메뉴 건너뛰기




Volumn 6, Issue 8, 2009, Pages 455-464

Systems pathology-taking molecular pathology into a new dimension

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; TRASTUZUMAB; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 70350005352     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2009.102     Document Type: Review
Times cited : (61)

References (70)
  • 1
    • 53649095010 scopus 로고    scopus 로고
    • A network solution
    • Henney, A. & superti-Furga, G. A network solution. Nature 455, 730-731 (2008).
    • (2008) Nature , vol.455 , pp. 730-731
    • Henney, A.1    Superti-Furga, G.2
  • 2
    • 33745368556 scopus 로고    scopus 로고
    • Inhibition of the late sodium current as a potential cardioprotective principle: Effects of the late sodium current inhibitor ranolazine
    • Belardinelli, L., shryock, J. C. & Fraser, H. inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart 92 (Suppl. 4), iv6-iv14 (2006).
    • (2006) Heart , vol.92 , Issue.SUPPL. 4
    • Belardinelli, L.1    Shryock, J.C.2    Fraser, H.3
  • 3
    • 33745392178 scopus 로고    scopus 로고
    • Late sodium current in the pathophysiology of cardiovascular disease: Consequences of sodium-calcium overload
    • Noble, D. & Noble, P. J. Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload. Heart 92 (Suppl. 4), iv1-iv5 (2006).
    • (2006) Heart , vol.92 , Issue.SUPPL. 4
    • Noble, D.1    Noble, P.J.2
  • 5
    • 73849100653 scopus 로고    scopus 로고
    • [online]
    • FDA Approves New Treatment for Chest Pain, FDA [online], http://www.fda.gov/Newsevents/ Newsroom/PressAnnouncements/2006/ ucm108587.htm (2009).
    • (2009) FDA Approves New Treatment for Chest Pain
  • 6
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the Pi3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns, K. et al. A functional genetic approach identifies the Pi3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12, 395-402 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1
  • 7
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in Her2-overexpressing breast cancer
    • valabrega, G., Montemurro, F. & Aglietta, M. Trastuzumab: mechanism of action, resistance and future perspectives in Her2-overexpressing breast cancer. Ann. Oncol. 18, 977-984 (2007).
    • (2007) Ann. Oncol. , vol.18 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 8
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & weinberg, r. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 10
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • elston, C. w. & ellis, i. O. Pathological prognostic factors in breast cancer. i. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19, 403-410 (1991).
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 11
    • 33745653114 scopus 로고    scopus 로고
    • Metaplastic breast carcinomas are basal-like tumours
    • reis-Filho, J. s. et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology 49, 10-21 (2006).
    • (2006) Histopathology , vol.49 , pp. 10-21
    • Reis-Filho, J.S.1
  • 12
    • 37248999372 scopus 로고    scopus 로고
    • Triple negative tumours: A critical review
    • reis-Filho, J. s. & Tutt, A. N. Triple negative tumours: a critical review. Histopathology 52, 108-118 (2008).
    • (2008) Histopathology , vol.52 , pp. 108-118
    • Reis-Filho, J.S.1    Tutt, A.N.2
  • 13
    • 58849100464 scopus 로고    scopus 로고
    • Do 'basal-like' breast cancers really exist?
    • Gusterson, B. Do 'basal-like' breast cancers really exist? Nat. Rev. Cancer 9, 128-134 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 128-134
    • Gusterson, B.1
  • 14
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 15
    • 44949149181 scopus 로고    scopus 로고
    • Comparative genomic hybridisation arrays: High-throughput tools to determine targeted therapy in breast cancer
    • Tan, D. s. & reis-Filho, J. s. Comparative genomic hybridisation arrays: high-throughput tools to determine targeted therapy in breast cancer. Pathobiology 75, 63-74 (2008).
