The seizure locus encodes the Drosophila homolog of the HERG potassium channel

Journal of Neuroscience

Volumn 17, Issue 3, 1997, Pages 882-890

  Wang, Xinjing ^a   Reynolds, Elaine R ^a,b   Déak, Péter ^a,c   Hall, Linda M ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

cloned potassium channel; Drosophila melanogaster; eag gene family; gene mapping; HERG; hyperexcitability; I(Kr); ion channel turn over; seizure gene; sodium channel regulation; temperature induced paralysis; transformation; transgenic animals

Indexed keywords

POTASSIUM CHANNEL;

ARTICLE; DROSOPHILA MELANOGASTER; GENE LOCUS; GENE MAPPING; GENE MUTATION; LONG QT SYNDROME; MISSENSE MUTATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0031030414     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-03-00882.1997     Document Type: Article

References (18)

1. Brodie C, Brody M, Sampson SR (1989) Characterization of the relation between sodium channels and electrical activity in cultured rat skeletal myotubes: regulatory aspects. Brain Res 488:186-194.
2. Cai H, Kiefel P, Yee J, Duncan I (1994) A yeast artificial chromosome clone map of the Drosophila genome. Genetics 136:1385-1399.
3. Catterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:s15-s48.
4. Chandy KG, Gutman GA (1995) Voltage-gated potassium channel genes. In: Ligand- and voltage-gated ion channels (North RA, ed), pp 1-71. Boca Raton, FL: CRC.
5. Chouinard SW, Wilson GF, Schlimgen AK, Ganetzky B (1995) A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila Hyperkinetic locus. Proc Natl Acad Sci USA 92:6763-6767.
6. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80:795-803.
7. Dargent B, Couraud F (1990) Down-regulation of voltage-dependent sodium channels initiated by sodium influx in developing neurons. Proc Natl Acad Sci USA 87:5907-5911.
8. Dargent B, Paillart C, Carlier E, Alcaraz G, Martin-Eauclaire MF, Couraud F (1994) Sodium channel internalization in developing neurons. Neuron 13:683-690.
9. Devereux J, Haeberli P, Smithies O (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387-395.
10. Elkins T, Ganetzky B (1990) Conduction in the giant nerve fiber pathway in temperature-sensitive paralytic mutants of Drosophila. J Neurogenet 6:207-219.
11. Feng G, Deák P, Chopra M, Hall LM (1995a) Cloning and functional analysis of tipE, a novel membrane protein that enhances Drosophila para sodium channel function. Cell 82:1001-1011.
12. Feng G, Deák P, Kasbekar DP, Gil DW, Hall LM (1995b) Cytogenetic and molecular localization of tipE: a gene affecting sodium channels in Drosophila melanogaster. Genetics 139:1679-1688.
13. Frohman MA, Dush MK, Martin GR (1988) Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonuclcotide primer. Proc Natl Acad Sci USA 85:8998-9002.
14. Warmke JW, Ganetzky B (1994) A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 91:3438-3442.
15. Willow M, Taylor SM, Catterall WA, Finnell RH (1986) Down-regulation of sodium channels in nerve terminals of spontaneously epileptic mice. Cell Mol Neurobiol 6:213-220.
16. Wu C-F, Ganetzky B (1992) Neurogenetic studies of ion channels in Drosophila. In: Ion channels, Vol 3 (Narahashi T, ed), pp 261-314. New York: Plenum.
17. + channels in cultured Drosophila "giant" neurons derived from Sh cDNA transformants: distinct properties, distribution, and turnover. J Neurosci 15:1406-1418.
18. Zheng W, Feng G, Ren D, Eberl DF, Hannan F, Dubald M, Hall LM (1995) Cloning and characterization of a calcium channel alpha 1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform. J Neurosci 15:1132-1143.