Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway

European Journal of Pharmacology

Volumn 715, Issue 1-3, 2013, Pages 62-71

  Li, Weifeng ^a   Huang, Huimin ^a   Zhang, Yanmin ^a   Fan, Ting ^a   Liu, Xia ^a   Xing, Wei ^a   Niu, Xiaofeng ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Nitric oxide; Nuclear factor kappa B; Phospho ERK1 2; Phospho p38MAPK; Pro inflammatory cytokines; Tetrahydrocoptisine

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; STYLOPINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CHRONIC INFLAMMATION; CONTROLLED STUDY; CORYDALIS; CORYDALIS IMPATIENS; CYTOTOXICITY; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; EAR EDEMA; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERFERON PRODUCTION; MALE; MOUSE; NONHUMAN; PAW EDEMA; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

NITRIC OXIDE; NUCLEAR FACTOR-KAPPA B; PHOSPHO-ERK1/2; PHOSPHO-P38MAPK; PRO-INFLAMMATORY CYTOKINES; TETRAHYDROCOPTISINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BERBERINE ALKALOIDS; CARRAGEENAN; CELL SURVIVAL; CORYDALIS; CYTOKINES; EDEMA; GENE EXPRESSION REGULATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; NITRIC OXIDE; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; XYLENES;

EID: 84885475471     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.06.017     Document Type: Article

References (53)

