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Volumn 38, Issue 10, 2008, Pages 857-875

Evaluation of the role of peroxisome proliferator-activated receptor α (PPARα in mouse liver tumor induction by trichloroethylene and metabolites

Author keywords

Chloral hydrate; Dichloroacetic acid; Liver tumors; Perchloroethylene; PPAR ; Trichloroacetic acid; Trichloroethylene

Indexed keywords

DICHLOROACETIC ACID; DRUG METABOLITE; MOLECULAR MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

EID: 56449124307     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440802209796     Document Type: Review
Times cited : (38)

References (149)
  • 2
    • 33749643166 scopus 로고    scopus 로고
    • A meta-analysis of occupational trichloroethylene exposure and multiple myeloma or leukaemia
    • Alexander, D.D., Mink, P.J., Mandel, J.H., and Kelsh, M.A. (2006). A meta-analysis of occupational trichloroethylene exposure and multiple myeloma or leukaemia. Occup. Med. (Lond.) 56:485-493.
    • (2006) Occup. Med. (Lond.) , vol.56 , pp. 485-493
    • Alexander, D.D.1    Mink, P.J.2    Mandel, J.H.3    Kelsh, M.A.4
  • 3
    • 9444234519 scopus 로고    scopus 로고
    • Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    • Anderson, S.P., Dunn, C., Laughter, A., Yoon L., Swanson, C., Stulnig, T.M., Steffensen, K.R., Chandraratna, R.A., Gustafsson, J.A., and Corton, J.C. (2004a). Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver. Mol. Pharmacol. 66:1440-1452.
    • (2004) Mol. Pharmacol , vol.66 , pp. 1440-1452
    • Anderson, S.P.1    Dunn, C.2    Laughter, A.3    Yoon, L.4    Swanson, C.5    Stulnig, T.M.6    Steffensen, K.R.7    Chandraratna, R.A.8    Gustafsson, J.A.9    Corton, J.C.10
  • 4
    • 10844247029 scopus 로고    scopus 로고
    • The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes
    • Anderson, S.P., Howroyd, P., Liu, J., Qian,. X., Bahnemann, R., Swanson, C., Kwak, M.K., Kensler, T.W., and Corton, J.C. (2004b). The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. J. Biol. Chem. 279:52390-52398.
    • (2004) J. Biol. Chem , vol.279 , pp. 52390-52398
    • Anderson, S.P.1    Howroyd, P.2    Liu, J.3    Qian, X.4    Bahnemann, R.5    Swanson, C.6    Kwak, M.K.7    Kensler, T.W.8    Corton, J.C.9
  • 5
    • 0036730442 scopus 로고    scopus 로고
    • Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice
    • Anderson, S.P., Yoon, L., Richard, E.B., Dunn, C.S., Cattley, R.C., and Corton, J.C. (2002). Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Hepatology. 36:544-554.
    • (2002) Hepatology , vol.36 , pp. 544-554
    • Anderson, S.P.1    Yoon, L.2    Richard, E.B.3    Dunn, C.S.4    Cattley, R.C.5    Corton, J.C.6
  • 6
    • 0027960682 scopus 로고
    • ras proto-oncogene activation in dichloroacetic acid-trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice
    • Anna, C.H., Maronpot, R.R., Pereira, M.A., Foley, J.F., Malarkey, D.E., and Anderson, M.W. (1994). ras proto-oncogene activation in dichloroacetic acid-trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice. Carcinogenesis 15:2255-2561.
    • (1994) Carcinogenesis , vol.15 , pp. 2255-2561
    • Anna, C.H.1    Maronpot, R.R.2    Pereira, M.A.3    Foley, J.F.4    Malarkey, D.E.5    Anderson, M.W.6
  • 8
    • 0028932625 scopus 로고
    • Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation
    • Austin, E.W., Okita, J.R., Okita, R. T., Larson, J.L., and Bull, R.J. (1995). Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation. Toxicology 97:59-69.
    • (1995) Toxicology , vol.97 , pp. 59-69
    • Austin, E.W.1    Okita, J.R.2    Okita, R.T.3    Larson, J.L.4    Bull, R.J.5
  • 10
    • 0035147169 scopus 로고    scopus 로고
    • Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene
    • Bartosiewicz, M., Penn, S., and Buckpitt, A. (2001). Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ. Health Perspect. 109:71-74.
    • (2001) Environ. Health Perspect , vol.109 , pp. 71-74
    • Bartosiewicz, M.1    Penn, S.2    Buckpitt, A.3
  • 13
    • 0024390938 scopus 로고
    • Metabolism, toxicity, and carcinogenicity of trichloroethylene
    • Bruckner, J.V., Davis, B.D., and Blancato, J.N. (1989). Metabolism, toxicity, and carcinogenicity of trichloroethylene. Crit. Rev. Toxicol. 20:31-50.
    • (1989) Crit. Rev. Toxicol , vol.20 , pp. 31-50
    • Bruckner, J.V.1    Davis, B.D.2    Blancato, J.N.3
  • 14
    • 0345270447 scopus 로고    scopus 로고
    • Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany
    • Bruning, T., Pesch, B., Wiesenhutter, B., Rabstein, S., Lammert, M., Baumuller, A., and Bolt, H.M. (2003). Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany. Am. J. Ind. Med. 43:274-285.
    • (2003) Am. J. Ind. Med , vol.43 , pp. 274-285
    • Bruning, T.1    Pesch, B.2    Wiesenhutter, B.3    Rabstein, S.4    Lammert, M.5    Baumuller, A.6    Bolt, H.M.7
  • 15
    • 0021923010 scopus 로고
    • Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect study
    • Buben, J.A., and O'Flaherty, E.J. (1985). Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect study. Toxicol Appl Pharmacol. 78:105-122.
    • (1985) Toxicol Appl Pharmacol , vol.78 , pp. 105-122
    • Buben, J.A.1    O'Flaherty, E.J.2
  • 16
    • 0025005335 scopus 로고
    • Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate
    • Bull, R.J., Sanchez, I.M., Nelson, M.A., Larson, J.L., and Lansing, A.J. (1990). Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology 63:341-359.
    • (1990) Toxicology , vol.63 , pp. 341-359
    • Bull, R.J.1    Sanchez, I.M.2    Nelson, M.A.3    Larson, J.L.4    Lansing, A.J.5
  • 17
    • 0033947603 scopus 로고    scopus 로고
    • Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate
    • Bull, R.J. (2000). Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. Environ. Health Perspect. 108 (Suppl. 2):241-259.
    • (2000) Environ. Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 241-259
    • Bull, R.J.1
  • 19
    • 33748185237 scopus 로고    scopus 로고
    • Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis
    • Caldwell, J.C., and Keshava, N. (2006). Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis. Environ. Health Perspect. 114:1457-1463.
    • (2006) Environ. Health Perspect , vol.114 , pp. 1457-1463
    • Caldwell, J.C.1    Keshava, N.2
  • 20
    • 40149083899 scopus 로고    scopus 로고
    • Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures
    • Caldwell, J.C., Keshava, N., and Evans, M.V. (2007). Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures. Environ. Mol. Mutagen. 49:142-154.
