메뉴 건너뛰기




Volumn 47, Issue 2, 2011, Pages 173-181

Hepatocyte growth factor and keratinocyte growth factor enhance IL-1-induced IL-8 secretion through different mechanisms in Caco-2 epithelial cells

Author keywords

AKT; Colon; HGF; IL 1; IL 8; Inflammation; Intestine; KGF; PI3K

Indexed keywords

ANDROSTANE DERIVATIVE; INTERLEUKIN 1; INTERLEUKIN 8; KERATINOCYTE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; SCATTER FACTOR; WORTMANNIN;

EID: 79952241603     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-010-9365-4     Document Type: Article
Times cited : (6)

References (40)
  • 1
    • 0742270691 scopus 로고    scopus 로고
    • Hepatocyte Growth Factor Treatment Ameliorates Diarrhea and Bowel Inflammation in a Rat Model of Inflammatory Bowel Disease
    • DOI 10.1016/j.jpedsurg.2003.10.001
    • LG Arthur MZ Schwartz KA Kuenzler R Birbe 2004 Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease J. Pediatr. Surg. 39 139 143 10.1016/j.jpedsurg.2003. 10.001 14966727 (Pubitemid 38146424)
    • (2004) Journal of Pediatric Surgery , vol.39 , Issue.2 , pp. 139-143
    • Arthur, L.G.1    Schwartz, M.Z.2    Kuenzler, K.A.3    Birbe, R.4    Ford, H.5    Arthur, L.G.6
  • 3
    • 0033072530 scopus 로고    scopus 로고
    • Growth factors in inflammatory bowel disease
    • 1:STN:280:DyaK1M7lt1yjsQ%3D%3D 10.1002/ibd.3780050108 10028449
    • PL Beck DK Podolsky 1999 Growth factors in inflammatory bowel disease Inflamm. Bowel Dis. 5 44 60 1:STN:280:DyaK1M7lt1yjsQ%3D%3D 10.1002/ibd. 3780050108 10028449
    • (1999) Inflamm. Bowel Dis. , vol.5 , pp. 44-60
    • Beck, P.L.1    Podolsky, D.K.2
  • 5
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • DOI 10.1016/S0968-0004(01)01958-2, PII S0968000401019582
    • DP Brazil BA Hemmings 2001 Ten years of protein kinase B signalling: a hard Akt to follow Trends Biochem. Sci. 26 657 664 1:CAS:528: DC%2BD3MXotFSmsrg%3D 10.1016/S0968-0004(01)01958-2 11701324 (Pubitemid 33042488)
    • (2001) Trends in Biochemical Sciences , vol.26 , Issue.11 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 6
    • 0034769703 scopus 로고    scopus 로고
    • HGF- and KGF-induced activation of PI-3K/p70 S6 kinase pathway in corneal epithelial cells: Its relevance in wound healing
    • DOI 10.1006/exer.2001.1026
    • G Chandrasekher AH Kakazu HE Bazan 2001 HGF- and KGF-induced activation of PI-3 K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing Exp. Eye Res. 73 191 202 1:CAS:528:DC%2BD3MXkvFyjsrs%3D 10.1006/exer.2001.1026 11446769 (Pubitemid 32977949)
    • (2001) Experimental Eye Research , vol.73 , Issue.2 , pp. 191-202
    • Chandrasekher, G.1    Kakazu, A.H.2    Bazan, H.E.P.3
  • 7
    • 30844448578 scopus 로고    scopus 로고
    • KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
    • DOI 10.1194/jlr.M500154-JLR200
    • Y Chang J Wang X Lu DP Thewke RJ Mason 2005 KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells J. Lipid Res. 46 2624 2635 1:CAS:528:DC%2BD2MXhtlWmsLfP 10.1194/jlr.M500154-JLR200 16162944 (Pubitemid 43107474)
    • (2005) Journal of Lipid Research , vol.46 , Issue.12 , pp. 2624-2635
    • Chang, Y.1    Wang, J.2    Lu, X.3    Thewke, D.P.4    Mason, R.J.5
  • 8
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • DOI 10.1038/sj.onc.1209088, PII 1209088