1. Adams, D.O., Hamilton, T.A., 1984. The cell biology of macrophage activation. Annu. Rev. Immunol. 2, 283-318.
2. Adeyemi, O.O., Yemitan, O.K., Afolabi, L, 2008. Inhibition of chemically induced inflammation and pain by orally and topically administered leaf extract of Manihot esculenta Crantz in rodents. J. Ethnopharmacol. 119, 6-11.
3. Andonegui, G., Bonder, CS., Green, F., Mullaly, S.C., Zbytnuik, L., Raharjo, E., Kubes, P., 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J. Clin. Invest. 111, 1011-1020. (Pubitemid 36397477)
4. Baeuerle, P.A., Henkel, T., 1994. Function and activation of NF-kappaB in the immune system. Annu. Rev. Immunol. 12, 141-179.
5. Bhat, N.R., Zhang, P., Lee, J.C., Hogan, E.L., 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18, 1633-1641. (Pubitemid 28103071)
6. Brieva, A., Guerrero, A., Alonso-Lebrero, J.L., Pivel, J.P., 2001. Inmunoferons, a glycoconjugate of natural origin, inhibits LPS-induced TNF-α production and inflammatory responses. Int. Immunopharmacol. 1, 1979-1987. (Pubitemid 32835128)
7. Byeon, S.E., Chung, J.Y., Lee, Y.G., Kim, B.H., Kim, K.H., Cho, J.Y, 2008. In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J. Ethnopharmacol. 119, 145-152.
8. Carlson, P.R., O'Neill-Davis, L, Chang, J., Lewis, A.J., 1985. Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents. Agents Actions. 17, 197-204. (Pubitemid 16189984)
9. Castardo, J.C., Prudente, A.S., Ferreira, J., Guimarães, CL., Monache, F.D., Filho, V.C, Otuki, M.F., Cabrini, DA, 2008. Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema. J. Ethnopharmacol. 118, 405-411.
10. Cho, J.Y., Baik, K.U., Jung, J.H., Park, M.H., 2000. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur. J. Pharmacol. 398, 399-407. (Pubitemid 30349105)
11. Choi, M.S., Lee, S.H., Cho, H.S., Kim, Y, Yun, Y.P., Jung, H.Y, Jung, J.K., Lee, B.C., Pyo, H.B., Hong, J.T., 2007. Inhibitory effect of obovatol on nitric oxide production and activation of NF-κB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells. Eur. J. Pharmacol. 556, 181-189. (Pubitemid 46098933)
12. Cuschieri, J., Maier, R.V., 2005. Mitogen-activated protein kinase (MAPK). Crit. Care Med. 33, S417-S419. (Pubitemid 41785976)
13. Davis, R.J., 1994. MAPKs: new JNK expands the group. Trends Biochem. Sci. 19, 470-473. (Pubitemid 24342759)
14. Denzlinger, C, Rapp, S., Hagmann, W., Keppler, D., 1985. Leukotrienes as mediators in tissue trauma. Science 230, 330-332. (Pubitemid 16225668)
15. Dumitru, CD., Ceci, J.D., Tsatsanis, C, Kontoyiannis, D., Stamatakis, K., Lin, J.-H., Patriotis, C, Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N., 2000. TNF - a Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway. Cell 103, 1071-1083. (Pubitemid 32040907)
16. Frode, TS., Souza, G.E., Calixto, J.B., 2002. The effects of IL-6 and IL-10 and their specific antibodies in the acute inflammatory responses induced by carragee-nan in the mouse model of pleurisy. Cytokine 17, 149-156. (Pubitemid 34920659)
17. Gu, S., Gao, J., Hou, X., Ding, B., Zhang, W., Gao, S., Ding, X., 2009. Effects of penetration enhancers on Shuangwu traumatic formula: in vitro percutaneous absorption and in vivo pharmacodynamic evaluation of an herb medicine. Eur. J. Pharm. Biopharm. 73, 385-390.
18. Haberlein, H., Tschiersch, K.P., Boonen, G., Hiller, K.O., 1996. Chelidonium majus L: Components with in vitro affinity for the GABA[A] receptor. Positive cooperation of alkaloids. Planta Med. 62, 227-231.
19. Halici, Z., Dengiz, G.O., Odabasoglu, F., Suleyman, H., Cadirci, E., Halici, M., 2007. Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. Eur. J. Pharmacol. 566, 215-221. (Pubitemid 46805091)
20. Ho, F.M., Lai, CC, Huang, L.J., Kuo, T.C, Chao, C.M., Lin, W.W., 2004. The antiinflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. Br. J. Pharmacol. 141, 1037-1047. (Pubitemid 38510088)
21. Hong, S.K., Kim, H.J., Song, CS., Choi, I.S., Lee, J.B., Park, S.Y, 2012. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Int. Immunopharmacol. 13, 23-27.
22. Hosseinzadeh, H., Haddadkhodaparast, M.H., Arash, A.R., 2003. Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats. Phytother. Res. 17, 422-425. (Pubitemid 36565357)
23. Huang, G.-J., Pan, C-H., Liu, F.-C, Wu, T.-S., Wu, C-H., 2012. Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the X-carrageenan-induced paw edema model. Food Chem. Toxicol. 50, 1485-1493.
24. Jackson, L., Evers, B.M., 2006. In: Dalgleish, A.G., Haefner, B. (Eds.), Chronic inflammation and pathogenesis of gi and pancreatic cancers The Link Between Inflammation and Cancer. Springer, US, pp. 39-65.
25. Jang, S.I., Kim, B.H., Lee, W.Y., An, S.J., Choi, H.G., Jeon, B.H., Chung, H.T., Rho, J.R., Kim, Y.J., Chai, K.Y., 2004. Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells. Arch. Pharm. Res. 27, 923-929.
26. Kim, H.P., Son, K.H., Chang, H.W., Kang, S.S., 2004. Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. J. Pharmacol. Sci. 96, 229-245. (Pubitemid 40013328)
27. Khan, A.Q., Khan, R., Rehman, M.U., Lateef, A., Tahir, M., Ali, F., Sultana, S., 2012. Soy isoflavones (daidzein & genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice. Toxicology. 302, 266-274.
