Comparative analysis of a cryptic thienamycin-like gene cluster identiWed in Streptomyces Xavogriseus by genome mining

Archives of Microbiology

Volumn 194, Issue 6, 2012, Pages 549-555

  Blanco, Gloria ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

Lactam; Antibiotic; Carbapenem; Epithienamycin; Streptomyces cattleya

Indexed keywords

CARBAPENEM; THIENAMYCIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL GENOME; BACTERIAL STRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; CPHT GENE; CPHU GENE; DNA SEQUENCE; ESCHERICHIA COLI; GENE CLUSTER; GENE IDENTIFICATION; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES CATTLEYA; STREPTOMYCES FLAVOGRISEUS; THNA GENE; THND GENE; THNE GENE; THNL GENE; THNN GENE; THNO GENE; THNQ GENE; THNT GENE;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; DATA MINING; GENOME, BACTERIAL; MOLECULAR STRUCTURE; MULTIGENE FAMILY; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; THIENAMYCINS;

STREPTOMYCES; STREPTOMYCES CATTLEYA;

EID: 84865866401     PISSN: 03028933     EISSN: 1432072X     Source Type: Journal    
DOI: 10.1007/s00203-011-0781-y     Document Type: Article

References (24)

1. Baltz RH (2008) Renaissance in antibacterial discovery from actinomycetes. Curr Opin Pharmacol 8:557-563
2. Baltz RH (2010) Genomics and ancient origins of the daptomycin biosynthetic gene cluster. J Antibiot 63:506-511
3. Barbe V, Bouzon M, Mangenot S, Badet B, Poulain J, Segurens B, Vallenet D, Marlière P, Weissenbach J (2011) Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and Xuorometabolites. J Bacteriol 193:5055-5056
4. Bibb JJ, Findlay PR, Johnson MW (1984) The relationship between base composition and codon usage in bacterial genes and its use in the simple and reliable identiWcation of protein-coding sequences. Gene 30:157-166 (Pubitemid 15201773)
5. Bodner JJ, Phelan RM, Freeman MF, Li R, Townsend CA (2010) Nonheme iron oxygenases generate natural structural diversity in carbapenem antibiotics. J Am Chem Soc 132:12-13
6. Cassidy PJ, Albers-Schonberg G, Goegelman RT, Miller T, Arison B, Stapley EO, Birnbaum J (1981) Epithienamycins. II. Isolation and structure assignment. J Antibiot 34:637-648 (Pubitemid 11002531)
7. Coulthurst SJ, Barnard AML, Salmond GPC (2005) Regulation and biosynthesis of carbapenem antibiotics in bacteria. Nat Rev Microbiol 3:295-306 (Pubitemid 40443723)
8. Cox ARJ, Thompson NR, Bycroft B, Stewart GSAB, Williams P, Salmond GPC (1998) A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens. Microbiology 144:201-209 (Pubitemid 28045228)
9. Demain AL (2009) Antibiotics: natural products essential to humanhealth. Med Res Rev 29:821-842
10. Derzelle S, Duchaud E, Kunst F, Danchin A, Bertin P (2002) IdentiWcation, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens. Appl Environ Microbiol 68:3780-3789 (Pubitemid 34836685)
11. Freeman MF, Moshos KA, Bodner MJ, Li R, Townsed CA (2008) Four enzymes deWne the incorporation of coenzyme A in thienamycin biosynthesis. Proc Natl Acad Sci USA 105:11128-11133
12. Hamed RB, Batchelar ET, Mecinovic J, Claridge TD, ShoWeld CJ (2009) Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S, 5S)-transcarboxymethylproline. ChemBioChem 10:246-250
13. Kahan JS, Kahan FM, Goegelman R, Currie SA, Jackson M, Stapley EO, Miller TW, Miller AK, Hendlin D, Mochales S, Hernandez S, WoodruV HB, Birnbaum J (1979) Thienamycin, a new β-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties. J Antibiot 23:1255-1265
14. McGowan SJ, Sebaihia M, Porter LE, Stewart GSAB, Williams P, Bycroft BW, Salmond GPC (1996) Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway. Mol Microbiol 22:415-426 (Pubitemid 26373827)
15. Nicolau DP (2008) Carbapenems: a potent class of antibiotics. Expert Opin Investig Drugs 9:23-37 (review) (Pubitemid 351233746)
16. Núñez LE, Méndez C, Braña AF, Blanco G, Salas JA (2003) The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol 10:1-20
17. RodloV AC, Goldstein EJC, Torres A (2006) Two decades of imipenem therapy. J Antimicrob Chemother 58:916-929
18. Rodríguez M, Núñez LE, Braña AF, Méndez C, Salas JA, Blanco G (2008) IdentiWcation of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya. Mol Microbiol 69:633-645 (Pubitemid 351962561)
19. Rodríguez M, Méndez C, Salas JA, Blanco G (2010) Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya. J Antibiot 63:135-138
20. Rodríguez M, Núñez LE, Braña AF, Méndez C, Salas JA, Blanco G (2011) Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya. Antimicrob Agents Chemother 55:1638-1649
21. Shibamoto N, Koki A, Nishino M, Nakamura K, Kiyoshima K, Okamura K, Okabe M, Okamoto R, Fukagawa Y, Shimuchi Y, Ishikura T (1980) PS-6 and PS-7, new beta-lactam antibiotics isolation, physicochemical properties and structures. J Antibiot 33:1128-1137 (Pubitemid 11201995)
22. Stapley EO, Cassidy PJ, Tunac J, Monaghan RL, Jackson M, Hernandez S, Zimmerman SB, Mata JM, Currie SA, Daoust D, Hedlin D (1981) Epithienamycins- novel beta-lactams retaled to thienamycin. I. Production and antibacterial acitivity. J Antibiot 34:628-636 (Pubitemid 11002530)
23. Walsh CT, Fischbach MA (2010) Natural products version 2.0: connecting genes to molecules. J Am Chem Soc 132:2469-2493
24. Zerikly M, Challis GL (2009) Strategies for the discovery of new natural products by genome mining. ChemBioChem 10:625-633