메뉴 건너뛰기




Volumn 2013, Issue , 2013, Pages

Advanced systems biology methods in drug discovery and translational biomedicine

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; NEW DRUG; TRANSCRIPTOME;

EID: 84885612492     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/742835     Document Type: Review
Times cited : (57)

References (72)
  • 2
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • 2-s2.0-78650373804 10.1038/nrg2918
    • Barabási A.-L., Gulbahce N., Loscalzo J., Network medicine: a network-based approach to human disease. Nature Reviews Genetics 2011 12 1 56 68 2-s2.0-78650373804 10.1038/nrg2918
    • (2011) Nature Reviews Genetics , vol.12 , Issue.1 , pp. 56-68
    • Barabási, A.-L.1    Gulbahce, N.2    Loscalzo, J.3
  • 3
    • 35748935235 scopus 로고    scopus 로고
    • Proteins, drug targets and the mechanisms they control: The simple truth about complex networks
    • DOI 10.1038/nrd2381, PII NRD2381
    • Araujo R. P., Liotta L. A., Petricoin E. F., Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nature Reviews Drug Discovery 2007 6 11 871 880 2-s2.0-35748935235 10.1038/nrd2381 (Pubitemid 350042395)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 871-880
    • Araujo, R.P.1    Liotta, L.A.2    Petricoin, E.F.3
  • 4
    • 77649182705 scopus 로고    scopus 로고
    • Unveiling the role of network and systems biology in drug discovery
    • 2-s2.0-77649182705 10.1016/j.tips.2009.11.006
    • Pujol A., Mosca R., Farrés J., Aloy P., Unveiling the role of network and systems biology in drug discovery. Trends in Pharmacological Sciences 2010 31 3 115 123 2-s2.0-77649182705 10.1016/j.tips.2009.11.006
    • (2010) Trends in Pharmacological Sciences , vol.31 , Issue.3 , pp. 115-123
    • Pujol, A.1    Mosca, R.2    Farrés, J.3    Aloy, P.4
  • 5
    • 80052946331 scopus 로고    scopus 로고
    • Systems biology - Biomedical modeling
    • 190, ARTICLE TR2 2-s2.0-84855562712
    • Sobie E. A., Lee Y.-S., Jenkins S. L., Iyengar R., Systems biology-biomedical modeling. Science Signaling 2011 4 190, article tr2 2-s2.0-84855562712
    • (2011) Science Signaling , vol.4
    • Sobie, E.A.1    Lee, Y.-S.2    Jenkins, S.L.3    Iyengar, R.4
  • 6
    • 70350005352 scopus 로고    scopus 로고
    • Systems pathology - Taking molecular pathology into a new dimension
    • 2-s2.0-70350005352 10.1038/nrclinonc.2009.102
    • Faratian D., Clyde R. G., Crawford J. W., Harrison D. J., Systems pathology-taking molecular pathology into a new dimension. Nature Reviews Clinical Oncology 2009 6 8 455 464 2-s2.0-70350005352 10.1038/nrclinonc.2009.102
    • (2009) Nature Reviews Clinical Oncology , vol.6 , Issue.8 , pp. 455-464
    • Faratian, D.1    Clyde, R.G.2    Crawford, J.W.3    Harrison, D.J.4
  • 7
    • 80052947609 scopus 로고    scopus 로고
    • Introduction to network analysis in systems biology
    • 190, ARTICLE TR5 2-s2.0-80052947609 10.1126/scisignal.2001965
    • Ma'ayan A., Introduction to network analysis in systems biology. Science Signaling 2011 4 190, article tr5 2-s2.0-80052947609 10.1126/scisignal.2001965
    • (2011) Science Signaling , vol.4
    • Ma'Ayan, A.1
  • 8
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • 2-s2.0-79952674000 10.1016/j.cell.2011.02.016
    • Vidal M., Cusick M. E., Barabási A.-L., Interactome networks and human disease. Cell 2011 144 6 986 998 2-s2.0-79952674000 10.1016/j.cell.2011. 02.016
    • (2011) Cell , vol.144 , Issue.6 , pp. 986-998
    • Vidal, M.1    Cusick, M.E.2    Barabási, A.-L.3
  • 9
    • 84877730113 scopus 로고    scopus 로고
    • Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of "date" and "party" hubs
    • Chang X., Xu T., Li Y., Wang K., Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of "date" and "party" hubs. Scientific Reports 2013 3, article 1691
    • (2013) Scientific Reports , pp. 31691
    • Chang, X.1    Xu, T.2    Li, Y.3    Wang, K.4
  • 10
    • 33750533388 scopus 로고    scopus 로고
    • Physicochemical modelling of cell signalling pathways
    • DOI 10.1038/ncb1497, PII NCB1497
    • Aldridge B. B., Burke J. M., Lauffenburger D. A., Sorger P. K., Physicochemical modelling of cell signalling pathways. Nature Cell Biology 2006 8 11 1195 1203 2-s2.0-33750533388 10.1038/ncb1497 (Pubitemid 44660581)
    • (2006) Nature Cell Biology , vol.8 , Issue.11 , pp. 1195-1203
    • Aldridge, B.B.1    Burke, J.M.2    Lauffenburger, D.A.3    Sorger, P.K.4
  • 11
    • 80053096839 scopus 로고    scopus 로고
    • An introduction to dynamical systems
    • 191, ARTICLE TR6 2-s2.0-80053096839 10.1126/scisignal.2001982
    • Sobie E. A., An introduction to dynamical systems. Science Signaling 2011 4 191, article tr6 2-s2.0-80053096839 10.1126/scisignal.2001982
    • (2011) Science Signaling , vol.4
    • Sobie, E.A.1
  • 12
    • 80053234250 scopus 로고    scopus 로고
    • Developing models in virtual cell
    • 192, ARTICLE TR12 2-s2.0-80053234250 10.1126/scisignal.2001970
    • Neves S. R., Developing models in virtual cell. Science Signaling 2011 4 192, article tr12 2-s2.0-80053234250 10.1126/scisignal.2001970
    • (2011) Science Signaling , vol.4
    • Neves, S.R.1
  • 13
    • 80053122204 scopus 로고    scopus 로고
    • Obtaining and estimating kinetic parameters from the literature
    • 191, ARTICLE TR8 2-s2.0-80053122204 10.1126/scisignal.2001988
    • Neves S. R., Obtaining and estimating kinetic parameters from the literature. Science Signaling 2011 4 191, article tr8 2-s2.0-80053122204 10.1126/scisignal.2001988
    • (2011) Science Signaling , vol.4
    • Neves, S.R.1
  • 14
    • 80053266761 scopus 로고    scopus 로고
    • Biomedical model fitting and error analysis
    • 192, ARTICLE TR9 2-s2.0-80053266761 10.1126/scisignal.2001983
    • Costa K. D., Kleinstein S. H., Hershberg U., Biomedical model fitting and error analysis. Science Signaling 2011 4 192, article tr9 2-s2.0-80053266761 10.1126/scisignal.2001983
    • (2011) Science Signaling , vol.4
    • Costa, K.D.1    Kleinstein, S.H.2    Hershberg, U.3
  • 15
    • 36049044199 scopus 로고    scopus 로고
    • Executable cell biology
    • DOI 10.1038/nbt1356, PII NBT1356
    • Fisher J., Henzinger T. A., Executable cell biology. Nature Biotechnology 2007 25 11 1239 1249 2-s2.0-36049044199 10.1038/nbt1356 (Pubitemid 350089829)
    • (2007) Nature Biotechnology , vol.25 , Issue.11 , pp. 1239-1249
    • Fisher, J.1    Henzinger, T.A.2
  • 17
    • 71449120701 scopus 로고    scopus 로고
    • Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
    • 2-s2.0-71449120701 10.1038/msb.2009.87
    • Saez-Rodriguez J., Alexopoulos L. G., Epperlein J., Samaga R., Lauffenburger D. A., Klamt S., Sorger P. K., Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology 2009 5, article 331 2-s2.0-71449120701 10.1038/msb.2009.87
    • (2009) Molecular Systems Biology , vol.5331
    • Saez-Rodriguez, J.1    Alexopoulos, L.G.2    Epperlein, J.3    Samaga, R.4    Lauffenburger, D.A.5    Klamt, S.6    Sorger, P.K.7
  • 18
    • 33947507091 scopus 로고    scopus 로고
    • Computational systems biology in drug discovery and development: Methods and applications
    • DOI 10.1016/j.drudis.2007.02.013, PII S1359644607000943
