메뉴 건너뛰기




Volumn 171, Issue 6, 2003, Pages 3194-3201

IL-6 induces NF-κB activation in the intestinal epithelia

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

EID: 0041832287     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.6.3194     Document Type: Article
Times cited : (202)

References (48)
  • 2
    • 0030823183 scopus 로고    scopus 로고
    • IL-6 and APPs: Anti-inflammatory and immunosuppressive mediators
    • Tilg, H., C. A. Dinarello. and J. W. Mier. 1997. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol. Today 18:428.
    • (1997) Immunol. Today , vol.18 , pp. 428
    • Tilg, H.1    Dinarello, C.A.2    Mier, J.W.3
  • 3
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya, R., J. Mudter, S. Finotto, J. Mullberg, T. Jostock, S. Wirtz, M. Schutz, B. Bartsch, M. Holtmann, C. Becker, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat. Med. 6:583.
    • (2000) Nat. Med. , vol.6 , pp. 583
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6    Schutz, M.7    Bartsch, B.8    Holtmann, M.9    Becker, C.10
  • 4
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto, M., K. Yoshizaki, T. Kishimoto, and H. Ito. 2000. IL-6 is required for the development of Th1 cell-mediated murine colitis. J. Immunol. 164:4878.
    • (2000) J. Immunol. , vol.164 , pp. 4878
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 9
    • 0031017468 scopus 로고    scopus 로고
    • Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6
    • Weinstein, D. L., B. L. O'Neill, and E. S. Metcalf. 1997. Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6. Infect. Immun. 65:395.
    • (1997) Infect. Immun. , vol.65 , pp. 395
    • Weinstein, D.L.1    O'Neill, B.L.2    Metcalf, E.S.3
  • 10
    • 0035057564 scopus 로고    scopus 로고
    • Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6
    • Sitaraman, S. V., D. Merlin, L. Wang, M. Wong, A. T. Gewirtz, M. Si-Tahar, and J. L. Madara. 2001. Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6. J. Clin. Invest. 107:861.
    • (2001) J. Clin. Invest. , vol.107 , pp. 861
    • Sitaraman, S.V.1    Merlin, D.2    Wang, L.3    Wong, M.4    Gewirtz, A.T.5    Si-Tahar, M.6    Madara, J.L.7
  • 11
    • 0031255051 scopus 로고    scopus 로고
    • Interleukin-1β and interferon-γ regulate interleukin-6 production in cultured human intestinal epithelial cells
    • Parikh, A. A., A. L. Salzman, J. E. Fischer, C. Szabo, and P. O. Hasselgren. 1997. Interleukin-1β and interferon-γ regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock 8:249.
    • (1997) Shock , vol.8 , pp. 249
    • Parikh, A.A.1    Salzman, A.L.2    Fischer, J.E.3    Szabo, C.4    Hasselgren, P.O.5
  • 15
    • 0032193240 scopus 로고    scopus 로고
    • The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells
    • Panja, A., S. Goldberg, L. Eckmann, P. Krishen, and L. Mayer. 1998. The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells. J. Immunol. 161:3675.
    • (1998) J. Immunol. , vol.161 , pp. 3675
    • Panja, A.1    Goldberg, S.2    Eckmann, L.3    Krishen, P.4    Mayer, L.5
  • 16
    • 0000935584 scopus 로고    scopus 로고
    • Molecular and cellular biology of interleukin-6 and its receptor
    • Keller, E. T., J. Wanagat, and W. B. 1996. Ershler. Molecular and cellular biology of interleukin-6 and its receptor. Front. Biosci. 1:d340.
    • (1996) Front. Biosci. , vol.1
    • Keller, E.T.1    Wanagat, J.2    Ershler, W.B.3
  • 17
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • Krebs, D. L., and D. J. Hilton. 2001. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378.
    • (2001) Stem Cells , vol.19 , pp. 378
    • Krebs, D.L.1    Hilton, D.J.2
  • 18
    • 0036892964 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease
    • Greenhalgh, C. J., M. E. Miller, D. J. Hilton, and P. K. Lund. 2002. Suppressors of cytokine signaling: relevance to gastrointestinal function and disease. Gastroenterology 123:2064.
    • (2002) Gastroenterology , vol.123 , pp. 2064
    • Greenhalgh, C.J.1    Miller, M.E.2    Hilton, D.J.3    Lund, P.K.4
  • 20
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2:725.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725
    • Li, Q.1    Verma, I.M.2
  • 21
    • 0031808369 scopus 로고    scopus 로고
    • Mediation by NF-ΚB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors
    • Jobin, C., C. Hellerbrand, L. L. Licato, D. A. Brenner, and R. B. Sartor. 1998. Mediation by NF-ΚB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut 42:779.
    • (1998) Gut , vol.42 , pp. 779
    • Jobin, C.1    Hellerbrand, C.2    Licato, L.L.3    Brenner, D.A.4    Sartor, R.B.5
  • 22
    • 0035139792 scopus 로고    scopus 로고
    • Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer
    • Yamamoto, Y., and R. B. Gaynor. 2001. Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107:135.
