Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 32, 2011, Pages 13053-13058

  Young, Travis S ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Bacterial resistance; Bioengineering; Thiopeptide

Indexed keywords

ALANINE; BACTERIAL PROTEIN; CYTOCHROME P450; ELONGATION FACTOR TU; HYDROXYPROLINE; ISOLEUCINE; ISOTOPE; MACROCYCLIC COMPOUND; PROTEIN PRECURSOR; THIAZOLYL PEPTIDE GE 37468; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYCLIZATION; ENTROPY; GENE CLUSTER; GENE EXPRESSION; GENE IDENTIFICATION; GENE INACTIVATION; GENE TARGETING; GENETIC ENGINEERING; GENETIC MANIPULATION; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING; STREPTOMYCES; STREPTOMYCES LIVIDANS;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, LIQUID; COMPUTATIONAL BIOLOGY; GENE EXPRESSION; HYDROXYPROLINE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OXIDATION-REDUCTION; PEPTIDES, CYCLIC; SEQUENCE ANALYSIS, PROTEIN; STREPTOMYCES; STREPTOMYCES LIVIDANS; THIAZOLES;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOMYCES; STREPTOMYCES LIVIDANS;

EID: 80051981726     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110435108     Document Type: Article

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