Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 4, 1998, Pages 983-988

  Zhou, Yuan Chun ^a   Waxman, David J ^a  

^a BOSTON UNIVERSITY   (United States)

Author keywords

Chlorinated hydrocarbons; DHEA S; Peroxisome proliferators; PPAR ; Trichloroacetic acid; Trichloroethylene

Indexed keywords

CHLORINATED HYDROCARBON; DICHLOROACETIC ACID; LIVER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PRASTERONE SULFATE; RECEPTOR SUBTYPE; STEROID; TRICHLOROACETIC ACID; TRICHLOROETHYLENE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL STRAIN COS1; CONFERENCE PAPER; CONTROLLED STUDY; GENE INDUCTION; GENETIC TRANSFECTION; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031691204     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s4983     Document Type: Conference Paper

References (40)

1. Campos-Outcalt D. Trichloroethylene:environmental and occupational exposure. Am Fam Physician 46:495-500 (1992).
2. Candura SM, Faustman EM. Trichloroethylene:toxicology and health hazards. G Ital Med Lav 13:17-25 (1991).
3. Buben JA, O'Flaherty EJ. Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene:a dose-effect study. Toxicol Appl Pharmacol 78:105-122 (1985).
4. Schoonjans K, Martin G, Staels B, Auwerx J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol 8:159-166 (1997).
5. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-3022 (1995).
6. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR γ 2, a lipid-activated transcription factor. [Published erratum appears in Cell 80(6):following 957 (1995)]. Cell 79:1147-1156 (1994).
7. Waxman DJ. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. J Endocrinol 150 Suppl:S129-S147 (1996).
8. Gordon GB, Shantz LM, Talalay P. Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone. Adv Enz Reg 26:355-382 (1987).
9. Schwartz AG, Whitcomb JM, Nyce JW, Lewbar ML, Pashko LL. Dehydroepiandrosterone and structural analogs:a new class of cancer chemopreventive agents. Adv Cancer Res 51:391-424 (1988).
10. Wu HQ, Masser BJ, Tweedie DJ, Milewich L, Frenkel RA, Martin WC, Estabrook RW, Prough RA. Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-4501VA1 (P-450LA omega) by dehydroepiandrosterone in rats:a possible peroxisomal proliferator. Cancer Res 49:2337-2343 (1989).
11. Frenkel RA, Slaughter CA, Orth K, Moomaw CR, Hicks SH, Snyder JM, Bennett M, Prough RA, Putnam RS, Milewich L. Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. J Steroid Biochem 35:333-342 (1990).
12. Yamada J, Sakuma M, Ikeda T, Fukuda K, Suga T. Characteristics of dehydroepiandrosterone as a peroxisome proliferator. Biochim Biophys Acta 1092:233-243 (1991).
13. Rao MS, Reid B, Ide H, Subbarao V, Reddy JK Dehydroepiandrosterone-induced peroxisome proliferation in rat:evaluation of sex differences. Proc Soc Exp Biol Med 207:186-190 (1994).
14. Prough RA, Webb SJ, Wu HQ, Lapenson DP, Waxman DJ. Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. Cancer Res 54:2878-2886 (1994).
15. Hayashi F, Tamura H, Yamada J, Kasai H, Suga T. Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats. Carcinogenesis 15:2215-2219 (1994).
16. +2 channel blockers. Biochem J 301:753-758 (1994).
17. Yamada J, Sakuma M, Ikeda T, Suga T. Activation of dehydroepiandrosterone as a peroxisome proliferator by sulfate conjugation. Arch Biochem Biophys 313:379-381 (1994).
18. Chia SE, Goh VH, Ong CN. Endocrine profiles of male workers with exposure to trichloroethylene. Am J Ind Med 32:217-222 (1997).
19. Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650 (1990).
20. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 91:7355-7359 (1994).
21. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6:1634-1641 (1992).
22. Peters JM, Zhou YC, Ram PA, Lee SST, Gonzalez FJ, Waxman DJ Peroxisome proliferator-activated receptor α required for gene induction by dehydroepiandrosterone-3β -sulfate. Mol Pharmacol 50:67-74 (1996).
23. Muerhoff AS, Griffin KJ, Johnson EF. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. J Biol Chem 267:19051-19053 (1992).
24. Zhu Y, Alvares K, Huang Q, Rao MS, Reddy JK. Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem 268:26817-26820 (1993).
25. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Develop 6:329-344 (1992).
26. Sundseth SS, Waxman DJ. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omegahydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J Biol Chem 267:3915-3921 (1992).
27. Okita TT, Okita JR. Characterization of a cytochrome P450 from di(2-ethylhexyl)phthalate-treated rats which hydroxylates fatty acids. Arch Biochem Biophys 294:475-481 (1992).
28. Herren-Freund SL, Pereira MA, Khoury MD, Olson G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol Appl Pharmacol 90:183-189 (1987).
29. Bruckner JV, Davis BD, Blancato JN. Metabolism, toxicity, and carcinogenicity of trichloroethylene. Crit Rev Toxicol 20:31-50 (1989).
30. Hess R, Staubli W, Riess W. Nature of the hepatomegalic effect produced by ethyl-chloroptienoxy-siobutyrate in the rat. Nature 208:856-888 (1969).
31. 3H]-thymidine and Salmonella mutagenesis assays. Cancer Res 40:36-41 (1980).
32. Costa AK, Ivanetich KM. Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P450 system. Biochem Pharmacol 29:2863-2869 (1980).
33. Elcombe CR. Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene:a biochemical human hazard assessment. Arch Toxicol Suppl 8:6-17 (1985).
34. Gottlicher M, Widmark E, Li Q, Gustafsson JA. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 89:4653-4657 (1992).
35. Yu K, Bayona W, Kallen CB, Harding HP, Ravera GP, McMahon G, Brown M, Lazar MA. Differential activation of peroxisome proliferator-activated receptors by cicosanoids. J Biol Chem 270:23975-23983 (1995).
36. Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and cicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci USA 94:4312-4317 (1997).
37. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-774 (1992).
38. Hsu MH, Palmer GNA, Griffin KJ, Johnson KF. A single amino acid change in the mouse peroxisome proliferator-activated receptor α alters transcriptional responses to peroxisome proliferators. Mol Pharmacol 48:559-567 (1995).
39. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ). J Biol Chem 270:12953-12956 (1995).
40. Reuter S, Mayer D. Transport of dehydroepiandrosterone and dehydroepiandrosterone sulphate into rat hepatocytes. J Steroid Biochem Mol Biol 54:227-235 (1995).