Interleukin (IL)-13 and IL-4 are potent inhibitors of IL-8 secretion by human intestinal epithelial cells

Digestive Diseases and Sciences

Volumn 44, Issue 3, 1999, Pages 649-655

  Lügering, Norbert ^a   Kucharzik, Torsten ^a   Kraft, Matthias ^a   Winde, Günther ^a   Sorg, Clemens ^a   Stoll, Reinhard ^a   Domschke, Wolfram ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Interleukin 8; Intestinal epithelial cells; TH 2 cytokines

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 8;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE EPITHELIUM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION;

EID: 0033030214     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026638330843     Document Type: Article

References (40)

1. 1. Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF: A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95:55-65, 1995
2. 2. Schuerer-Maly CC, Eckmann L, Kagnoff MF, Falco MT, Maly FE: Colonic epithelial cell lines as a source of interleukin-8; stimulation by inflammatory cytokines and bacterial lipopolysaccharide. Immunology 81:85-91, 1994
3. 3. McGee DW, Bamberg T, Vitkus SJD, McGhee JR: A synergistic relationship between TNF-a, IL-1β, and TGF-β1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line. Immunology 86:6-11, 1995
4. 4. Eckmann L, Jung HC, Schuerer-Maly CC, Panja A, Morzycka-Wroblewska E, Kagnoff MF: Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin-8. Gastroenterology 105:1689-1697, 1993
5. 5. Reinecker HC, Loh EY, Ringler DJ, Mehta A, Rombeau JL, MacDermott RP: Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 108:40-50, 1995
6. 6. Hirsch T, Eggstein S, Frank S, Farthmann EH, v Specht B-U: Expression of GM-CSF and a functional GM-CSF receptor in the human colon carcinoma cell lines SW403. Biochem Biophys Res Commun 217:138, 1995
7. 7. McCormick BA, Hofman PM, Kim J, Carnes DK, Miller SI, Madara JL: Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils. J Cell Biol 131:1599-1608, 1995
8. 8. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL: Salmonella typhimurium attachment to human intestinal epithelial monolayers: Transcellular signalling to subepithelial neutrophils. J Cell Biol 123:895-907, 1993
9. 9. Huang GTJ, Eckmann L, Savidge TC, Kagnoff MF: Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM-1) expression and neutrophil adhesion. J Clin Invest 98:572-583, 1996
10. 10. Hart PH, Ahern MJ, Smith MD, Finlay-Jones JJ: Regulatory effects of IL-13 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis. Clin Exp Immunol 99:331-339, 1995
11. 11. Bogdan C, Nathan C: Modulation and macrophage function by transforming growth factor beta, interleukin-4 and interleukin-10. Ann NY Acad Sci 685:713-739, 1993
12. 12. Hart PH, Ahern MJ, Smith MD, Finlay-Jones JJ: Comparison of the suppressive effects of interleukin-10 and interleukin-4 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis. Immunology 84:536, 1995
13. 13. Te Velde AA, De Waal Malefyt R, Huijibens RJF, de Vries JE, Figdor CG: IL-10 stimulates monocyte FcyR surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-γ, IL-4, and IL-10. J Immunol 149:4048-4052, 1992
14. 14. De Waal M, Haanen J, Spits-, et al: IL-10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by human monocytes. J Exp Med 174:1209, 1991
15. 15. Minty A, Chalon P, Derocq J, et al: Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362:248-250, 1993
16. 16. de Waal Malefyt R, Figdor CG, Huijbens R, et al: Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation with IFN-γ or IL-10. J Immunol 151:6370-6381, 1993
17. 17. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor-α production. J Exp Med 181:537-546, 1995