    • Materi W., Wishart D. S., Computational systems biology in drug discovery and development: methods and applications. Drug Discovery Today 2007 12 7-8 295 303 2-s2.0-33947507091 10.1016/j.drudis.2007.02.013 (Pubitemid 46467486)
    • (2007) Drug Discovery Today , vol.12 , Issue.7-8 , pp. 295-303
    • Materi, W.1    Wishart, D.S.2
  • 20
    • 76249105279 scopus 로고    scopus 로고
    • Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network
    • 9, ARTICLE R91 2-s2.0-76249105279 10.1186/gb-2009-10-9-r91
    • Linghu B., Snitkin E. S., Hu Z., Xia Y., DeLisi C., Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network. Genome Biology 2009 10 9, article R91 2-s2.0-76249105279 10.1186/gb-2009-10-9-r91
    • (2009) Genome Biology , vol.10
    • Linghu, B.1    Snitkin, E.S.2    Hu, Z.3    Xia, Y.4    Delisi, C.5
  • 21
    • 77649222972 scopus 로고    scopus 로고
    • Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets
    • 2-s2.0-77649222972 10.1371/journal.pcbi.1000662 e1000662
    • Suthram S., Dudley J. T., Chiang A. P., Chen R., Hastie T. J., Butte A. J., Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Computational Biology 2010 6 2 2-s2.0-77649222972 10.1371/journal.pcbi.1000662 e1000662
    • (2010) PLoS Computational Biology , vol.6 , Issue.2
    • Suthram, S.1    Dudley, J.T.2    Chiang, A.P.3    Chen, R.4    Hastie, T.J.5    Butte, A.J.6
  • 22
    • 77952310528 scopus 로고    scopus 로고
    • A human functional protein interaction network and its application to cancer data analysis
    • 5, ARTICLE R53 2-s2.0-77952310528 10.1186/gb-2010-11-5-r53
    • Wu G., Feng X., Stein L., A human functional protein interaction network and its application to cancer data analysis. Genome Biology 2010 11 5, article R53 2-s2.0-77952310528 10.1186/gb-2010-11-5-r53
    • (2010) Genome Biology , vol.11
    • Wu, G.1    Feng, X.2    Stein, L.3
  • 24
    • 84876806691 scopus 로고    scopus 로고
    • Dynamic regulatory network controlling TH17 cell differentiation
    • Yosef N., Shalek A. K., Gaublomme J. T., Dynamic regulatory network controlling TH17 cell differentiation. Nature 2013 496 7446 461 468
    • (2013) Nature , vol.496 , Issue.7446 , pp. 461-468
    • Yosef, N.1    Shalek, A.K.2    Gaublomme, J.T.3
  • 26
    • 35348891430 scopus 로고    scopus 로고
    • Network-based classification of breast cancer metastasis
    • DOI 10.1038/msb4100180, PII MSB4100180
    • Chuang H.-Y., Lee E., Liu Y.-T., Lee D., Ideker T., Network-based classification of breast cancer metastasis. Molecular Systems Biology 2007 3, article 140 2-s2.0-35348891430 10.1038/msb4100180 (Pubitemid 47587026)
    • (2007) Molecular Systems Biology , vol.3 , pp. 140
    • Chuang, H.-Y.1    Lee, E.2    Liu, Y.-T.3    Lee, D.4    Ideker, T.5
  • 29
    • 84866873258 scopus 로고    scopus 로고
    • Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression
    • Chuang H. Y., Rassenti L., Salcedo M., Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression. Blood 2012 120 13 2639 2649
    • (2012) Blood , vol.120 , Issue.13 , pp. 2639-2649
    • Chuang, H.Y.1    Rassenti, L.2    Salcedo, M.3
  • 30
    • 84859499974 scopus 로고    scopus 로고
    • Hepatitis c virus network based classification of hepatocellular cirrhosis and carcinoma
    • 2-s2.0-84859499974 10.1371/journal.pone.0034460 e34460
    • Huang T., Wang J., Cai Y.-D., Yu H., Chou K.-C., Hepatitis c virus network based classification of hepatocellular cirrhosis and carcinoma. PLoS ONE 2012 7 4 2-s2.0-84859499974 10.1371/journal.pone.0034460 e34460
