메뉴 건너뛰기




Volumn 14, Issue 10, 2013, Pages 20793-20808

Lipid transport and metabolism in healthy and osteoarthritic cartilage

Author keywords

Cartilage; Cholesterol; Chondrocyte; Lipid; Nutrition; Osteoarthritis

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN;

EID: 84885935481     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141020793     Document Type: Review
Times cited : (83)

References (105)
  • 1
    • 0014148941 scopus 로고
    • Lipid content of human costal and articular cartilage
    • Stockwell, R.A. Lipid content of human costal and articular cartilage. Ann. Rheum. Dis. 1967, 26, 481-486.
    • (1967) Ann. Rheum. Dis. , vol.26 , pp. 481-486
    • Stockwell, R.A.1
  • 2
    • 0025947255 scopus 로고
    • Basic cell metabolism of articular cartilage. Manometric studies
    • Otte, P. Basic cell metabolism of articular cartilage. Manometric studies. Z. Rheumatol. 1991, 50, 304-312.
    • (1991) Z. Rheumatol. , vol.50 , pp. 304-312
    • Otte, P.1
  • 3
    • 78650947739 scopus 로고    scopus 로고
    • Lipid metabolism and osteoarthritis: Lessons from atherosclerosis
    • Gkretsi, V.; Simopoulou, T.; Tsezou, A. Lipid metabolism and osteoarthritis: Lessons from atherosclerosis. Prog. Lipid Res. 2011, 50, 133-140.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 133-140
    • Gkretsi, V.1    Simopoulou, T.2    Tsezou, A.3
  • 4
    • 78649710211 scopus 로고    scopus 로고
    • Expression pattern differences between osteoarthritic chondrocytes and mesenchymal stem cells during chondrogenic differentiation
    • Bernstein, P.; Sticht, C.; Jacobi, A.; Liebers, C.; Manthey, S.; Stiehler, M. Expression pattern differences between osteoarthritic chondrocytes and mesenchymal stem cells during chondrogenic differentiation. Osteoarthr. Cartil. 2010, 18, 1596-1607.
    • (2010) Osteoarthr. Cartil. , vol.18 , pp. 1596-1607
    • Bernstein, P.1    Sticht, C.2    Jacobi, A.3    Liebers, C.4    Manthey, S.5    Stiehler, M.6
  • 5
    • 0014852780 scopus 로고
    • Ultrastructure of articular cartilage in experimentally produced lipoarthrosis
    • Ghadially, F.N.; Mehta, P.N.; Kirkaldy-Willis, W.H. Ultrastructure of articular cartilage in experimentally produced lipoarthrosis. J. Bone Jt. Surg. Am. 1970, 52, 1147-1158.
    • (1970) J. Bone Jt. Surg. Am. , vol.52 , pp. 1147-1158
    • Ghadially, F.N.1    Mehta, P.N.2    Kirkaldy-Willis, W.H.3
  • 6
    • 0028302391 scopus 로고
    • Cartilage proteoglycans: Structure and potential functions
    • Roughley, P.J.; Lee, E.R. Cartilage proteoglycans: Structure and potential functions. Microsc. Res. Tech. 1994, 28, 385-397.
    • (1994) Microsc. Res. Tech. , vol.28 , pp. 385-397
    • Roughley, P.J.1    Lee, E.R.2
  • 7
    • 0031706086 scopus 로고    scopus 로고
    • Composition and dynamics of articular cartilage: Structure, function, and maintaining healthy state
    • Cohen, N.P.; Foster, R.J.; Mow, V.C. Composition and dynamics of articular cartilage: Structure, function, and maintaining healthy state. J. Orthop. Sports Phys. Ther. 1998, 28, 203-215.
    • (1998) J. Orthop. Sports Phys. Ther. , vol.28 , pp. 203-215
    • Cohen, N.P.1    Foster, R.J.2    Mow, V.C.3
  • 8
    • 0017187038 scopus 로고
    • Transport of solutes through cartilage: Permeability to large molecules
    • Maroudas, A. Transport of solutes through cartilage: Permeability to large molecules. J. Anat. 1976, 122, 335-347.
    • (1976) J. Anat. , vol.122 , pp. 335-347
    • Maroudas, A.1
  • 9
    • 0034669838 scopus 로고    scopus 로고
    • High resolution imaging of the distribution and permeability of methyl viologen dication in bovine articular cartilage using scanning electrochemical microscopy
    • Gonsalves, M.; Macpherson, J.V.; O'Hare, D.; Winlove, C.P.; Unwin, P.R. High resolution imaging of the distribution and permeability of methyl viologen dication in bovine articular cartilage using scanning electrochemical microscopy. Biochim. Biophys. Acta 2001, 1524, 66-74.
    • (2001) Biochim. Biophys. Acta , vol.1524 , pp. 66-74
    • Gonsalves, M.1    McPherson, J.V.2    O'Hare, D.3    Winlove, C.P.4    Unwin, P.R.5
  • 10
    • 0015338395 scopus 로고
    • Alterations in the permeability of articular cartilage by proteolytic enzymes
    • Lotke, P.A.; Granda, J.L. Alterations in the permeability of articular cartilage by proteolytic enzymes. Arthritis Rheum. 1972, 15, 302-308.
    • (1972) Arthritis Rheum. , vol.15 , pp. 302-308
    • Lotke, P.A.1    Granda, J.L.2
  • 11
    • 33751422500 scopus 로고    scopus 로고
    • Fatty acid transport in articular cartilage
    • Arkill, K.P.; Winlove, C.P. Fatty acid transport in articular cartilage. Arch. Biochem. Biophys. 2006, 456, 71-78.
