Gene expression changes induced by skin sensitizers in the KeratinoSens® cell line: Discriminating Nrf2-dependent and Nrf2-independent events

Toxicology in Vitro

Volumn 27, Issue 8, 2013, Pages 2225-2232

  Emter, Roger ^a   van der Veen, Jochem W ^b,d   Adamson, Greg ^c   Ezendam, Janine ^b   van Loveren, Henk ^b,d   Natsch, Andreas ^a  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c Givaudan US ^*  (United States)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Gene expression; Keratinocytes; KeratinoSens ; Nrf2; Skin sensitization; Small interfering RNA

Indexed keywords

HEAT SHOCK PROTEIN; LUCIFERASE; MESSENGER RNA; POLYSORBATE 80; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2;

AKR1C2 GENE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL ACTIVITY; CELL ASSAY; CELL LINE; CELL SCREENING; CELL STRESS; CONTROLLED STUDY; ENZYME INDUCTION; FALSE POSITIVE RESULT; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENETIC MARKER; IN VITRO STUDY; INTRACELLULAR SIGNALING; KERATINOCYTE; MOLECULAR MECHANICS; PROTEIN ANALYSIS; PROTEIN FUNCTION; REPORTER GENE; SCREENING TEST; SKIN SENSITIZATION;

2,4-DINITROCHLOROBENZENE; ANTIOXIDANT RESPONSE ELEMENT; ARE; DIMETHYLSULFOXIDE; DMSO; DNCB; FCS; FETAL CALF SERUM; GENE EXPRESSION; KEAP1; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; KERATINOCYTES; KERATINOSENS™; LLNA; LOCAL LYMPH NODE ASSAY; NRF2; NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2; QRT-PCR; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; SDS; SKIN SENSITIZATION; SMALL INTERFERING RNA; SODIUM DODECYL SULFATE;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; CELL LINE; GENE EXPRESSION; HEME OXYGENASE-1; HUMANS; HYDROXYSTEROID DEHYDROGENASES; LUCIFERASES; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; RNA, MESSENGER; SKIN IRRITANCY TESTS;

EID: 84885697004     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.09.009     Document Type: Article

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