Adsorption of α-synuclein to supported lipid bilayers: Positioning and role of electrostatics

ACS Chemical Neuroscience

Volumn 4, Issue 10, 2013, Pages 1339-1351

  Hellstrand, Erik ^a   Grey, Marie ^a   Ainalem, Marie Louise ^b   Ankner, John ^c   Forsyth, V Trevor ^d,g   Fragneto, Giovanna ^d   Haertlein, Michael ^d   Dauvergne, Marie Therese ^d   Nilsson, Hanna ^a   Brundin, Patrik ^e,f   Linse, Sara ^a   Nylander, Tommy ^a   Sparr, Emma ^a  

^a LUND UNIVERSITY   (Sweden)

^b EUROPEAN SPALLATION SOURCE ERIC   (Sweden)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d INSTITUT LAUE LANGEVIN   (France)

^e LUND UNIVERSITY   (Sweden)

^f VAN ANDEL RESEARCH INSTITUTE   (United States)

^g KEELE UNIVERSITY   (United Kingdom)

Author keywords

synuclein; amyloidosis; bilayer; Lewy body; neutron diffraction; Parkinson; perdeuterated protein

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ALPHA SYNUCLEIN; CARDIOLIPIN; DIOLEOYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE;

ADSORPTION; ANALYTICAL EQUIPMENT; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDRODYNAMICS; IONIC STRENGTH; LIPID BILAYER; LIPID COMPOSITION; MEMBRANE MODEL; MITOCHONDRIAL MEMBRANE; MOLECULAR DYNAMICS; NERVE CELL MEMBRANE; NEUTRON ACTIVATION ANALYSIS; NEUTRON REFLECTOMETRY; NEUTRON SCATTERING; PARKINSON DISEASE; PATHOGENESIS; PH; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; QUARTZ CRYSTAL MICROBALANCE; STATIC ELECTRICITY; SUBSTANTIA NIGRA; WATER CONTENT;

ADSORPTION; ALPHA-SYNUCLEIN; AMYLOIDOSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEWY BODIES; LIPID BILAYERS; MEMBRANE LIPIDS; NEURONS; NEUTRON DIFFRACTION; PARKINSON DISEASE; PHOSPHOLIPIDS; STATIC ELECTRICITY;

EID: 84886057818     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400066t     Document Type: Article

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