    • (2007) Environ. Mol. Mutagen , vol.49 , pp. 142-154
    • Caldwell, J.C.1    Keshava, N.2    Evans, M.V.3
  • 21
    • 0031470895 scopus 로고    scopus 로고
    • The significance of mouse liver tumor formation for carcinogenic risk assessment: Results and conclusions from a survey of ten years of testing by the agrochemical industry
    • Carmichael, N.G., Enzmann, H., Pate, I., and Waechter, F. (1997). The significance of mouse liver tumor formation for carcinogenic risk assessment: Results and conclusions from a survey of ten years of testing by the agrochemical industry. Environ. Health Perspect. 105:1196-1203.
    • (1997) Environ. Health Perspect , vol.105 , pp. 1196-1203
    • Carmichael, N.G.1    Enzmann, H.2    Pate, I.3    Waechter, F.4
  • 22
    • 0029620853 scopus 로고
    • Biochemical, pathologic and morphometric alterations induced in male B6C3F1mouse liver by short-term exposure to dichloroacetic acid
    • Carter, J.H., Carter, H.W., and DeAngelo, A.B. (1995). Biochemical, pathologic and morphometric alterations induced in male B6C3F1mouse liver by short-term exposure to dichloroacetic acid. Toxicol. Lett. 81:55-71.
    • (1995) Toxicol. Lett , vol.81 , pp. 55-71
    • Carter, J.H.1    Carter, H.W.2    DeAngelo, A.B.3
  • 23
    • 0024314929 scopus 로고
    • Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver
    • Cattley, R.C., and Popp, J.A. (1989). Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res. 49:3246-3251.
    • (1989) Cancer Res , vol.49 , pp. 3246-3251
    • Cattley, R.C.1    Popp, J.A.2
  • 24
    • 0023521213 scopus 로고
    • Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl)phthalate for 2 years
    • Cattley, R.C., Conway, J.G., and Popp, J.A. (1987). Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl)phthalate for 2 years. Cancer Lett. 38:15-22.
    • (1987) Cancer Lett , vol.38 , pp. 15-22
    • Cattley, R.C.1    Conway, J.G.2    Popp, J.A.3
  • 25
    • 0031904294 scopus 로고    scopus 로고
    • A subchronic exposure to trichloroethylene causes lipid peroxidation and hepatocellular proliferation in male B6C3F1 mouse liver
    • Channel, S.R., Latendresse, J.R., Kidney, J.K., Grabau, J.H., Lane, J.W., Steel-Goodwin, L., and Gothaus, M.C. (1998). A subchronic exposure to trichloroethylene causes lipid peroxidation and hepatocellular proliferation in male B6C3F1 mouse liver. Toxicol. Sci. 43:145-154.
    • (1998) Toxicol. Sci , vol.43 , pp. 145-154
    • Channel, S.R.1    Latendresse, J.R.2    Kidney, J.K.3    Grabau, J.H.4    Lane, J.W.5    Steel-Goodwin, L.6    Gothaus, M.C.7
  • 26
    • 2542635631 scopus 로고    scopus 로고
    • Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    • Cheung, C., Akiyama, T.E., Ward, J.M., Nicol, C.J., Feigenbaum, L., Vinson, C., and Gonzalez, F.J. (2004). Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Res. 64:3849-3854.
    • (2004) Cancer Res , vol.64 , pp. 3849-3854
    • Cheung, C.1    Akiyama, T.E.2    Ward, J.M.3    Nicol, C.J.4    Feigenbaum, L.5    Vinson, C.6    Gonzalez, F.J.7
  • 27
    • 33748209170 scopus 로고    scopus 로고
    • Issues in the pharmacokinetics of trichloroethylene and its metabolites
    • Chiu, W.A., Okino, M.S., Lipscomb, J.C., and Evans, M.V. (2006). Issues in the pharmacokinetics of trichloroethylene and its metabolites. Environ. Health Perspect. 114:1450-1456.
    • (2006) Environ. Health Perspect , vol.114 , pp. 1450-1456
    • Chiu, W.A.1    Okino, M.S.2    Lipscomb, J.C.3    Evans, M.V.4
  • 28
    • 0343090508 scopus 로고    scopus 로고
    • Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment
    • Clewell, H.J. 3rd, Gentry, P.R., Covington, T.R., and Gearhart, J.M. (2000). Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. Environ. Health Perspect. 108:S283-S305.
    • (2000) Environ. Health Perspect , vol.108
    • Clewell 3rd, H.J.1    Gentry, P.R.2    Covington, T.R.3    Gearhart, J.M.4
  • 29
    • 0034034671 scopus 로고    scopus 로고
    • Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators
    • Corton, J.C., Anderson, S.P., and Stauber, A. (2000). Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu. Rev. Pharmacol. Toxicol. 40:491-518.
    • (2000) Annu. Rev. Pharmacol. Toxicol , vol.40 , pp. 491-518
    • Corton, J.C.1    Anderson, S.P.2    Stauber, A.3
  • 30
    • 0031715770 scopus 로고    scopus 로고
    • Down-regulation of cytochrome P4502C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals
    • Corton, J.C., Fan, L.Q., Brown, S. Anderson, S.P., Bocos, D., Cattley, R.C., Mode, A. and Gustafsson, J.A. (1998). Down-regulation of cytochrome P4502C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals. Mol. Pharmacol. 54:463-473.
    • (1998) Mol. Pharmacol , vol.54 , pp. 463-473
    • Corton, J.C.1    Fan, L.Q.2    Brown, S.3    Anderson, S.P.4    Bocos, D.5    Cattley, R.C.6    Mode, A.7    Gustafsson, J.A.8
  • 31
    • 0034677853 scopus 로고    scopus 로고
    • Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators
    • Corton, J.C., Lapinskas, P.J., and Gonzalez, F.J. (1999). Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators. Mutat. Res. 448:139-151.
    • (1999) Mutat. Res , vol.448 , pp. 139-151
    • Corton, J.C.1    Lapinskas, P.J.2    Gonzalez, F.J.3
  • 32
    • 0024394728 scopus 로고
    • Genetic toxicology of 1,1,2-trichloroethylene
    • Crebelli, R., and Carere, A. (1989). Genetic toxicology of 1,1,2-trichloroethylene. Mutat. Res. 221:11-37.
    • (1989) Mutat. Res , vol.221 , pp. 11-37
    • Crebelli, R.1    Carere, A.2
  • 33
    • 77957179532 scopus 로고
    • Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse
    • Daniel, F.B., DeAngelo, A.B., Stober, J.A., Olson, G.R., and Page, N.P. (1992a). Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 19:159-168.
    • (1992) Fundam. Appl. Toxicol , vol.19 , pp. 159-168
    • Daniel, F.B.1    DeAngelo, A.B.2    Stober, J.A.3    Olson, G.R.4    Page, N.P.5
  • 34
    • 0026662739 scopus 로고
    • Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat
    • Daniel, F.B., Robinson, M., Stober, J.A., Page, N.P., and Olson, G.R. (1992b). Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat. Drug Chem Toxicol. 15:217-332.
    • (1992) Drug Chem Toxicol , vol.15 , pp. 217-332
    • Daniel, F.B.1    Robinson, M.2    Stober, J.A.3    Page, N.P.4    Olson, G.R.5
  • 35
    • 0032867057 scopus 로고    scopus 로고
    • Chronic peroxisome proliferation and hepatomegaly associated with the hepatocellular tumorigenesis of di(2-ethylhexyl)phthalate and the effects of recovery
    • David, R.M., Moore, M.R., Cifone, M.A. Finney, D.C., and Guest, D. (1999). Chronic peroxisome proliferation and hepatomegaly associated with the hepatocellular tumorigenesis of di(2-ethylhexyl)phthalate and the effects of recovery. Toxicol. Sci. 50:195-205.