18. 18. Endo T, Fumitaka O, Sone S: LPS-dependent cyclooxygenase-2 induction in human monocytes is down-regulated by IL-13, but not by IFN-γ. J Immunol 156:2240, 1996
19. 19. Zurawski G, De Vries JE: Interleukin-13, an interleukin-4 like cytokine that acts on monocytes and B cells, but not on T-cells. Immunol Today 15:19-26, 1995
20. 2+-binding protein MRP8/14. Immunology 91:130-134, 1997
21. 21. Kucharzik T, Lügering N, Weigelt H, Adolf M, Domschke W, Stoll R: Immunoregulatory properties of Interleukin-13 in patients with inflammatory bowel disease. Comparison with Interleukin-4 and Interleukin-10. Clin Exp Immunol 104:483-490, 1996
22. 22. Kucharzik T, Lügering N, Adolf M, Domschke W, Stoll R: Synergistic effect of immunoregulatory cytokines on peripheral blood monocytes from patients with inflammatory bowel disease. Dig Dis Sci 42:805-812, 1996
23. 23. Grimm MC, Elsbury SKO, Pavli P, Doe WF: Interleukin-8: Cells of origin in inflammatory bowel disease. Gut 38:90-98, 1996
24. 24. Daig R, Andus T, Aschenbrenner E, Falk W, Schölmerich J, Gross V: Increased interleukin-8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 38:216-222, 1996
25. 25. Izutani R, Loh EY, Reinecker HC, et al: Increased expression of interleukin-8 mRNA in ulcerative colitis and Crohn's disease mucosa and epithelial cells. Inflamm Bowel Dis 1:37, 1995
26. 26. MacDermott RP: Alterations of the mucosa immune system in inflammatory bowel disease. J Gastroenterol 31:907, 1996
27. 27. Kucharzik T, Lügering N, Pauls HG, Domschke W, Stoll R: IL-4, IL-10 and IL-13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells. Clin Exp Immunol 111:152-157, 1998
28. 28. Lügering N, Kucharzik T, Stein H, Winde G, Lügering A, Hasilik A, Domschke W, Stoll R: IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory bowel disease. Dig Dis Sci 43:706-714, 1998
29. 29. Isaacs KL, Sartor RB, Haeskil JS: Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 103:1587-1595, 1992
30. 30. Mahida YR, Wu K, Jewell DP: Enhanced production of interleukin 1-β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 28:745-753, 1987
31. 31. Reinecker HC, Steffen M, Witthoeft T, Pfleuger I, Schreiber S, McDermott RP, Raedler A: Enhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 94:174-181, 1993
32. 32. Oppenheim JJ, Zachariae CO, Mukaida N, Matsushima K. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol 9:617, 1991
33. 33. Berkman N, Robichaud A, Krishnan VL, Roesems G, Robbins R, Jose PJ, Barnes PJ, Chung KF: Expression of RANTES in human airway epithelial cells: Effect of corticosteroids and interleukin-4, -10 and -13. Immunology 87:599, 1996
34. 34. Kolios G, Robertson DAF, Jordan NJ, Minty A, Caput D, Ferrara P, Westwick J: Interleukin-8 production by the human colon epithelial cell line HT-29; modulation by interleukin-13. Br J Pharmacol 119:351, 1996
35. 35. Schreiber S, Heinig T, Thiele HG, Raedler A: Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 108:1434-1444, 1995
36. 36. West GA, Mutsuura T, Levine AD, Klein JS, Fiocchi C: Interleukin-4 in inflammatory bowel disease and mucosa immune reactivity. Gastroenterology 110:1683-1695, 1996
37. 37. Herfarth HH, Mohanty SP, Rath HC, Tonkonogy S, Sartor RB: Interleukin-10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers. Gut 39:836-845, 1996
38. + lamina propria lymphokine secretion profiles in inflammatory bowel disease. J Immunol 157:1261-1270, 1996
39. 39. Camerini V, Panwala C, Kronenberg M: Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine. J Immunol 151:1765, 1993
40. 40. Pang G, Buret A, O'Loughlin E, Smith A, Batey R, Clancy R: Immunologic, functional and morphological characterization of three new human small intestinal epithelial cell lines. Gastroenterology 11:8-18, 1996