    • JQ Cheng CW Lindsley GZ Cheng H Yang SV Nicosia 2005 The Akt/PKB pathway: molecular target for cancer drug discovery Oncogene 24 7482 7492 1:CAS:528:DC%2BD2MXht1Wis7vJ 10.1038/sj.onc.1209088 16288295 (Pubitemid 41637988)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 10
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • G Dong Z Chen Z-Y Li NT Yen CC Bancroft C Van Waes 2001 Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma Cancer Res. 61 5911 5918 1:CAS:528:DC%2BD3MXlvVCgu70%3D 11479233 (Pubitemid 32769111)
    • (2001) Cancer Research , vol.61 , Issue.15 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.-Y.3    Yeh, N.T.4    Bancroft, C.C.5    Van Waes, C.6
  • 11
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • 1:CAS:528:DC%2BD1MXlsFSltrc%3D 10.1146/annurev.immunol.021908.132612 19302047
    • CA Dinarello 2009 Immunological and inflammatory functions of the interleukin-1 family Annu. Rev. Immunol. 27 519 550 1:CAS:528: DC%2BD1MXlsFSltrc%3D 10.1146/annurev.immunol.021908.132612 19302047
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 12
    • 0027146545 scopus 로고
    • Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8
    • L Eckmann HC Hung C Schurer-Maly A Panja E Morzycka-Wroblewska MF Kagnoff 1993 Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin-8 Gastroenterology 105 1689 1697 1:CAS:528:DyaK2cXnsFWntg%3D%3D 8253345 (Pubitemid 24002784)
    • (1993) Gastroenterology , vol.105 , Issue.6 , pp. 1689-1697
    • Eckmann, L.1    Hyun Chae Jung2    Schurer-Maly, C.3    Panja, A.4    Morzycka-Wroblewska, E.5    Kagnoff, M.F.6
  • 13
    • 0032730547 scopus 로고    scopus 로고
    • Analysis of the cellular basis of keratinocyte growth factor overexpression in inflammatory bowel disease
    • 1:CAS:528:DC%2BD3cXhvV2jsQ%3D%3D 10.1136/gut.45.6.848 10562583
    • PW Finch AL Cheng 1999 Analysis of the cellular basis of keratinocyte growth factor overexpression in inflammatory bowel disease Gut 45 848 855 1:CAS:528:DC%2BD3cXhvV2jsQ%3D%3D 10.1136/gut.45.6.848 10562583
    • (1999) Gut , vol.45 , pp. 848-855
    • Finch, P.W.1    Cheng, A.L.2
  • 14
    • 0031811114 scopus 로고    scopus 로고
    • Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor
    • 1:CAS:528:DyaK1cXjsFSit70%3D 9612260
    • M Goke M Kanai DK Podolsky 1998 Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor Am. J. Physiol. 274 G809 G818 1:CAS:528:DyaK1cXjsFSit70%3D 9612260
    • (1998) Am. J. Physiol. , vol.274
    • Goke, M.1    Kanai, M.2    Podolsky, D.K.3
  • 15
    • 0037250136 scopus 로고    scopus 로고
    • Efficacy of repifermin (keratinocyte growth factor-2) against abnormalities in gastrointestinal mucosal transport in a murine model of colitis
    • B Greenwood-Van Meerveld K Venkova K Connolly 2003 Efficacy of repifermin (keratinocyte growth factor-2) against abnormalities in gastrointestinal mucosal transport in a murine model of colitis J. Pharm. Pharmacol. 55 67 75 1:CAS:528:DC%2BD3sXhtFKhsLc%3D 10.1111/j.2042-7158.2003.tb02435.x 12625869 (Pubitemid 36142083)
    • (2003) Journal of Pharmacy and Pharmacology , vol.55 , Issue.1 , pp. 67-75
    • Greenwood-Van Meerveld, B.1    Venkova, K.2    Connolly, K.3
  • 16
    • 0028905398 scopus 로고
    • Regulation of interleukin-8 production in a human colon epithelial cell line (HT 29)
