메뉴 건너뛰기




Volumn 44, Issue 4, 2009, Pages 285-296

Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor

Author keywords

Histamine; Histamine H2 receptor; IEL; IFN ; TCR

Indexed keywords

CYTOKINE; DIMAPRIT; FAMOTIDINE; GAMMA INTERFERON; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; IONOMYCIN; MEPYRAMINE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 65049086172     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0019-9     Document Type: Article
Times cited : (21)

References (51)
  • 1
    • 17144373268 scopus 로고    scopus 로고
    • Gastrointestinal food allergy: New insights into pathophysiology and clinical perspectives
    • Bischoff S, Crowe SE. Gastrointestinal food allergy: New insights into pathophysiology and clinical perspectives. Gastroenterology. 2005;128:1089-113.
    • (2005) Gastroenterology , vol.128 , pp. 1089-1113
    • Bischoff, S.1    Crowe, S.E.2
  • 3
    • 0025216985 scopus 로고
    • The jejunal secretion of histamine is increased in active Crohn's disease
    • Knutson L, Ahrenstedt O, Odlind B, Hallgren R. The jejunal secretion of histamine is increased in active Crohn's disease. Gastroenterology. 1990;98:849-54.
    • (1990) Gastroenterology , vol.98 , pp. 849-854
    • Knutson, L.1    Ahrenstedt, O.2    Odlind, B.3    Hallgren, R.4
  • 4
    • 10744225624 scopus 로고    scopus 로고
    • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    • Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology. 2004;126:693-702.
    • (2004) Gastroenterology , vol.126 , pp. 693-702
    • Barbara, G.1    Stanghellini, V.2    De Giorgio, R.3    Cremon, C.4    Cottrell, G.S.5    Santini, D.6
  • 5
    • 33645130900 scopus 로고    scopus 로고
    • Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract
    • Sander LE, Lorentz A, Sellge G, Coeffier M, Neipp M, Veres T, et al. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut. 2006;55:498-504.
    • (2006) Gut , vol.55 , pp. 498-504
    • Sander, L.E.1    Lorentz, A.2    Sellge, G.3    Coeffier, M.4    Neipp, M.5    Veres, T.6
  • 6
    • 0029164318 scopus 로고
    • Molecular pharmacological aspects of histamine receptors
    • Leurs R, Smit MJ, Timmerman H. Molecular pharmacological aspects of histamine receptors. Pharmacol Ther. 1995;66:413-63.
    • (1995) Pharmacol Ther , vol.66 , pp. 413-463
    • Leurs, R.1    Smit, M.J.2    Timmerman, H.3
  • 7
    • 0035119027 scopus 로고    scopus 로고
    • Genomics meets histamine receptors: New subtypes, new receptors
    • Hough LB. Genomics meets histamine receptors: New subtypes, new receptors. Mol Pharmacol. 2001;59:415-9.
    • (2001) Mol Pharmacol , vol.59 , pp. 415-419
    • Hough, L.B.1
  • 8
    • 0035959904 scopus 로고    scopus 로고
    • Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
    • Jutel M, Watanabe T, Klunker S, Akdis M, Thomet OA, Malolepszy J, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature. 2001;413:420-5.
    • (2001) Nature , vol.413 , pp. 420-425
    • Jutel, M.1    Watanabe, T.2    Klunker, S.3    Akdis, M.4    Thomet, O.A.5    Malolepszy, J.6
  • 10
    • 0035124477 scopus 로고    scopus 로고
    • The effects of histamine on interferon gamma production are dependent on the stimulatory signals
    • Osna N, Elliott K, Khan MM. The effects of histamine on interferon gamma production are dependent on the stimulatory signals. Int Immunopharmacol. 2001;1:135-45.
    • (2001) Int Immunopharmacol , vol.1 , pp. 135-145
    • Osna, N.1    Elliott, K.2    Khan, M.M.3
  • 11
    • 1642390181 scopus 로고    scopus 로고
    • Regulation of Con A-dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine
    • Sonobe Y, Nakane H, Watanabe T, Nakano K. Regulation of Con A-dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine. Inflamm Res. 2004;53:87-92.
    • (2004) Inflamm Res , vol.53 , pp. 87-92
    • Sonobe, Y.1    Nakane, H.2    Watanabe, T.3    Nakano, K.4
  • 12
    • 0030069137 scopus 로고    scopus 로고
    • Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages
    • Takamatsu S, Nakashima I, Nakano K. Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages. J Immunol. 1996;156:778-85.
    • (1996) J Immunol , vol.156 , pp. 778-785
    • Takamatsu, S.1    Nakashima, I.2    Nakano, K.3
  • 13
    • 21144445876 scopus 로고    scopus 로고
    • Histamine and histidine decarboxylase up-regulation in colorectal cancer: Correlation with tumor stage
