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Volumn 150, Issue 6, 2009, Pages 2732-2739

P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and indian hedgehog-dependent mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHOLESTEROL; CYTOCHROME P450 REDUCTASE; MESSENGER RNA; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; THYMIDINE;

EID: 66649126963     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0043     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 18844367746 scopus 로고    scopus 로고
    • Minireview: Regulation of steroidogenesis by electron transfer
    • DOI 10.1210/en.2005-0096
    • Miller WL 2005 Minireview: regulation of steroidogenesis by electron transfer. Endocrinology 146:2544-2550 (Pubitemid 40695556)
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2544-2550
    • Miller, W.L.1
  • 2
    • 0014670327 scopus 로고
    • Resolution of the cytochrome P-450-containing ω-hydroxylation system of liver microsomes into three components
    • Lu AY, Junk KW, Coon MJ 1969 Resolution of the cytochrome P-450-containing ω-hydroxylation system of liver microsomes into three components. J Biol Chem 244:3714-3721
    • (1969) J Biol Chem , vol.244 , pp. 3714-3721
    • Lu, A.Y.1    Junk, K.W.2    Coon, M.J.3
  • 3
    • 34347219795 scopus 로고    scopus 로고
    • Apparent manifesting heterozygosity in P450 oxidoreductase deficiency and its effect on coexisting 21-hydroxylase deficiency
    • DOI 10.1210/jc.2006-2345
    • Scott RR, Gomes LG, Huang N, Van Vliet G, Miller WL 2007 Apparent manifesting heterozygosity in P450 oxidoreductase deficiency and its effects on coexisting 21-hydroxylase deficiency. J Clin Endocrinol Metab 92:2318-2322 (Pubitemid 46997140)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.6 , pp. 2318-2322
    • Scott, R.R.1    Gomes, L.G.2    Huang, N.3    Van Vliet, G.4    Miller, W.L.5
  • 4
    • 0029974620 scopus 로고    scopus 로고
    • The ubiquitously expressed human CYP51 encodes lanosterol 14α- Demethylase, a cytochrome P450 whose expression is regulated by oxysterols
    • DOI 10.1006/abbi.1996.0193
    • Strömstedt M, Rozman D, Waterman MR 1996 The ubiquitously expressed CYP51 encodes lanosterol 14-α demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch Biochem Biophys 329:73-81 (Pubitemid 26143399)
    • (1996) Archives of Biochemistry and Biophysics , vol.329 , Issue.1 , pp. 73-81
    • Stromstedt, M.1    Rozman, D.2    Waterman, M.R.3
  • 5
    • 0030872361 scopus 로고    scopus 로고
    • Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
    • DOI 10.1093/emboj/16.14.4163
    • Fujii H, Sato T, Kaneko S, Gotoh O, Fujii-Kuriyama Y, Osawa K, Kato S, Hamada H 1997 Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J 16:4163-4173 (Pubitemid 27298169)
    • (1997) EMBO Journal , vol.16 , Issue.14 , pp. 4163-4173
    • Fujii, H.1    Sato, T.2    Kaneko, S.3    Gotoh, O.4    Fujii-Kuriyama, Y.5    Osawa, K.6    Kato, S.7    Hamada, H.8
  • 6
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines M 1997 The heme oxigenase system: a regulator of second messenger gases. Ann Rev Pharmacol Toxicol 37:517-554 (Pubitemid 27238886)
    • (1997) Annual Review of Pharmacology and Toxicology , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 7
    • 0033070951 scopus 로고    scopus 로고
    • Cytochrome P450 in synthesis of steroid hormones, bile acids, vitamin D3, and cholesterol
    • 43-47
    • Pikuleva I, Waterman M 1999 Cytochrome P450 in synthesis of steroid hormones, bile acids, vitamin D3, and cholesterol. Mol Aspects Med 20:33-42, 43-47
    • (1999) Mol Aspects Med , vol.20 , pp. 33-42
    • Pikuleva, I.1    Waterman, M.2
  • 10
    • 0037155271 scopus 로고    scopus 로고
    • Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase
    • DOI 10.1074/jbc.M111408200
    • Shen AL, O'Leary KA, Kasper CB 2002 Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-Cytochrome P450 oxidoreductase. J Biol Chem 277:6536-6541 (Pubitemid 34968452)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.8 , pp. 6536-6541
    • Shen, A.L.1    O'Leary, K.A.2    Kasper, C.B.3
  • 12
    • 43749123253 scopus 로고    scopus 로고
    • Genetic and clinical features of P450 oxidoreductase deficiency
    • Scott RR, Miller WL 2008 Genetic and clinical features of P450 oxidoreductase deficiency. Horm Res 69:266-275
