Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state

Journal of Neuroscience

Volumn 33, Issue 42, 2013, Pages 16586-16593

  Yang, Yang ^a,b   Vasylyev, Dmytro V ^a,b   Dib Hajj, Fadia ^a,b   Veeramah, Krishna R ^c   Hammer, Michael F ^c   Dib Hajj, Sulayman D ^a,b   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; GLUTAMIC ACID; LYSINE; POTASSIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; AUTISM; BRAIN ELECTROPHYSIOLOGY; CHANNEL GATING; DEPOLARIZATION; EPILEPSY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; KINETICS; MOLECULAR DYNAMICS; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTING STATE NETWORK; SEQUENCE ANALYSIS; STRUCTURAL EQUATION MODELING; VOLTAGE CLAMP;

AUTISTIC DISORDER; CHILD; EPILEPSY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION;

EID: 84885465054     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2307-13.2013     Document Type: Article

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