Extracellular Mg2+ regulates activation of rat eag potassium channel

Pflugers Archiv European Journal of Physiology

Volumn 432, Issue 2, 1996, Pages 301-312

  Terlau, Heinrich ^a   Ludwig, Jost ^b   Steffan, Rüdiger ^a,c   Pongs, Olaf ^b   Stühmer, Walter ^a   Heinemann, Stefan H ^c  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c AG Molec und Zellulare Biophysik   (Germany)

Author keywords

Activation kinetics; Kinetic model; Magnesium pH; Oocyte expression system; Potassium (K) channels; Rat eag

Indexed keywords

MAGNESIUM; POTASSIUM CHANNEL; DIVALENT CATION; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE ACTIVATION; GENE EXPRESSION; KINETICS; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; RAT; XENOPUS; ANIMAL; DRUG EFFECT; EXTRACELLULAR SPACE; METABOLISM; OSMOLARITY; PHYSIOLOGY; TIME; XENOPUS LAEVIS;

ANIMALS; CATIONS, DIVALENT; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; EXTRACELLULAR SPACE; HYDROGEN-ION CONCENTRATION; MAGNESIUM; OOCYTES; OSMOLAR CONCENTRATION; POTASSIUM CHANNELS; RATS; TIME FACTORS; XENOPUS LAEVIS;

EID: 0030162697     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050137     Document Type: Article

References (28)

1. + channel genes. CRC Handbook of receptors and channels. CRC Press, Boca Raton, Fla. pp. 1-71
2. Cole KS, Moore JW (1960) Potassium ion current in the squid giant axon: dynamic characteristic. Biophys J 1:1-4
3. Gilly WF, Armstrong CM (1982) Divalent cations and the activation kinetics of potassium channels in squid giant axons J Gen Physiol 79:965-996
4. Good NE, Izawa S (1972) Hydrogen ion buffers. Methods Enzymol 24:53-68
5. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflügers Arch 391:85-100
6. Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer Associates, Mass.
7. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117:500-544
8. + current in guinea-pig cardiac myocytes. J Physiol (Lond) 419:297-320
9. 2+. Voltage and concentration dependence of calcium into the pore. J Gen Physiol 88:321-347
10. + channel determined by construction of multimeric cDNAs Neuron 9:861-871
11. 2+ block of cloned potassium channels. Eur Biophys J 22:237-247
12. Ludwig J, Terlau H, Wunder F, Brüggemann A, Pardo LA, Marquardt A, Stühmer W, Pongs O (1994) Functional expression of a rat homologue of the voltage gated ether à gogo potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO J 13:4451-4458
13. MacKinnon R (1991) Determination of the subunits stoichiometry of a voltage-activated potassium channel. Nature 350:232-235
14. 2+. Nature 325:152-159
15. 2+ of NMDA responces in spinal cord neurones. Nature 309:261-263
16. McCormack K, Joiner WJ, Heinemann SH (1994) A characterization of the activating structural rearrangements in voltage-dependent Shaker Kchannels Neuron 12:301-315
17. Methfessel C, Witzemann V, Takahashi T, Mishina M, Numa S, Sakmann B (1986) Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor Pflügers Arch 407:577-588
18. Nowak L, Bregestovski P, Ascher P, Herbert A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-465
19. 2+. Eur Biophys J 18:317-326
20. Pusch M, Conti F, Stühmer W (1989) Intracellular magnesium blocks sodium outward currents in a voltage- and dose dependent manner. Biophys J 55: 1267-1271
21. Rudy B (1988) Diversity and ubiquity of K channels. Neuroscience 25:729-749
22. Shrager P (1974) Ionic conductance changes in voltage clamped crayfish axons at low pH. J Gen Physiol 64:666-690
23. Spires S, Begenisich T (1992) Chemical properties of the divalent cation binding site on potassium channels. J Gen Physiol 100:181-193
24. Spires S, Begenisich T (1994) Modulation of potassium channel gating by external divalent cations. J Gen Physiol 104: 675-692
25. Spires S, Begenisich T (1995) Voltage-independent transitions in squid axon potassium channels. Biophys J 68:491-500
26. Stühmer W (1992 ) Electrophysiological recordings from Xenopus oocytes. Methods Enzymol 207:319-339
27. Stühmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A, Pongs O (1988) Potassium channels expressed from rat brain cDNA have delayed rectifier properties. FEBS Lett 242:199-206
28. Zagotta WN, Hoshi T, Aldrich RW (1994) Shaker potassium channel gating, III. Evaluation of kinetic-models for activation. J Gen Physiol 103:321-362