Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

Cancer Research

Volumn 58, Issue 10, 1998, Pages 2196-2199

  Yuan, Bao Zhu ^a   Miller, Mark J ^a   Keck, Catherine L ^a   Zimonjic, Drazen B ^a   Thorgeirsson, Snorri S ^a   Popescu, Nicholas C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA;

ARTICLE; BREAST CANCER; CHROMOSOMAL LOCALIZATION; CHROMOSOME 8P; CHROMOSOME DELETION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CANCER; LIVER CELL CARCINOMA; LUNG CANCER; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RAT; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 8; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MOLECULAR SEQUENCE DATA; PROTEINS; RATS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0032524031     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bishop, J. M. The molecular genetics of cancer. Science (Washington DC), 235: 305-311, 1987.
2. Croce, C. M., and Nowell, P. C. Molecular basis of human B cell neoplasia. Blood, 65: 1-7, 1985.
3. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
4. Knudson, A. G. Antioncogenes and human cancer. Proc. Natl. Acad. Sci. USA, 90: 10914-10121, 1993.
5. Simonetti, R. G., Camma, C., Fiorello, F., Politi, F., D'Amico, G., and Pagliaro, L. Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig. Dis. Sci., 36: 962-972, 1991.
6. Harris, C. C. Hepatocellular carcinogenesis: recent advances and speculations. Cancer Cells, 2: 146-148, 1990.
7. Lisitsyn, N., Lisitsyn, N., and Wigler, M. Cloning the differences between two complex genomes. Science (Washington DC), 259: 946-951, 1993.
8. Homma, Y., and Emori, Y. A dual functional signal mediator showing RhoGAP and phospholipase Cδ stimulating activities. EMBO J., 14: 286-291, 1995.
9. Wang, G., Zhu, D., Ye, X., and Chen, R. Establishment and characterization of a tumor cell line, QGY-7703, derived from hepatocellular carcinoma of a Qidong patient. Chin. J. Oncol., 3: 241-244, 1981.
10. Lisitsyn, N. A., Lisitsina, N. M., Dalbagni, G., Barker, P., Sanchez, C. A., Gnarra, J., Linehan, W. M., Reid, B. J., and Wigler, M. H. Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. USA, 92: 151-155, 1995.
11. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. Basic local alignment search tool. J. Mol. Biol., 215: 403-410, 1990.
12. Kallioniemi, A., Kallioniemi, O. P., Sudar, D., Rutovitz, D., Gray, J. W., Waldman, F., and Pinkel, D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (Washington DC), 258: 818-821, 1992.
13. Zimonjic, D. B., Rezanka, L., DiPaolo, J. A., and Popescu, N. C. Refined localization of the erbB-3 proto-oncogene by direct visualization of FISH signals on LUT-inverted and contrast-enhanced digital images of DAPI-banded chromosomes. Cancer Genet. Cytogenet., 80: 100-102, 1995.
14. Nobes, C. D., and Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell, 81: 53-62, 1995.
15. Khosravi-Far, R., Campbell, S., Rossman, K. L., and Der, C. J. increasing complexity of Ras signal transduction: involvement of Rho family proteins. Adv. Cancer Res., 69: 59-105, 1997.
16. Quilliam, L. A., Khosravi-Far, R., Huff, S. Y., and Der, C. J. Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays, 17: 395-404, 1995.
17. Wang, D. Z., Nur, E. K. M. S., Tikoo, A., Montague, W., and Maruta, H. The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors. Cancer Res., 57: 2478-2484, 1997.
18. Emi, M., Fujiwara, Y., Ohata, H., Tsuda, H., Hirohashi, S., Koike, M., Miyaki, M., Monden, M., and Nakamura, Y. Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma. Genes Chromosomes Cancer, 7: 152-157, 1993.
19. Visakorpi, T., Kallioniemi, A. H., Syvanen, A. C., Hyytinen, E. R., Karhu, R., Tammela, T., Isola, J. J., and Kallioniemi, O. P. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res., 55: 342-347, 1995.
20. Bergerheim, U. S., Kunimi, K., Collins, V. P., and Ekman, P. Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma. Genes Chromosomes Cancer, 3: 215-220, 1991.
21. Cher, M. L., MacGrogan, D., Bookstein, R., Brown, J. A., Jenkins, R. B., and Jensen, R. H. Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer. Genes Chromosomes Cancer, 11: 153-162, 1994.
22. Fujiwara, Y., Ohata, H., Emi, M., Okui, K., Koyama, K., Tsuchiya, E., Nakajima, T., Monden, M., Mori, T., Kurimasa, A., Oshimura, M., and Nakamura, Y. A 3-Mb physical map of the chromosome region 8p21.3→p22, including a 600kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer. Genes Chromosomes Cancer, 10: 7-14, 1994.
23. Chinen, K., Isomura, M., Izawa, K., Fujiwara, Y., Ohata, H., Iwamasa, T., and Nakamura, Y. Isolation of 45 exon-like fragments from 8p22-p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas. Cytogenet. Cell Genet., 75: 190-196, 1996.
24. Brothman, A. R. Cytogenetic studies in prostate cancer: are we making progress? Cancer Genet. Cytogenet., 95: 116-121, 1997.
25. Petersen, I., Bujard, M., Petersen, S., Wolf, G., Goeze, A., Schwendel, A., Langreck, H., Gellert, K., Reichel, M., Just, K., du Manoir, S., Cremer, T., Dietel, M., and Ried, T. Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Res., 57: 2331-2335, 1997.
26. Isola, J. J., Kallioniemi, O. P., Chu, L. W., Fuqua, S. A., Hilsenbeck, S. G., Osborne, C. K., and Waldman, F. M. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am. J. Pathol., 147: 905-911, 1995.
27. Marchio, A., Meddeb, M., Pineau, P., Danglot, G., Tiollais, P., Bernheim, A., and Dejean, A. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer, 18: 59-65, 1997.