Amiodarone has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced paw edema

European Journal of Pharmacology

Volumn 566, Issue 1-3, 2007, Pages 215-221

  Halici, Zekai ^a   Dengiz, Gunnur Ozbakis ^b   Odabasoglu, Fehmi ^c   Suleyman, Halis ^a   Cadirci, Elif ^c   Halici, Mesut ^c  

^a ATATURK UNIVERSITY   (Turkey)

^b ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

^c ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Acute inflammation; Amiodarone; Anti oxidant enzyme; Carrageenan; Myeloperoxidase

Indexed keywords

AMIODARONE; CARRAGEENAN; CATALASE; DICLOFENAC; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL STUDY; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

AMIODARONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CARRAGEENAN; CATALASE; DICLOFENAC; EDEMA; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HINDLIMB; MALE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 34249328520     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.03.046     Document Type: Article

References (49)

1. Aebi H. Catalase. Methods Enzymol. 105 (1984) 121-126
2. Babior B.M., Kipnes R.S., and Curnutte J.T. The production by leucocytes of superoxide, a potential bactericidal agent. J. Clin. Invest. 52 (1973) 741-744
3. Boughton-Smith N.K., Deakin A.M., Follenfant R.L., Whittle B.J.R., and Coarland L.G. Role of oxygen radicals and arachidonic acid metabolites in the reverse passive arthus reaction and carrageenin paw edema in the rat. Br. J. Pharmacol. 110 (1999) 896-902
4. Bowd A.D. Animal care courses: helping fulfill the mandate of animal care committees in Canada. J. Appl. Anim. Welf. Sci. 1 (1998) 353-360
5. Bradley P.P., Priebat D.A., Christensen R.D., and Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78 (1982) 206-209
6. Briukhanov V.M., Zverev I.F., and Elkin V.I. The effect of calcium antagonists on the development of inflammatory effect in rat. Exp. Clin. Pharmacol. 57 (1994) 47-49 (in Russian)
7. Carlberg I., and Mannervik B. Glutathione reductase. Methods Enzymol. 113 (1985) 484-490
8. Chen G., Kamal M., Hannon R., and Warner T.D. Regulation of cyclo-oxygenase gene expression in rat smooth muscle cells by catalase. Biochem. Pharmacol. 55 (1998) 1621-1631
9. Da Motta J.I., Cunha F.Q., Vargaftig B.B., and Ferreira S.H. Drug modulation of antigen-induced paw edema in guinea-pig: effects of lipopolysaccaride, tumor necrosis factor and leucocyte depletion. Br. J. Pharmacol. 112 (1994) 111-116
10. Del Maestro R.F., Thaw H.H., and Bjork J. Free radicals as mediators of tissue injury. Acta Physiol. Scand. 492 Suppl, 43 (1980)
11. Di Rosa M., and Willoughby D.A. Screens for anti-inflammatory drugs. J. Pharm. Pharmacol. 23 (1971) 297
12. Gonzalez E.R., Kannewurf B.S., and Ornato J.P. Intravenous amiodarone for ventricular arrhythmias: overview and clinical use. Resuscitation 1 (1998) 33-42
13. Gualillo O., Eiras S., Lago F., Dieguez C., and Casanueva F.F. Evaluated serum leptin concentrations induced by experimental acute inflammation. J. Ethnopharmacol. 75 (2001) 213-218
14. Habig W.H., and Jakoby W.B. Assays for differentiation glutathione-S-transferase. Methods Enzymol. 77 (1981) 398-405
15. Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause or consequence?. Lancet 344 (1994) 721-724
16. Heller A., Koch T., Schmeck J., and Ackern K.V. Lipid mediators in inflammatory disorders. Drugs 554 (1998) 487-496
17. Ialenti A., Ianaro A., Moncada S., and Di Rosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol. 211 (1995) 177-182
18. Ide T., Tsutsui H., Kinugawa S., Utsumi H., and Takeshita A. Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action. J. Card. Fail. 5 (1999) 54
19. Jain N.K., Kulkami S.K., and Singh A. Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals. Eur. J. Pharmacol. 415 (2001) 85-94
20. Kimura S., and Ikeda-Saito M. Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family. Proteins: Struct., Funct., Genet. 3 (1988) 113-120
21. Lee C.S., Jang Y.Y., Song J.S., Song J.H., and Han E.S. Ambroxol inhibits peroxynitrite-induced damage of α1-antiproteinase and free radical production in activated phagocytic cells. Pharmacol. Toxicol. 91 (2002) 140-149
22. Leeder R.G., Rafeiro E., Brien J.F., Mandin C.C., and Massey T.E. Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro. J. Biochem. Toxicol. 11 (1996) 147-160
