1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 91-100

  Desideri, Nicoletta ^a   Fioravanti, Rossella ^a   Proietti Monaco, Luca ^a   Biava, Mariangela ^a   Yáñez, Matilde ^b   Ortuso, Francesco ^c   Alcaro, Stefano ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

1,5 Diphenylpenta 2,4 dien 1 ones; Docking; hMAO B inhibitors; Monoamine oxidase; Structure activity relationship

Indexed keywords

1 (2 HYDROXYPHENYL) 5 PHENYLPENTA 2,4 DIEN 1 ONE; 3 HYDROXY 1 (2 HYDROXYPHEYNYL) 5 PHENYLPENTA 2,4 DIEN 1 ONE; 5 (4 CHLOROPHENYL) 1 (2 HYDROXY 4 METHOXYPHENYL)PENTA 2,4 DIEN 1 ONE; 5 (4 CHLOROPHENYL) 1 (2,4 DIHYDROXYPHENYL)PENTA 2,4 DIEN 1 ONE; HYDROXYL GROUP; MONOAMINE OXIDASE B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; IC 50; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; QUANTUM CHEMISTRY;

CELLS, CULTURED; CURCUMIN; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MONOAMINE OXIDASE INHIBITORS; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870165862     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.006     Document Type: Article

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