    • 1:CAS:528:DyaK2MXltleiur0%3D 10.1016/0016-5085(95)90436-0 7875467
    • V Gross T Andus R Daig E Aschenbrenner J Scholmerich W Falk 1995 Regulation of interleukin-8 production in a human colon epithelial cell line (HT 29) Gastroenterology 108 653 661 1:CAS:528:DyaK2MXltleiur0%3D 10.1016/0016-5085(95)90436-0 7875467
    • (1995) Gastroenterology , vol.108 , pp. 653-661
    • Gross, V.1    Andus, T.2    Daig, R.3    Aschenbrenner, E.4    Scholmerich, J.5    Falk, W.6
  • 17
    • 34447640543 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances IL-1β stimulated IL-8 secretion by Caco-2 epithelial cells
    • DOI 10.1007/s11626-007-9018-4
    • J Grygas N Steiger C LeSeur B Unger D McGee 2007 Hepatocyte growth factor enhances IL-1β stimulated IL-8 secretion by Caco-2 epithelial cells In Vitro Cell. Dev. Biol. 43 147 152 1:CAS:528:DC%2BD2sXhtVSqsbnJ 10.1007/s11626-007-9018-4 (Pubitemid 47091836)
    • (2007) In Vitro Cellular and Developmental Biology - Animal , vol.43 , Issue.3-4 , pp. 147-152
    • Grygas, J.1    Steiger, N.2    LeSeur, C.L.3    Unger, B.L.4    McGee, D.W.5
  • 19
    • 27944464966 scopus 로고    scopus 로고
    • Mucosal repair and growth factors: Recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease
    • DOI 10.1007/s00535-005-1705-x
    • A Ido M Numata M Kodama H Tsubouchi 2005 Mucosal repair and growth factors: recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease J. Gastroenterol. 40 925 931 10.1007/s00535-005- 1705-x 16261428 (Pubitemid 41662515)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.10 , pp. 925-931
    • Ido, A.1    Numata, M.2    Kodama, M.3    Tsubouchi, H.4
  • 20
    • 51349158231 scopus 로고    scopus 로고
    • Signaling adaptors used by Toll-like receptors: An update
    • 1:CAS:528:DC%2BD1cXhtlSrsbzO 10.1016/j.cyto.2008.07.010 18706831
    • EF Kenny LAJ O'Neill 2008 Signaling adaptors used by Toll-like receptors: an update Cytokine 43 342 349 1:CAS:528:DC%2BD1cXhtlSrsbzO 10.1016/j.cyto.2008. 07.010 18706831
    • (2008) Cytokine , vol.43 , pp. 342-349
    • Kenny, E.F.1    O'Neill, L.A.J.2
  • 21
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NF-κB by the Akt/PKB kinase
    • DOI 10.1016/S0960-9822(99)80265-6
    • LP Kane VS Shapiro D Stokoe A Weiss 1999 Induction of NF-κB by the Akt/PKB kinase Curr. Biol. 9 601 604 1:CAS:528:DyaK1MXjvVeks7w%3D 10.1016/S0960-9822(99)80265-6 10359702 (Pubitemid 29273109)
    • (1999) Current Biology , vol.9 , Issue.11 , pp. 601-604
    • Kane, L.P.1    Shapiro, V.S.2    Stokoe, D.3    Weiss, A.4
  • 23
    • 40049097843 scopus 로고    scopus 로고
    • Role of the intestinal barrier in inflammatory bowel disease
    • DOI 10.3748/wjg.14.401
    • M Laukoetter M Nava A Nusrat 2008 Role of the intestinal barrier in inflammatory bowel disease World J. Gastroenterol. 14 401 407 1:CAS:528:DC%2BD1cXjvFKkt7c%3D 10.3748/wjg.14.401 18200662 (Pubitemid 351320848)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 401-407
    • Laukoetter, M.G.1    Nava, P.2    Nusrat, A.3
  • 24
    • 0025442212 scopus 로고
    • Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease
    • 1:STN:280:DyaK3czjslCgsg%3D%3D 10.1136/gut.31.6.686 2379873
    • M Ligumsky PL Simon F Karmeli D Rachmilewitz 1990 Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease Gut 31 686 689 1:STN:280:DyaK3czjslCgsg%3D%3D 10.1136/gut.31.6.686 2379873