    • (2006) Arch. Biochem. Biophys. , vol.456 , pp. 71-78
    • Arkill, K.P.1    Winlove, C.P.2
  • 13
    • 0015074392 scopus 로고
    • The nutritional pathways of articular cartilage. An autoradiographic study in rabbits using 35S injected intravenously
    • Honner, R.; Thompson, R.C. The nutritional pathways of articular cartilage. An autoradiographic study in rabbits using 35S injected intravenously. J. Bone Jt. Surg. Am. 1971, 53, 742-748.
    • (1971) J. Bone Jt. Surg. Am. , vol.53 , pp. 742-748
    • Honner, R.1    Thompson, R.C.2
  • 14
    • 0014468169 scopus 로고
    • The nutrition of mature and immature cartilage in rabbits. An autoradiographic study
    • Hodge, J.A.; McKibbin, B. The nutrition of mature and immature cartilage in rabbits. An autoradiographic study. J. Bone Jt. Surg. Br. 1969, 51, 140-147.
    • (1969) J. Bone Jt. Surg. Br. , vol.51 , pp. 140-147
    • Hodge, J.A.1    McKibbin, B.2
  • 15
    • 0018023392 scopus 로고
    • Subchondral route for nutrition to articular cartilage in the rabbit. Measurement of diffusion with hydrogen gas in vivo
    • Ogata, K.; Whiteside, L.A.; Lesker, P.A. Subchondral route for nutrition to articular cartilage in the rabbit. Measurement of diffusion with hydrogen gas in vivo. J. Bone Jt. Surg. Am. 1978, 60, 905-910.
    • (1978) J. Bone Jt. Surg. Am. , vol.60 , pp. 905-910
    • Ogata, K.1    Whiteside, L.A.2    Lesker, P.A.3
  • 16
    • 70349213369 scopus 로고    scopus 로고
    • In situ measurement of transport between subchondral bone and articular cartilage
    • Pan, J.; Zhou, X.; Li, W.; Novotny, J.E.; Doty, S.B.; Wang, L. In situ measurement of transport between subchondral bone and articular cartilage. J. Orthop. Res. 2009, 27, 1347-1352.
    • (2009) J. Orthop. Res. , vol.27 , pp. 1347-1352
    • Pan, J.1    Zhou, X.2    Li, W.3    Novotny, J.E.4    Doty, S.B.5    Wang, L.6
  • 17
    • 44449159269 scopus 로고    scopus 로고
    • Solute transport in the deep and calcified zones of articular cartilage
    • Arkill, K.P.; Winlove, C.P. Solute transport in the deep and calcified zones of articular cartilage. Osteoarthr. Cartil. 2008, 16, 708-714.
    • (2008) Osteoarthr. Cartil. , vol.16 , pp. 708-714
    • Arkill, K.P.1    Winlove, C.P.2
  • 18
    • 0014602153 scopus 로고
    • A pathway for nutrients from the medullary cavity to the articular cartilage of the human femoral head
    • Greenwald, A.S.; Haynes, D.W. A pathway for nutrients from the medullary cavity to the articular cartilage of the human femoral head. J. Bone Jt. Surg. Br. 1969, 51, 747-753.
    • (1969) J. Bone Jt. Surg. Br. , vol.51 , pp. 747-753
    • Greenwald, A.S.1    Haynes, D.W.2
  • 19
    • 33747394448 scopus 로고    scopus 로고
    • The normal human chondro-osseous junctional region: Evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces
    • doi:10.1186/1471-2474-7-52
    • Lyons, T.J.; McClure, S.F.; Stoddart, R.W.; McClure, J. The normal human chondro-osseous junctional region: Evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces. BMC Musculoskelet. Disord. 2006, doi:10.1186/1471-2474-7-52.
    • (2006) BMC Musculoskelet. Disord.
    • Lyons, T.J.1    McClure, S.F.2    Stoddart, R.W.3    McClure, J.4
  • 21
    • 0029363876 scopus 로고
    • Microvascular architecture and exchange in synovial joints
    • Levick, J.R. Microvascular architecture and exchange in synovial joints. Microcirculation 1995, 2, 217-233.
    • (1995) Microcirculation , vol.2 , pp. 217-233
    • Levick, J.R.1
  • 23
    • 0030587570 scopus 로고    scopus 로고
    • Contributions of fluid convection and electrical migration to transport in cartilage: Relevance to loading
    • Garcia, A.M.; Frank, E.H.; Grimshaw, P.E.; Grodzinsky, A.J. Contributions of fluid convection and electrical migration to transport in cartilage: Relevance to loading. Arch. Biochem. Biophys. 1996, 333, 317-325.
    • (1996) Arch. Biochem. Biophys. , vol.333 , pp. 317-325
    • Garcia, A.M.1    Frank, E.H.2    Grimshaw, P.E.3    Grodzinsky, A.J.4
  • 24
    • 0025281850 scopus 로고
    • Influence of cyclic loading on the nutrition of articular cartilage
    • O'Hara, B.P.; Urban, J.P.; Maroudas, A. Influence of cyclic loading on the nutrition of articular cartilage. Ann. Rheum. Dis. 1990, 49, 536-539.