    • (2008) Pathobiology , vol.75 , pp. 63-74
    • Tan, D.S.1    Reis-Filho, J.S.2
  • 16
    • 33749022506 scopus 로고    scopus 로고
    • Basal-like breast cancer and the BrCA1 phenotype
    • Turner, N. C. & reis-Filho, J. s. Basal-like breast cancer and the BrCA1 phenotype. Oncogene 25, 5846-5853 (2006).
    • (2006) Oncogene , vol.25 , pp. 5846-5853
    • Turner, N.C.1    Reis-Filho, J.S.2
  • 17
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey, L. A. et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin. Cancer Res. 13, 2329-2334 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2329-2334
    • Carey, L.A.1
  • 18
    • 23844549918 scopus 로고    scopus 로고
    • Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    • rouzier, r. et al. Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin. Cancer Res. 11, 5678-5685 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5678-5685
    • Rouzier, R.1
  • 19
    • 37249078187 scopus 로고    scopus 로고
    • Predictive markers in breast cancer-the future
    • Faratian, D. & Bartlett, J. Predictive markers in breast cancer-the future. Histopathology 52, 91-98 (2008).
    • (2008) Histopathology , vol.52 , pp. 91-98
    • Faratian, D.1    Bartlett, J.2
  • 20
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • wood, L. D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007).
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 21
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006).
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1
  • 22
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (eBCTCG)
    • early Breast Cancer Trialists' Collaborative Group (eBCTCG). effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365, 1687-1717 (2005).
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 23
    • 33845914783 scopus 로고    scopus 로고
    • 2-year follow-up of trastuzumab after adjuvant chemotherapy in Her2-positive breast cancer: A randomised controlled trial
    • smith, i. et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in Her2-positive breast cancer: a randomised controlled trial. Lancet 369, 29-36 (2007).
    • (2007) Lancet , vol.369 , pp. 29-36
    • Smith, I.1
  • 24
    • 37649017916 scopus 로고    scopus 로고
    • Dynamic computational modeling in the search for better breast cancer drug therapy
    • Faratian, D. Moodie, s. L., Harrison D. J. & Goryanin, i. Dynamic computational modeling in the search for better breast cancer drug therapy. Pharmacogenomics 8, 1757-1761 (2007).
    • (2007) Pharmacogenomics , vol.8 , pp. 1757-1761
    • Faratian, D.1    Moodie, S.L.2    Harrison, D.J.3    Goryanin, I.4
  • 25
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'reilly, K. e. et al. mTOr inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 66, 1500-1508 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1
  • 26
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, i. & Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3, 711-715 (2004).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 27
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • sherr, C. J. Cancer cell cycles. Science 274, 1672-1677 (1996).
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 28
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko, B. N. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7, 165-176 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 29
    • 43049176242 scopus 로고    scopus 로고
    • Giving space to cell signaling
    • Kholodenko, B. N. & Kolch, w. Giving space to cell signaling. Cell 133, 566-567 (2008).
    • (2008) Cell , vol.133 , pp. 566-567
    • Kholodenko, B.N.1    Kolch, W.2
  • 30
    • 57349097152 scopus 로고    scopus 로고
    • Dynamic proteomics of individual cancer cells in response to a drug
    • Cohen, A. A. et al. Dynamic proteomics of individual cancer cells in response to a drug. Science 322, 1511-1516 (2008).
    • (2008) Science , vol.322 , pp. 1511-1516
    • Cohen, A.A.1
  • 31
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano, H. Biological robustness. Nat. Rev. Genet. 5, 826-837 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 826-837
    • Kitano, H.1
  • 32
    • 0000188718 scopus 로고    scopus 로고
    • Highly optimized tolerance: Robustness and design in complex systems
    • Carlson, J. M. & Doyle, J. Highly optimized tolerance: robustness and design in complex systems. Phys. Rev. Lett. 84, 2529-2532 (2000).
