메뉴 건너뛰기




Volumn 126, Issue 20, 2013, Pages 4614-4626

Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

Author keywords

Akt; Camp; ERK2; GPCR; Heterotrimeric G proteins; Oscillations; Pi3K; Torc2

Indexed keywords

ACTIN; ADENYLATE CYCLASE; CHEMOATTRACTANT; CYCLIC AMP; F ACTIN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1;

EID: 84885445895     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.122952     Document Type: Article
Times cited : (26)

References (74)
  • 1
    • 0016294131 scopus 로고
    • Signal propagation during aggregation in the slime mould Dictyostelium discoideum
    • Alcantara, F. and Monk, M. (1974). Signal propagation during aggregation in the slime mould Dictyostelium discoideum. J. Gen. Microbiol. 85, 321-334.
    • (1974) J. Gen. Microbiol. , vol.85 , pp. 321-334
    • Alcantara, F.1    Monk, M.2
  • 2
    • 79952797165 scopus 로고    scopus 로고
    • FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells
    • Börner, S., Schwede, F., Schlipp, A., Berisha, F., Calebiro, D., Lohse, M. J. and Nikolaev, V. O. (2011). FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nat. Protoc. 6, 427-438.
    • (2011) Nat. Protoc. , vol.6 , pp. 427-438
    • Börner, S.1    Schwede, F.2    Schlipp, A.3    Berisha, F.4    Calebiro, D.5    Lohse, M.J.6    Nikolaev, V.O.7
  • 3
    • 0021326961 scopus 로고
    • Caffeine blocks activation of cyclic AMP synthesis in Dictyostelium discoideum
    • Brenner, M. and Thoms, S. D. (1984). Caffeine blocks activation of cyclic AMP synthesis in Dictyostelium discoideum. Dev. Biol. 101, 136-146.
    • (1984) Dev. Biol. , vol.101 , pp. 136-146
    • Brenner, M.1    Thoms, S.D.2
  • 5
    • 0035337704 scopus 로고    scopus 로고
    • The phosphorylated C-terminus of cAR1 plays a role in celltype-specific gene expression and STATa tyrosine phosphorylation
    • Briscoe, C., Moniakis, J., Kim, J. Y., Brown, J. M., Hereld, D., Devreotes, P. N. and Firtel, R. A. (2001). The phosphorylated C-terminus of cAR1 plays a role in celltype-specific gene expression and STATa tyrosine phosphorylation. Dev. Biol. 233, 225-236.
    • (2001) Dev. Biol. , vol.233 , pp. 225-236
    • Briscoe, C.1    Moniakis, J.2    Kim, J.Y.3    Brown, J.M.4    Hereld, D.5    Devreotes, P.N.6    Firtel, R.A.7
  • 6
    • 33749473004 scopus 로고    scopus 로고
    • Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay
    • Brzostowski, J. A. and Kimmel, A. R. (2006). Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay. Mol. Biol. Cell 17, 4220-4227.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4220-4227
    • Brzostowski, J.A.1    Kimmel, A.R.2
  • 7
    • 0037162285 scopus 로고    scopus 로고
    • Galpha-mediated inhibition of developmental signal response
    • Brzostowski, J. A., Johnson, C. and Kimmel, A. R. (2002). Galpha-mediated inhibition of developmental signal response. Curr. Biol. 12, 1199-1208.
    • (2002) Curr. Biol. , vol.12 , pp. 1199-1208
    • Brzostowski, J.A.1    Johnson, C.2    Kimmel, A.R.3
  • 8
    • 1842783708 scopus 로고    scopus 로고
    • A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement
    • Brzostowski, J. A., Parent, C. A. and Kimmel, A. R. (2004). A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev. 18, 805-815.
