Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response

Phytotherapy Research

Volumn 24, Issue 2, 2010, Pages 163-168

  Yu, Chun Shu ^a   Lai, Kuang Chi ^b,c   Yang, Jai Sing ^a   Chiang, Jo Hua ^d   Lu, Chi Cheng ^d   Wu, Chang Lin ^a   Lin, Jing Pin ^a   Liao, Ching Lung ^a   Tang, Nou Ying ^a   Wood, W Gibson ^e   Chung, Jing Gung ^a,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e UNIVERSITY OF MINNESOTA   (United States)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

BALB c mice; In vivo; Phagocytosis; Quercetin; WEHI 3 cells

Indexed keywords

CD11B ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CELL MARKER; OLIVE OIL; PROTEIN MAC 3; QUERCETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; IMMUNE RESPONSE; LEUKEMIA CELL; LIVER WEIGHT; MALE; MOUSE; MURINE LEUKEMIA; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; SPLEEN; SPLEEN WEIGHT; T LYMPHOCYTE;

ANIMALS; BIOLOGICAL MARKERS; KILLER CELLS, NATURAL; LEUKEMIA, EXPERIMENTAL; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE; PHAGOCYTOSIS; QUERCETIN; SPLEEN;

ANIMALIA; MURINAE; MUS;

EID: 75849152717     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2841     Document Type: Article

References (28)

1. Chen TJ, Shen SC, Lin HY, Chien LL, Chen YC. 2004. Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase. Toxicol Lett 147: 1-13.
2. Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. 2006. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136: 2715-2721.
3. He Q, Na X. 2001. The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo. Leuk Res 25: 455-461.
4. Hibasami H, Mitani A, Katsuzaki H, Imai K, Yoshioka K, Komiya T. 2005. Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. Int J Mol Med 15: 805-809.
5. Huang YT, Hwang JJ, Lee PP et al. 1999. Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128: 999-1010.
6. Kandaswami C, Lee LT, Lee PP et al. 2005. The antitumor activities of flavonoids. In Vivo 19: 895-909.
7. Lee LT, Huang YT, Hwang JJ et al. 2004. Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. Biochem Pharmacol 67: 2103-2114.
8. Lee TJ, Kim OH, Kim YH et al. 2006. Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 240: 234-242.
9. Lin HY, Juan SH, Shen SC, Hsu FL, Chen YC. 2003. Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. Biochem Pharmacol 66: 1821-1832.
10. Loken MR, Green CI, Wells DA. 2000. Immunofluorescence of surface markers. In Flow Cytometry: A Practical Approach, Ormerod MG (ed.). Oxford University Press: Oxford, 61-82.
11. Mertens-Talcott SU, Talcott ST, Percival SS. 2003. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 133: 2669-2674.
12. Mutoh M, Takahashi M, Fukuda K et al. 2000. Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Jpn J Cancer Res 91: 686-691.
13. Naderi GA, Asgary S, Sarraf-Zadegan N, Shirvany H. 2003. Antioxidant effect of flavonoids on the susceptibility of LDL oxidation. Mol Cell Biochem 246: 193-196.
14. Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H. 2004. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25: 647-659.
15. Ong CS, Tran E, Nguyen TT et al. 2004. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncol Rep 11: 727-733.
16. Piantelli M, Rossi C, Iezzi M et al. 2006. Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions. J Cell Physiol 207: 23-29.
17. Shen SC, Chen YC, Hsu FL, Lee WR. 2003. Differential apoptosisinducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. J Cell Biochem 89: 1044-1055.
18. Singhal RL, Yeh YA, Praja N, Olah E, Sledge GW, Jr, Weber G. 1995. Quercetin down-regulates signal transduction in human breast carcinoma cells. Biochem Biophys Res Commun 208: 425-431.
19. Stachowska E, Baskiewicz-Masiuk M, Dziedziejko VB et al. 2007. Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression. Lipids 42: 707-716.
20. Su CC, Yang JS, Lin SY et al. 2008. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo 22: 63-68.
21. Tan WF, Lin LP, Li MH et al. 2003. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol 459: 255-262.
22. van Erk MJ, Roepman P, van der Lende TR et al. 2005. Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr 44: 143-156.
23. Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J. 2006. Quercetin down-regulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 287: 109-116.
24. Wenzel U, Kuntz S, Brendel MD, Daniel H. 2000. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res 60: 3823-3831.
25. Yang JS, Kok LF, Lin YH et al. 2006. Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo. Anticancer Res 26: 219-225.
26. Yu FS, Yu CS, Chan JK et al. 2006. The effects of emodin on the expression of cytokines and functions of leukocytes from Sprague-Dawley rats. In Vivo 20: 147-151.
27. Zhang X, Xu Q, Saiki I. 2000. Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression. Clin Exp Metastasis 18: 415-421.
28. Zhang XM, Huang SP, Xu Q. 2004. Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. Cancer Chemother Pharmacol 53: 82-88.