    • (1990) Ann. Rheum. Dis. , vol.49 , pp. 536-539
    • O'Hara, B.P.1    Urban, J.P.2    Maroudas, A.3
  • 25
    • 34447509660 scopus 로고    scopus 로고
    • Global analyses of gene expression in early experimental osteoarthritis
    • Appleton, C.T.G.; Pitelka, V.; Henry, J.; Beier, F. Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum. 2007, 56, 1854-1868.
    • (2007) Arthritis Rheum. , vol.56 , pp. 1854-1868
    • Appleton, C.T.G.1    Pitelka, V.2    Henry, J.3    Beier, F.4
  • 27
    • 84862830296 scopus 로고    scopus 로고
    • Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints
    • Pan, J.; Wang, B.; Li, W.; Zhou, X.; Scherr, T.; Yang, Y.; Price, C.; Wang, L. Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints. Bone 2012, 51, 212-217.
    • (2012) Bone , vol.51 , pp. 212-217
    • Pan, J.1    Wang, B.2    Li, W.3    Zhou, X.4    Scherr, T.5    Yang, Y.6    Price, C.7    Wang, L.8
  • 28
    • 1042266622 scopus 로고    scopus 로고
    • Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth
    • Wu, S.; de Luca, F. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. J. Biol. Chem. 2004, 279, 4642-4647.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4642-4647
    • Wu, S.1    de Luca, F.2
  • 29
    • 66649126963 scopus 로고    scopus 로고
    • P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol-and Indian hedgehog-dependent mechanisms
    • Aguilar, A.; Wu, S.; de Luca, F. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol-and Indian hedgehog-dependent mechanisms. Endocrinology 2009, 150, 2732-2739.
    • (2009) Endocrinology , vol.150 , pp. 2732-2739
    • Aguilar, A.1    Wu, S.2    de Luca, F.3
  • 30
    • 34648813473 scopus 로고    scopus 로고
    • Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes
    • Simopoulou, T.; Malizos, K.N.; Tsezou, A. Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes. Clin. Exp. Rheumatol. 2007, 25, 605-612.
    • (2007) Clin. Exp. Rheumatol. , vol.25 , pp. 605-612
    • Simopoulou, T.1    Malizos, K.N.2    Tsezou, A.3
  • 31
    • 77954700085 scopus 로고    scopus 로고
    • Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes
    • Tsezou, A.; Iliopoulos, D.; Malizos, K.N.; Simopoulou, T. Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes. J. Orthop. Res. 2010, 28, 1033-1039.
    • (2010) J. Orthop. Res. , vol.28 , pp. 1033-1039
    • Tsezou, A.1    Iliopoulos, D.2    Malizos, K.N.3    Simopoulou, T.4
  • 32
    • 0028929853 scopus 로고
    • Synovial fluid lipids and apolipoproteins: A contemporary perspective
    • Prete, P.E.; Gurakar-Osborne, A.; Kashyap, M.L. Synovial fluid lipids and apolipoproteins: A contemporary perspective. Biorheology 1995, 32, 1-16.
    • (1995) Biorheology , vol.32 , pp. 1-16
    • Prete, P.E.1    Gurakar-Osborne, A.2    Kashyap, M.L.3
  • 34
    • 84868593930 scopus 로고    scopus 로고
    • Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage
    • Cillero-Pastor, B.; Eijkel, G.; Kiss, A.; Blanco, F.J.; Heeren, R.M.A. Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage. Anal. Chem. 2012, 84, 8909-8916.
    • (2012) Anal. Chem. , vol.84 , pp. 8909-8916
    • Cillero-Pastor, B.1    Eijkel, G.2    Kiss, A.3    Blanco, F.J.4    Heeren, R.M.A.5
  • 36
    • 0025907055 scopus 로고
    • The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage
    • Lippiello, L.; Walsh, T.; Fienhold, M. The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism 1991, 40, 571-576.
    • (1991) Metabolism , vol.40 , pp. 571-576
    • Lippiello, L.1    Walsh, T.2    Fienhold, M.3
  • 37
    • 0028863255 scopus 로고
    • Differences in fatty acid composition of immature and mature articular cartilage in humans and sheep
    • Cleland, K.A.; James, M.J.; Neumann, M.A.; Gibson, R.A.; Cleland, L.G. Differences in fatty acid composition of immature and mature articular cartilage in humans and sheep. Lipids 1995, 30, 949-953.
    • (1995) Lipids , vol.30 , pp. 949-953
    • Cleland, K.A.1    James, M.J.2    Neumann, M.A.3    Gibson, R.A.4    Cleland, L.G.5
  • 38
    • 0019818738 scopus 로고
    • Lipid composition of two types of chondrocytes in primary culture
    • Le Lous, M.; Corvol, M.T.; Maroteaux, P. Lipid composition of two types of chondrocytes in primary culture. Calcif. Tissue Int. 1981, 33, 403-407.
    • (1981) Calcif. Tissue Int. , vol.33 , pp. 403-407
    • Le Lous, M.1    Corvol, M.T.2    Maroteaux, P.3
  • 39
    • 0025326963 scopus 로고
    • Metabolic and ultrastructural changes in articular cartilage of rats fed dietary supplements of omega-3 fatty acids
    • Lippiello, L.; Fienhold, M.; Grandjean, C. Metabolic and ultrastructural changes in articular cartilage of rats fed dietary supplements of omega-3 fatty acids. Arthritis Rheum. 1990, 33, 1029-1036.