    • (2000) Phys. Rev. Lett. , vol.84 , pp. 2529-2532
    • Carlson, J.M.1    Doyle, J.2
  • 33
    • 58149240299 scopus 로고    scopus 로고
    • Standards and ontologies in computational systems biology
    • sauro, H. M. & Bergmann, F. T. standards and ontologies in computational systems biology. Essays Biochem. 45, 211-222 (2008).
    • (2008) Essays Biochem. , vol.45 , pp. 211-222
    • Suro, H.M.1    Bergmann, F.T.2
  • 34
    • 0037342537 scopus 로고    scopus 로고
    • The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models
    • Hucka, M. et al. The systems biology markup language (sBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19, 524-531 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 524-531
    • Hucka, M.1
  • 36
    • 0041344538 scopus 로고    scopus 로고
    • A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulininduced erbB signalling
    • Hatakeyama, M. et al. A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulininduced erbB signalling. Biochem. J. 373, 451-463 (2003).
    • (2003) Biochem. J. , vol.373 , pp. 451-463
    • Hatakeyama, M.1
  • 37
    • 31444453554 scopus 로고    scopus 로고
    • Computational modelling of erbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity
    • Hendriks, B. s. et al. Computational modelling of erbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity. Syst. Biol. (Stevenage) 153, 22-33 (2006).
    • (2006) Syst. Biol. (Stevenage) , vol.153 , pp. 22-33
    • Hendriks, B.S.1
  • 38
    • 0033570090 scopus 로고    scopus 로고
    • Quantification of short term signaling by the epidermal growth factor receptor
    • Kholodenko, B. N., Demin, O. v., Moehren, G. & Hoek, J. B. Quantification of short term signaling by the epidermal growth factor receptor. J. Biol. Chem. 274, 30169-30181 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30169-30181
    • Kholodenko, B.N.1    Demin, O.V.2    Moehren, G.3    Hoek, J.B.4
  • 39
    • 0842288229 scopus 로고    scopus 로고
    • Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
    • Markevich, N. i., Hoek, J. B. & Kholodenko, B. N. signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell Biol. 164, 353-359 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 353-359
    • Markevich, N.I.1    Hoek, J.B.2    Kholodenko, B.N.3
  • 40
    • 33744927122 scopus 로고    scopus 로고
    • Modeling the effects of Her/erbB1-3 coexpression on receptor dimerization and biological response
    • shankaran, H., wiley, H. s. & resat, H. Modeling the effects of Her/erbB1-3 coexpression on receptor dimerization and biological response. Biophys. J. 90, 3993-4009 (2006).
    • (2006) Biophys. J. , vol.90 , pp. 3993-4009
    • Shankaran, H.1    Wiley, H.S.2    Resat, H.3
  • 41
    • 34547684426 scopus 로고    scopus 로고
    • Computational approaches to the topology, stability and dynamics of metabolic networks
    • steuer, r. Computational approaches to the topology, stability and dynamics of metabolic networks. Phytochemistry 68, 2139-2151 (2007).
    • (2007) Phytochemistry , vol.68 , pp. 2139-2151
    • Steuer, R.1
  • 42
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized eGF receptors
    • schoeberl, B., eichler-Jonsson, C., Gilles, e. D. & Muller, G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized eGF receptors. Nat. Biotechnol. 20, 370-375 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 43
    • 28844441230 scopus 로고    scopus 로고
    • A systems model of signaling identifies a molecular basis set for cytokineinduced apoptosis
    • Janes, K. A. et al. A systems model of signaling identifies a molecular basis set for cytokineinduced apoptosis. Science 310, 1646-1653 (2005).