    • (2004) Genes Dev. , vol.18 , pp. 805-815
    • Brzostowski, J.A.1    Parent, C.A.2    Kimmel, A.R.3
  • 9
    • 0027976354 scopus 로고
    • Mutation of the third intracellular loop of the cAMP receptor, cAR1, of Dictyostelium yields mutants impaired in multiple signaling pathways
    • Caterina, M. J., Milne, J. L. and Devreotes, P. N. (1994). Mutation of the third intracellular loop of the cAMP receptor, cAR1, of Dictyostelium yields mutants impaired in multiple signaling pathways. J. Biol. Chem. 269, 1523-1532.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1523-1532
    • Caterina, M.J.1    Milne, J.L.2    Devreotes, P.N.3
  • 10
    • 0028933878 scopus 로고
    • Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G proteincoupled chemoattractant receptor from Dictyostelium
    • Caterina, M. J., Devreotes, P. N., Borleis, J. and Hereld, D. (1995). Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G proteincoupled chemoattractant receptor from Dictyostelium. J. Biol. Chem. 270, 8667-8672.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8667-8672
    • Caterina, M.J.1    Devreotes, P.N.2    Borleis, J.3    Hereld, D.4
  • 11
    • 30044443294 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase
    • Comer, F. I. and Parent, C. A. (2006). Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase. Mol. Biol. Cell 17, 357-366.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 357-366
    • Comer, F.I.1    Parent, C.A.2
  • 12
    • 64849103757 scopus 로고    scopus 로고
    • G protein-coupled receptors stimulation and the control of cell migration
    • Cotton, M. and Claing, A. (2009). G protein-coupled receptors stimulation and the control of cell migration. Cell. Signal. 21, 1045-1053.
    • (2009) Cell. Signal. , vol.21 , pp. 1045-1053
    • Cotton, M.1    Claing, A.2
  • 13
    • 80052768977 scopus 로고    scopus 로고
    • CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration
    • Décaillot, F. M., Kazmi, M. A., Lin, Y., Ray-Saha, S., Sakmar, T. P. and Sachdev, P. (2011). CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration. J. Biol. Chem. 286, 32188-32197.
    • (2011) J. Biol. Chem. , vol.286 , pp. 32188-32197
    • Décaillot, F.M.1    Kazmi, M.A.2    Lin, Y.3    Ray-Saha, S.4    Sakmar, T.P.5    Sachdev, P.6
  • 14
    • 33947424807 scopus 로고    scopus 로고
    • Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization
    • DeFea, K. A. (2007). Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization. Annu. Rev. Physiol. 69, 535-560.
    • (2007) Annu. Rev. Physiol. , vol.69 , pp. 535-560
    • DeFea, K.A.1
  • 15
    • 84857911676 scopus 로고    scopus 로고
    • GRK2: multiple roles beyond G protein-coupled receptor desensitization
    • Evron, T., Daigle, T. L. and Caron, M. G. (2012). GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol. Sci. 33, 154-164.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 154-164
    • Evron, T.1    Daigle, T.L.2    Caron, M.G.3
  • 16
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling
    • Ferguson, S. S. (2001). Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53, 1-24.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 1-24
    • Ferguson, S.S.1
  • 18
    • 0020073481 scopus 로고
    • Cell behavior in Dictyostelium discoideum: preaggregation response to localized cyclic AMP pulses
    • Futrelle, R. P., Traut, J. and McKee, W. G. (1982). Cell behavior in Dictyostelium discoideum: preaggregation response to localized cyclic AMP pulses. J. Cell Biol. 92, 807-821.
    • (1982) J. Cell Biol. , vol.92 , pp. 807-821
    • Futrelle, R.P.1    Traut, J.2    McKee, W.G.3
  • 19
    • 0037200061 scopus 로고    scopus 로고
    • Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization
    • Gaudreau, R., Le Gouill, C., Venne, M. H., Stankova, J. and Rola-Pleszczynski, M. (2002). Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. J. Biol. Chem. 277, 31567-31576.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31567-31576
    • Gaudreau, R.1    Le Gouill, C.2    Venne, M.H.3    Stankova, J.4    Rola-Pleszczynski, M.5
  • 20
    • 77953080728 scopus 로고    scopus 로고
    • The onset of collective behavior in social amoebae
    • New York, N.Y.
    • Gregor, T., Fujimoto, K., Masaki, N. and Sawai, S. (2010). The onset of collective behavior in social amoebae. Science (New York, N.Y.) 328, 1021-1025.