    • (1990) Arthritis Rheum. , vol.33 , pp. 1029-1036
    • Lippiello, L.1    Fienhold, M.2    Grandjean, C.3
  • 40
    • 0027954013 scopus 로고
    • Dietary lipids modify the fatty acid composition of cartilage, isolated chondrocytes and matrix vesicles
    • Xu, H.; Watkins, B.A.; Adkisson, H.D. Dietary lipids modify the fatty acid composition of cartilage, isolated chondrocytes and matrix vesicles. Lipids 1994, 29, 619-625.
    • (1994) Lipids , vol.29 , pp. 619-625
    • Xu, H.1    Watkins, B.A.2    Adkisson, H.D.3
  • 41
    • 0026152252 scopus 로고
    • Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes
    • Nagao, M.; Ishii, S.; Murata, Y.; Akino, T. Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes. J. Orthop. Res. 1991, 9, 341-347.
    • (1991) J. Orthop. Res. , vol.9 , pp. 341-347
    • Nagao, M.1    Ishii, S.2    Murata, Y.3    Akino, T.4
  • 42
    • 84861407357 scopus 로고    scopus 로고
    • Nutritional interventions to prevent and treat osteoarthritis. Part I: Focus on fatty acids and macronutrients
    • Lopez, H.L. Nutritional interventions to prevent and treat osteoarthritis. Part I: Focus on fatty acids and macronutrients. PMR 2012, 4, S145-S154.
    • (2012) PMR , vol.4
    • Lopez, H.L.1
  • 43
    • 33746507884 scopus 로고    scopus 로고
    • Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: Differential proinflammatory cytokine profile between celecoxib and aceclofenac
    • Alvarez-Soria, M.A.; Largo, R.; Santillana, J.; Sánchez-Pernaute, O.; Calvo, E.; Hernández, M.; Egido, J.; Herrero-Beaumont, G. Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: Differential proinflammatory cytokine profile between celecoxib and aceclofenac. Ann. Rheum. Dis. 2006, 65, 998-1005.
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 998-1005
    • Alvarez-Soria, M.A.1    Largo, R.2    Santillana, J.3    Sánchez-Pernaute, O.4    Calvo, E.5    Hernández, M.6    Egido, J.7    Herrero-Beaumont, G.8
  • 44
    • 55349126753 scopus 로고    scopus 로고
    • Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis
    • Alvarez-Soria, M.A.; Herrero-Beaumont, G.; Moreno-Rubio, J.; Calvo, E.; Santillana, J.; Egido, J.; Largo, R. Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis. Osteoarthr. Cartil. 2008, 16, 1484-1493.
    • (2008) Osteoarthr. Cartil. , vol.16 , pp. 1484-1493
    • Alvarez-Soria, M.A.1    Herrero-Beaumont, G.2    Moreno-Rubio, J.3    Calvo, E.4    Santillana, J.5    Egido, J.6    Largo, R.7
  • 45
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the ω-6/ω-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos, A.P. The importance of the ω-6/ω-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. 2008, 233, 674-688.
    • (2008) Exp. Biol. Med. , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 46
    • 0034925520 scopus 로고    scopus 로고
    • Phospholipid composition of articular cartilage boundary lubricant
    • Sarma, A.V.; Powell, G.L.; LaBerge, M. Phospholipid composition of articular cartilage boundary lubricant. J. Orthop. Res. 2001, 19, 671-676.
    • (2001) J. Orthop. Res. , vol.19 , pp. 671-676
    • Sarma, A.V.1    Powell, G.L.2    LaBerge, M.3
  • 49
    • 0043068196 scopus 로고    scopus 로고
    • Radiographic osteoarthritis and serum cholesterol
    • Al-Arfaj, A.S. Radiographic osteoarthritis and serum cholesterol. Saudi Med. J. 2003, 24, 745-747.
    • (2003) Saudi Med. J. , vol.24 , pp. 745-747
    • Al-Arfaj, A.S.1
  • 50
    • 0031784590 scopus 로고    scopus 로고
    • Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study
    • Stürmer, T.; Sun, Y.; Sauerland, S.; Zeissig, I.; Günther, K.P.; Puhl, W.; Brenner, H. Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J. Rheumatol. 1998, 25, 1827-1832.
    • (1998) J. Rheumatol. , vol.25 , pp. 1827-1832
    • Stürmer, T.1    Sun, Y.2    Sauerland, S.3    Zeissig, I.4    Günther, K.P.5    Puhl, W.6    Brenner, H.7
  • 51
    • 0028998579 scopus 로고
    • Association between metabolic factors and knee osteoarthritis in women: The Chingford Study
    • Hart, D.J.; Doyle, D.V.; Spector, T.D. Association between metabolic factors and knee osteoarthritis in women: The Chingford Study. J. Rheumatol. 1995, 22, 1118-1123.
    • (1995) J. Rheumatol. , vol.22 , pp. 1118-1123
    • Hart, D.J.1    Doyle, D.V.2    Spector, T.D.3
  • 52
    • 84859480250 scopus 로고    scopus 로고
    • The effects of statins on osteoarthritis structural progression: Another glimpse of the Holy Grail?
    • Conaghan, P.G. The effects of statins on osteoarthritis structural progression: Another glimpse of the Holy Grail? Ann. Rheum. Dis. 2012, 71, 633-634.
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 633-634
    • Conaghan, P.G.1
  • 54
    • 84879550749 scopus 로고    scopus 로고
    • Statin use and clinical osteoarthritis in the general population: A longitudinal study
    • Kadam, U.T.; Blagojevic, M.; Belcher, J. Statin use and clinical osteoarthritis in the general population: A longitudinal study. J. Gen. Intern. Med. 2013, 28, 943-949.