    • (2005) Science , vol.310 , pp. 1646-1653
    • Janes, K.A.1
  • 45
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the Pi3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns, K. et al. A functional genetic approach identifies the Pi3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12, 395-402 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1
  • 46
    • 5144226211 scopus 로고    scopus 로고
    • PTeN activation contributes to tumor inhibition by trastuzumab, and loss of PTeN predicts trastuzumab resistance in patients
    • Nagata, Y. et al. PTeN activation contributes to tumor inhibition by trastuzumab, and loss of PTeN predicts trastuzumab resistance in patients. Cancer Cell 6, 117-127 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1
  • 47
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabasi, A. L. & Oltvai, Z. N. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5, 101-113 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 101-113
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 48
    • 33750608852 scopus 로고    scopus 로고
    • The role of modelling in identifying drug targets for diseases of the cell cycle
    • Clyde, r. G., Bown, J. L., Hupp, T. r., Zhelev, N. & Crawford, J. w. The role of modelling in identifying drug targets for diseases of the cell cycle. J. R. Soc. Interface 3, 617-627 (2006).
    • (2006) J. R. Soc. Interface , vol.3 , pp. 617-627
    • Clyde, R.G.1    Bown, J.L.2    Hupp, T.R.3    Zhelev, N.4    Crawford, J.W.5
  • 50
    • 32044469430 scopus 로고    scopus 로고
    • Systems biology and the heart
    • Noble, D. systems biology and the heart. Biosystems 83, 75-80 (2006).
    • (2006) Biosystems , vol.83 , pp. 75-80
    • Noble, D.1
  • 52
    • 0024673614 scopus 로고
    • A comparison of variant theories of intact biochemical systems. I. Enzyme-enzyme interactions and biochemical systems theory
    • sorribas, A. & savageau, M. A. A comparison of variant theories of intact biochemical systems. i. enzyme-enzyme interactions and biochemical systems theory. Math. Biosci. 94, 161-193 (1989).
    • (1989) Math. Biosci. , vol.94 , pp. 161-193
    • Sorribas, A.1    Savageau, M.A.2
  • 53
    • 0036195958 scopus 로고    scopus 로고
    • Metabolic control analysis in drug discovery and disease
    • Cascante, M. et al. Metabolic control analysis in drug discovery and disease. Nat. Biotechnol. 20, 243-249 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 243-249
    • Cascante, M.1
  • 54
    • 0005123140 scopus 로고
    • Power-law approach to modeling biological systems. 1. Theory
    • savageau, M. A. & voit, e. O. Power-law approach to modeling biological systems. 1. Theory. J. Ferment. Technol. 60, 221-228 (1982).
    • (1982) J. Ferment. Technol. , vol.60 , pp. 221-228
    • Savageau, M.A.1    Voit, E.O.2
  • 55
    • 0036845322 scopus 로고    scopus 로고
    • Models-of-data and models-of-processes in the post-genomic era
    • voit, e. O. Models-of-data and models-of-processes in the post-genomic era. Math. Biosci. 180, 263-274 (2002).
    • (2002) Math. Biosci. , vol.180 , pp. 263-274
    • Voit, E.O.1
  • 56
    • 34447498286 scopus 로고    scopus 로고
    • Systems biology by the rules: Hybrid intelligent systems for pathway modeling and discovery
    • Bosl, w. J. systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery. BMC Syst. Biol. 1, 13 (2007).
    • (2007) BMC Syst. Biol. , vol.1 , pp. 13
    • Bosl, W.J.1
  • 58
    • 80055120376 scopus 로고    scopus 로고
    • Technical demonstration of whole genome array comparative genomic hybridization
    • Kennett, J. Y., watson, s. K., saprunoff, H., Heryet, C. & Lam, w. L. Technical demonstration of whole genome array comparative genomic hybridization. J. Vis. Exp. 5, 870 (2008).
    • (2008) J. Vis. Exp. , vol.5 , pp. 870
    • Kennett, J.Y.1    Watson, S.K.2    Saprunoff, H.3    Heryet, C.4    Lam, W.L.5
  • 59
    • 80055119523 scopus 로고    scopus 로고
    • Laser capture microdissection of mammalian tissue
    • edwards, r. A. Laser capture microdissection of mammalian tissue. J. Vis. Exp. 309 (2007).