    • (2001) J. Clin. Invest. , vol.107 , pp. 135
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 23
    • 0029764610 scopus 로고    scopus 로고
    • Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: Consequences for CD1 1b/CDI 8-mediated interactions with neutrophils
    • Parkos, C. A., S. P. Colgan, M. S. Diamond, A. Nusrat, T. W. Liang, T. A. Springer, and J. L. Madara, 1996. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD1 1b/CDI 8-mediated interactions with neutrophils. Mol. Med. 2:489.
    • (1996) Mol. Med. , vol.2 , pp. 489
    • Parkos, C.A.1    Colgan, S.P.2    Diamond, M.S.3    Nusrat, A.4    Liang, T.W.5    Springer, T.A.6    Madara, J.L.7
  • 24
    • 0024296564 scopus 로고
    • Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families
    • Staunton, D. E., S. D. Marlin, C. Stratowa, M. L. Dustin, and T. A. Springer. 1988. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925.
    • (1988) Cell , vol.52 , pp. 925
    • Staunton, D.E.1    Marlin, S.D.2    Stratowa, C.3    Dustin, M.L.4    Springer, T.A.5
  • 25
    • 0030017256 scopus 로고    scopus 로고
    • Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion
    • Huang, G. T., L. Eckmann, T. C. Savidge, and M. F. Kagnoff. 1996. Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J. Clin. Invest. 98:572.
    • (1996) J. Clin. Invest. , vol.98 , pp. 572
    • Huang, G.T.1    Eckmann, L.2    Savidge, T.C.3    Kagnoff, M.F.4
  • 26
    • 0027464093 scopus 로고
    • Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-γ in a highly polarized fashion
    • Colgan, S. P., C. A. Parkos, C. Delp, M. A. Amaout, and J. L. Madara. 1993. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-γ in a highly polarized fashion. J. Cell Biol. 120:785.
    • (1993) J. Cell Biol. , vol.120 , pp. 785
    • Colgan, S.P.1    Parkos, C.A.2    Delp, C.3    Amaout, M.A.4    Madara, J.L.5
  • 27
    • 0035214691 scopus 로고    scopus 로고
    • Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice
    • Bums, R. C., J. Rivera-Nieves, C. A. Moskaluk, S. Matsumoto, F. Cominelli, and K. Ley. 2001. Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice. Gastroenterology 121:1428.
    • (2001) Gastroenterology , vol.121 , pp. 1428
    • Bums, R.C.1    Rivera-Nieves, J.2    Moskaluk, C.A.3    Matsumoto, S.4    Cominelli, F.5    Ley, K.6
  • 28
    • 0036288638 scopus 로고    scopus 로고
    • Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
    • Yacyshyn, B. R., W. Y. Chey, J. Goff, B. Salzberg, R. Baerg, A. L. Buchman, J. Tami, R. Yu, E. Gibiansky, and W. R. Shanahan. 2002. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 51:30.
    • (2002) Gut , vol.51 , pp. 30
    • Yacyshyn, B.R.1    Chey, W.Y.2    Goff, J.3    Salzberg, B.4    Baerg, R.5    Buchman, A.L.6    Tami, J.7    Yu, R.8    Gibiansky, E.9    Shanahan, W.R.10
  • 29
    • 0026631785 scopus 로고
    • Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines
    • Kvale, D., P. Krajci, and P. Brandtzaeg. 1992. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines. Scand. J. Immmunol. 35:669.
    • (1992) Scand. J. Immmunol. , vol.35 , pp. 669
    • Kvale, D.1    Krajci, P.2    Brandtzaeg, P.3
  • 31
    • 0034714221 scopus 로고    scopus 로고
    • Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D
    • Wooten, D. K., X. Xie, D. Barios, R. A. Busche, G. D. Longmore, and S. S. Watowich. 2000. Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D. J. Biol. Chem. 275:26566.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26566
    • Wooten, D.K.1    Xie, X.2    Barios, D.3    Busche, R.A.4    Longmore, G.D.5    Watowich, S.S.6
  • 32
    • 0028921613 scopus 로고
    • Transcriptional regulation of the intercellular adhesion molecule-1 ene by inflammatory cytokines in human endothelial cells: Essential roles of a variant NF-κB site and p65 homodimers
    • Ledebur, H. C., and T. P. Parks. 1995. Transcriptional regulation of the intercellular adhesion molecule-1 ene by inflammatory cytokines in human endothelial cells: essential roles of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:933.
    • (1995) J. Biol. Chem. , vol.270 , pp. 933
    • Ledebur, H.C.1    Parks, T.P.2
  • 33
    • 0031944478 scopus 로고    scopus 로고
    • Interleukin-6-specific activation of the C/EBPδ gene in hepatocytes is mediated by Stat3 and Spl
    • Cantwell, C. A., E. Stemeck, and P. F. Johnson. 1998. Interleukin-6-specific activation of the C/EBPδ gene in hepatocytes is mediated by Stat3 and Spl. Mol. Cell. Biol. 18:2108.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2108
    • Cantwell, C.A.1    Stemeck, E.2    Johnson, P.F.3
  • 35
    • 0022172245 scopus 로고
    • Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border