    • (2008) Horm Res , vol.69 , pp. 266-275
    • Scott, R.R.1    Miller, W.L.2
  • 15
    • 3342918965 scopus 로고    scopus 로고
    • Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome
    • Adachi M, Tachibana K, Asakura Y, Yamamoto T, Hanaki K, Oka A 2004 Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. Am J Med Genet 128:333-339 (Pubitemid 38988634)
    • (2004) American Journal of Medical Genetics , vol.128 A , Issue.4 , pp. 333-339
    • Adachi, M.1    Tachibana, K.2    Asakura, Y.3    Yamamoto, T.4    Hanaki, K.5    Oka, A.6
  • 19
    • 0016736856 scopus 로고
    • Trapezoidocephaly, mid-facial hypoplasia and cartilage abnormalities with multiple synostoses and skeletal fractures
    • Antley R, Bixler D 1975 Trapezoidocephaly, mid-facial hypoplasia and cartilage abnormalities with multiple synostoses and skeletal fractures. Birth Defects Orig Artic Ser 11:397-401
    • (1975) Birth Defects Orig Artic Ser , vol.11 , pp. 397-401
    • Antley, R.1    Bixler, D.2
  • 20
    • 0037387601 scopus 로고    scopus 로고
    • Disorders of cholesterol biosynthesis: Prototypic metabolic malformation syndromes
    • Herman GE 2003 Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet 12:R75-R88 (Pubitemid 36442957)
    • (2003) Human Molecular Genetics , vol.12 , Issue.REV. ISS. 1
    • Herman, G.E.1
  • 21
    • 1042266622 scopus 로고    scopus 로고
    • Role of Cholesterol in the Regulation of Growth Plate Chondrogenesis and Longitudinal Bone Growth
    • DOI 10.1074/jbc.M305518200
    • Wu S, De Luca F 2004 Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. J Biol Chem 6:4642-4647 (Pubitemid 38199056)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 4642-4647
    • Wu, S.1    De Luca, F.2
  • 22
    • 0016641043 scopus 로고
    • Solubilization and partial characterization of rat liver squalene epoxidase
    • Ono T, Bloch K 1975 Solubilization and partial characterization of rat liver squalene epoxidase. J Biol Chem 250:1571-1579
    • (1975) J Biol Chem , vol.250 , pp. 1571-1579
    • Ono, T.1    Bloch, K.2
  • 23
    • 0037223886 scopus 로고    scopus 로고
    • Many facets of mammalian lanosterol 14α-demethylase from the evolutionarily conserved cytochrome P450 family CYP51
    • DOI 10.1016/S0003-9861(02)00418-6, PII S0003986102004186
    • Debeljak N, Fink M, Rozman D 2003 Many facets of mammalian lanosterol 14α-demethylase from the evolutionarily conserved cytochrome P450 family CYP51. Arch Biochem Biophys 409:159-171 (Pubitemid 36042912)
    • (2003) Archives of Biochemistry and Biophysics , vol.409 , Issue.1 , pp. 159-171
    • Debeljak, N.1    Fink, M.2    Rozman, D.3
  • 24
    • 0022374725 scopus 로고
    • Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases: A new variant of congenital adrenal hyperplasia
    • Peterson RE, Imperato-Mc Ginley J, Gautier T, Shackleton C 1985 Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia. N Engl J Med 313:1182-1191 (Pubitemid 16205335)
    • (1985) New England Journal of Medicine , vol.313 , Issue.19 , pp. 1182-1191
    • Peterson, R.E.1    Imperato-McGinley, J.2    Gautier, T.3    Shackleton, C.4
  • 25
    • 0022590907 scopus 로고
    • Congenital adrenal hyperplasia
    • Miller WL 1986 Congenital adrenal hyperplasia. N Engl J Med 314:1321-1322 (Pubitemid 16101402)
    • (1986) New England Journal of Medicine , vol.314 , Issue.20 , pp. 1321-1322
    • Miller, W.L.1
  • 27
    • 0032543288 scopus 로고    scopus 로고
    • FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome
    • Chun K, Siegel-Bartelt J, Chitayat D, Phillips J, RayPN1998 FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome. Am. J Med Genet 77:219-224
    • (1998) Am. J Med Genet , vol.77 , pp. 219-224
    • Chun, K.1    Siegel-Bartelt, J.2    Chitayat, D.3    Phillips, J.4    Ray, P.N.5
  • 29
    • 0029983966 scopus 로고    scopus 로고
    • Spectrum of craniosynostosis phenotypes associated with novel mutations at the fibroblast growth factor receptor 2 locus
    • Pulleyn LJ, Reardon W, Wilkes D, Rutland P, Jones BM, Hayward R, Hall CM, Brueton L, Chun N, Lammer E, Malcolm S, Winter RM 1996 Spectrum of craniosynostosis phenotypes associated with novel mutations at the fibroblast growth factor receptor 2 locus. Eur J Hum Genet 4:283-291 (Pubitemid 26378953)
    • (1996) European Journal of Human Genetics , vol.4 , Issue.5 , pp. 283-291
