Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Nature Neuroscience

Volumn 13, Issue 9, 2010, Pages 1056-1058

  Zhang, Xiaofei ^a,d   Bertaso, Federica ^a,e   Yoo, Jong W ^b   Baumgärtel, Karsten ^a   Clancy, Sinead M ^a   Lee, Van ^c   Cienfuegos, Cynthia ^c   Wilmot, Carly ^c   Avis, Jacqueline ^c   Hunyh, Truc ^c   Daguia, Catherine ^c   Schmedt, Christian ^c   Noebels, Jeffrey ^b   Jegla, Timothy ^a,f  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^d BURNHAM INSTITUTE   (United States)

^e UNIV MONTPELLIER   (France)

^f PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PENTETRAZOLE; POTASSIUM CHANNEL KV12 2; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; CONVULSANT AGENT; KCNH3 PROTEIN, MOUSE; POTASSIUM CHANNEL HERG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EPILEPSY; GENE DELETION; HIPPOCAMPUS; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE; SPIKE WAVE; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; GENETICS; HUMAN; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; TOXICITY; VIDEORECORDING; XENOPUS;

ACTION POTENTIALS; ANIMALS; CELL LINE; CELLS, CULTURED; CONVULSANTS; EPILEPSY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PENTYLENETETRAZOLE; PYRAMIDAL CELLS; SEIZURES; VIDEO RECORDING; XENOPUS; IN VITRO TECHNIQUES;

EID: 77956187224     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2610     Document Type: Article

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