    • Masini E, Fabbroni V, Giannini L, Vannacci A, Messerini L, Perna F, et al. Histamine and histidine decarboxylase up-regulation in colorectal cancer: Correlation with tumor stage. Inflamm Res. 2005;54(Suppl 1):S80-1.
    • (2005) Inflamm Res , vol.54 , Issue.SUPPL. 1
    • Masini, E.1    Fabbroni, V.2    Giannini, L.3    Vannacci, A.4    Messerini, L.5    Perna, F.6
  • 14
    • 0036896170 scopus 로고    scopus 로고
    • Urinary excretion of N -methylhistamine as a marker of disease activity in inflammatory bowel disease
    • Winterkamp S, Weidenhiller M, Otte P, Stolper J, Schwab D, Hahn EG, et al. Urinary excretion of N -methylhistamine as a marker of disease activity in inflammatory bowel disease. Am J Gastroenterol. 2002;97:3071-7.
    • (2002) Am J Gastroenterol , vol.97 , pp. 3071-3077
    • Winterkamp, S.1    Weidenhiller, M.2    Otte, P.3    Stolper, J.4    Schwab, D.5    Hahn, E.G.6
  • 17
    • 14644422227 scopus 로고    scopus 로고
    • Exogenous histamine stimulates colorectal cancer implant growth via immunosuppression in mice
    • Tomita K, Okabe S. Exogenous histamine stimulates colorectal cancer implant growth via immunosuppression in mice. J Pharmacol Sci. 2005;97:116-23.
    • (2005) J Pharmacol Sci , vol.97 , pp. 116-123
    • Tomita, K.1    Okabe, S.2
  • 18
    • 0034043052 scopus 로고    scopus 로고
    • H2-antagonists in the treatment of colon and breast cancer
    • Bolton E, King J, Morris DL. H2-antagonists in the treatment of colon and breast cancer. Semin Cancer Biol. 2000;10:3-10.
    • (2000) Semin Cancer Biol , vol.10 , pp. 3-10
    • Bolton, E.1    King, J.2    Morris, D.L.3
  • 19
    • 0025837843 scopus 로고
    • Regulatory functions for murine intraepithelial lymphocytes in mucosal responses
    • Kiyono H, Fujihashi K, Taguchi T, Aicher WK, McGhee JR. Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunol Res. 1991;10:324-30.
    • (1991) Immunol Res , vol.10 , pp. 324-330
    • Kiyono, H.1    Fujihashi, K.2    Taguchi, T.3    Aicher, W.K.4    McGhee, J.R.5
  • 20
    • 0026540112 scopus 로고
    • A rapid method for isolating murine intestine intraepithelial lymphocytes with high yield and purity
    • Mosley RL, Klein JR. A rapid method for isolating murine intestine intraepithelial lymphocytes with high yield and purity. J Immunol Methods. 1992;156:19-26.
    • (1992) J Immunol Methods , vol.156 , pp. 19-26
    • Mosley, R.L.1    Klein, J.R.2
  • 21
    • 2542477129 scopus 로고    scopus 로고
    • Starting at the beginning: New perspectives on the biology of mucosal T cells
    • Cheroutre H. Starting at the beginning: New perspectives on the biology of mucosal T cells. Annu Rev Immunol. 2004;22:217-46.
    • (2004) Annu Rev Immunol , vol.22 , pp. 217-246
    • Cheroutre, H.1
  • 22
    • 23344451487 scopus 로고    scopus 로고
    • IELs: Enforcing law and order in the court of the intestinal epithelium
    • Cheroutre H. IELs: Enforcing law and order in the court of the intestinal epithelium. Immunol Rev. 2005;206:114-31.
    • (2005) Immunol Rev , vol.206 , pp. 114-131
    • Cheroutre, H.1
  • 23
    • 0035162229 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: Exploring the third way in immunology
    • Hayday A, Theodoridis E, Ramsburg E, Shires J. Intraepithelial lymphocytes: Exploring the third way in immunology. Nat Immunol. 2001;2:997-1003.
    • (2001) Nat Immunol , vol.2 , pp. 997-1003
    • Hayday, A.1    Theodoridis, E.2    Ramsburg, E.3    Shires, J.4
  • 24
    • 0025840350 scopus 로고
    • Novel function for intestinal intraepithelial lymphocytes murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5
    • Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, et al. Novel function for intestinal intraepithelial lymphocytes murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991;147:3736-44.
    • (1991) J Immunol , vol.147 , pp. 3736-3744
    • Taguchi, T.1    Aicher, W.K.2    Fujihashi, K.3    Yamamoto, M.4    McGhee, J.R.5    Bluestone, J.A.6
  • 26
    • 0028117098 scopus 로고
    • Modulation of epithelial cell growth by intraepithelial gamma delta T cells
    • Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science. 1994;266:1253-5.
    • (1994) Science , vol.266 , pp. 1253-1255
    • Boismenu, R.1    Havran, W.L.2
  • 27
    • 0025312989 scopus 로고
    • Analysis of Th1 and Th2 cells in murine gut-associated tissues frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5
    • Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, et al. Analysis of Th1 and Th2 cells in murine gut-associated tissues frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J Immunol. 1990;145:68-77.
    • (1990) J Immunol , vol.145 , pp. 68-77
    • Taguchi, T.1    McGhee, J.R.2    Coffman, R.L.3    Beagley, K.W.4    Eldridge, J.H.5    Takatsu, K.6
  • 28
    • 0030239819 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions
    • Lundqvist C, Melgar S, Yeung MM, Hammarstrom S, Hammarstrom ML. Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions. J Immunol. 1996;157:1926-34.
    • (1996) J Immunol , vol.157 , pp. 1926-1934
    • Lundqvist, C.1    Melgar, S.2    Yeung, M.M.3    Hammarstrom, S.4    Hammarstrom, M.L.5
  • 29
    • 33645118120 scopus 로고    scopus 로고
    • Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
    • Di Sabatino A, Ciccocioppo R, Cupelli F, Cinque B, Millimaggi D, Clarkson MM, et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut. 2006;55:469-77.
    • (2006) Gut , vol.55 , pp. 469-477
    • Di Sabatino, A.1    Ciccocioppo, R.2    Cupelli, F.3    Cinque, B.4    Millimaggi, D.5    Clarkson, M.M.6
  • 30
    • 0027255458 scopus 로고
    • Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors
    • Kawaguchi M, Nanno M, Umesaki Y, Matsumoto S, Okada Y, Cai Z, et al. Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors. Proc Natl Acad Sci USA. 1993;90:8591-4.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8591-8594
    • Kawaguchi, M.1    Nanno, M.2    Umesaki, Y.3    Matsumoto, S.4    Okada, Y.5    Cai, Z.6
  • 31
    • 52949095370 scopus 로고    scopus 로고
    • Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes
    • Horio Y, Osawa S, Takagaki K, Hishida A, Furuta T, Ikuma M. Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes. Cytokine. 2008;44:92-5.
    • (2008) Cytokine , vol.44 , pp. 92-95
    • Horio, Y.1    Osawa, S.2    Takagaki, K.3    Hishida, A.4    Furuta, T.5    Ikuma, M.6
  • 32
    • 23944433719 scopus 로고    scopus 로고
    • Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: Identification of 4-methylhistamine as the first potent and selective H4 receptor agonist
    • Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: Identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther. 2005;314:1310-21.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1310-1321
    • Lim, H.D.1    van Rijn, R.M.2    Ling, P.3    Bakker, R.A.4    Thurmond, R.L.5    Leurs, R.6
  • 33
    • 30844452189 scopus 로고    scopus 로고
    • An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity
    • Montufar-Solis D, Klein JR. An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity. J Immunol Methods. 2006;308:251-4.
    • (2006) J Immunol Methods , vol.308 , pp. 251-254
    • Montufar-Solis, D.1    Klein, J.R.2
  • 34
    • 18244405367 scopus 로고    scopus 로고
    • Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells
    • Takahashi HK, Yoshida A, Iwagaki H, Yoshino T, Itoh H, Morichika T, et al. Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells. J Pharmacol Exp Ther. 2002;300:227-35.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 227-235
    • Takahashi, H.K.1    Yoshida, A.2    Iwagaki, H.3    Yoshino, T.4    Itoh, H.5    Morichika, T.6
  • 35
    • 0035668614 scopus 로고    scopus 로고
    • Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization
    • Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest. 2001;108:1865-73.
    • (2001) J Clin Invest , vol.108 , pp. 1865-1873
    • Mazzoni, A.1    Young, H.A.2    Spitzer, J.H.3    Visintin, A.4    Segal, D.M.5
  • 36
    • 0025936929 scopus 로고
    • Phenotypic complexity of intraepithelial lymphocytes of the small intestine
    • Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol. 1991;147:1746-51.
    • (1991) J Immunol , vol.147 , pp. 1746-1751
    • Lefrancois, L.1
  • 37
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol. 1999;162:3749-52.
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6
  • 38
    • 33644775585 scopus 로고    scopus 로고
    • Histamine receptors are hot in immunopharmacology
    • Akdis CA, Simons FE. Histamine receptors are hot in immunopharmacology. Eur J Pharmacol. 2006;533:69-76.
    • (2006) Eur J Pharmacol , vol.533 , pp. 69-76
    • Akdis, C.A.1    Simons, F.E.2
  • 39
    • 0037307987 scopus 로고    scopus 로고
    • Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner
    • Morichika T, Takahashi HK, Iwagaki H, Yoshino T, Tamura R, Yokoyama M, et al. Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner. J Pharmacol Exp Ther. 2003;304:624-33.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 624-633
    • Morichika, T.1    Takahashi, H.K.2    Iwagaki, H.3    Yoshino, T.4    Tamura, R.5    Yokoyama, M.6
  • 40
    • 0035478713 scopus 로고    scopus 로고
    • Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells
    • Caron G, Delneste Y, Roelandts E, Duez C, Bonnefoy JY, Pestel J, et al. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J Immunol. 2001;167:3682-6.
    • (2001) J Immunol , vol.167 , pp. 3682-3686
    • Caron, G.1    Delneste, Y.2    Roelandts, E.3    Duez, C.4    Bonnefoy, J.Y.5    Pestel, J.6
  • 41
    • 0030916116 scopus 로고    scopus 로고
    • Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones
    • Lagier B, Lebel B, Bousquet J, Pene J. Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones. Clin Exp Immunol. 1997;108:545-51.
    • (1997) Clin Exp Immunol , vol.108 , pp. 545-551
    • Lagier, B.1    Lebel, B.2    Bousquet, J.3    Pene, J.4
  • 42
    • 0035124146 scopus 로고    scopus 로고
    • Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes
    • Osna N, Elliott K, Khan MM. Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes. Int Immunopharmacol. 2001;1:85-96.
    • (2001) Int Immunopharmacol , vol.1 , pp. 85-96
    • Osna, N.1    Elliott, K.2    Khan, M.M.3
  • 43
    • 0031595502 scopus 로고    scopus 로고
    • CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization
    • Watanabe M, Hosoda Y, Okamoto S, Yamazaki M, Inoue N, Ueno Y, et al. CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization. Clin Immunol Immunopathol. 1998;88:46-55.
    • (1998) Clin Immunol Immunopathol , vol.88 , pp. 46-55
    • Watanabe, M.1    Hosoda, Y.2    Okamoto, S.3    Yamazaki, M.4    Inoue, N.5    Ueno, Y.6
  • 44
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol. 1997;150:823-32.
    • (1997) Am J Pathol , vol.150 , pp. 823-832
    • Parronchi, P.1    Romagnani, P.2    Annunziato, F.3    Sampognaro, S.4    Becchio, A.5    Giannarini, L.6
  • 46
    • 0036402139 scopus 로고    scopus 로고
    • Histamine H(2) receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model
    • Takahashi K, Tanaka S, Furuta K, Ichikawa A. Histamine H(2) receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model. Biochem Biophys Res Commun. 2002;297:1205-10.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 1205-1210
    • Takahashi, K.1    Tanaka, S.2    Furuta, K.3    Ichikawa, A.4
  • 47
    • 29144529103 scopus 로고    scopus 로고
    • Effect of pre-operative short course famotidine on tumor infiltrating lymphocytes in colorectal cancer: A double blind, placebo controlled, prospective randomized study
    • Kapoor S, Pal S, Sahni P, Dattagupta S, Kanti Chattopadhyay T. Effect of pre-operative short course famotidine on tumor infiltrating lymphocytes in colorectal cancer: A double blind, placebo controlled, prospective randomized study. J Surg Res. 2005;129:172-5.
    • (2005) J Surg Res , vol.129 , pp. 172-175
    • Kapoor, S.1    Pal, S.2    Sahni, P.3    Dattagupta, S.4    Kanti Chattopadhyay, T.5
  • 48
    • 0027973588 scopus 로고
    • Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth
    • Adams WJ, Lawson JA, Morris DL. Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Gut. 1994;35:1632-6.
    • (1994) Gut , vol.35 , pp. 1632-1636
    • Adams, W.J.1    Lawson, J.A.2    Morris, D.L.3
  • 50
    • 0037148437 scopus 로고    scopus 로고
    • Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells
    • Matsumoto S, Imaeda Y, Umemoto S, Kobayashi K, Suzuki H, Okamoto T. Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Br J Cancer. 2002;86:161-7.
    • (2002) Br J Cancer , vol.86 , pp. 161-167
    • Matsumoto, S.1    Imaeda, Y.2    Umemoto, S.3    Kobayashi, K.4    Suzuki, H.5    Okamoto, T.6
  • 51
    • 0030925013 scopus 로고    scopus 로고
    • Pilot study - Cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: Results of a small randomized control trial
    • Adams WJ, Morris DL. Pilot study - cimetidine enhances lymphocyte infiltration of human colorectal carcinoma: Results of a small randomized control trial. Cancer. 1997;80:15-21.
    • (1997) Cancer , vol.80 , pp. 15-21
    • Adams, W.J.1    Morris, D.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.