    • (2013) J. Gen. Intern. Med. , vol.28 , pp. 943-949
    • Kadam, U.T.1    Blagojevic, M.2    Belcher, J.3
  • 55
    • 84872066639 scopus 로고    scopus 로고
    • Associations between statin use and changes in pain, function and structural progression: A longitudinal study of persons with knee osteoarthritis
    • Riddle, D.L.; Moxley, G.; Dumenci, L. Associations between statin use and changes in pain, function and structural progression: A longitudinal study of persons with knee osteoarthritis. Ann. Rheum. Dis. 2013, 72, 196-203.
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 196-203
    • Riddle, D.L.1    Moxley, G.2    Dumenci, L.3
  • 56
    • 11844305614 scopus 로고    scopus 로고
    • Association of statin use and development and progression of hip osteoarthritis in elderly women
    • Beattie, M.S.; Lane, N.E.; Hung, Y.-Y.; Nevitt, M.C. Association of statin use and development and progression of hip osteoarthritis in elderly women. J. Rheumatol. 2005, 32, 106-110.
    • (2005) J. Rheumatol. , vol.32 , pp. 106-110
    • Beattie, M.S.1    Lane, N.E.2    Hung, Y.-Y.3    Nevitt, M.C.4
  • 57
    • 84860389970 scopus 로고    scopus 로고
    • Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3
    • Aktas, E.; Sener, E.; Gocun, P.U. Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3. J. Orthop. Traumatol. 2011, 12, 145-151.
    • (2011) J. Orthop. Traumatol. , vol.12 , pp. 145-151
    • Aktas, E.1    Sener, E.2    Gocun, P.U.3
  • 58
    • 79952253318 scopus 로고    scopus 로고
    • Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
    • Yudoh, K.; Karasawa, R. Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). Aging 2010, 2, 990-998.
    • (2010) Aging , vol.2 , pp. 990-998
    • Yudoh, K.1    Karasawa, R.2
  • 60
    • 77957555605 scopus 로고    scopus 로고
    • Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation
    • Barter, M.J.; Hui, W.; Lakey, R.L.; Catterall, J.B.; Cawston, T.E.; Young, D.A. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. Ann. Rheum. Dis. 2010, 69, 2189-2198.
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 2189-2198
    • Barter, M.J.1    Hui, W.2    Lakey, R.L.3    Catterall, J.B.4    Cawston, T.E.5    Young, D.A.6
  • 63
    • 0026504508 scopus 로고
    • Efficacy of cod liver oil as an adjunct to non-steroidal anti-inflammatory drug treatment in the management of osteoarthritis in general practice
    • Stammers, T.; Sibbald, B.; Freeling, P. Efficacy of cod liver oil as an adjunct to non-steroidal anti-inflammatory drug treatment in the management of osteoarthritis in general practice. Ann. Rheum. Dis. 1992, 51, 128-129.
    • (1992) Ann. Rheum. Dis. , vol.51 , pp. 128-129
    • Stammers, T.1    Sibbald, B.2    Freeling, P.3
  • 64
    • 77952921830 scopus 로고    scopus 로고
    • Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line
    • Iacono, A.; Gómez, R.; Sperry, J.; Conde, J.; Bianco, G.; Meli, R.; Gómez-Reino, J.J.; Smith, A.B.; Gualillo, O. Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum. 2010, 62, 1675-1682.
    • (2010) Arthritis Rheum. , vol.62 , pp. 1675-1682
    • Iacono, A.1    Gómez, R.2    Sperry, J.3    Conde, J.4    Bianco, G.5    Meli, R.6    Gómez-Reino, J.J.7    Smith, A.B.8    Gualillo, O.9
  • 65
    • 42149165525 scopus 로고    scopus 로고
    • Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis
    • Wang, Y.; Wluka, A.E.; Hodge, A.M.; English, D.R.; Giles, G.G.; O'Sullivan, R.; Cicuttini, F.M. Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis. Osteoarthr. Cartil. 2008, 16, 579-583.
    • (2008) Osteoarthr. Cartil. , vol.16 , pp. 579-583
    • Wang, Y.1    Wluka, A.E.2    Hodge, A.M.3    English, D.R.4    Giles, G.G.5    O'Sullivan, R.6    Cicuttini, F.M.7
  • 67
    • 80051790329 scopus 로고    scopus 로고
    • Regulation of osteoarthritis by ω-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease
    • Knott, L.; Avery, N.C.; Hollander, A.P.; Tarlton, J.F. Regulation of osteoarthritis by ω-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease. Osteoarthr. Cartil. 2011, 19, 1150-1157.
    • (2011) Osteoarthr. Cartil. , vol.19 , pp. 1150-1157
    • Knott, L.1    Avery, N.C.2    Hollander, A.P.3    Tarlton, J.F.4
  • 68
    • 84905179075 scopus 로고    scopus 로고
    • Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice
    • doi:10.1136/annrheumdis-2013-203231
    • Huang, M.-J.; Wang, L.; Jin, D.; Zhang, Z.-M.; Chen, T.-Y.; Jia, C.-H.; Wang, Y.; Zhen, X.-C.; Huang, B.; Yan, B.; et al. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann. Rheum. Dis. 2013, doi:10.1136/annrheumdis-2013-203231.
    • (2013) Ann. Rheum. Dis.
