang X, Liu Y, Zhang S, Liu J, Ma Y & Zhang J 2012 Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo. Tumor Biology.
-
(2012)
Tumor Biology
-
-
Zhu, Y.1
Zhang, X.2
Liu, Y.3
Zhang, S.4
Liu, J.5
Ma, Y.6
Zhang, J.7
|