    • (1990) Gut , vol.31 , pp. 686-689
    • Ligumsky, M.1    Simon, P.L.2    Karmeli, F.3    Rachmilewitz, D.4
  • 25
    • 0035974823 scopus 로고    scopus 로고
    • Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells
    • DOI 10.1038/sj.onc.1204688
    • PB Mehta CN Robson DE Neal HY Leung 2001 Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells Oncogene 20 5359 5365 1:CAS:528:DC%2BD3MXmslGns78%3D 10.1038/sj.onc. 1204688 11536048 (Pubitemid 32844067)
    • (2001) Oncogene , vol.20 , Issue.38 , pp. 5359-5365
    • Mehta, P.B.1    Robson, C.N.2    Neal, D.E.3    Leung, H.Y.4
  • 26
    • 34250352380 scopus 로고    scopus 로고
    • Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-κB transcription factors
    • DOI 10.1074/jbc.M606878200
    • H Niu Z Chang B Peng Q Xia W Lu P Huang MS Tsao PJ Chiao 2007 Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-κB transcription factors J. Biol. Chem. 282 6001 6011 1:CAS:528:DC%2BD2sXitVCjur4%3D 10.1074/jbc.M606878200 17200110 (Pubitemid 47100871)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.9 , pp. 6001-6011
    • Niu, J.1    Chang, Z.2    Peng, B.3    Xia, Q.4    Lu, W.5    Huang, P.6    Tsao, M.-S.7    Chiao, P.J.8
  • 27
    • 34250017174 scopus 로고    scopus 로고
    • Investigation of interleukin 1β-mediated regulation of NF-κB activation in colonic cells reveals divergence between PKB and PDK-transduced events
    • DOI 10.1007/s11010-006-9375-4
    • K Parhar S Eivemark K Assi A Gomez-Munoz A Yee B Salh 2007 Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events Mol. Cell. Biochem. 300 113 127 1:CAS:528:DC%2BD2sXlvFaqs78%3D 10.1007/s11010-006-9375-4 17136479 (Pubitemid 46881821)
    • (2007) Molecular and Cellular Biochemistry , vol.300 , Issue.1-2 , pp. 113-127
    • Parhar, K.1    Eivemark, S.2    Assi, K.3    Gomez-Munoz, A.4    Yee, A.5    Salh, B.6
  • 29
    • 0029760745 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
    • DOI 10.1074/jbc.271.40.24850
    • N Rahimi E Tremblay B Elliott 1996 Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells J. Biol. Chem. 271 24850 24855 1:CAS:528:DyaK28XmtFegt7k%3D 10.1074/jbc.271.40.24850 8798760 (Pubitemid 26333236)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.40 , pp. 24850-24855
    • Rahimi, N.1    Tremblay, E.2    Elliott, B.3
  • 31
    • 9644265343 scopus 로고    scopus 로고
    • CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway
    • DOI 10.1016/j.cyto.2004.09.007, PII S1043466604002844
    • A Sturm DC Baumgart JH d'Heureuse A Hotz B Wiedenmann AU Dignass 2005 CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway Cytokine 29 42 48 1:CAS:528:DC%2BD2cXhtVaqsbjF 15579377 (Pubitemid 39576701)
    • (2005) Cytokine , vol.29 , Issue.1 , pp. 42-48
    • Sturm, A.1    Baumgart, D.C.2    D'Heureuse, J.H.3    Hotz, A.4    Wiedenmann, B.5    Dignass, A.U.6
  • 32
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • 1:CAS:528:DC%2BD2MXlt1eqtLo%3D 10.1111/j.1582-4934.2005.tb00337.x 15784165
    • G Song G Ouyang S Bao 2005 The activation of Akt/PKB signaling pathway and cell survival J. Cell. Mol. Med. 9 59 71 1:CAS:528:DC%2BD2MXlt1eqtLo%3D 10.1111/j.1582-4934.2005.tb00337.x 15784165
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 33
