In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3901-3904

  Saiki, Ryotaro ^a   Yoshizawa, Yuki ^a   Minarini, Anna ^b   Milelli, Andrea ^b   Marchetti, Chiara ^b   Tumiatti, Vincenzo ^b   Toida, Toshihiko ^a   Kashiwagi, Keiko ^c   Igarashi, Kazuei ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CHIBA INSTITUTE OF SCIENCE   (Japan)

Author keywords

NMDA receptor channel blocker; Polymethylene teraamine derivative

Indexed keywords

MEMANTINE; N 1 ,N 1' (DECANE 1,10 DIYL)BIS[N 5 (2 METHOXYBENZYL)PENTANE 1,5 DIAMINE]; N 1 ,N 1' (DODECANE 1,12 DIYL)BIS[N 6 (2,2 DIPHENYLETHYL)HEXANE 1,6 DIAMINE]; N 1 ,N 1' (HEXANE 1,6 DIYL)BIS[N 5 (2 METHOXYBENZYL)PENTANE 1,5 DIAMINE]; N 1 ,N 1' (HEXANE 1,6 DIYL)BIS[N 8 (2 METHOXYBENZYL)OCTANE 1,8 DIAMINE]; N 1 ,N 1' (OCTANE 1,8 DIYL)BIS[N 6 (2 METHOXYBENZYL)HEXANE 1,6 DIAMINE]; N 1 ,N 1' (OCTANE 1,8 DIYL)BIS[N 6 (2,2 DIPHENYLETHYL)HEXANE 1,6 DIAMINE]; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; FOREBRAIN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LD 50; LIPOPHILICITY; MOUSE; NONHUMAN; OOCYTE; THROMBOSIS; XENOPUS LAEVIS;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MEMANTINE; MICE; MOLECULAR STRUCTURE; POLYAMINES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOSIS;

MUS;

EID: 84878891247     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.063     Document Type: Article

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