    • Huang, M.-J.1    Wang, L.2    Jin, D.3    Zhang, Z.-M.4    Chen, T.-Y.5    Jia, C.-H.6    Wang, Y.7    Zhen, X.-C.8    Huang, B.9    Yan, B.10
  • 70
    • 0025105650 scopus 로고
    • Purification and characterization of a phospholipase A2 from human osteoarthritic synovial fluid
    • Parks, T.P.; Lukas, S.; Hoffman, A.F. Purification and characterization of a phospholipase A2 from human osteoarthritic synovial fluid. Adv. Exp. Med. Biol. 1990, 275, 55-81.
    • (1990) Adv. Exp. Med. Biol. , vol.275 , pp. 55-81
    • Parks, T.P.1    Lukas, S.2    Hoffman, A.F.3
  • 71
    • 0025774380 scopus 로고
    • Enzymatic activity and distribution of phospholipase A2 in human cartilage
    • Pruzanski, W.; Bogoch, E.; Stefanski, E.; Wloch, M.; Vadas, P. Enzymatic activity and distribution of phospholipase A2 in human cartilage. Life Sci. 1991, 48, 2457-2462.
    • (1991) Life Sci. , vol.48 , pp. 2457-2462
    • Pruzanski, W.1    Bogoch, E.2    Stefanski, E.3    Wloch, M.4    Vadas, P.5
  • 72
    • 0022624603 scopus 로고
    • Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: A possible signal for IL 1 action
    • Chang, J.; Gilman, S.C.; Lewis, A.J. Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: A possible signal for IL 1 action. J. Immunol. 1986, 136, 1283-1287.
    • (1986) J. Immunol. , vol.136 , pp. 1283-1287
    • Chang, J.1    Gilman, S.C.2    Lewis, A.J.3
  • 73
    • 84872668800 scopus 로고    scopus 로고
    • Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet
    • Triantaphyllidou, I.-E.; Kalyvioti, E.; Karavia, E.; Lilis, I.; Kypreos, K.E.; Papachristou, D.J. Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet. Osteoarthr. Cartil. 2013, 21, 322-330.
    • (2013) Osteoarthr. Cartil. , vol.21 , pp. 322-330
    • Triantaphyllidou, I.-E.1    Kalyvioti, E.2    Karavia, E.3    Lilis, I.4    Kypreos, K.E.5    Papachristou, D.J.6
  • 74
    • 0034733622 scopus 로고    scopus 로고
    • Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis
    • Tiku, M.L.; Shah, R.; Allison, G.T. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J. Biol. Chem. 2000, 275, 20069-20076.
    • (2000) J. Biol. Chem. , vol.275 , pp. 20069-20076
    • Tiku, M.L.1    Shah, R.2    Allison, G.T.3
  • 75
    • 25444435354 scopus 로고    scopus 로고
    • The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: A pathogenic role in osteoarthritis
    • Shah, R.; Raska, K.; Tiku, M.L. The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: A pathogenic role in osteoarthritis. Arthritis Rheum. 2005, 52, 2799-2807.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2799-2807
    • Shah, R.1    Raska, K.2    Tiku, M.L.3
  • 76
    • 31044435908 scopus 로고    scopus 로고
    • Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4-hydroxynonenal to cartilage degradation
    • Morquette, B.; Shi, Q.; Lavigne, P.; Ranger, P.; Fernandes, J.C.; Benderdour, M. Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4-hydroxynonenal to cartilage degradation. Arthritis Rheum. 2006, 54, 271-281.
    • (2006) Arthritis Rheum. , vol.54 , pp. 271-281
    • Morquette, B.1    Shi, Q.2    Lavigne, P.3    Ranger, P.4    Fernandes, J.C.5    Benderdour, M.6
  • 77
    • 70350188294 scopus 로고    scopus 로고
    • Differential effects of the antioxidant N-acetylcysteine on the production of catabolic mediators in IL-1β-stimulated human osteoarthritic synoviocytes and chondrocytes
    • Roman-Blas, J.A.; Contreras-Blasco, M.A.; Largo, R.; Alvarez-Soria, M.A.; Castañeda, S.; Herrero-Beaumont, G. Differential effects of the antioxidant N-acetylcysteine on the production of catabolic mediators in IL-1β-stimulated human osteoarthritic synoviocytes and chondrocytes. Eur. J. Pharmacol. 2009, 623, 125-131.
    • (2009) Eur. J. Pharmacol. , vol.623 , pp. 125-131
    • Roman-Blas, J.A.1    Contreras-Blasco, M.A.2    Largo, R.3    Alvarez-Soria, M.A.4    Castañeda, S.5    Herrero-Beaumont, G.6
  • 78
    • 14644412448 scopus 로고    scopus 로고
    • Cholesterol secretion and homeostasis in chondrocytes: A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression
    • Gentili, C.; Tutolo, G.; Pianezzi, A.; Cancedda, R.; Descalzi Cancedda, F. Cholesterol secretion and homeostasis in chondrocytes: A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression. Matrix Biol. 2005, 24, 35-44.
    • (2005) Matrix Biol. , vol.24 , pp. 35-44
    • Gentili, C.1    Tutolo, G.2    Pianezzi, A.3    Cancedda, R.4    Descalzi Cancedda, F.5
  • 79
    • 73549119107 scopus 로고    scopus 로고
    • Control of chondrocyte gene expression by actin dynamics: A novel role of cholesterol/Ror-α signalling in endochondral bone growth
    • Woods, A.; James, C.G.; Wang, G.; Dupuis, H.; Beier, F. Control of chondrocyte gene expression by actin dynamics: A novel role of cholesterol/Ror-α signalling in endochondral bone growth. J. Cell. Mol. Med. 2009, 13, 3497-3516.