    • (2010) Science , vol.328 , pp. 1021-1025
    • Gregor, T.1    Fujimoto, K.2    Masaki, N.3    Sawai, S.4
  • 21
    • 0017029087 scopus 로고
    • Signal emission and signal propagation during early aggregation in Dictyostelium discoideum
    • Gross, J. D., Peacey, M. J. and Trevan, D. J. (1976). Signal emission and signal propagation during early aggregation in Dictyostelium discoideum. J. Cell Sci. 22, 645-656.
    • (1976) J. Cell Sci. , vol.22 , pp. 645-656
    • Gross, J.D.1    Peacey, M.J.2    Trevan, D.J.3
  • 22
    • 78650767353 scopus 로고    scopus 로고
    • FYVEdependent endosomal targeting of an arrestin-related protein in amoeba
    • Guetta, D., Langou, K., Grunwald, D., Klein, G. and Aubry, L. (2010). FYVEdependent endosomal targeting of an arrestin-related protein in amoeba. PLoS ONE 5, e15249.
    • (2010) PLoS ONE , vol.5
    • Guetta, D.1    Langou, K.2    Grunwald, D.3    Klein, G.4    Aubry, L.5
  • 23
    • 0028298289 scopus 로고
    • Localization of ligand-induced phosphorylation sites to serine clusters in the Cterminal domain of the Dictyostelium cAMP receptor, cAR1
    • Hereld, D., Vaughan, R., Kim, J. Y., Borleis, J. and Devreotes, P. (1994). Localization of ligand-induced phosphorylation sites to serine clusters in the Cterminal domain of the Dictyostelium cAMP receptor, cAR1. J. Biol. Chem. 269, 7036-7044.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7036-7044
    • Hereld, D.1    Vaughan, R.2    Kim, J.Y.3    Borleis, J.4    Devreotes, P.5
  • 24
    • 0028093610 scopus 로고
    • CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
    • Insall, R., Kuspa, A., Lilly, P. J., Shaulsky, G., Levin, L. R., Loomis, W. F. and Devreotes, P. (1994a). CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545.
    • (1994) J. Cell Biol. , vol.126 , pp. 1537-1545
    • Insall, R.1    Kuspa, A.2    Lilly, P.J.3    Shaulsky, G.4    Levin, L.R.5    Loomis, W.F.6    Devreotes, P.7
  • 25
    • 0028287369 scopus 로고
    • Two cAMP receptors activate common signaling pathways in Dictyostelium
    • Insall, R. H., Soede, R. D., Schaap, P. and Devreotes, P. N. (1994b). Two cAMP receptors activate common signaling pathways in Dictyostelium. Mol. Biol. Cell 5, 703-711.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 703-711
    • Insall, R.H.1    Soede, R.D.2    Schaap, P.3    Devreotes, P.N.4
  • 26
    • 0035937571 scopus 로고    scopus 로고
    • Receptor-mediated activation of heterotrimeric G-proteins in living cells
    • New York, N.Y.
    • Janetopoulos, C., Jin, T. and Devreotes, P. (2001). Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (New York, N.Y.) 291, 2408-2411.
    • (2001) Science , vol.291 , pp. 2408-2411
    • Janetopoulos, C.1    Jin, T.2    Devreotes, P.3
  • 27
    • 66549109124 scopus 로고    scopus 로고
    • How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum
    • Jin, T., Xu, X., Fang, J., Isik, N., Yan, J., Brzostowski, J. A. and Hereld, D. (2009). How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol. Res. 43, 118-127.
    • (2009) Immunol. Res. , vol.43 , pp. 118-127
    • Jin, T.1    Xu, X.2    Fang, J.3    Isik, N.4    Yan, J.5    Brzostowski, J.A.6    Hereld, D.7
  • 28
    • 79956073406 scopus 로고    scopus 로고
    • Collective oscillations in developing cells: insights from simple systems
    • Kamino, K., Fujimoto, K. and Sawai, S. (2011). Collective oscillations in developing cells: insights from simple systems. Dev. Growth Differ. 53, 503-517.