23. Mason J.W. Amiodarone. N. Eng. J. Med. 316 (1987) 455-466
24. Matés J.M., and Sánchez-Jiménez F. Antioxidant enzymes and their implications in pathophysiologic processes. Front. Biosc. 4 (1999) 339-345
25. Matsui H., Murata Y., Kobayashi F., Shiba R., Momo K., Kondo Y., Nakahara A., and Muto H. Diclofenac-induced gastric mucosal fluorescence in rats. Dig. Dis. Sci. 46 (2001) 338-344
26. McCord J.M. Superoxide production and human disease. In: Jesaitis A., and Dratz E. (Eds). Molecular Basis of Oxidative Damage by Leukocytes (1992), CRC, Boca Raton, FL 225-239
27. McCord J.M., and Roy R.S. The pathophysiology of superoxide: roles in inflammation and ischemia. Can. J. Physiol. Pharm. 60 (1982) 1346-1352
28. Meister A., and Anderson M.E. Glutathione. Annu. Rev. Biochem. 52 (1983) 711-760
29. Moncada S., Ferreira S.H., and Vane J.R. Prostaglandins, aspirin-like drugs and the edema of inflammation. Nature 246 (1973) 217-219
30. Paino I.M.M., Ximenes V.F., da Fonseca L.M., Kanegae M.P.P., Khalil N.M., and Brunetti I.L. Effect of therapeutic plasma concentrations of non-steroidal anti-inflammatory drugs on the production of reactive oxygen species by activated rat neutrophils. Braz. J. Med. Biol. Res. 38 (2005) 543-551
31. Ribeiro S.M.R., Campello A.P., Nascimento A.J., and Kluppel L.W. Effect of amiodarone (amiodarone) on the antioxidant enzymes, lipid peroxidation and mitochondrial metabolism. Cell Biochem. Funct. 15 (1997) 145-152
32. Rocha A.C.C., Fernandes E.S., Quintao N.L.M., Campos M.M., and Calixto J.B. Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br. J. Pharmacol. 148 (2006) 688-695
33. Rrivier J.M., Pommery N., and Lhermittes M. Antioxidant defence capacity modulation of two human cell lines by amiodarone and desethylamiodarone. Toxicol. In Vitro 11 (1997) 209-216
34. Saleh T.S.F., Calixto J.B., and Medeiros Y.S. Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan. Peptides 20 (1999) 949-956
35. Salvemini D., Wang Z.Q., Bourdon D.M., Stern M.K., Currie M.G., and Manning P.T. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur. J. Pharmacol. 303 (1996) 217-220
36. Salvemini D., Wang Z.Q., Wyatt P., Bourdon D.M., Marino M.H., Manning P.T., and Currie M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118 (1996) 829-838
37. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryls groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192-205
38. 2-Cl-system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs. Biochem. Pharmacol. 41 (1991) 975-984
39. Shield M.J. Diclofenac/misoprostol: novel findings and their clinical potential. J. Rheumatol. 25 Suppl 51 (1998) 31-41
40. Sin Y.M., Pook S.H., Tan T.M., Pettersson A., Kara A.U., and The V.F. Changes in glutathione and its associated enzymes during carrageenan-induced acute inflammation in mice. Comp. Biochem. Physiol. 116 (1997) 191-195
41. Sirajudeen K.N.S., Selvi R.T., Devaraj H., and Devaraj S.N. The role of oxidative stress in amiodarone-induced lung and liver toxicity in the rat. Med. Sci. Res. 26 (1998) 619-621
42. Suleyman H., Odabasoglu F., Aslan A., Cakir A., Karagoz Y., Gocer F., Halici M., and Bayir Y. Antiinflammatory and antiulcer effects of aqueous extract of Lobaria pulmonaria. Phytomedicine 10 (2003) 552-557
43. Sun Y., Larry W.O., and Ying L. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34 (1988) 497-500
44. Vrobel T.R., Miller P.E., Mostow N.D., and Rakita L. A general overview of amiodarone toxicity: its prevention, detection, and management. Prog. Cardiovasc. Dis. 31 (1989) 393-426
45. Welinder K.G. Superfamily of plant, fungal and bacterial peroxidases. Curr. Opin. Struct. Biol. 2 (1992) 388-393
46. Winterbourn C.C. Superoxide as an intracellular radical sink. Free Radic. Biol. Med. 14 (1993) 85-90
47. Wilson B.D., Clarkson C.E., and Lippmann M.L. Amiodarone causes decreased cell-mediated immune responses and inhibits the phospholipase C signalling pathway. Lung 171 (1993) 137-148
48. Winter C.A., Ristey E.A., and Nuss G.W. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547
49. Wu Y., Zhoua C., Songa L., Li X., Shi S., Moa J., Chena H., Bai H., Wu X., Zhaoa J., Zhang R., Haod X., Sund H., and Zhaoa Y. Effect of total phenolics from Laggera alata on acute and chronic inflammation models. J. Ethnopharmacol. 108 (2006) 243-250