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 3497-3516
    • Woods, A.1    James, C.G.2    Wang, G.3    Dupuis, H.4    Beier, F.5
  • 80
    • 8444244889 scopus 로고    scopus 로고
    • Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage
    • Kakinuma, T.; Yasuda, T.; Nakagawa, T.; Hiramitsu, T.; Akiyoshi, M.; Akagi, M.; Sawamura, T.; Nakamura, T. Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum. 2004, 50, 3495-3503.
    • (2004) Arthritis Rheum. , vol.50 , pp. 3495-3503
    • Kakinuma, T.1    Yasuda, T.2    Nakagawa, T.3    Hiramitsu, T.4    Akiyoshi, M.5    Akagi, M.6    Sawamura, T.7    Nakamura, T.8
  • 81
    • 33846907573 scopus 로고    scopus 로고
    • Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis
    • Akagi, M.; Kanata, S.; Mori, S.; Itabe, H.; Sawamura, T.; Hamanishi, C. Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis. Osteoarthr. Cartil. 2007, 15, 281-290.
    • (2007) Osteoarthr. Cartil. , vol.15 , pp. 281-290
    • Akagi, M.1    Kanata, S.2    Mori, S.3    Itabe, H.4    Sawamura, T.5    Hamanishi, C.6
  • 82
    • 70349758283 scopus 로고    scopus 로고
    • Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1
    • Zushi, S.; Akagi, M.; Kishimoto, H.; Teramura, T.; Sawamura, T.; Hamanishi, C. Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1. Arthritis Rheum. 2009, 60, 3007-3016.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3007-3016
    • Zushi, S.1    Akagi, M.2    Kishimoto, H.3    Teramura, T.4    Sawamura, T.5    Hamanishi, C.6
  • 83
    • 77956884110 scopus 로고    scopus 로고
    • Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress
    • Kishimoto, H.; Akagi, M.; Zushi, S.; Teramura, T.; Onodera, Y.; Sawamura, T.; Hamanishi, C. Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress. Osteoarthr. Cartil. 2010, 18, 1284-1290.
    • (2010) Osteoarthr. Cartil. , vol.18 , pp. 1284-1290
    • Kishimoto, H.1    Akagi, M.2    Zushi, S.3    Teramura, T.4    Onodera, Y.5    Sawamura, T.6    Hamanishi, C.7
  • 84
    • 3242713272 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-κB
    • Nishimura, S.; Akagi, M.; Yoshida, K.; Hayakawa, S.; Sawamura, T.; Munakata, H.; Hamanishi, C. Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-κB. Osteoarthr. Cartil. 2004, 12, 568-576.
    • (2004) Osteoarthr. Cartil. , vol.12 , pp. 568-576
    • Nishimura, S.1    Akagi, M.2    Yoshida, K.3    Hayakawa, S.4    Sawamura, T.5    Munakata, H.6    Hamanishi, C.7
  • 85
    • 59249083300 scopus 로고    scopus 로고
    • Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes
    • Akagi, M.; Ueda, A.; Teramura, T.; Kanata, S.; Sawamura, T.; Hamanishi, C. Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes. Osteoarthr. Cartil. 2009, 17, 271-275.
    • (2009) Osteoarthr. Cartil. , vol.17 , pp. 271-275
    • Akagi, M.1    Ueda, A.2    Teramura, T.3    Kanata, S.4    Sawamura, T.5    Hamanishi, C.6
  • 86
    • 0025147620 scopus 로고
    • Lipid and cell metabolic changes associated with essential fatty acid enrichment of articular chondrocytes
    • Lippiello, L. Lipid and cell metabolic changes associated with essential fatty acid enrichment of articular chondrocytes. Proc. Soc. Exp. Biol. Med. 1990, 195, 282-287.
    • (1990) Proc. Soc. Exp. Biol. Med. , vol.195 , pp. 282-287
    • Lippiello, L.1
  • 87
    • 0033977182 scopus 로고    scopus 로고
    • N-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation
    • Curtis, C.L.; Hughes, C.E.; Flannery, C.R.; Little, C.B.; Harwood, J.L.; Caterson, B. N-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J. Biol. Chem. 2000, 275, 721-724.
    • (2000) J. Biol. Chem. , vol.275 , pp. 721-724
    • Curtis, C.L.1    Hughes, C.E.2    Flannery, C.R.3    Little, C.B.4    Harwood, J.L.5    Caterson, B.6
  • 88
    • 67349266985 scopus 로고    scopus 로고
    • Relative efficacies of ω-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis
    • Zainal, Z.; Longman, A.J.; Hurst, S.; Duggan, K.; Caterson, B.; Hughes, C.E.; Harwood, J.L. Relative efficacies of ω-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthr. Cartil. 2009, 17, 896-905.
    • (2009) Osteoarthr. Cartil. , vol.17 , pp. 896-905
    • Zainal, Z.1    Longman, A.J.2    Hurst, S.3    Duggan, K.4    Caterson, B.5    Hughes, C.E.6    Harwood, J.L.7
  • 90
    • 38149114635 scopus 로고    scopus 로고
    • Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    • Gilbert, S.J.; Blain, E.J.; Duance, V.C.; Mason, D.J. Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway. Arthritis Rheum. 2008, 58, 209-220.