    • 0027506178 scopus 로고
    • Enhancement of human hepatocyte growth factor production by interleukin- 1α and -1β and tumor necrosis factor-α by fibroblasts in culture
    • M Tamura N Arakaki H Tsubouchi H Takada Y Daikuhara 1993 Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture J. Biol. Chem. 268 8140 8145 1:CAS:528:DyaK3sXitlajsLs%3D 7681834 (Pubitemid 23120397)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.11 , pp. 8140-8145
    • Tamura, M.1    Arakaki, N.2    Tsubouchi, H.3    Takada, H.4    Daikuhara, Y.5
  • 35
    • 0344109562 scopus 로고    scopus 로고
    • Keratinocyte growth factor: A unique player in epithelial repair processes
    • DOI 10.1016/S1359-6101(98)00010-0, PII S1359610198000100
    • S Werner 1998 Keratinocyte growth factor: a unique player in epithelial repair processes Cytokine Growth Factor Rev. 9 153 165 1:CAS:528: DyaK1cXmtFOrtL8%3D 10.1016/S1359-6101(98)00010-0 9754709 (Pubitemid 28376451)
    • (1998) Cytokine and Growth Factor Reviews , vol.9 , Issue.2 , pp. 153-165
    • Werner, S.1
  • 36
    • 0026695949 scopus 로고
    • Large induction of keratinocyte growth factor expression in the dermis during wound healing
    • 1:CAS:528:DyaK38XlsVynt70%3D 10.1073/pnas.89.15.6896
    • S Werner KG Peters MT Longaker F Fuller-Pace MJ Banda LT Williams 1992 Large induction of keratinocyte growth factor expression in the dermis during wound healing Proc. Nat. Acad. Sci. U.S.A. 89 6896 6900 1:CAS:528: DyaK38XlsVynt70%3D 10.1073/pnas.89.15.6896
    • (1992) Proc. Nat. Acad. Sci. U.S.A. , vol.89 , pp. 6896-6900
    • Werner, S.1    Peters, K.G.2    Longaker, M.T.3    Fuller-Pace, F.4    Banda, M.J.5    Williams, L.T.6
  • 37
    • 2142679042 scopus 로고    scopus 로고
    • Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro
    • DOI 10.1042/CS19980351
    • AJ Wilson K Byron PR Gibson 1999 Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro Clin. Sci. Lond. 97 385 390 1:CAS:528:DyaK1MXmsFOhsbc%3D 10.1042/CS19980351 10464065 (Pubitemid 29425336)
    • (1999) Clinical Science , vol.97 , Issue.3 , pp. 385-390
    • Wilson, A.J.1    Byron, K.2    Gibson, P.R.3
  • 38
    • 3042743988 scopus 로고    scopus 로고
    • Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
    • DOI 10.1158/0008-5472.CAN-04-0343
    • L Yang HC Dan M Sun Q Liu XM Sun RI Feldman AD Hamilton M Polokoff SV Nicosia M Herlyn SM Sebti JQ Cheng 2004 Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt Cancer Res. 64 4394 399 1:CAS:528:DC%2BD2cXltlOrs74%3D 10.1158/0008-5472.CAN-04-0343 15231645 (Pubitemid 38856907)
    • (2004) Cancer Research , vol.64 , Issue.13 , pp. 4394-4399
    • Yang, L.1    Dan, H.C.2    Sun, M.3    Liu, Q.4    Sun, X.-M.5    Feldman, R.I.6    Hamilton, A.D.7    Polokoff, M.8    Nicosia, S.V.9    Herlyn, M.10    Sebti, S.M.11    Cheng, J.Q.12
  • 40
    • 47949116890 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease
    • 10.1002/ibd.20480 18452220
    • NP Zimmerman RA Vongsa MK Wendt MB Dwinell 2008 Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease Inflamm. Bowel Dis. 14 1000 1011 10.1002/ibd.20480 18452220
    • (2008) Inflamm. Bowel Dis. , vol.14 , pp. 1000-1011
    • Zimmerman, N.P.1    Vongsa, R.A.2    Wendt, M.K.3    Dwinell, M.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.