Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 300-307

  Ramdhan, Doni Hikmat ^a   Kamijima, Michihiro ^a   Yamada, Naoyasu ^a   Ito, Yuki ^a   Yanagiba, Yukie ^a   Nakamura, Daichi ^a   Okamura, Ai ^a   Ichihara, Gaku ^a   Aoyama, Toshifumi ^b   Gonzalez, Frank J ^c   Nakajima, Tamie ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CYP2E1; Hepatotoxicity; Metabolism; NF B; PPAR ; Trichloroethylene

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHLORAL HYDRATE; CYTOCHROME P450; CYTOCHROME P450 2E1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN P52; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYP2E1 GENE; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HISTOPATHOLOGY; INFLAMMATION; LIVER TOXICITY; MALE; METABOLISM; METABOLITE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; RECEPTOR UPREGULATION;

ANIMALS; CYTOCHROME P-450 CYP2E1; LIVER; MALE; MICE; MICE, TRANSGENIC; TRICHLOROETHYLENE;

MUS;

EID: 50849106388     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.04.020     Document Type: Article

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