Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene

Toxicology and Applied Pharmacology

Volumn 182, Issue 1, 2002, Pages 55-65

  Bull, Richard J ^a,b   Orner, Gayle A ^a   Cheng, Rita S ^a   Stillwell, Lisa ^a   Stauber, Anja J ^b   Sasser, Lyle B ^a   Lingohr, Melissa K ^b   Thrall, Brian D ^a,b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

c Jun; Dichloroacetate; H ras; Liver tumors; Mutation analysis; Trichloroacetate; Trichloroethylene

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; DICHLOROACETIC ACID; PROTEIN C JUN; RAS PROTEIN; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; GENE MUTATION; LIVER TUMOR; MALE; METABOLITE; MOUSE; MUTATION RATE; NONHUMAN; PHENOTYPE; STAINING;

EID: 0036078665     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9427     Document Type: Article

References (48)

1. Ras proto-oncogene activation in dichloroacetic-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice
2. Dichloroacetate (DCA) dosimetry: Interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer
3. Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloracetate and dichloroacetate
4. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
5. Computer program for the analysis of mutational spectra: Application to p53 mutations
6. Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment
7. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in male B6C3F1 mouse
8. Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids
9. Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: Dose-response determination and modes of action
10. Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment
11. U. S. environmental protection agency: Proposed guidelines for carcinogen risk assessment; notice
12. Ras oncogene activation during hepatocarcinogenesis in B6C3F1 mice by dichloroacetic and trichloroacetic acids
13. Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites
14. Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 × C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens
15. Detection of a cellular oncogene in spontaneous liver tumors of B6C3F1 mice
16. Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras
17. Effect of pre-treatment with dichloroacetic acid or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent dose in B6C3F1 mice
18. +/−3-7. LC mouse lymphoma cells
19. Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferators
20. 4-antagonist, LY171883
21. p21 (Ras) downstream effectors are increased in activity or expression in mouse liver tumors but do not differentiate between RAS-mutated and RAS-wild-type lesions
22. Effects of dichloroacetate-treatment on carbohydrate metabolism in B6C3F1 mice
23. Differences in the detection of c-Jun/ubiquitin immunoreactive proteins by different c-Jun antibodies
24. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
25. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
26. Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver
27. Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice
28. Trans-Activation of PPARα and PPARγ by structurally diverse environmental chemicals
29. H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice
30. Mutations in the ras proto-oncogene: Clues to etiology and molecular pathogenesis of mouse liver tumors
31. The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice
32. In vivo MRI measurements of tumor growth induced by dichloroacetate: Implications for mode of action
33. c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: Comparison with the expression of pi-class glutathione S-transferase
34. Increased expression of c-myc, and c-H-ras in dichloroacetate- and trichloroacetate-induced liver tumors in B6C3F1 mice
35. Overview on the mechanisms of carcinogenic action of dichloroacetic acid in the male B6C3F1 mouse: Application to the construction of a biologically-based dose-response model
36. Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice
37. Activated oncogenes in B6C3F1 mouse liver tumors: Implications for risk assessment
38. The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice
39. Dichloroacetic acid reduces Ha-ras codon 61 mutations in liver tumors from female B6C3F1 mice
40. In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes
41. Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours
42. Differences in phenotype and cell replicative behavior of hepatic tumors inducted by dichloroacetate (DCA) and trichloroacetate (TCA)
43. Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro
44. H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells
45. Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3F1 mouse