    • (2012) PLoS ONE , vol.7 , Issue.4
    • Huang, T.1    Wang, J.2    Cai, Y.-D.3    Yu, H.4    Chou, K.-C.5
  • 33
    • 44249113841 scopus 로고    scopus 로고
    • Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth
    • DOI 10.1126/science.1152662
    • Bromberg K. D., Ma'ayan A., Neves S. R., Iyengar R., Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 2008 320 5878 903 909 2-s2.0-44249113841 10.1126/science.1152662 (Pubitemid 351929582)
    • (2008) Science , vol.320 , Issue.5878 , pp. 903-909
    • Bromberg, K.D.1    Ma'ayan, A.2    Neves, S.R.3    Iyengar, R.4
  • 34
    • 80051692878 scopus 로고    scopus 로고
    • Comparing signaling networks between normal and transformed hepatocytes using discrete logical models
    • 2-s2.0-80051692878 10.1158/0008-5472.CAN-10-4453
    • Saez-Rodriguez J., Alexopoulos L. G., Zhang M. S., Morris M. K., Lauffenburger D. A., Sorger P. K., Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Research 2011 71 16 5400 5411 2-s2.0-80051692878 10.1158/0008-5472.CAN-10-4453
    • (2011) Cancer Research , vol.71 , Issue.16 , pp. 5400-5411
    • Saez-Rodriguez, J.1    Alexopoulos, L.G.2    Zhang, M.S.3    Morris, M.K.4    Lauffenburger, D.A.5    Sorger, P.K.6
  • 35
    • 84864285545 scopus 로고    scopus 로고
    • Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
    • Rozenblatt-Rosen O., Deo R. C., Padi M., Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature 2012 487 491 495
    • (2012) Nature , vol.487 , pp. 491-495
    • Rozenblatt-Rosen, O.1    Deo, R.C.2    Padi, M.3
  • 36
    • 84876907931 scopus 로고    scopus 로고
    • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
    • Zhang B., Gaiteri C., Bodea L. G., Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell 2013 153 3 707 720
    • (2013) Cell , vol.153 , Issue.3 , pp. 707-720
    • Zhang, B.1    Gaiteri, C.2    Bodea, L.G.3
  • 37
    • 35348988164 scopus 로고    scopus 로고
    • Network analysis of oncogenic Ras activation in cancer
    • DOI 10.1126/science.1144642
    • Stites E. C., Trampont P. C., Ma Z., Ravichandran K. S., Network analysis of oncogenic Ras activation in cancer. Science 2007 318 5849 463 467 2-s2.0-35348988164 10.1126/science.1144642 (Pubitemid 47614534)
    • (2007) Science , vol.318 , Issue.5849 , pp. 463-467
    • Stites, E.C.1    Trampont, P.C.2    Ma, Z.3    Ravichandran, K.S.4
  • 38
    • 77950223515 scopus 로고    scopus 로고
    • Signal transduction networks in cancer: Quantitative parameters influence network topology
    • 2-s2.0-77950223515 10.1158/0008-5472.CAN-09-3234
    • Klinke D. J. II, Signal transduction networks in cancer: quantitative parameters influence network topology. Cancer Research 2010 70 5 1773 1782 2-s2.0-77950223515 10.1158/0008-5472.CAN-09-3234
    • (2010) Cancer Research , vol.70 , Issue.5 , pp. 1773-1782
    • Klinke, D.J.I.I.1
  • 39
    • 79551555770 scopus 로고    scopus 로고
    • A computational and experimental study of the regulatory mechanisms of the complement system
    • 2-s2.0-79551555770 10.1371/journal.pcbi.1001059 e1001059
    • Liu B., Zhang J., Tan P. Y., Hsu D., Blom A. M., Leong B., Sethi S., Ho B., Ding J. L., Thiagarajan P. S., A computational and experimental study of the regulatory mechanisms of the complement system. PLoS Computational Biology 2011 7 1 2-s2.0-79551555770 10.1371/journal.pcbi.1001059 e1001059
    • (2011) PLoS Computational Biology , vol.7 , Issue.1
    • Liu, B.1    Zhang, J.2    Tan, P.Y.3    Hsu, D.4    Blom, A.M.5    Leong, B.6    Sethi, S.7    Ho, B.8    Ding, J.L.9    Thiagarajan, P.S.10
  • 41