    • (1999) Toxicol. Sci , vol.50 , pp. 195-205
    • David, R.M.1    Moore, M.R.2    Cifone, M.A.3    Finney, D.C.4    Guest, D.5
  • 36
    • 0026346879 scopus 로고
    • Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics
    • Davidson, I.W., and Beliles, R.P. (1991). Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. Drug Metab. Rev. 23:493-599.
    • (1991) Drug Metab. Rev , vol.23 , pp. 493-599
    • Davidson, I.W.1    Beliles, R.P.2
  • 37
    • 0020067649 scopus 로고
    • Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment
    • De La Iglesia, F.A., Lewis, J.E., Buchanan, R.A., Marcus, E.L., and McMahon, G. (1982) Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment. Atherosclerosis 43:19-37.
    • (1982) Atherosclerosis , vol.43 , pp. 19-37
    • De La Iglesia, F.A.1    Lewis, J.E.2    Buchanan, R.A.3    Marcus, E.L.4    McMahon, G.5
  • 38
    • 0024389625 scopus 로고
    • Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids
    • DeAngelo, A.B., Daniel, F.B., McMillan, L., Wernsing, P., and Savage, R.E., Jr. (1989). Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids. Toxicol Appl Pharmacol. 101:285-298.
    • (1989) Toxicol Appl Pharmacol , vol.101 , pp. 285-298
    • DeAngelo, A.B.1    Daniel, F.B.2    McMillan, L.3    Wernsing, P.4    Savage Jr., R.E.5
  • 39
    • 0030592952 scopus 로고    scopus 로고
    • The carcinogenicity of dichloroacetic acid in the male fischer 344 rat
    • DeAngelo, A.B., Daniel, F.B., Most, B.M., and Olson, G.R. (1996). The carcinogenicity of dichloroacetic acid in the male fischer 344 rat. Toxicology 114:207-221.
    • (1996) Toxicology , vol.114 , pp. 207-221
    • DeAngelo, A.B.1    Daniel, F.B.2    Most, B.M.3    Olson, G.R.4
  • 40
    • 0030694391 scopus 로고    scopus 로고
    • Failure of monochloroacetic acid and trichloroacetic acid administered in the drinking water to produce liver cancer in male F344/N rats
    • DeAngelo, A.B., Daniel, F.B., Most, B.M., and Olson, G.R. (1997). Failure of monochloroacetic acid and trichloroacetic acid administered in the drinking water to produce liver cancer in male F344/N rats. J. Toxicol. Environ. Health 52:425-445.
    • (1997) J. Toxicol. Environ. Health , vol.52 , pp. 425-445
    • DeAngelo, A.B.1    Daniel, F.B.2    Most, B.M.3    Olson, G.R.4
  • 41
    • 0026093018 scopus 로고
    • The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse
    • DeAngelo, A.B., Daniel, F.B., Stober, J.A., and Olson, G.R. (1991). The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 16:337-347.
    • (1991) Fundam. Appl. Toxicol , vol.16 , pp. 337-347
    • DeAngelo, A.B.1    Daniel, F.B.2    Stober, J.A.3    Olson, G.R.4
  • 42
    • 0033601128 scopus 로고    scopus 로고
    • Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: Dose-response determination and modes of action
    • DeAngelo, A.B., George, M.H., and House, D.E. (1999). Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: Dose-response determination and modes of action. J. Toxicol. Environ. Health A 48:485-507.
    • (1999) J. Toxicol. Environ. Health A , vol.48 , pp. 485-507
    • DeAngelo, A.B.1    George, M.H.2    House, D.E.3
  • 43
    • 0027305268 scopus 로고
    • The mitogenic potential of trichloroethylene in B6C3F1 mice
    • Dees, C., and Travis, C. (1993). The mitogenic potential of trichloroethylene in B6C3F1 mice. Toxicol. Lett. 69:129-137.
    • (1993) Toxicol. Lett , vol.69 , pp. 129-137
    • Dees, C.1    Travis, C.2
  • 44
    • 0028137509 scopus 로고
    • Trichloroacetate stimulation of liver DNA synthesis in male and female mice
    • Dees, C., and Travis, C. (1994). Trichloroacetate stimulation of liver DNA synthesis in male and female mice. Toxic. Lett. 70:343-355.
    • (1994) Toxic. Lett , vol.70 , pp. 343-355
    • Dees, C.1    Travis, C.2
  • 45
    • 0025633791 scopus 로고
    • Effect of di(2-ethylhexyl)phthalate on enzyme activity levels in liver and serum of rats
    • Dirvin, H.A., van den Brock, P.H., and Jongeneelen, F.J. (1990). Effect of di(2-ethylhexyl)phthalate on enzyme activity levels in liver and serum of rats. Toxicology 65:199-207.
    • (1990) Toxicology , vol.65 , pp. 199-207
    • Dirvin, H.A.1    van den Brock, P.H.2    Jongeneelen, F.J.3
  • 46
    • 0022335175 scopus 로고
    • Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment
    • Elcombe, C.R. (1985). Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment. Arch. Toxicol. Suppl. 8:6-17.
    • (1985) Arch. Toxicol. Suppl , vol.8 , pp. 6-17
    • Elcombe, C.R.1
  • 47
    • 0021808807 scopus 로고
    • Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: Possible relevance to species differences in hepatocarcinogenicity
    • Elcombe, C.R., Rose, M.S., and Pratt, I.S. (1985). Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: Possible relevance to species differences in hepatocarcinogenicity. Toxicol. Appl. Pharmacol. 79:365-376.
    • (1985) Toxicol. Appl. Pharmacol , vol.79 , pp. 365-376
    • Elcombe, C.R.1    Rose, M.S.2    Pratt, I.S.3
  • 48
    • 0025636068 scopus 로고
    • Effects of prolonged treatment with phthalate ester on rat liver
    • Ganning, A.E., Olsson, M.J., Brunk, U., and Dallner, G. (1990). Effects of prolonged treatment with phthalate ester on rat liver. Pharmacol. Toxicol. 67:392-401.
    • (1990) Pharmacol. Toxicol , vol.67 , pp. 392-401
    • Ganning, A.E.1    Olsson, M.J.2    Brunk, U.3    Dallner, G.4
  • 50
    • 0033866929 scopus 로고    scopus 로고
    • Carcinogenicity of chloral hydrate administered in drinking water to the male F344//N rat and male B6C3F mouse
    • George, M.H., Moore, T., Kilburn, S. Olson, G.R., and DeAngelo, A.B. (2000). Carcinogenicity of chloral hydrate administered in drinking water to the male F344//N rat and male B6C3F mouse. Toxicol. Pathol. 28: 610-618.
    • (2000) Toxicol. Pathol , vol.28 , pp. 610-618
    • George, M.H.1    Moore, T.2    Kilburn, S.3    Olson, G.R.4    DeAngelo, A.B.5
  • 52
    • 0023269323 scopus 로고
    • Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity
    • Goldsworthy, T.L., and Popp, J.A. (1987). Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity. Toxicol. Appl. Pharmacol. 88:225-233.