    • Mooseker, M. S. 1985. Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border. Annu. Rev. Cell Biol. 1:209.
    • (1985) Annu. Rev. Cell Biol. , vol.1 , pp. 209
    • Mooseker, M.S.1
  • 37
    • 0035011324 scopus 로고    scopus 로고
    • Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: Transport of bacterial peptides influences expression of MHC class I molecules
    • Merlin, D., M. Si-Tahar, S. V. Sitaraman, K. Eastbum, I. Williams, X. Liu, M. A. Hediger, and J. L. Madara. 2001. Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class I molecules. Gastroenterology 120:1666.
    • (2001) Gastroenterology , vol.120 , pp. 1666
    • Merlin, D.1    Si-Tahar, M.2    Sitaraman, S.V.3    Eastbum, K.4    Williams, I.5    Liu, X.6    Hediger, M.A.7    Madara, J.L.8
  • 39
    • 0026052725 scopus 로고
    • Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region: Induction by cytokines and phorbol ester
    • Voraberger, G., R. Schafer, and C. Stratowa. 1991. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region: induction by cytokines and phorbol ester. J. Immunol. 147:2777.
    • (1991) J. Immunol. , vol.147 , pp. 2777
    • Voraberger, G.1    Schafer, R.2    Stratowa, C.3
  • 40
    • 0030952837 scopus 로고    scopus 로고
    • Flanking sequences for the human intercellular adhesion molecule-1 NF-κB response element are necessary for tumor necrosis factor α-induced gene expression
    • Paxton, L. L., L. J. Li, V. Secor, J. L. Duff, S. M. Naik, N. Shibagaki, and S. W. Caughman. 1997. Flanking sequences for the human intercellular adhesion molecule-1 NF-κB response element are necessary for tumor necrosis factor α-induced gene expression. J. Biol. Chem. 272:15928.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15928
    • Paxton, L.L.1    Li, L.J.2    Secor, V.3    Duff, J.L.4    Naik, S.M.5    Shibagaki, N.6    Caughman, S.W.7
  • 41
    • 0032477945 scopus 로고    scopus 로고
    • Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB
    • Seitz, C. S., Q. Lin, H. Deng, and P. A. Khavari. 1998. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB. Proc. Natl. Acad. Sci. USA 95:2307.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2307
    • Seitz, C.S.1    Lin, Q.2    Deng, H.3    Khavari, P.A.4
  • 42
    • 0032833681 scopus 로고    scopus 로고
    • Systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury
    • Thaloor, D., K. J. Miller, J. Gephart, P. O. Mitchell, and G. K.1999. Pavlath: systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury. Aro. J. Physiol. 277:C320.
    • (1999) Aro. J. Physiol. , vol.277
    • Thaloor, D.1    Miller, K.J.2    Gephart, J.3    Mitchell, P.O.4    Pavlath, G.K.5
  • 44
    • 0037031938 scopus 로고    scopus 로고
    • The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation
    • Sitaraman, S. V., L. Wang, M. Wong, M. Bruewer, M. Hobert, C. H. Yun, D. Merlin, and J. L. Madara. 2002. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J. Biol. Chem. 277:33188.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33188
    • Sitaraman, S.V.1    Wang, L.2    Wong, M.3    Bruewer, M.4    Hobert, M.5    Yun, C.H.6    Merlin, D.7    Madara, J.L.8
  • 45
    • 0027315712 scopus 로고
    • Evidence for an acute phase response in human intestinal epithelial cells
    • Molmenti, E. P., T. Ziambaras, and D. H. Perlmutter. 1993. Evidence for an acute phase response in human intestinal epithelial cells. J. Biol. Chem. 268:14116.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14116
    • Molmenti, E.P.1    Ziambaras, T.2    Perlmutter, D.H.3
  • 46
    • 0033551802 scopus 로고    scopus 로고
    • Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
    • Chen, R. H., M. C. Chang, Y. H. Su, Y. T. Tsai, and M. L. Kuo. 1999. Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J. Biol. Chem. 274:23013.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23013
    • Chen, R.H.1    Chang, M.C.2    Su, Y.H.3    Tsai, Y.T.4    Kuo, M.L.5
  • 47
    • 0035957951 scopus 로고    scopus 로고
    • Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt
    • Yang, C. H., A. Murti, S. R. Pfeffer, J. G. Kim, D. B. Donner, and L. M. Pfeffer. 2001. Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt. J. Biol. Chem. 276:13756.
    • (2001) J. Biol. Chem. , vol.276 , pp. 13756
    • Yang, C.H.1    Murti, A.2    Pfeffer, S.R.3    Kim, J.G.4    Donner, D.B.5    Pfeffer, L.M.6
  • 48
    • 0035825596 scopus 로고    scopus 로고
    • The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6
    • Kuo, M. L., S. E. Chuang, M. T. Lin, and S. Y. Yang. 2001. The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6. Oncogene 20:677.
    • (2001) Oncogene , vol.20 , pp. 677
    • Kuo, M.L.1    Chuang, S.E.2    Lin, M.T.3    Yang, S.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.