Evolution of the clusters of genes for Mactam antibiotics: A model for evolutive combinatorial assembly of new β-lactams

International Microbiology

Volumn 1, Issue 4, 1998, Pages 271-278

  Liras, Paloma ^a   Rodriguez Garcïa, Antonio ^a   Martin, Juan F ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

Gene clusters; Microbial evolution; Penicillium; Streptomyccs; Lactam antibiotics

Indexed keywords

ALPHA AMINOADIPYL CYSTEINYL VALINE SYNTHETASE; ALPHA-AMINOADIPYL-CYSTEINYL-VALINE SYNTHETASE; ANTIINFECTIVE AGENT; BETA LACTAM; PEPTIDE SYNTHASE;

ACTINOMYCETALES; BACTERIUM; COMBINATORIAL CHEMISTRY; FUNGUS; GENETICS; MOLECULAR EVOLUTION; MULTIGENE FAMILY; REVIEW;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; BACTERIA; BETA-LACTAMS; COMBINATORIAL CHEMISTRY TECHNIQUES; EVOLUTION, MOLECULAR; FUNGI; MULTIGENE FAMILY; PEPTIDE SYNTHASES;

EID: 0032227324     PISSN: 11396709     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Abraham EP, Newton GGF (1961) The structure of cephalosporin C. Biochem J 79:377-393
2. Aharonowitz Y, Cohen G, Martin JF ( 1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Annu Rev Microbiol 46:461-495
3. Baker BJ, Dotzlaf JE, Yeh WK (1991) Deacetoxycephalosporin C hydroxylase of Strcptomyccs clamligerus. Purification, characterization, bifunctionality, and evolutionary implication. J Biol Chem 266:5087-5093
4. Bairedo JL, van Solingen P, Dfez B, Älvarez E, Cantoral JM, Kattevilder A, Smaal EB, Groenen MA, Veenstra AE, Martin JF(1989) Cloning and characterization of the acyl-coenzyme A: 6-aminopcnicillanic-acidacyltransferase gene of Pénicillium clirysogenuin. Gene 83:291-300
5. Cohen G, Shiffman D, Mevarech M, Aharonowitz Y (1990) Microbial isopenicillin N synthase genes: structure, function, diversity and evolution. Trends Biochem 8:105-111
6. Coque JJR, Liras P, Lâiz L, Martin JF (1991) A gene encoding lysine 6-aminotransferase, which forms the β-lactam precursor α-aminoadipic acid, is located in the cluster of ccphamycin biosynthetic genes in Nocanlia lactamdurans. J Bacteriol 173:6258-6264
7. Coque JJR, Martfn JF, Calzada JG, Liras P (1991) The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peplidc synthetase, and pcbC of Nocanlia lactamdurans are clustered together in an organization different from the same genes in Acrcmonium chrysogeniim and Pénicillium chrysogeinim. Mol Microbiol 5:1125-1133
8. Coque JJR, Martfn JF, Liras P (1993) Characterization and expression in Streptomyces liridans of cefD and cefE, gene from Nocanlia lactamdurans: the organization of the cephamycin gene cluster differs from that in Strcptomyccs clavtiligerns. Mol Gen Genet 236:453-158
9. Coque JJR, Liras P, Martin JF (1993) Gene for a β-lactamase, a penicillinbinding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocanlia laclaimliirans. EMBO J 12:631-639
10. Coque JJR, Enguita FJ, Martin JF, Liras P (1995) A two-protein component 7a-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin to 7-methoxycephalosporin C. J Bacteriol 177:2230-2235
11. Cundliffe E (1989) How antibiotic-producing organisms avoid suicide. Annu Rev Microbiol 43:207-233
12. Dotzlaf JE, Yeh WK (1989) Copurification and characterization of deacetylcephalosporin C synthetase/hydroxylase from Cephalosporiwn acremoniuin. J Bacteriol 169:1611-1618
13. de la Fuente JL, Rumbero A, Martin JF, Liras P (1997) Δ-1-Piperideine-6-carboxylate dehydrogenase, a new enzyme that forms α-aminoadipate in Strcptomyccs claruligerus and other cephamycin C producing aclinomycetes. Biochem J 326:59-64