    • (1987) Toxicol. Appl. Pharmacol , vol.88 , pp. 225-233
    • Goldsworthy, T.L.1    Popp, J.A.2
  • 53
    • 0027517501 scopus 로고
    • Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital
    • Grasl-Kraupp, B., Waldhor, T., Huber, W., and Schulte-Hermann, R. (1993). Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital. Carcinogenesis 14:2407-2412.
    • (1993) Carcinogenesis , vol.14 , pp. 2407-2412
    • Grasl-Kraupp, B.1    Waldhor, T.2    Huber, W.3    Schulte-Hermann, R.4
  • 54
    • 0020683937 scopus 로고
    • Relationship between morphological changes and lipid-lowering action of pchlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man
    • Hanefeld, J., Kemmer, C., and Kadner, E. (1983). Relationship between morphological changes and lipid-lowering action of pchlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man. Atherosclerosis 46:239-246.
    • (1983) Atherosclerosis , vol.46 , pp. 239-246
    • Hanefeld, J.1    Kemmer, C.2    Kadner, E.3
  • 58
    • 13444311098 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis
    • Hays, T., Rusyn, I., Burns, A.M., Kennett, M.J., Ward, J.M., Gonzalez, F.J., and Peters, J.M. (2005). Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26:219-227.
    • (2005) Carcinogenesis , vol.26 , pp. 219-227
    • Hays, T.1    Rusyn, I.2    Burns, A.M.3    Kennett, M.J.4    Ward, J.M.5    Gonzalez, F.J.6    Peters, J.M.7
  • 60
    • 0023510171 scopus 로고
    • The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver
    • Herren-Freund, S.L., Pereira, M.A., Khoury, M.D., and Olson, G. (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90:183-189.
    • (1987) Toxicol. Appl. Pharmacol , vol.90 , pp. 183-189
    • Herren-Freund, S.L.1    Pereira, M.A.2    Khoury, M.D.3    Olson, G.4
  • 61
    • 4544331684 scopus 로고    scopus 로고
    • Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)
    • Howroyd, P., Swanson, C., Dunn, C., Cattley, R.C., and Corton, J.C. (2004). Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Toxicol. Pathol. 32:591-599.
    • (2004) Toxicol. Pathol , vol.32 , pp. 591-599
    • Howroyd, P.1    Swanson, C.2    Dunn, C.3    Cattley, R.C.4    Corton, J.C.5
  • 63
    • 85012849890 scopus 로고    scopus 로고
    • WHO International Agency for Research on Cancer. Some pharmaceutical drugs
    • IARC
    • IARC. (1996). WHO International Agency for Research on Cancer. Some pharmaceutical drugs. IARC Monogr. Eval. Carcinogen. Risk Chem. Hum. 66:391-426.
    • (1996) IARC Monogr. Eval. Carcinogen. Risk Chem. Hum , vol.66 , pp. 391-426
  • 64
    • 0033938537 scopus 로고    scopus 로고
    • Effects of di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver
    • Isenberg, J.S. Kamendulis, L.M., Smith, J.H., Ackley, D.C., Pugh, G., Jr., Lington, A.W., and Klaunig, J.E. (2000). Effects of di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver. Toxicol. Sci. 56:73-85.
    • (2000) Toxicol. Sci , vol.56 , pp. 73-85
    • Isenberg, J.S.1    Kamendulis, L.M.2    Smith, J.H.3    Ackley, D.C.4    Pugh Jr., G.5    Lington, A.W.6    Klaunig, J.E.7
  • 65
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 67
    • 0035072943 scopus 로고    scopus 로고
    • Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice
    • Kato-Weinstein, J., Stauber, A.J., Orner, G.A., Thrall, B.D., and Bull R. (2001). Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice. J. Appl. Toxicol. 21:91-89.
    • (2001) J. Appl. Toxicol , vol.21 , pp. 91-89
    • Kato-Weinstein, J.1    Stauber, A.J.2    Orner, G.A.3    Thrall, B.D.4    Bull, R.5
  • 68
    • 33748188907 scopus 로고    scopus 로고
    • Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity
    • Keshava, N., and Caldwell, J.C. (2006). Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity. Environ. Health Perspect. 114:1464-1470.
    • (2006) Environ. Health Perspect , vol.114 , pp. 1464-1470
    • Keshava, N.1    Caldwell, J.C.2
  • 69
    • 33751517697 scopus 로고    scopus 로고
    • Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice
    • Kim, D., and Ghanayem, B.I. (2006). Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/-and wild-type mice. Drug Metab. Dispos. 34:2020-2027.
    • (2006) Drug Metab. Dispos , vol.34 , pp. 2020-2027
    • Kim, D.1    Ghanayem, B.I.2
  • 71
    • 2342640244 scopus 로고    scopus 로고
    • Experimental cancer studies of chlorinated by-products
    • Komulainen., H. (2004). Experimental cancer studies of chlorinated by-products. Toxicology 198:239-248.
    • (2004) Toxicology , vol.198 , pp. 239-248
    • Komulainen, H.1
  • 72
    • 0026684304 scopus 로고
    • Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice
    • Larson, J.L., and Bull, R.J. (1992). Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115:268-277.
    • (1992) Toxicol. Appl. Pharmacol , vol.115 , pp. 268-277
    • Larson, J.L.1    Bull, R.J.2
  • 73
    • 0035018536 scopus 로고    scopus 로고
    • Hepatic and renal toxicities associated with perchloroethylene
    • Lash, L.H., and Parker, J.C. (2001). Hepatic and renal toxicities associated with perchloroethylene. Pharmacol. Rev. 53:177-208.
    • (2001) Pharmacol. Rev , vol.53 , pp. 177-208
    • Lash, L.H.1    Parker, J.C.2
  • 74
    • 0033945538 scopus 로고    scopus 로고
    • Modes of action of trichloroethylene for kidney tumorigenesis
    • Lash, L.H., Parker, J.C., and Scott, C.S. (2000). Modes of action of trichloroethylene for kidney tumorigenesis. Environ. Health Perspect. 108 (Suppl. 2):225-240.
    • (2000) Environ. Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 225-240
    • Lash, L.H.1    Parker, J.C.2    Scott, C.S.3
  • 75
    • 0030880918 scopus 로고    scopus 로고
    • Dissimilar characteristics of N-methyl-N-nitrosourea-initiated foci and tumors promoted by dichloroacetic acid or trichloroacetic acid in the liver of female B6C3F1 mice
    • Latendresse, J.R., and Pereira, M.A. (1997). Dissimilar characteristics of N-methyl-N-nitrosourea-initiated foci and tumors promoted by dichloroacetic acid or trichloroacetic acid in the liver of female B6C3F1 mice. Toxicol. Pathol. 25:433-440.
    • (1997) Toxicol. Pathol , vol.25 , pp. 433-440
    • Latendresse, J.R.1    Pereira, M.A.2
  • 76
    • 4444347319 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver
    • Laughter, A.R., Dunn, C.S., Swanson, C.L., Howroyd, P., Cattley, R.C., and Corton, J.C. (2004). Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. Toxicology 203:83-98.