    • (2011) Dev. Growth Differ. , vol.53 , pp. 503-517
    • Kamino, K.1    Fujimoto, K.2    Sawai, S.3
  • 29
    • 0344585389 scopus 로고    scopus 로고
    • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G proteincoupled receptor kinase 6
    • Kavelaars, A., Vroon, A., Raatgever, R. P., Fong, A. M., Premont, R. T., Patel, D. D., Lefkowitz, R. J. and Heijnen, C. J. (2003). Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G proteincoupled receptor kinase 6. J. Immunol. 171, 6128-6134.
    • (2003) J. Immunol. , vol.171 , pp. 6128-6134
    • Kavelaars, A.1    Vroon, A.2    Raatgever, R.P.3    Fong, A.M.4    Premont, R.T.5    Patel, D.D.6    Lefkowitz, R.J.7    Heijnen, C.J.8
  • 30
    • 22744455266 scopus 로고    scopus 로고
    • A Rab21/LIM-only/CHLIM complex regulates phagocytosis via both activating and inhibitory mechanisms
    • Khurana, T., Brzostowski, J. A. and Kimmel, A. R. (2005). A Rab21/LIM-only/CHLIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J. 24, 2254-2264.
    • (2005) EMBO J. , vol.24 , pp. 2254-2264
    • Khurana, T.1    Brzostowski, J.A.2    Kimmel, A.R.3
  • 31
    • 0030766477 scopus 로고    scopus 로고
    • Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses
    • Kim, J. Y., Soede, R. D., Schaap, P., Valkema, R., Borleis, J. A., Van Haastert, P. J., Devreotes, P. N. and Hereld, D. (1997). Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J. Biol. Chem. 272, 27313-27318.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27313-27318
    • Kim, J.Y.1    Soede, R.D.2    Schaap, P.3    Valkema, R.4    Borleis, J.A.5    Van Haastert, P.J.6    Devreotes, P.N.7    Hereld, D.8
  • 32
    • 70349428806 scopus 로고    scopus 로고
    • Chemotaxis: finding the way forward with Dictyostelium
    • King, J. S. and Insall, R. H. (2009). Chemotaxis: finding the way forward with Dictyostelium. Trends Cell Biol. 19, 523-530.
    • (2009) Trends Cell Biol. , vol.19 , pp. 523-530
    • King, J.S.1    Insall, R.H.2
  • 33
    • 0021956577 scopus 로고
    • Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum
    • Klein, P., Theibert, A., Fontana, D. and Devreotes, P. N. (1985). Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum. J. Biol. Chem. 260, 1757-1764.
    • (1985) J. Biol. Chem. , vol.260 , pp. 1757-1764
    • Klein, P.1    Theibert, A.2    Fontana, D.3    Devreotes, P.N.4
  • 34
    • 0035860777 scopus 로고    scopus 로고
    • Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
    • Kraft, K., Olbrich, H., Majoul, I., Mack, M., Proudfoot, A. and Oppermann, M. (2001). Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. J. Biol. Chem. 276, 34408-34418.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34408-34418
    • Kraft, K.1    Olbrich, H.2    Majoul, I.3    Mack, M.4    Proudfoot, A.5    Oppermann, M.6
  • 36
    • 77951188014 scopus 로고    scopus 로고
    • Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2
    • Liao, X. H., Buggey, J. and Kimmel, A. R. (2010). Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell Sci. 123, 983-992.
    • (2010) J. Cell Sci. , vol.123 , pp. 983-992
    • Liao, X.H.1    Buggey, J.2    Kimmel, A.R.3
  • 37
    • 10044250005 scopus 로고    scopus 로고
    • Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells
    • Ma, L., Janetopoulos, C., Yang, L., Devreotes, P. N. and Iglesias, P. A. (2004). Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys. J. 87, 3764-3774.
    • (2004) Biophys. J. , vol.87 , pp. 3764-3774
    • Ma, L.1    Janetopoulos, C.2    Yang, L.3    Devreotes, P.N.4    Iglesias, P.A.5
  • 38
    • 2442526725 scopus 로고    scopus 로고
    • Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA
    • Maeda, M., Lu, S., Shaulsky, G., Miyazaki, Y., Kuwayama, H., Tanaka, Y., Kuspa, A. and Loomis, W. F. (2004). Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science 304, 875-878.
