Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway

Life Sciences

Volumn 88, Issue 15-16, 2011, Pages 725-729

  Tsutsumi, Yasuo M ^a   Tsutsumi, Rie ^a   Mawatari, Kazuaki ^a   Nakaya, Yutaka ^a   Kinoshita, Michiko ^a   Tanaka, Katsuya ^a   Oshita, Shuzo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Ginseng; Ginsenoside; Ischemia reperfusion

Indexed keywords

CALCIUM ION; COMPOUND K; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GINSENOSIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOBLOTTING; IN VIVO STUDY; MALE; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANDROSTADIENES; ANIMALS; CALCIUM; GINSENOSIDES; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

MUS; PANAX GINSENG;

EID: 79953283184     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.02.011     Document Type: Article

References (36)

1. 2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes. Br J Pharmacol 2004;142(3):567-75.
2. Chan E, Wong CY, Wan CW, Kwok CY, Wu JH, Ng KM, So CH, Au AL, Poon CC, Seto SW, Kwan YW, Yu PH, Chan SW. Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. Am J Chin Med 2010;38(4):815-27.
3. 2 enhance Fas-induced cell death of human astrocytoma cells through distinct apoptotic signaling pathways. Cancer Res Treat 2009;41(1):36-44.
4. Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29(9):1109-18.
5. Choo MK, Sakurai H, Kim DH, Saiki I. A ginseng saponin metabolite suppresses tumor necrosis factor-α-promoted metastasis by suppressing nuclear factor-κB signaling in murine colon cancer cells. Oncol Rep 2008;19(3):595-600. (Pubitemid 351330423)
6. Chu SF, Zhang JT. New achievements in ginseng research and its future prospects. Chin J Integr Med 2009;15(6):403-8.
7. Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev 2007;12(3-4):181-8. (Pubitemid 350176691)
8. Fuzzati N. Analysis methods of ginsenosides. J Chromatogr B Analyt Technol Biomed Life Sci 2004;812(1-2):119-33. (Pubitemid 39535405)
9. 1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats. J Huazhong Univ Sci Technol Med Sci 2002;22(3):212-5.
10. Halestrap AP, Clarke SJ, Khaliulin I. The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta 2007;1767(8):1007-31. (Pubitemid 47101788)
11. Hasegawa H, Sung JH, Benno Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med 1997;63(5):436-40. (Pubitemid 27399983)
12. 1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite. Planta Med 1998;64(8):696-700.
13. Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res 2006;70(2):240-53.
14. Ho YS, So KF, Chang RC. Anti-aging herbal medicine-how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res Rev 2010;9(3):354-62.
15. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. Caveolin-3 expression and caveolae are required for isofluraneinduced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol 2008;44(1):123-30.
16. 3H] flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides. Neurochem Res 2004;29(12):2257-66.
17. Kim DS, Chang YJ, Zedk U, Zhao P, Liu YQ, Yang CR. Dammarane saponins from Panax ginseng. Phytochemistry 1995;40(5):1493-7.
18. 2. Int J Biochem Cell Biol 1998;30(3):327-38.
19. 1. Biosci Biotechnol Biochem 2000;64(12):2739-43.
20. Kong HL, Wang JP, Li ZQ, Zhao SM, Dong J, Zhang WW. Anti-hypoxic effect of ginsenoside Rbl on neonatal rat cardiomyocytes is mediated through the specific activation of glucose transporter-4 ex vivo. Acta Pharmacol Sin 2009;30(4):396-403.
21. 2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening. Acta Pharmacol Sin 2010;31(6):687-95.
22. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6(5):513-9. (Pubitemid 30305900)
23. Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 2005;25(5):1069-73. (Pubitemid 41404031)
24. Liao BC, Hou RC, Wang JS, Jeng KC. Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells. J Biomed Sci 2006;13(5):613-9. (Pubitemid 44496862)
25. Morin D, Assaly R, Paradis S, Berdeaux A. Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection. Curr Med Chem 2009;16(33):4382-98.
26. Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol Pharm Bull 2003;26(11):1581-4. (Pubitemid 41699639)
27. Park JS, Park EM, Kim DH, Jung K, Jung JS, Lee EJ, Hyun JW, Kang JL, Kim HS. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009;209(1-2):40-9.
28. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J 2007;21 (7):1565-74. (Pubitemid 46684858)
29. Reed JC, Kroemer G. Mechanisms of mitochondrial membrane permeabilization. Cell Death Differ 2000;7(12):1145. (Pubitemid 32042220)
30. Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T. Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore. J Biol Chem 2001;276(51):48093-9.
31. Tsutsumi YM, Patel HH, Huang D, Roth DM. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Am J Physiol Heart Circ Physiol 2006;291(2):H979-83.
32. Tsutsumi YM, Yokoyama T, Horikawa Y, Roth DM, Patel HH. Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci 2007;81(15):1223-7. (Pubitemid 47513165)
33. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation 2008;118(19):1979-88.
34. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology 2010;112(5):1136-45.
35. Wang W, Zhao Y, Rayburn ER, Hill DL, Wang H, Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol 2007;59(5):589-601.
36. Wang Z, Li M, Wu WK, Tan HM, Geng DF. Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction. Cardiovasc Drugs Ther 2008;22(6):443-52.