    • (2004) Toxicology , vol.203 , pp. 83-98
    • Laughter, A.R.1    Dunn, C.S.2    Swanson, C.L.3    Howroyd, P.4    Cattley, R.C.5    Corton, J.C.6
  • 77
    • 0035943681 scopus 로고    scopus 로고
    • Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson
    • Lawrence, J.W., Li, Y., Chen, S., DeLuca, J.G., Berger, J.P., Umbenhauer, D.R., Moller, D.E., and Zhou, G. (2001). Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson. J. Biol. Chem. 276:31521-31527.
    • (2001) J. Biol. Chem , vol.276 , pp. 31521-31527
    • Lawrence, J.W.1    Li, Y.2    Chen, S.3    DeLuca, J.G.4    Berger, J.P.5    Umbenhauer, D.R.6    Moller, D.E.7    Zhou, G.8
  • 79
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee, S.S., Pineau, T., Drago, J., Lee, E.J., Owens, J.W., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H., and Gonzalez, F.J. (1995). Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:3012-3022.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 80
    • 33744789211 scopus 로고    scopus 로고
    • Trichloroethylene: Mechanisms of renal toxicity and renal cancer and relevance to risk assessment
    • Lock, E.A., and Reed, C.J. (2006). Trichloroethylene: Mechanisms of renal toxicity and renal cancer and relevance to risk assessment. Toxicol. Sci. 91:313-331.
    • (2006) Toxicol. Sci , vol.91 , pp. 313-331
    • Lock, E.A.1    Reed, C.J.2
  • 81
    • 0024509605 scopus 로고
    • Biochemical mechanisms of induction of hepatic peroxisome proliferation
    • Lock, E.A., Mitchell, A.M., and Elcombe, C.R. (1989). Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol. 29:145-163.
    • (1989) Annu. Rev. Pharmacol. Toxicol , vol.29 , pp. 145-163
    • Lock, E.A.1    Mitchell, A.M.2    Elcombe, C.R.3
  • 82
    • 0037098862 scopus 로고    scopus 로고
    • Interactions of fluorochemicals with rat liver fatty acid-binding protein
    • Luebker, D.J., Hansen, K.J., Bass, N.M., Butenhoff, J.L, and Seacat, A.M. (2002). Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology 176:175-185.
    • (2002) Toxicology , vol.176 , pp. 175-185
    • Luebker, D.J.1    Hansen, K.J.2    Bass, N.M.3    Butenhoff, J.L.4    Seacat, A.M.5
  • 83
    • 56449093756 scopus 로고    scopus 로고
    • Mahle, D.A., Godfrey, R.J., Buttler, G.W., Narayanan, L.A., Taylor, A., and Fisher, J.W., (2001). Pharmacokinetics and metabolism of dichloroacetic and trichloroacetic acid administered in drinking water in rats and mice. USAF Technical Report. (AFRL-HE-WP-TR-2001-0059), AFRL/HE, Operational Toxicology Branch, WPAFB, OH 34433.
    • Mahle, D.A., Godfrey, R.J., Buttler, G.W., Narayanan, L.A., Taylor, A., and Fisher, J.W., (2001). Pharmacokinetics and metabolism of dichloroacetic and trichloroacetic acid administered in drinking water in rats and mice. USAF Technical Report. (AFRL-HE-WP-TR-2001-0059), AFRL/HE, Operational Toxicology Branch, WPAFB, OH 34433.
  • 84
    • 0032585881 scopus 로고    scopus 로고
    • Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals
    • Maloney, E.K., andWaxman, D.J. (1999). Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol. Appl. Pharmacol. 161:209-218.
    • (1999) Toxicol. Appl. Pharmacol , vol.161 , pp. 209-218
    • Maloney, E.K.1    andWaxman, D.J.2
  • 85
    • 0025160366 scopus 로고
    • Subchronic 90 day toxicity of dichloroacetic and trichloroacetic acid in rats
    • Mather, G.G., Exon, J.H., and Koller, L.D. (1990). Subchronic 90 day toxicity of dichloroacetic and trichloroacetic acid in rats. Toxicology 64:71-80.
    • (1990) Toxicology , vol.64 , pp. 71-80
    • Mather, G.G.1    Exon, J.H.2    Koller, L.D.3
  • 86
    • 0033799773 scopus 로고    scopus 로고
    • PPAR-alpha: A key to the mechanism of hepatoprotection by clofibrate
    • Mehendale, H.M. (2000). PPAR-alpha: A key to the mechanism of hepatoprotection by clofibrate. Toxicol. Sci. 57:187-190.
    • (2000) Toxicol. Sci , vol.57 , pp. 187-190
    • Mehendale, H.M.1
  • 88
    • 0034661013 scopus 로고    scopus 로고
    • Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes
    • Merdink, J.L., Bull, R.J., and Schultz, I.R. (2000). Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Free Radical Biol .Med. 29:125-130.
    • (2000) Free Radical Biol .Med , vol.29 , pp. 125-130
    • Merdink, J.L.1    Bull, R.J.2    Schultz, I.R.3
  • 89
    • 0031723692 scopus 로고    scopus 로고
    • The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice
    • Merdink, J.L., Gonzalez-Leon, A., Bull, R.J., and Schultz, I.R. (1998). The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice. Toxicol. Sci. 45:33-41.
    • (1998) Toxicol. Sci , vol.45 , pp. 33-41
    • Merdink, J.L.1    Gonzalez-Leon, A.2    Bull, R.J.3    Schultz, I.R.4
  • 90
    • 0034646944 scopus 로고    scopus 로고
    • In vivo MRI measurements of tumor growth induced by dichloroacetate: Implications for mode of action
    • Miller, J.H., Minard, K., Wind, R.A., Orner, G.A., Sasser, L.B., and Bull, R.J. (2000). In vivo MRI measurements of tumor growth induced by dichloroacetate: Implications for mode of action. Toxicology 145:115-125.
    • (2000) Toxicology , vol.145 , pp. 115-125
    • Miller, J.H.1    Minard, K.2    Wind, R.A.3    Orner, G.A.4    Sasser, L.B.5    Bull, R.J.6
  • 91
    • 0020473257 scopus 로고
    • Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide
    • Miller, R.E., and Guengerich, F.P. (1982). Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide. Biochemistry 21:1090-1097.
    • (1982) Biochemistry , vol.21 , pp. 1090-1097
    • Miller, R.E.1    Guengerich, F.P.2
  • 92
    • 0022355236 scopus 로고
    • Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate
    • Mitchell, F.E., Price, S.C., Hinton, R.H., Grasso, P., and Bridges, J.W. (1985). Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 81:371-392.
    • (1985) Toxicol. Appl. Pharmacol , vol.81 , pp. 371-392
    • Mitchell, F.E.1    Price, S.C.2    Hinton, R.H.3    Grasso, P.4    Bridges, J.W.5
  • 93
    • 0033932461 scopus 로고    scopus 로고
    • Mutagenicity of trichloroethylene and its metabolites: Implications for the risk assessment of trichloroethylene
    • Moore, M.M., and Harrington-Brock, K. (2000). Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene. Environ. Health Perspect. 108 (Suppl. 2):215-223.
    • (2000) Environ. Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 215-223
    • Moore, M.M.1    Harrington-Brock, K.2
  • 94
    • 33646180263 scopus 로고    scopus 로고
    • Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis
    • Morimura, K., Cheung, C., Ward, J.M., Reddy, J.K., and Gonzalez, J.F. (2006). Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. Carcinogenesis 27:1074-1080.