28. Li, C.C., Hsiang, C.Y., Lo, H.Y., Pai, F.T., Wu, S.L., Ho, T.Y., 2012. Genipin inhibits lipopolysaccharide-induced acute systemic inflammation in mice as evidenced by nuclear factor-kappaB bioluminescent imaging-guided transcriptomic analysis. Food Chem. Toxicol. 50, 2978-2986.
29. Liu, P., Duan, J.A., Hua, Y.Q., Tang, Y.P., Yao, X., Su, S.L., 2011. Effects of xiang-fu-si-wu decoction and its main components for dysmenorrhea on uterus contraction. J. Ethnopharmacol. 133, 591-597.
30. Madan, B., Mandal, B.C., Kumar, S., Ghosh, B., 2003. Canscora decussata (Roxb.) Schult (Gentianaceae) inhibits LPS-induced expression of ICAM-1 and E-selectin on endothelial cells and carageenan-induced paw-edema in rats. J. Ethnopharmacol. 89, 211-216. (Pubitemid 37378195)
31. Marroquin-Segura, R., Flores-Pimentel, M., Carreón-Sánchez, R., Garcia-Burciaga, M.M., Mora-Guevara, J.L.A., Aguilar-Contreras, A., Hernandez-Abad, V.J., 2009. The effect of the aqueous extract of Helietta parvifolia A. Gray (Rutaceae) stem bark on carrageenan-induced paw oedema and granuloma tissue formation in mice. J. Ethnopharmacol 124, 639-641.
32. Nacife, V.P., Soeiro, M.N., Gomes, R.N., D'Avila, H., Castro-Faria Neto, H.C., Meirelles, M.N., 2004. Morphological and biochemical characterization of macrophages activated by carrageenan and lipopolysaccharide in vivo. Cell Struct. Funct. 29, 27-34. (Pubitemid 39206717)
33. Oberbeck, R., Schmitz, D., Wilsenack, K., Schüler, M., Biskup, C., Schedlowski, M., Nast-Kolb, D., Exton, M.S., 2003. Prolactin modulates survival and cellular immune functions in septic mice. J. Surg. Res. 113, 248-256. (Pubitemid 37040897)
34. Olajide, O.A., Makinde, J.M., Awe, S.O., 1999. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J. Ethnopharmacol. 66, 113-117. (Pubitemid 29305423)
35. Otero, M., Lago, R., Lago, F., Reino, J.J., Gualillo, O., 2005. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7, R581-R591.
36. Otuki, M.F., Vieira-Lima, F., Malheiros, Â., Yunes, R.A., Calixto, J.B., 2005. Topical antiinflammatory effects of the ether extract from Protium kleinii and α-amyrin pentacyclic triterpene. Eur. J. Pharm. Biopharm. 507, 253-259. (Pubitemid 40126862)
37. Pauwels, R., Balzarini, J., Baba, M., Snoeck, R., Schols, D., Herdewijn, P., Desmyter, J., De Clercq, E., 1988. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J. Virol. Methods 20, 309-321.
38. Pyo, S., 1994. The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage. Arch. Pharm. Res. 17, 93-99.
39. Reddy, D.B., Reddanna, P., 2009. Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Biochem. Biophys. Res. Commun 381, 112-117.
40. Rummel, C., Gerstberger, R., Roth, J., Hubschle, T., 2011. Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats. Cytokine 56, 739-748.
41. Sadeghi, H., Hajhashemi, V., Minaiyan, M., Movahedian, A., Talebi, A., 2011. A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats. Eur. J. Pharmacol. 667, 396-401.
42. Sautebin, L., 2000. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia 71 (Supplement 1), S48-S57. (Pubitemid 30621695)
43. Schottenfeld, D., Beebe-Dimmer, J., 2006. Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA: Cancer J. Clin. 56, 69-83.
44. Titheradge, M.A., 1999. Nitric oxide in septic shock. BBA-Bioenergetics 1411, 437-455. (Pubitemid 29221966)
45. Vinegar, R., Truax, J.F., Selph, J.L., Johnston, P.R., Venable, A.L., McKenzie, K.K., 1987. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed. Proc. 46, 118-126.
46. Wang, C., Wang, S., Fan, G., Zou, H., 2010. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal. Bioanal. Chem. 396, 1731-1740.
47. White, M., 1999. Mediators of inflammation and the inflammatory process. J. Allergy Clin. Immunol. 103, S378-S381. (Pubitemid 29136279)
48. Wise, G.E., Yao, S., 2003. Expression of tumour necrosis factor-alpha in the rat dental follicle. Arch. Oral Biol. 48, 47-54. (Pubitemid 36453328)
49. Wu, L., Fan, N., Lin, M., Chu, I., Huang, S., Hu, C., Han, S., 2008. Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators. J. Agric. Food Chem. 56, 2341-2349. (Pubitemid 351570423)
50. Xie, C., Kang, J., Li, Z., Schauss, A.G., Badger, T.M., Nagarajan, S., Wu, T., Wu, X., 2012. The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-αlpha and IL-6 production through inhibiting NF-kappaB activation and MAPK pathway. J. Nutr. Biochem. 23, 1184-1191.
51. Yadav, S.K., Adhikary, B., Chand, S., Maity, B., Bandyopadhyay, S.K., Chattopadhyay, S., 2012. Molecular mechanism of indomethacin-induced gastropathy. Free Radic. Biol. Med. 52, 1175-1187.
52. Yoon, H.J., Moon, M.E., Park, H.S., Im, S.Y., Kim, Y.H., 2007. Chitosan oligosaccharide (COS) inhibits LPS-induced inflammatory effects in RAW 264.7 macrophage cells. Biochem. Biophys. Res. Commun. 358, 954-959. (Pubitemid 46802483)
53. Yun, K.J., Kim, J.Y., Kim, J.B., Lee, K.W., Jeong, S.Y., Park, H.J., Jung, H.J., Cho, Y.W., Yun, K., Lee, K.T., 2008. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. nt. Immunopharmacol. 8, 431-441. (Pubitemid 351227435)