Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-κB

Osteoarthritis and Cartilage

Volumn 12, Issue 7, 2004, Pages 568-576

  Nishimura, Shunji ^a   Akagi, Masao ^a   Yoshida, Koji ^a   Hayakawa, Sumio ^a   Sawamura, Tatsuya ^b   Munakata, Hiroshi ^a   Hamanishi, Chiaki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Cultured chondrocytes; NF B; Oxidized LDL; ROS

Indexed keywords

ACETOACETIC ACID; ASCORBIC ACID; CELL EXTRACT; DICHLOROFLUORESCEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCLONAL ANTIBODY; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CATTLE; CELL CULTURE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; HYPERCHOLESTEROLEMIA; HYPOTHESIS; INCUBATION TIME; LIPID PEROXIDATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RISK FACTOR; SPECTROFLUOROMETRY; TEMPERATURE MEASUREMENT;

ANIMALS; ASCORBIC ACID; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; LIPOPROTEINS, LDL; MICROSCOPY, CONFOCAL; NF-KAPPA B; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RECEPTORS, LDL; RECEPTORS, OXIDIZED LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3242713272     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2004.04.005     Document Type: Article

References (36)

1. Hart D.J. Doyle D.V. Spector T.D. Association between metabolic factors and knee osteoarthritis in women: the Chingford Study J Rheumatol 22 1995 1118-1123
2. Carroll G.J. Bayliss C.E. Treatment of the arthropathy of familial hypercholesterolaemia Ann Rheum Dis 42 1983 206-209
3. McAlindon T.E. Jacques P. Zhang Y. Hannan M.T. Aliabadi P. Weissman B. et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 39 1996 648-656
4. Lippiello L. The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage Metabolism 40 1991 571-576
5. Stockwell R.A. Lipid in the matrix of ageing articular cartilage Nature 207 1965 427-428
6. Tiku M.L. Shah R. Allison G.T. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis J Biol Chem 275 2000 20069-20076
7. Tiku M.L. Gupta S. Deshmukh D.R. Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants Free Radic Res 30 1999 395-405
8. Curtis C.L. Hughes C.E. Flannery C.R. Little C.B. Harwood J.L. Caterson B. N-3 fatty acid specifically modulate catabolic factors involved in articular cartilage degradation J Biol Chem 275 2000 721-724
9. Dai L. Zhang Z. Winyard P.G. Gaffney K. Jones H. Blake D.R. et al. A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid Free Radic Biol Med 22 1997 705-710
10. Dai L. Lamb D.J. Leake D.S. Kus M.L. Jones H.W. Morris C.J. et al. Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients Free Radic Res 32 2000 479-486
11. Bostan M. Brasoveanu L.I. Livescu A. Manda G. Neagu M. Iordachescu D. Effects of synovial fluid on the respiratory burst of granulocytes in rheumatoid arthritis J Cell Mol Med 5 2001 188-194
12. Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis Circulation 95 1997 1062-1071
13. Sawamura T. Kume N. Aoyama T. Moriwaki H. Hoshikawa H. Aiba Y. et al. An endothelial receptor for oxidized low-density lipoprotein Nature 386 1997 73-77
14. Nakagawa T. Akagi M. Hoshikawa H. Chen M. Yasuda T. Mukai S. et al. Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis Arthritis Rheum 46 2002 2486-2494
15. Nakagawa T. Yasuda T. Hoshikawa H. Shimizu M. Kakinuma T. Chen M. et al. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt Biochem Biophys Res Commun 299 2002 91-97
16. Iademarco M.F. McQuuillan J.J. Rosen G.D. Dean D.C. Characterization of the promoter for vascular cell adhesion molecule-1 J Biol Chem 267 1992 16323-16329
17. Neish A.S. Williams A.J. Palmer H.J. Whitley M.Z. Collins T. Functional analysis of the human vascular cell adhesion molecule-1 promoter J Exp Med 176 1992 1583-1593
18. Bass D.A. Parce J.W. Dechatelet L.R. Szejda P. Seeds M.C. Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation J Immunol 130 1983 1910-1917
19. LeBel C.P. Ali S.F. Mckee M. Bondy S.C. Organometal-induced increases in oxygen reactive species: the potential of 2′, 7′-dichlorofluorescin diacetate as an index of neurotoxic damage Toxicol Appl Pharmacol 104 1990 17-24
20. Rosenkranz A.R. Schmaldienst S. Stuhlmeier K.M. Chen W. Knapp W. Zlabinger G.J. A microplate assay for the detection of oxidative products using 2′, 7′-dichlorofluorescin diacetate J Immunol Methods 156 1992 39-45
21. Elbashir S.M. Harborth J. Lendeckel W. Yalcin A. Weber K. Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture Nature 411 2001 494-498
22. Elbashir S.M. Lendeckel W. Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs Gene Dev 15 2001 188-200
23. Rodgers J.T. Patel P. Hennes J.L. Bolognia S.L. Mascotti D.P. Use of biotin-labeled nucleic acids for protein purification and agarose-based chemiluminescent electromobility shift assays Anal Biochem 277 2000 254-259
24. Zulueta J.J. Sawhney R. Yu F.S. Cote C.C. Hassoun P.M. Intracellular generation of reactive oxygen species in endothelial cells exposed to anoxia-reoxygenation Am J Physiol 272 1997 897-902
25. Cominacini L. Garbin U. Pasini A.F. Davoli A. Campagnola M. Pastorino A.M. et al. Oxidized low density lipoprotein increases the production of intracellular reactive oxygen species in endothelial cells: inhibitory effect of lacidipine J Hypertens 16 1998 1913-1919
26. Schmidt K.N. Traenckner E.B. Meier B. Baeuerle P.A. Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B J Biol Chem 270 1995 27136-27142
27. Tsao P.S. Buitrago R. Chan J.R. Cooke J.P. Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1 Circulation 94 1996 1682-1689
28. Maeba R. Maruyama A. Tarutani O. Ueta N. Shimasaki H. Oxidized low density lipoprotein induces the production of superoxide by neutrophils FEBS Lett 377 1995 309-312
29. Lander H.M. An essential role for free radicals and derived species in signal transduction FASEB J 11 1997 118-124
30. Cathacart M.K. McNally A.K. Morel D.W. Chisolm G.M. Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein to a cytotoxin J Immunol 142 1989 1963-1969
31. Schreck R. Rieber P. Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messenger in the activation of the NF-kappa B transcription factor and HIV-1 EMBO J 10 1991 2247-2258
32. Schreck R. Meier B. Mannel D.M. Droge W. Baeuerle P.A. Dithiocarbamates as potent inhibitors of NF-kappa B activation in intact cells J Exp Med 175 1992 1181-1194
33. Weber C. Erl W. Pietsch A. Strobel M. Ziegler-Heitbrock H.W. Weber P.C. Antioxidants inhibit monocyte adhesion by suppressing NF-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals Arterioscler Thromb 14 1994 1665-1673
34. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors Oncogene 18 1999 6853-6866
35. Handel M.L. McMorrow L.B. Gravallese E.M. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65 Arthritis Rheum 38 1995 1762-1770
36. Relic B. Bentires-Alj M. Ribbens C. Franchimont N. Guerne P.A. Benoit V. et al. TNF-α protects human primary articular chondrocytes from nitric oxide-induced apoptosis via NF-kappa B Lab Invest 82 2002 1661-1672