    • (2006) Carcinogenesis , vol.27 , pp. 1074-1080
    • Morimura, K.1    Cheung, C.2    Ward, J.M.3    Reddy, J.K.4    Gonzalez, J.F.5
  • 95
    • 0034054536 scopus 로고    scopus 로고
    • Sexdependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha)
    • Nakajima, T., Kamijo, Y., Usuda, N., Liang, Y., Fukushima, Y., Kametani, K., Gonzalez, F.J., and Aoyama, T. (2000). Sexdependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha). Carcinogenesis 21:677-682.
    • (2000) Carcinogenesis , vol.21 , pp. 677-682
    • Nakajima, T.1    Kamijo, Y.2    Usuda, N.3    Liang, Y.4    Fukushima, Y.5    Kametani, K.6    Gonzalez, F.J.7    Aoyama, T.8
  • 97
    • 56449083346 scopus 로고
    • Carcinogenesis bioassay of trichloroethylene
    • National Cancer Institute, Washington, DC: NCI
    • National Cancer Institute. (1976). Carcinogenesis bioassay of trichloroethylene. NCI-CG-TR-1 DHEW/Pub/NIH-76-802. Washington, DC: NCI.
    • (1976) NCI-CG-TR-1 DHEW/Pub/NIH-76-802
  • 98
    • 56449119192 scopus 로고    scopus 로고
    • National Toxicology Program. (1983). NTP carcinogenesis studies of trichloroethylene (without epidhlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 243:1-174.
    • National Toxicology Program. (1983). NTP carcinogenesis studies of trichloroethylene (without epidhlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 243:1-174.
  • 99
    • 56449124362 scopus 로고    scopus 로고
    • National Toxicology Program. (1982). Carcinogenesis bioassay of di(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 rats and B6C3F1 mice (feed studies). Natl. Toxicol. Program Tech. Rep. Ser 217:1-127.
    • National Toxicology Program. (1982). Carcinogenesis bioassay of di(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 rats and B6C3F1 mice (feed studies). Natl. Toxicol. Program Tech. Rep. Ser 217:1-127.
  • 100
    • 2342655164 scopus 로고
    • NTP toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) CAS No. 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies)
    • National Toxicology Program
    • National Toxicology Program. (1986). NTP toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) CAS No. 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl. Toxicol. Program Tech. Res. Ser. 311:1-197.
    • (1986) Natl. Toxicol. Program Tech. Res. Ser , vol.311 , pp. 1-197
  • 101
    • 56449110180 scopus 로고    scopus 로고
    • National Toxicology Program. (1988). NTP toxicology and carcinogenesis studies of trichloroethylene (CAS No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 273:1-299.
    • National Toxicology Program. (1988). NTP toxicology and carcinogenesis studies of trichloroethylene (CAS No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 273:1-299.
  • 102
    • 0036482990 scopus 로고    scopus 로고
    • National Toxicology Program. (2002). NTP Technical report on the toxicology and carcinogenesis studies of chloral hydrate (CAS No. 302-17-0) in B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 502:1-197.
    • National Toxicology Program. (2002). NTP Technical report on the toxicology and carcinogenesis studies of chloral hydrate (CAS No. 302-17-0) in B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 502:1-197.
  • 103
    • 0024462258 scopus 로고
    • Dichloroacetic acid and trichloroacetic acid-induced DNAstrand breaks are independent of peroxisome proliferation
    • Nelson, M.A., Lansing, A.J., Sanchez, I.M., Bull, R.J., and Springer, D.L. (1989). Dichloroacetic acid and trichloroacetic acid-induced DNAstrand breaks are independent of peroxisome proliferation. Toxicology 58:239-248.
    • (1989) Toxicology , vol.58 , pp. 239-248
    • Nelson, M.A.1    Lansing, A.J.2    Sanchez, I.M.3    Bull, R.J.4    Springer, D.L.5
  • 104
    • 0026587509 scopus 로고
    • Effects of joint exposures to selected peroxisome proliferators on hepatic acyl-CoA oxidase activity in male B6C3F1 mice
    • Ochs, J.B., Baldwin, L.A., Leonard, D.A., and Calabrese, E.J. (1992). Effects of joint exposures to selected peroxisome proliferators on hepatic acyl-CoA oxidase activity in male B6C3F1 mice. Hum. Exp. Toxicol. 11:83-88.
    • (1992) Hum. Exp. Toxicol , vol.11 , pp. 83-88
    • Ochs, J.B.1    Baldwin, L.A.2    Leonard, D.A.3    Calabrese, E.J.4
  • 105
    • 0023819178 scopus 로고
    • The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat
    • Odum, J. Green, T., Foster, J.R., and Hext, P.M. (1988). The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol. 92:103-112.
    • (1988) Toxicol. Appl. Pharmacol , vol.92 , pp. 103-112
    • Odum, J.1    Green, T.2    Foster, J.R.3    Hext, P.M.4
  • 106
    • 0028093483 scopus 로고
    • Fatty acid composition in liver, serum and brain of rat inhalated with trichloroethylene
    • Okamoto, T., and Shiwaku, K. (1994). Fatty acid composition in liver, serum and brain of rat inhalated with trichloroethylene. Exp. Toxicol. Pathol. 46:133-141.
    • (1994) Exp. Toxicol. Pathol , vol.46 , pp. 133-141
    • Okamoto, T.1    Shiwaku, K.2
  • 107
    • 0031952238 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-alpha expression in human liver
    • Palmer, C.N., Hsu, M.H., Griffin, K.J., Raucy, J.L., and Johnson, E.F. (1998). Peroxisome proliferator activated receptor-alpha expression in human liver. Mol. Pharmacol. 53:14-22.
    • (1998) Mol. Pharmacol , vol.53 , pp. 14-22
    • Palmer, C.N.1    Hsu, M.H.2    Griffin, K.J.3    Raucy, J.L.4    Johnson, E.F.5
  • 108
    • 0029890311 scopus 로고    scopus 로고
    • Parrish, J.M., Austin, Stevens E.W., Kinder, D.H., and Bull R.J. (1996). Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. Toxicology 110:103-111.
    • Parrish, J.M., Austin, Stevens E.W., Kinder, D.H., and Bull R.J. (1996). Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. Toxicology 110:103-111.
  • 109
    • 0029872439 scopus 로고    scopus 로고
    • Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice
    • Pereira, M.A., and Phelps, J.B. (1996). Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 102:133-141.
    • (1996) Cancer Lett , vol.102 , pp. 133-141
    • Pereira, M.A.1    Phelps, J.B.2
  • 110
    • 0031148563 scopus 로고    scopus 로고
    • Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice
    • Pereira, M.A., Li, K., and Kramer, P.M. (1997). Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 115:15-23.
    • (1997) Cancer Lett , vol.115 , pp. 15-23
    • Pereira, M.A.1    Li, K.2    Kramer, P.M.3
  • 111
    • 1342331492 scopus 로고    scopus 로고
    • Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice
    • Pereira, M.A., Wang, W., Kramer, P.M., and Tao, L. (2004). Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice. Toxicol. Sci. 77:243-248.
