A structure-activity study to identify novel and efficient substrates of the human semicarbazide-sensitive amine oxidase/VAP-1 enzyme

Biochimie

Volumn 92, Issue 7, 2010, Pages 858-868

  Bonaiuto, Emanuela ^a   Lunelli, Michele ^b   Scarpa, Marina ^b   Vettor, Roberto ^a   Milan, Gabriella ^a   Di Paolo, Maria Luisa ^a,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TRENTO   (Italy)

^c NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

Computational docking; PH dependence; Semicarbazide sensitive amine oxidases; SSAO VAP 1 substrates; Structure function relationships

Indexed keywords

1,12 DODECANEDIAMINE; AMINE OXIDASE (COPPER CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING); BENZYLAMINE; DODECANE; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1; AMINE; AOC3 PROTEIN, HUMAN; BUTANE; CELL ADHESION MOLECULE; PROTEIN BINDING; RECOMBINANT PROTEIN; SEMICARBAZIDE DERIVATIVE;

ADIPOCYTE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IONIC STRENGTH; MOLECULAR DOCKING; PH; STRUCTURE ACTIVITY RELATION; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG DEVELOPMENT; KINETICS; METABOLISM; OSMOLARITY;

ADIPOCYTES; AMINE OXIDASE (COPPER-CONTAINING); AMINES; BUTANES; CATALYTIC DOMAIN; CELL ADHESION MOLECULES; CELL MEMBRANE; DRUG DISCOVERY; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; OSMOLAR CONCENTRATION; PROTEIN BINDING; RECOMBINANT PROTEINS; SEMICARBAZIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953540713     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.03.006     Document Type: Article

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