    • 39149143293 scopus 로고    scopus 로고
    • A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
    • DOI 10.1038/msb.2008.2, PII MSB20082
    • Mani K. M., Lefebvre C., Wang K., Lim W. K., Basso K., Dalla-Favera R., Califano A., A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas. Molecular Systems Biology 2008 4, article 169 2-s2.0-39149143293 10.1038/msb.2008.2 (Pubitemid 351253195)
    • (2008) Molecular Systems Biology , vol.4 , pp. 169
    • Mani, K.M.1    Lefebvre, C.2    Wang, K.3    Lim, W.K.4    Basso, K.5    Dalla-Favera, R.6    Califano, A.7
  • 42
    • 43249114206 scopus 로고    scopus 로고
    • Network-based global inference of human disease genes
    • DOI 10.1038/msb.2008.27, PII MSB200827
    • Wu X., Jiang R., Zhang M. Q., Li S., Network-based global inference of human disease genes. Molecular Systems Biology 2008 4, article 189 2-s2.0-43249114206 10.1038/msb.2008.27 (Pubitemid 351655223)
    • (2008) Molecular Systems Biology , vol.4 , pp. 189
    • Wu, X.1    Jiang, R.2    Zhang, M.Q.3    Li, S.4
  • 43
    • 76749134818 scopus 로고    scopus 로고
    • Associating genes and protein complexes with disease via network propagation
    • 2-s2.0-76749134818 10.1371/journal.pcbi.1000641 1000641
    • Vanunu O., Magger O., Ruppin E., Shlomi T., Sharan R., Associating genes and protein complexes with disease via network propagation. PLoS Computational Biology 2010 6 1 2-s2.0-76749134818 10.1371/journal.pcbi.1000641 1000641
    • (2010) PLoS Computational Biology , vol.6 , Issue.1
    • Vanunu, O.1    Magger, O.2    Ruppin, E.3    Shlomi, T.4    Sharan, R.5
  • 44
    • 84855906454 scopus 로고    scopus 로고
    • Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action
    • 2-s2.0-84855906454 10.1146/annurev-pharmtox-010611-134520
    • Zhao S., Iyengar R., Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Annual Review of Pharmacology and Toxicology 2012 52 505 521 2-s2.0-84855906454 10.1146/annurev-pharmtox-010611- 134520
    • (2012) Annual Review of Pharmacology and Toxicology , vol.52 , pp. 505-521
    • Zhao, S.1    Iyengar, R.2
  • 47
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • 2-s2.0-54249155522 10.1038/nchembio.118
    • Hopkins A. L., Network pharmacology: the next paradigm in drug discovery. Nature Chemical Biology 2008 4 11 682 690 2-s2.0-54249155522 10.1038/nchembio.118
    • (2008) Nature Chemical Biology , vol.4 , Issue.11 , pp. 682-690
    • Hopkins, A.L.1
  • 49
    • 68249111344 scopus 로고    scopus 로고
    • Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts
    • 2-s2.0-68249111344 10.1371/journal.pcbi.1000450 e1000450
    • Li J., Zhu X., Chen J. Y., Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts. PLoS Computational Biology 2009 5 7 2-s2.0-68249111344 10.1371/journal.pcbi.1000450 e1000450
    • (2009) PLoS Computational Biology , vol.5 , Issue.7
    • Li, J.1    Zhu, X.2    Chen, J.Y.3
  • 51
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • DOI 10.1126/science.1158140
    • Campillos M., Kuhn M., Gavin A.-C., Jensen L. J., Bork P., Drug target identification using side-effect similarity. Science 2008 321 5886 263 266 2-s2.0-47249146126 10.1126/science.1158140 (Pubitemid 351989100)
    • (2008) Science , vol.321 , Issue.5886 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.-C.3    Jensen, L.J.4    Bork, P.5
  • 52
    • 84866446560 scopus 로고    scopus 로고
    • Drug target prediction using adverse event report systems: A pharmacogenomic approach
    • Takarabe M., Kotera M., Nishimura Y., Goto S., Yamanishi Y., Drug target prediction using adverse event report systems: a pharmacogenomic approach. Bioinformatics 2012 28 18 i611 i618