    • (2004) Toxicol. Sci , vol.77 , pp. 243-248
    • Pereira, M.A.1    Wang, W.2    Kramer, P.M.3    Tao, L.4
  • 112
    • 0034524943 scopus 로고    scopus 로고
    • Occupational risk factors for renal cell carcinoma: Agent-specific results from a case-control study in Germany, MURC Study Group. Multicenter urothelial and renal cancer study
    • Pesch, B., Haerting, J., Ranft, U., Klimpel, A., Oelschlagel, B., and Schill, W. (2000). Occupational risk factors for renal cell carcinoma: Agent-specific results from a case-control study in Germany, MURC Study Group. Multicenter urothelial and renal cancer study. Int. J. Epidemiol. 29:1014-1024.
    • (2000) Int. J. Epidemiol , vol.29 , pp. 1014-1024
    • Pesch, B.1    Haerting, J.2    Ranft, U.3    Klimpel, A.4    Oelschlagel, B.5    Schill, W.6
  • 113
    • 0031781381 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver
    • Peters, J.M., Aoyama, T., Cattley, R.C., Nobumitsu, U., Hashimoto, T., and Gonzalez, F.J. (1998). Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis 19:1989-1994.
    • (1998) Carcinogenesis , vol.19 , pp. 1989-1994
    • Peters, J.M.1    Aoyama, T.2    Cattley, R.C.3    Nobumitsu, U.4    Hashimoto, T.5    Gonzalez, F.J.6
  • 114
    • 0031418657 scopus 로고    scopus 로고
    • Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
    • Peters, J.M., Cattley, R.C., and Gonzalez, F.J. (1997). Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis 18:2029-2033.
    • (1997) Carcinogenesis , vol.18 , pp. 2029-2033
    • Peters, J.M.1    Cattley, R.C.2    Gonzalez, F.J.3
  • 115
    • 26044475136 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated-alpha and liver cancer: Where do we stand?
    • Peters, J.M., Cheung, C., and Gonzalez, F.J., (2005). Peroxisome proliferator-activated-alpha and liver cancer: Where do we stand? J. Mol. Med. 83:774-785.
    • (2005) J. Mol. Med , vol.83 , pp. 774-785
    • Peters, J.M.1    Cheung, C.2    Gonzalez, F.J.3
  • 116
    • 0034052579 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis
    • Peters, J.M., Rusyn, I., Rose, M.L., Gonzalez, F.J., and Thurman, R.G. (2000). Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis 21:823-826.
    • (2000) Carcinogenesis , vol.21 , pp. 823-826
    • Peters, J.M.1    Rusyn, I.2    Rose, M.L.3    Gonzalez, F.J.4    Thurman, R.G.5
  • 117
  • 118
    • 0034502784 scopus 로고    scopus 로고
    • Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure
    • Poon, R., Nadeau, B., and Chu, I. (2000). Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure. J. Appl. Toxicol. 20:455-461.
    • (2000) J. Appl. Toxicol , vol.20 , pp. 455-461
    • Poon, R.1    Nadeau, B.2    Chu, I.3
  • 119
    • 0021842689 scopus 로고
    • Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice
    • Prout, M.S., Provan, W.M., and Green, T. (1985). Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice. Toxicol. Appl. Pharcacol. 79:389-400.
    • (1985) Toxicol. Appl. Pharcacol , vol.79 , pp. 389-400
    • Prout, M.S.1    Provan, W.M.2    Green, T.3
  • 121
    • 0030478960 scopus 로고    scopus 로고
    • Hepatocarcinogenesis of peroxisome proliferators
    • Rao, M.S., and Reddy, J.K. (1996). Hepatocarcinogenesis of peroxisome proliferators. Ann N Y Acad Sci. 804:573-587.
    • (1996) Ann N Y Acad Sci , vol.804 , pp. 573-587
    • Rao, M.S.1    Reddy, J.K.2
  • 122
    • 0022560429 scopus 로고
    • Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug
    • Reddy, J.K., Reddy, M.K., Usman, M.I., Lalwani, N.D., and Rao, M.S. (1986). Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug. Environ. Health Perspect. 65:317-327.
    • (1986) Environ. Health Perspect , vol.65 , pp. 317-327
    • Reddy, J.K.1    Reddy, M.K.2    Usman, M.I.3    Lalwani, N.D.4    Rao, M.S.5
  • 123
    • 0025900416 scopus 로고
    • The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenenesis in B6C3F1 male mice
    • Richmond, R.E., DeAngelo, A.B., Potter, C.L., and Daniel, F.B. (1991). The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenenesis in B6C3F1 male mice. Carcinogenesis 12:1383-1387.
    • (1991) Carcinogenesis , vol.12 , pp. 1383-1387
    • Richmond, R.E.1    DeAngelo, A.B.2    Potter, C.L.3    Daniel, F.B.4
  • 124
    • 0022463003 scopus 로고
    • Induction of neoplastic lesions in the livers of C57BL x C3HF1 mice by chloral hydrate
    • Rijhsinghani, K.S., Abrahams, C., Swerdlow, M.A., Rao, K.V., and Ghose, T. (1986). Induction of neoplastic lesions in the livers of C57BL x C3HF1 mice by chloral hydrate. Cancer Detect. Prev. 9:279-288.
    • (1986) Cancer Detect. Prev , vol.9 , pp. 279-288
    • Rijhsinghani, K.S.1    Abrahams, C.2    Swerdlow, M.A.3    Rao, K.V.4    Ghose, T.5
  • 127
    • 0025004561 scopus 로고
    • Early induction of reparative hyperplasia in the liver of B6C3F1 mice treated with dichloroacetate and trichloroacetate
    • Sanchez, I.M., and Bull, R.J. (1990). Early induction of reparative hyperplasia in the liver of B6C3F1 mice treated with dichloroacetate and trichloroacetate. Toxicology 64:33-46.
    • (1990) Toxicology , vol.64 , pp. 33-46
    • Sanchez, I.M.1    Bull, R.J.2
  • 128
    • 0018969924 scopus 로고
    • The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
    • Schumann, A.M., Quast, J.F., and Watanabe, P.G. (1980). The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity. Toxicol. Appl Pharcol. 55:207-219.
    • (1980) Toxicol. Appl Pharcol , vol.55 , pp. 207-219
    • Schumann, A.M.1    Quast, J.F.2    Watanabe, P.G.3
  • 129
    • 0344276469 scopus 로고    scopus 로고
    • Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F mice following short-term exposure
    • Seng, J.E., Agrawal, N., Horsley, E.T.M., Leakey, T.I., Scherer, E.M., Xia, S., Allaben, W.T., and Leakey J.E.A. (2003). Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F mice following short-term exposure. Toxicol. Appl. Pharmacol. 193:281-292.
    • (2003) Toxicol. Appl. Pharmacol , vol.193 , pp. 281-292
    • Seng, J.E.1    Agrawal, N.2    Horsley, E.T.M.3    Leakey, T.I.4    Scherer, E.M.5    Xia, S.6    Allaben, W.T.7    Leakey, J.E.A.8
  • 130
    • 0023629398 scopus 로고
    • Metabolic and peroxisome proliferation studies with di(2-ethylhexyl)phthalate in rats and monkeys
    • Short, R.D., Robinson, E.C., Lington, A.W., and Chin, A.E. (1987). Metabolic and peroxisome proliferation studies with di(2-ethylhexyl)phthalate in rats and monkeys. Toxicol. Ind. Health 3:185-195.
