Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: Why a silent cluster is sleeping

Applied Microbiology and Biotechnology

Volumn 97, Issue 21, 2013, Pages 9451-9463

  Alvarez Alvarez R ^a,b   Martinez Burgo Y ^a   Perez Redondo R ^b   Brana A F ^c   Martin J F ^a   Liras, P ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

^c UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Clavulanic acid; Gene clusters; Genomes; Heterologous expression; Saccharomonospora viridis; Streptomyces clavuligerus. Streptomyces flavogriseus

Indexed keywords

CLAVULANIC ACID; GENE CLUSTERS; HETEROLOGOUS EXPRESSION; SACCHAROMONOSPORA VIRIDIS; STREPTOMYCES CLAVULIGERUS;

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLIC ACIDS; GENES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLYMERASE CHAIN REACTION;

GENE EXPRESSION;

CLAVULANIC ACID;

BIOASSAY; GENE; GENE EXPRESSION; GENOME; LIQUID CHROMATOGRAPHY; POLYMERASE CHAIN REACTION; YEAST;

ARTICLE; BIOSYNTHESIS; CCAR GENE; CLAR GENE; COSMID; CYP GENE; ESSENTIAL GENE; GENE CLUSTER; GENE EXPRESSION SYSTEM; HETEROLOGOUS EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; OPPA2 GENE; ORF12 GENE; ORF13 GENE; ORF14 GENE; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SILENT GENE; STREPTOMYCES; STREPTOMYCES FLAVOGRISEUS;

ACTINOBACTERIA (CLASS); SACCHAROMONOSPORA VIRIDIS; STREPTOMYCES; STREPTOMYCES CLAVULIGERUS; STREPTOMYCES FLAVOGRISEUS;

BIOSYNTHETIC PATHWAYS; CLAVULANIC ACID; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; MULTIGENE FAMILY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOMYCES;

EID: 84885953384     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5148-7     Document Type: Article

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