    • (2012) Bioinformatics , vol.28 , Issue.18
    • Takarabe, M.1    Kotera, M.2    Nishimura, Y.3    Goto, S.4    Yamanishi, Y.5
  • 56
    • 68249128647 scopus 로고    scopus 로고
    • Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
    • 2-s2.0-68249128647 10.1371/journal.pcbi.1000441 e1000441
    • Yang L., Chen J., He L., Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome. PLoS Computational Biology 2009 5 7 2-s2.0-68249128647 10.1371/journal.pcbi.1000441 e1000441
    • (2009) PLoS Computational Biology , vol.5 , Issue.7
    • Yang, L.1    Chen, J.2    He, L.3
  • 57
    • 79953669856 scopus 로고    scopus 로고
    • Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome - Clozapine-induced agranulocytosis as a case study
    • 2-s2.0-79953669856 10.1371/journal.pcbi.1002016 e1002016
    • Yang L., Wang K., Chen J., Jegga A. G., Luo H., Shi L., Wan C., Guo X., Qin S., He G., Feng G., He L., Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome-clozapine-induced agranulocytosis as a case study. PLoS Computational Biology 2011 7 3 2-s2.0-79953669856 10.1371/journal.pcbi.1002016 e1002016
    • (2011) PLoS Computational Biology , vol.7 , Issue.3
    • Yang, L.1    Wang, K.2    Chen, J.3    Jegga, A.G.4    Luo, H.5    Shi, L.6    Wan, C.7    Guo, X.8    Qin, S.9    He, G.10    Feng, G.11    He, L.12
  • 58
    • 78049445175 scopus 로고    scopus 로고
    • Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    • 2-s2.0-78049445175 10.1371/journal.pcbi.1000938 e1000938
    • Chang R. L., Xie L., Xie L., Bourne P. E., Palsson B. Ø., Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Computational Biology 2010 6 9 2-s2.0-78049445175 10.1371/journal.pcbi.1000938 e1000938
    • (2010) PLoS Computational Biology , vol.6 , Issue.9
    • Chang, R.L.1    Xie, L.2    Xie, L.3    Bourne, P.E.4    Palsson B.Ø5
  • 59
    • 84874060259 scopus 로고    scopus 로고
    • Predicting chemical toxicity effects based on chemical-chemical interactions
    • e56517
    • Chen L., Lu J., Zhang J., Feng K.-R., Zheng M.-Y., Cai Y.-D., Predicting chemical toxicity effects based on chemical-chemical interactions. PLoS ONE 2013 8 2 e56517
    • (2013) PLoS ONE , vol.8 , Issue.2
    • Chen, L.1    Lu, J.2    Zhang, J.3    Feng, K.-R.4    Zheng, M.-Y.5    Cai, Y.-D.6
  • 61
    • 79958754253 scopus 로고    scopus 로고
    • PREDICT: A method for inferring novel drug indications with application to personalized medicine
    • 2-s2.0-79958754253 10.1038/msb.2011.26
    • Gottlieb A., Stein G. Y., Ruppin E., Sharan R., PREDICT: a method for inferring novel drug indications with application to personalized medicine. Molecular Systems Biology 2011 7, article 496 2-s2.0-79958754253 10.1038/msb.2011.26
    • (2011) Molecular Systems Biology , vol.7496
    • Gottlieb, A.1    Stein, G.Y.2    Ruppin, E.3    Sharan, R.4
  • 63
    • 84855381399 scopus 로고    scopus 로고
    • A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy
    • 2-s2.0-84855381399 10.1158/0008-5472.CAN-11-2333
    • Jin G., Fu C., Zhao H., Cui K., Chang J., Wong S. T. C., A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Research 2012 72 1 33 44 2-s2.0-84855381399 10.1158/0008-5472.CAN-11-2333
    • (2012) Cancer Research , vol.72 , Issue.1 , pp. 33-44
    • Jin, G.1    Fu, C.2    Zhao, H.3    Cui, K.4    Chang, J.5    Wong, S.T.C.6
  • 64
    • 84884200376 scopus 로고    scopus 로고
    • Characterization of drug-induced transcriptional modules: Towards drug repositioning and functional understanding