    • Pulleyn, L.J.1
  • 30
    • 0032559318 scopus 로고    scopus 로고
    • Novel mutation in the FGFR2 gene at the same codon as the Crouzon syndrome mutations in a severe Pfeiffer syndrome type 2 case
    • DOI 10.1002/(SICI)1096-8628(19980123)75:3<252::AID-AJMG4>3.0.CO;2-S
    • Schaefer F, Anderson C, Can B, Say B 1998 Novel mutation in the FGFR2 gene at the same codon as the Crouzon syndrome mutations in a severe Pfeiffer syndrome type 2 case. Am J Med Genet 75:252-255 (Pubitemid 28076849)
    • (1998) American Journal of Medical Genetics , vol.75 , Issue.3 , pp. 252-255
    • Schaefer, F.1    Anderson, C.2    Can, B.3    Say, B.4
  • 33
    • 0030770714 scopus 로고    scopus 로고
    • Multiple malformation syndrome following fluconazole use in pregnancy: Report of an additional patient
    • DOI 10.1002/(SICI)1096-8628(19971031)72:3<253::AID-AJMG1>3.0.CO;2-S
    • Aleck KA, Bartley DL 1997 Multiple malformation syndrome following fluconazole use in pregnancy: report of an additional patient. Am J Med Genet 72:253-256 (Pubitemid 27424225)
    • (1997) American Journal of Medical Genetics , vol.72 , Issue.3 , pp. 253-256
    • Aleck, K.A.1    Bartley, D.L.2
  • 34
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B, Hammerschmidt M, McMahon AP 1999 Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086 (Pubitemid 29407348)
    • (1999) Genes and Development , vol.13 , Issue.16 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 35
    • 0036686233 scopus 로고    scopus 로고
    • Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development
    • Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Sävendhal L 2002 Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. J Endocrinol 174:R1-R6 (Pubitemid 34965776)
    • (2002) Journal of Endocrinology , vol.174 , Issue.2
    • Kindblom, J.M.1    Nilsson, O.2    Hurme, T.3    Ohlsson, C.4    Savendahl, L.5
  • 36
    • 29744468220 scopus 로고    scopus 로고
    • Conditional deletion of Indian hedgehog from collagen type 2α1-expressing cells results in abnormal endochondral bone formation
    • DOI 10.1002/path.1870
    • Razzaque MS, Soegiarto DW, Chang D, Long F, Lanske B 2005 Conditional deletion of Indian hedgehog from collagen type 2αI-expressing cells results in abnormal endochondral bone formation. J Pathol 207:453-461 (Pubitemid 43025694)
    • (2005) Journal of Pathology , vol.207 , Issue.4 , pp. 453-461
    • Razzaque, M.S.1    Soegiarto, D.W.2    Chang, D.3    Long, F.4    Lanske, B.5
  • 38
    • 33748796068 scopus 로고    scopus 로고
    • How does cholesterol affect the way Hedhehog works?
    • Wendler F, Franch-Marro X, Vincent JP 2006 How does cholesterol affect the way Hedhehog works? Development 133:3055-3061
    • (2006) Development , vol.133 , pp. 3055-3061
    • Wendler, F.1    Franch-Marro, X.2    Vincent, J.P.3
  • 40
    • 58149473438 scopus 로고    scopus 로고
    • Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis
    • Brokken LJ, Adamsson A, Paranko J, Toppari J 2009 Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Endocrinology 150:445-451
    • (2009) Endocrinology , vol.150 , pp. 445-451
    • Brokken, L.J.1    Adamsson, A.2    Paranko, J.3    Toppari, J.4
  • 43
    • 0035862976 scopus 로고    scopus 로고
    • The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo
    • DOI 10.1101/gad.851501
    • Sakai Y, Meno C, Fujii H, Nishino J, Shiratori H, Saijoh Y, Rossant J, Hamada H 2001 The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterior-posterior axis within the mouse embryo. Genes Dev 15:213-225 (Pubitemid 32107666)
    • (2001) Genes and Development , vol.15 , Issue.2 , pp. 213-225
    • Sakai, Y.1    Meno, C.2    Fujii, H.3    Nishino, J.4    Shiratori, H.5    Saijoh, Y.6    Rossant, J.7    Hamada, H.8
  • 44
    • 0035862977 scopus 로고    scopus 로고
    • The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
    • DOI 10.1101/gad.855001
    • Abu-Abed S, Dollé P, Metzger D, Beckett B, Chambon P, Petkovich M 2001 The retinoic acid metabolizing enzyme CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev 15:226-240 (Pubitemid 32107667)
    • (2001) Genes and Development , vol.15 , Issue.2 , pp. 226-240
    • Abu-Abed, S.1    Dolle, P.2    Metzger, D.3    Beckett, B.4    Chambon, P.5    Petkovich, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.