Safrole suppresses murine myelomonocytic leukemia WEHI-3 cells in vivo, and stimulates macrophage phagocytosis and natural killer cell cytotoxicity in leukemic mice

Environmental Toxicology

Volumn 28, Issue 11, 2013, Pages 601-608

  Yu, Fu Shun ^a   Yang, Jai Sing ^a   Yu, Chun Shu ^a   Chiang, Jo Hua ^b   Lu, Chi Cheng ^b   Chung, Hsiung Kwang ^a,c   Yu, Chien Chih ^a   Wu, Chih Chung ^d   Ho, Heng Chien ^a   Chung, Jing Gung ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Leukemic mice; Macrophage phagocytosis; Murine leukemia WEHI 3 cells; NK cell cytotoxicity; Safrole

Indexed keywords

HUMAN ORAL CANCER; INDUCED APOPTOSIS; INTRAPERITONEALLY; LEUKEMIC MICE; NATURAL KILLER CELLS; NK CELLS; SAFROLE; WEHI-3 CELLS;

ANTIGEN-ANTIBODY REACTIONS; CELL CULTURE; CELL PROLIFERATION; CYTOTOXICITY; DISEASES; DRUG PRODUCTS; MACROPHAGES;

MAMMALS;

CD11B ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; SAFROLE;

ALKENE; CANCER; CARCINOGEN; ECOTOXICOLOGY; IMMUNE SYSTEM; INHIBITION; PHYTOCHEMISTRY; RODENT; TUMOR; WEIGHT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CD3+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IN VIVO STUDY; LEUKEMIA CELL LINE; LEUKOCYTE; LIVER; MALE; MONOCYTE; MOUSE; MYELOMONOCYTIC LEUKEMIA; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEAL CAVITY; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL;

LEUKEMIC MICE; MACROPHAGE PHAGOCYTOSIS; MURINE LEUKEMIA WEHI-3 CELLS; NK CELL CYTOTOXICITY; SAFROLE;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD19; ANTIGENS, CD3; APOPTOSIS; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PHAGOCYTOSIS; SAFROLE; SPLEEN;

ANIMALIA; MURINAE; MUS; PIPER BETLE;

EID: 84886294245     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20756     Document Type: Article

References (32)

1. Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.2009.Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.Biosci Biotechnol Biochem73:2589-2594.
2. Chen CL, Chi CW, Chang KW, Liu TY.1999.Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history.Carcinogenesis20:2331-2334.
3. Chen J, Xu X.2010.Diet, epigenetic, and cancer prevention.Adv Genet71:237-255.
4. Chiang JH, Yang JS, Ma CY, Yang MD, Huang HY, Hsia TC, Kuo HM, Wu PP, Lee TH, Chung JG.2011.Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.Chem Res Toxicol24:20-29.
5. Daimon H, Sawada S, Asakura S, Sagami F.1997.Analysis of cytogenetic effects and DNA adduct formation induced by safrole in Chinese hamster lung cells.Teratog Carcinog Mutagen17:7-18.
6. Daimon H, Sawada S, Asakura S, Sagami F.1998.In vivo genotoxicity and DNA adduct levels in the liver of rats treated with safrole.Carcinogenesis19:141-146.
7. Glass B, Uharek L, Zeis M, Loeffler H, Mueller-Ruchholtz W, Gassmann W.1996.Graft-versus-leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells.Br J Haematol93:412-420.
8. Hendriks JJ, Slaets H, Carmans S, de Vries HE, Dijkstra CD, Stinissen P, Hellings N, 2008.Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages.J Neuroimmunol204:52-57.
9. Hung SL, Chen YL, Chen YT.2003.Effects of safrole on the defensive functions of human neutrophils.J Periodontal Res38:130-134.
10. IARC.1976.IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: Some naturally occurring substances.IARC Monogr Eval Carcinog Risk Chem Man10:1-342.
11. Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S.2004.Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States).Cancer Causes Control15:559-570.
12. Krop I, Shaffer AL, Fearon DT, Schlissel MS.1996.The signaling activity of murine CD19 is regulated during cell development.J Immunol157:48-56.
13. Lee JM, Liu TY, Wu DC, Tang HC, Leh J, Wu MT, Hsu HH, Huang PM, Chen JS, Lee CJ, Lee YC.2005.Safrole-DNA adducts in tissues from esophageal cancer patients: Clues to areca-related esophageal carcinogenesis.Mutat Res565:121-128.
14. Lin HC, Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Lu YC, Jan CR.2006.Safrole-induced cellular Ca2+ increases and death in human osteosarcoma cells.Pharmacol Res54:103-110.
15. Lin JP, Yang JS, Lin JJ, Lai KC, Lu HF, Ma CY, Sai-Chuen Wu R, Wu KC, Chueh FS, Gibson Wood W, Chung JG.2011.Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo.Environ Toxicol
16. Lin SY, Sheen LY, Chiang BH, Yang JS, Pan JH, Chang YH, Hsu YM, Chiang JH, Lu CC, Wu CL, Chung JG.2010.Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice.Nutr Cancer62:593-600.
17. Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL, Lu HF, Lee TH, Wood WG, Chung JG.2010.Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells.Mol Nutr Food Res54:967-976.
18. Lu HF, Liu JY, Hsueh SC, Yang YY, Yang JS, Tan TW, Kok LF, Lu CC, Lan SH, Wu SY, Liao SS, Ip SW, Chung JG.2007.(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo.In Vivo21:285-289.
19. Lu J, Guan S, Shen X, Qian W, Huang G, Deng X, Xie G.2011.Immunosuppressive activity of 8-gingerol on immune responses in mice.Molecules16:2636-2645.
20. Mahmoud NN, Carothers AM, Grunberger D, Bilinski RT, Churchill MR, Martucci C, Newmark HL, Bertagnolli MM.2000.Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.Carcinogenesis21:921-927.
21. Mitsuzumi H, Kusamiya M, Kurimoto T, Yamamoto I.1998.Requirement of cytokines for augmentation of the antigen-specific antibody responses by ascorbate in cultured murine T-cell-depleted splenocytes.Jpn J Pharmacol78:169-179.
22. Mulligan JK, Lathers DM, Young MR.2008.Tumors skew endothelial cells to disrupt NK cell. T-cell and macrophage functions.Cancer Immunol Immunother57:951-961.
23. Mutoh M, Takahashi M, Fukuda K, Komatsu H, Enya T, Matsushima-Hibiya Y, Mutoh H, Sugimura T, Wakabayashi K.2000.Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: Structure-activity relationship.Jpn J Cancer Res91:686-691.
24. Shan BE, Zhang JY, Li QX.2001.Human T cell and monocyte modulating activity of Rhizoma typhonii in vitro.Zhongguo Zhong Xi Yi Jie He Za Zhi21:768-772.
25. Thomas PT, Ratajczak HV, Aranyi C, Gibbons R, Fenters JD.1985.Evaluation of host resistance and immune function in cadmium-exposed mice.Toxicol Appl Pharmacol80:446-456.
26. Tsou MF, Peng CT, Shih MC, Yang JS, Lu CC, Chiang JH, Wu CL, Lin JP, Lo C, Fan MJ, Chung JG.2009.Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo.Leuk Res33:1505-1511.
27. Wang CK, Hwang LS.1993.Phenolic compounds of betel quid chewing juice.Food Sci20:458-471.
28. Wenzel U, Kuntz S, Brendel MD, Daniel H.2000.Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.Cancer Res60:3823-3831.
29. Yang JS, Kok LF, Lin YH, Kuo TC, Yang JL, Lin CC, Chen GW, Huang WW, Ho HC, Chung JG.2006.Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo.Anticancer Res26:219-225.
30. Yu CS, Lai KC, Yang JS, Chiang JH, Lu CC, Wu CL, Lin JP, Liao CL, Tang NY, Wood WG, Chung JG.2010.Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response.Phytother Res24:163-168.
31. Yu FS, Huang AC, Yang JS, Yu CS, Lu CC, Chiang JH, Chiu CF, Chung JG.2011a.Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.Environ Toxicol
32. Yu FS, Yang JS, Yu CS, Lu CC, Chiang JH, Lin CW, Chung JG, 2011b.Safrole induces apoptosis in human oral cancer HSC-3 cells.J Dent Res90:168-174.