    • Iskar M., Zeller G., Blattmann P., Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding. Molecular Systems Biology 2013 9 662
    • (2013) Molecular Systems Biology , vol.9 , pp. 662
    • Iskar, M.1    Zeller, G.2    Blattmann, P.3
  • 65
    • 59349083179 scopus 로고    scopus 로고
    • Mechanisms of drug combinations: Interaction and network perspectives
    • 2-s2.0-59349083179 10.1038/nrd2683
    • Jia J., Zhu F., Ma X., Cao Z. W., Li Y. X., Chen Y. Z., Mechanisms of drug combinations: interaction and network perspectives. Nature Reviews Drug Discovery 2009 8 2 111 128 2-s2.0-59349083179 10.1038/nrd2683
    • (2009) Nature Reviews Drug Discovery , vol.8 , Issue.2 , pp. 111-128
    • Jia, J.1    Zhu, F.2    Ma, X.3    Cao, Z.W.4    Li, Y.X.5    Chen, Y.Z.6
  • 66
    • 33747620519 scopus 로고    scopus 로고
    • Systems biology and combination therapy in the quest for clinical efficacy
    • DOI 10.1038/nchembio817, PII NCHEMBIO817
    • Fitzgerald J. B., Schoeberl B., Nielsen U. B., Sorger P. K., Systems biology and combination therapy in the quest for clinical efficacy. Nature Chemical Biology 2006 2 9 458 466 2-s2.0-33747620519 10.1038/nchembio817 (Pubitemid 44266307)
    • (2006) Nature Chemical Biology , vol.2 , Issue.9 , pp. 458-466
    • Fitzgerald, J.B.1    Schoeberl, B.2    Nielsen, U.B.3    Sorger, P.K.4
  • 67
    • 77956274693 scopus 로고    scopus 로고
    • Identification of optimal drug combinations targeting cellular networks: Integrating phospho-proteomics and computational network analysis
    • 2-s2.0-77956274693 10.1158/0008-5472.CAN-10-0460
    • Iadevaia S., Lu Y., Morales F. C., Mills G. B., Ram P. T., Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Research 2010 70 17 6704 6714 2-s2.0-77956274693 10.1158/0008-5472.CAN-10-0460
    • (2010) Cancer Research , vol.70 , Issue.17 , pp. 6704-6714
    • Iadevaia, S.1    Lu, Y.2    Morales, F.C.3    Mills, G.B.4    Ram, P.T.5
  • 68
    • 78650086757 scopus 로고    scopus 로고
    • Integrated computational model of cell cycle and checkpoint reveals different essential roles of Aurora-A and Plk1 in mitotic entry
    • 2-s2.0-78650086757 10.1039/c0mb00004c
    • Zou J., Luo S.-D., Wei Y.-Q., Yang S.-Y., Integrated computational model of cell cycle and checkpoint reveals different essential roles of Aurora-A and Plk1 in mitotic entry. Molecular BioSystems 2011 7 1 169 179 2-s2.0-78650086757 10.1039/c0mb00004c
    • (2011) Molecular BioSystems , vol.7 , Issue.1 , pp. 169-179
    • Zou, J.1    Luo, S.-D.2    Wei, Y.-Q.3    Yang, S.-Y.4
  • 69
    • 84868101830 scopus 로고    scopus 로고
    • Neighbor communities in drug combination networks characterize synergistic effect
    • Zou J., Ji P., Zhao Y.-L., Neighbor communities in drug combination networks characterize synergistic effect. Molecular BioSystems 2012 8 12 3185 3196
    • (2012) Molecular BioSystems , vol.8 , Issue.12 , pp. 3185-3196
    • Zou, J.1    Ji, P.2    Zhao, Y.-L.3
  • 71
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong L. N., Costello J. C., Liu H., Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nature Medicine 2012 18 10 1503 1510
    • (2012) Nature Medicine , vol.18 , Issue.10 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3
  • 72
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee M. J., Ye A. S., Gardino A. K., Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012 149 4 780 794
    • (2012) Cell , vol.149 , Issue.4 , pp. 780-794
    • Lee, M.J.1    Ye, A.S.2    Gardino, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.