    • (2007) J. Vis. Exp. , vol.309
    • Edwards, R.A.1
  • 60
    • 0036852721 scopus 로고    scopus 로고
    • Automated subcellular localization and quantification of protein expression in tissue microarrays
    • Camp, r. L., Chung, G. G. & rimm, D. L. Automated subcellular localization and quantification of protein expression in tissue microarrays. Nat. Med. 8, 1323-1327 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 1323-1327
    • Camp, R.L.1    Chung, G.G.2    Rimm, D.L.3
  • 61
    • 61849105469 scopus 로고    scopus 로고
    • Mass spectrometry based targeted protein quantification: Methods and applications
    • Pan, s. et al. Mass spectrometry based targeted protein quantification: methods and applications. J. Proteome Res. 8, 787-797 (2008).
    • (2008) J. Proteome Res. , vol.8 , pp. 787-797
    • Pan, S.1
  • 62
    • 33750456480 scopus 로고    scopus 로고
    • Reverse phase protein array: Validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
    • Tibes, r. et al. reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol. Cancer Ther. 5, 2512-2521 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2512-2521
    • Tibes, R.1
  • 63
    • 57049128693 scopus 로고    scopus 로고
    • Intravital imaging of metastatic behavior through a mammary imaging window
    • Kedrin, D. et al. intravital imaging of metastatic behavior through a mammary imaging window. Nat. Methods 5, 1019-1021 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 1019-1021
    • Kedrin, D.1
  • 64
    • 0035078397 scopus 로고    scopus 로고
    • Melanoma cell-derived factors stimulate glycosaminoglycan synthesis by fibroblasts cultured as monolayers and within contracted collagen lattices
    • edward, M. Melanoma cell-derived factors stimulate glycosaminoglycan synthesis by fibroblasts cultured as monolayers and within contracted collagen lattices. Br. J. Dermatol. 144, 465-470 (2001).
    • (2001) Br. J. Dermatol. , vol.144 , pp. 465-470
    • Edward, M.1
  • 65
    • 12144282230 scopus 로고    scopus 로고
    • The scientific value of preoperative studies and how they can be used
    • Dixon, J. M. The scientific value of preoperative studies and how they can be used. Breast Cancer Res. Treat. 87 (Suppl. 1), s19-s26 (2004).
    • (2004) Breast Cancer Res. Treat. , vol.87 , Issue.SUPPL. 1
    • Dixon, J.M.1
  • 66
    • 32944463744 scopus 로고    scopus 로고
    • Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer
    • Dowsett, M. et al. Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer. Clin. Cancer Res. 12, 1024s-1030s (2006).
    • (2006) Clin. Cancer Res. , vol.12
    • Dowsett, M.1
  • 67
    • 33846965616 scopus 로고    scopus 로고
    • Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    • Dowsett, M. et al. Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J. Natl Cancer Inst. 99, 167-170 (2007).
    • (2007) J. Natl Cancer Inst. , vol.99 , pp. 167-170
    • Dowsett, M.1
  • 68
    • 0036787761 scopus 로고    scopus 로고
    • Intraperitoneal therapy for stage III ovarian cancer: A therapy whose time has come¡
    • Alberts, D. s. et al. intraperitoneal therapy for stage iii ovarian cancer: a therapy whose time has come¡ J. Clin. Oncol. 20, 3944-3946 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3944-3946
    • Alberts, D.S.1
  • 69
    • 15244350408 scopus 로고    scopus 로고
    • Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma
    • Nagtegaal, i. D. et al. radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Virchows Arch. 446, 127-135 (2005).
    • (2005) Virchows Arch. , vol.446 , pp. 127-135
    • Nagtegaal, I.D.1
  • 70
    • 33744938180 scopus 로고    scopus 로고
    • Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome
    • Dolled-Filhart, M. et al. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 66, 5487-5494 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 5487-5494
    • Dolled-Filhart, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.