    • (2008) Arthritis Rheum. , vol.58 , pp. 209-220
    • Gilbert, S.J.1    Blain, E.J.2    Duance, V.C.3    Mason, D.J.4
  • 91
    • 34247551025 scopus 로고    scopus 로고
    • Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: An in vitro study
    • doi:10.1186/ar1961
    • Gilbert, S.J.; Blain, E.J.; Jones, P.; Duance, V.C.; Mason, D.J. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: An in vitro study. Arthritis Res. Ther. 2006, doi:10.1186/ar1961.
    • (2006) Arthritis Res. Ther.
    • Gilbert, S.J.1    Blain, E.J.2    Jones, P.3    Duance, V.C.4    Mason, D.J.5
  • 92
    • 84876875518 scopus 로고    scopus 로고
    • Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells
    • Simonaro, C.M.; Sachot, S.; Ge, Y.; He, X.; Deangelis, V.A.; Eliyahu, E.; Leong, D.J.; Sun, H.B.; Mason, J.B.; Haskins, M.E.; et al. Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells. PLoS One 2013, 8, e62715.
    • (2013) PLoS One , vol.8
    • Simonaro, C.M.1    Sachot, S.2    Ge, Y.3    He, X.4    Deangelis, V.A.5    Eliyahu, E.6    Leong, D.J.7    Sun, H.B.8    Mason, J.B.9    Haskins, M.E.10
  • 93
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante, M.; Sabatini, D.M. mTOR signaling at a glance. J. Cell Sci. 2009, 122, 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 94
    • 84868288958 scopus 로고    scopus 로고
    • Coupling nutrient sensing to metabolic homoeostasis: The role of the mammalian target of rapamycin complex 1 pathway
    • André, C.; Cota, D. Coupling nutrient sensing to metabolic homoeostasis: The role of the mammalian target of rapamycin complex 1 pathway. Proc. Nutr. Soc. 2012, 71, 502-510.
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 502-510
    • André, C.1    Cota, D.2
  • 95
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • Mordier, S.; Iynedjian, P.B. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem. Biophys. Res. Commun. 2007, 362, 206-211.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 96
    • 70349323414 scopus 로고    scopus 로고
    • Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside
    • Rivas, D.A.; Yaspelkis, B.B.; Hawley, J.A.; Lessard, S.J. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside. J. Endocrinol. 2009, 202, 441-451.
    • (2009) J. Endocrinol. , vol.202 , pp. 441-451
    • Rivas, D.A.1    Yaspelkis, B.B.2    Hawley, J.A.3    Lessard, S.J.4
  • 97
    • 84872171596 scopus 로고    scopus 로고
    • Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis
    • Wen, Z.-H.; Su, Y.-C.; Lai, P.-L.; Zhang, Y.; Xu, Y.-F.; Zhao, A.; Yao, G.-Y.; Jia, C.-H.; Lin, J.; Xu, S.; et al. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene 2013, 32, 160-170.
    • (2013) Oncogene , vol.32 , pp. 160-170
    • Wen, Z.-H.1    Su, Y.-C.2    Lai, P.-L.3    Zhang, Y.4    Xu, Y.-F.5    Zhao, A.6    Yao, G.-Y.7    Jia, C.-H.8    Lin, J.9    Xu, S.10
  • 98
    • 66349092892 scopus 로고    scopus 로고
    • Ceramide-induced autophagy: To junk or to protect cells?
    • Pattingre, S.; Bauvy, C.; Levade, T.; Levine, B.; Codogno, P. Ceramide-induced autophagy: To junk or to protect cells? Autophagy 2009, 5, 558-560.
    • (2009) Autophagy , vol.5 , pp. 558-560
    • Pattingre, S.1    Bauvy, C.2    Levade, T.3    Levine, B.4    Codogno, P.5
  • 99
    • 33846177854 scopus 로고    scopus 로고
    • The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors
    • Mathis, A.S.; Jin, S.; Friedman, G.S.; Peng, F.; Carl, S.M.; Knipp, G.T. The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors. J. Pharm. Sci. 2007, 96, 209-222.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 209-222
    • Mathis, A.S.1    Jin, S.2    Friedman, G.S.3    Peng, F.4    Carl, S.M.5    Knipp, G.T.6
  • 100
    • 77949539205 scopus 로고    scopus 로고
    • Cholesterol trafficking is required for mTOR activation in endothelial cells
    • Xu, J.; Dang, Y.; Ren, Y.R.; Liu, J.O. Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc. Natl. Acad. Sci. USA 2010, 107, 4764-4769.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4764-4769
    • Xu, J.1    Dang, Y.2    Ren, Y.R.3    Liu, J.O.4
  • 101
    • 57449120941 scopus 로고    scopus 로고
    • Autophagy: A new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase
    • Srinivas, V.; Bohensky, J.; Shapiro, I.M. Autophagy: A new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase. Cells Tissues Organs 2009, 189, 88-92.
    • (2009) Cells Tissues Organs , vol.189 , pp. 88-92
    • Srinivas, V.1    Bohensky, J.2    Shapiro, I.M.3
  • 103
    • 77649128750 scopus 로고    scopus 로고
    • Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
    • Caramés, B.; Taniguchi, N.; Otsuki, S.; Blanco, F.J.; Lotz, M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010, 62, 791-801.
    • (2010) Arthritis Rheum. , vol.62 , pp. 791-801
    • Caramés, B.1    Taniguchi, N.2    Otsuki, S.3    Blanco, F.J.4    Lotz, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.