Molecular architecture of a sodium channel S6 helix: Radial tuning of the voltage-gated sodium channel 1.7 activation gate

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13741-13747

  Yang, Yang ^a,b,c   Estacion, Mark ^a,b,c   Dib Hajj, Sulayman D ^a,b,c   Waxman, Stephen G ^a,b,c  

^a Department of Neurology ^*  (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION GATE; DELETION MUTATIONS; MOLECULAR ARCHITECTURE; SODIUM CHANNEL; STRUCTURAL MODELING;

ELECTROPHYSIOLOGY; MODEL STRUCTURES;

SODIUM;

LEUCINE; PHENYLALANINE; PROTEIN S6; SERINE; SODIUM CHANNEL; SODIUM CHANNEL NAV1.7; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DEPOLARIZATION; DNA HELIX; ERYTHROMELALGIA; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; HYPERPOLARIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; VOLTAGE CLAMP;

BIOPHYSICS; ELECTROPHYSIOLOGY; ION CHANNELS; MOLECULAR MODELING; MUTAGENESIS; PAIN; SODIUM CHANNELS;

AMINO ACID SEQUENCE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION;

EID: 84877708815     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.462366     Document Type: Article

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