14. Gutierrez S, Velasco J, Ferndndez FJ, Martin JF (1992) The ceJG gène of Cephalosporium acremonhim is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. J Bacteriol 174:3056-3064
15. Kimura H, Miyashita H, Sumino Y (1996) Organization and expression in Psciidomonas pntida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgeniis YK90. Appl Microbiol Biotechnol 45:490-501
16. Kovacevic S, Miller JR (1991) Cloning and sequencing of the α-lactam hydroxylase gene (cefF) from Streplomyces clcmtligems: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes. J Bacteriol 173:398-400
17. Kovacevic S, Tobin MB, Miller JR (1990) The α-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerns. J Bacteriol 172:3952-3958
18. Landan G, Cohen G, Aharonowitz Y, Shuali Y, Graur D, Shiffman D (1990) Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer. Mol Biol Evol 7:399-406
19. Madduri K, Stuttard C, Vining LC (1991) Cloning and location of a gene governing lysine t-aminotransferase, an enzyme initiating α-lactam biosynthesis in Streptomyces spp. J Bacteriol 173:985-988
20. Martin JF, Liras P (1989) Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis. In: Fiechter A (ed) Advances in Biochemical Engineering/Biotechnology. V'ol 39. Berlin: Springer Verlag, Heidelberg, pp 153-187
21. Martin JF (1998) New aspects of genes and enzymes for α-lactam antibiotic biosynthesis. Appl Microbiol Biotechnol (in press)
22. Nagarajan RL, Boeck LD, Gorman M, Hamill RL, Higgins CE, Hoehn MM, Stark W, Whitney JG (1971) α-lactam antibiotics from Streptomyces. J Am Chem Soc 93:2308-2310
23. Nozaki Y, Katayama N, Tsubotani S, Ono H, Okazaki H (1985) Cephabacin M1 -6, new 7-methoxycephem antibiotics of bacterial origin. I. A producing organism, fermentation, biological activities, and mode of action. J Antibiot (Tokyo) 38:1141-1151
24. Paradkar AS, Aidoo KA, Wong A, Jensen SE (1996) Molecular analysis of a β-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavnligerns. J Bacteriol 178:6266-6274
25. Pérez-LIarena FJ, Liras P, Rodrîguez-Garcfa A, Martîn JF (1997) A regulatory gene (rcoR) required for cephamycin and clavulanic acid production in Slreptomyces clavidigerus: Amplification results in overproduction of both β-lactam compounds. J Bacteriol 179:2053-2059
26. Pérez-LIarena F, Martfn JF, Galleni M, Coque JJR, de la Fuente JL, Frere JM, Liras P (1997) The Ma gene of. the cephamycin cluster of Streptomyces clanttigena encodes a class A β-lactamase of low enzymatic activity. J Bacteriol 179:6035-6040
27. Samson SM, Dotzlaf JE, Slisz ML, Becker GW, Van Frank RM, Veal LE, Yeh WK, Miller JR, Queener SW, Ingolia TD (1987) Cloning and expression of the fungal expandase/hydroxylase gene involved in cephalosporin biosynthesis. Biol Technology 5:1207-1214
28. Stapley EO, Jackson M, Hernandez S, Zimmerman SB, Currie SA, Mochales S, Mala JM, Woodruff HB, Hendlin D (1972) Cephamycins, a new family of β-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdiirans sp. Antimicrob Agents Chemother2:122-131
29. Ward JM, JE Hodgson (1993) The biosynthetic genes for clavulanic acid and cephamycin production occur as a "super cluster" in three Streptomyces. FEMS Microbiol Lett 110:239-242
30. Weigel BJ, Burgett SG, Chen VJ, Skatrud PL, Frolik CA, Queener SW, Ingolia TD (1988) Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans. J Bacteriol 170:3817-3826