Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets

PLoS Computational Biology

Volumn 6, Issue 2, 2010, Pages

  Suthram, Silpa ^a,b,c   Dudley, Joel T ^a,b,c   Chiang, Annie P ^a,b,c   Chen, Rong ^a,b,c   Hastie, Trevor J ^d   Butte, Atul J ^a,b,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

^d STANFORD LAW SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE THERAPY;

'CURRENT; DISEASE GENES; DISEASE SIMILARITIES; DRUG TARGETS; FUNCTIONAL MODULES; HUMAN DISEASE; HUMAN PROTEINS; NETWORK-BASED; PLURIPOTENT; QUANTITATIVE FRAMEWORKS;

PROTEINS;

ARTICLE; BIPOLAR DISORDER; CONTINGENCY TABLE; CROHN DISEASE; DRUG TARGETING; ENDOMETRIOSIS; GENE EXPRESSION; GENE TARGETING; HUMAN; MALARIA; PROSTATE TUMOR; PROTEIN INTERACTION; PROTEIN TARGETING; SCHIZOPHRENIA; BIOLOGY; CLASSIFICATION; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG DELIVERY SYSTEM; GENE EXPRESSION PROFILING; GENERAL ASPECTS OF DISEASE; GENETIC DATABASE; METHODOLOGY; NONPARAMETRIC TEST; RANDOMIZATION; STATISTICAL MODEL;

CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DISEASE; DRUG DELIVERY SYSTEMS; GENE EXPRESSION PROFILING; HUMANS; LINEAR MODELS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC;

EID: 77649222972     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000662     Document Type: Article

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