    • (1987) Toxicol. Ind. Health , vol.3 , pp. 185-195
    • Short, R.D.1    Robinson, E.C.2    Lington, A.W.3    Chin, A.E.4
  • 131
    • 0029150242 scopus 로고
    • In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes
    • Snyder, R.D., Pullman, J., Carter, J.H., Carter, H.W., and DeAngelo, A.B. (1995). In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes. Cancer Res. 55:3702-3705.
    • (1995) Cancer Res , vol.55 , pp. 3702-3705
    • Snyder, R.D.1    Pullman, J.2    Carter, J.H.3    Carter, H.W.4    DeAngelo, A.B.5
  • 132
    • 0032103380 scopus 로고    scopus 로고
    • Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro
    • Stauber, A.J., Bull, R.J., and Thrall, B.D. (1998). Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro. Toxicol. Appl. Pharmacol. 150:287-294.
    • (1998) Toxicol. Appl. Pharmacol , vol.150 , pp. 287-294
    • Stauber, A.J.1    Bull, R.J.2    Thrall, B.D.3
  • 133
    • 0031172480 scopus 로고    scopus 로고
    • Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA)
    • Stauber, A.J.,and Bull, R.J. (1997). Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA). Toxicol. Appl. Pharmacol. 144:235-246.
    • (1997) Toxicol. Appl. Pharmacol , vol.144 , pp. 235-246
    • Stauber, A.J.1    Bull, R.J.2
  • 134
    • 77957180793 scopus 로고
    • Adduction of hemoglobin and albumin in vivo by metabolites of trichloroethylene, trichloroacetate, and dichloroacetate in rats and mice
    • Stevens, D.K., Eyre, R.J., and Bull, R.J. (1992). Adduction of hemoglobin and albumin in vivo by metabolites of trichloroethylene, trichloroacetate, and dichloroacetate in rats and mice. Fundam. Appl. Toxicol. 19:336-342.
    • (1992) Fundam. Appl. Toxicol , vol.19 , pp. 336-342
    • Stevens, D.K.1    Eyre, R.J.2    Bull, R.J.3
  • 135
    • 0020059408 scopus 로고
    • The pharmacokinetics and macromolecular interactions of trichloroethylene in mice and rats
    • Stott, W.T., Quast, J.F., and Watanabe, P.G. (1982). The pharmacokinetics and macromolecular interactions of trichloroethylene in mice and rats. Toxicol. Appl. Pharmacol. 62:137-151.
    • (1982) Toxicol. Appl. Pharmacol , vol.62 , pp. 137-151
    • Stott, W.T.1    Quast, J.F.2    Watanabe, P.G.3
  • 136
    • 0025882831 scopus 로고
    • Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse
    • Styles, J.A., Wyatt, I., and Coutts C. (1991). Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse. Carcinogenesis 12:1715-1719.
    • (1991) Carcinogenesis , vol.12 , pp. 1715-1719
    • Styles, J.A.1    Wyatt, I.2    Coutts, C.3
  • 138
    • 0032616340 scopus 로고    scopus 로고
    • Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice
    • Tao, L., Ge, R., Xie, M., Kramer, P.M., and Pereira, M.A. (1999). Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice. J. Biochem. Mol. Toxicol. 13:231-237.
    • (1999) J. Biochem. Mol. Toxicol , vol.13 , pp. 231-237
    • Tao, L.1    Ge, R.2    Xie, M.3    Kramer, P.M.4    Pereira, M.A.5
  • 139
    • 0034308194 scopus 로고    scopus 로고
    • Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors
    • Tao, L., Yang, S., Xie, M., Kramer, P.M., and Pereira, M.A. (2000a). Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Letters. 158:185-193.
    • (2000) Cancer Letters , vol.158 , pp. 185-193
    • Tao, L.1    Yang, S.2    Xie, M.3    Kramer, P.M.4    Pereira, M.A.5
  • 140
    • 0034071060 scopus 로고    scopus 로고
    • Effects of Trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: Prevention by methionine
    • Tao, L., Yang, S., Xie, M., Kramer, P.M., and Pereira, M.A. (2000b). Effects of Trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: Prevention by methionine. Toxicol. Sci. 54:399-407.
    • (2000) Toxicol. Sci , vol.54 , pp. 399-407
    • Tao, L.1    Yang, S.2    Xie, M.3    Kramer, P.M.4    Pereira, M.A.5
  • 142
  • 143
    • 0034532156 scopus 로고    scopus 로고
    • Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate
    • Walgren, J.E., Kurtz, D.T.,and McMillan, J.M. (2000a). Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate. Res. Commun. Mol. Pathol. Pharmacol. 108:116-132.
    • (2000) Res. Commun. Mol. Pathol. Pharmacol , vol.108 , pp. 116-132
    • Walgren, J.E.1    Kurtz, D.T.2    McMillan, J.M.3
  • 144
    • 0033773932 scopus 로고    scopus 로고
    • The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes
    • Walgren, J.E., Kurtz, D.T., and McMillan, J.M. (2000b). The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes. Cell. Biol. Toxicol. 16:257-273.
    • (2000) Cell. Biol. Toxicol , vol.16 , pp. 257-273
    • Walgren, J.E.1    Kurtz, D.T.2    McMillan, J.M.3
  • 145
    • 1642326899 scopus 로고    scopus 로고
    • Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates
    • Walgren, J.L., Jollow, D.J., and McMillan, J.M. (2004). Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates. Toxicology 197:189-197.
    • (2004) Toxicology , vol.197 , pp. 189-197
    • Walgren, J.L.1    Jollow, D.J.2    McMillan, J.M.3
  • 146
    • 0033920977 scopus 로고    scopus 로고
    • Trichloroethylene and cancer: Epidemiologic evidence
    • Wartenberg, D., Reyner, D., and Scott, C.S. (2000). Trichloroethylene and cancer: Epidemiologic evidence. Environ. Health Perspect. 108 (Suppl. 2):161-176.
    • (2000) Environ. Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 161-176
    • Wartenberg, D.1    Reyner, D.2    Scott, C.S.3
  • 147
    • 0033920979 scopus 로고    scopus 로고
    • Exposure assessment of trichloroethylene
    • Wu, C., and Schaum, J. (2000). Exposure assessment of trichloroethylene. Environ. Health Perspect. 108 (Suppl. 2):359-363.
    • (2000) Environ. Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 359-363
    • Wu, C.1    Schaum, J.2
  • 148
    • 0027225513 scopus 로고
    • Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: Contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase
    • Yokoyama, Y., Tsuchida, S., Hatayama, I., and Sato, K. (1993). Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by
    • (1993) Carcinogenesis , vol.14 , pp. 393-398
    • Yokoyama, Y.1    Tsuchida, S.2    Hatayama, I.3    Sato, K.4
  • 149
    • 0031691204 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids
    • Zhou, Y.C., and Waxman, D.J. (1998). Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ. Health Perspect. 106(Suppl. 4):983-988.
    • (1998) Environ. Health Perspect , vol.106 , Issue.SUPPL. 4 , pp. 983-988
    • Zhou, Y.C.1    Waxman, D.J.2


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