    • (2004) Science , vol.304 , pp. 875-878
    • Maeda, M.1    Lu, S.2    Shaulsky, G.3    Miyazaki, Y.4    Kuwayama, H.5    Tanaka, Y.6    Kuspa, A.7    Loomis, W.F.8
  • 39
    • 51649090576 scopus 로고    scopus 로고
    • Oscillatory signaling and network responses during the development of Dictyostelium discoideum
    • McMains, V. C., Liao, X. H. and Kimmel, A. R. (2008). Oscillatory signaling and network responses during the development of Dictyostelium discoideum. Ageing Res. Rev. 7, 234-248.
    • (2008) Ageing Res. Rev. , vol.7 , pp. 234-248
    • McMains, V.C.1    Liao, X.H.2    Kimmel, A.R.3
  • 40
    • 80054782210 scopus 로고    scopus 로고
    • b-arrestin-dependent actin reorganization: bringing the right players together at the leading edge
    • Min, J. and Defea, K. (2011). b-arrestin-dependent actin reorganization: bringing the right players together at the leading edge. Mol. Pharmacol. 80, 760-768.
    • (2011) Mol. Pharmacol. , vol.80 , pp. 760-768
    • Min, J.1    Defea, K.2
  • 41
    • 4444377903 scopus 로고    scopus 로고
    • Novel single chain cAMP sensors for receptor-induced signal propagation
    • Nikolaev, V. O., Bünemann, M., Hein, L., Hannawacker, A. and Lohse, M. J. (2004). Novel single chain cAMP sensors for receptor-induced signal propagation. J. Biol. Chem. 279, 37215-37218.
    • (2004) J. Biol. Chem. , vol.279 , pp. 37215-37218
    • Nikolaev, V.O.1    Bünemann, M.2    Hein, L.3    Hannawacker, A.4    Lohse, M.J.5
  • 42
    • 33847340251 scopus 로고    scopus 로고
    • Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device-TAXIScan
    • Nitta, N., Tsuchiya, T., Yamauchi, A., Tamatani, T. and Kanegasaki, S. (2007). Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device-TAXIScan. J. Immunol. Methods 320, 155-163.
    • (2007) J. Immunol. Methods , vol.320 , pp. 155-163
    • Nitta, N.1    Tsuchiya, T.2    Yamauchi, A.3    Tamatani, T.4    Kanegasaki, S.5
  • 43
    • 0019489914 scopus 로고
    • The extracellular cyclic nucleotide phosphodiesterase of Dictyostelium discoideum.Purification and characterization
    • Orlow, S. J., Shapiro, R. I., Franke, J. and Kessin, R. H. (1981). The extracellular cyclic nucleotide phosphodiesterase of Dictyostelium discoideum. Purification and characterization. J. Biol. Chem. 256, 7620-7627.
    • (1981) J. Biol. Chem. , vol.256 , pp. 7620-7627
    • Orlow, S.J.1    Shapiro, R.I.2    Franke, J.3    Kessin, R.H.4
  • 44
    • 0001462976 scopus 로고    scopus 로고
    • Use of a fusion protein between GFP and an actin-binding domain to visualize transient filamentous-actin structures
    • Pang, K. M., Lee, E. and Knecht, D. A. (1998). Use of a fusion protein between GFP and an actin-binding domain to visualize transient filamentous-actin structures. Curr. Biol. 8, 405-408.
    • (1998) Curr. Biol. , vol.8 , pp. 405-408
    • Pang, K.M.1    Lee, E.2    Knecht, D.A.3
  • 45
    • 0032475863 scopus 로고    scopus 로고
    • G protein signaling events are activated at the leading edge of chemotactic cells
    • Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B. and Devreotes, P. N. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
    • (1998) Cell , vol.95 , pp. 81-91
    • Parent, C.A.1    Blacklock, B.J.2    Froehlich, W.M.3    Murphy, D.B.4    Devreotes, P.N.5
  • 47
    • 33846002381 scopus 로고    scopus 로고
    • The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells
    • Sai, J., Walker, G., Wikswo, J. and Richmond, A. (2006). The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt and chemotaxis in HL60 cells. J. Biol. Chem. 281, 35931-35941.
    • (2006) J. Biol. Chem. , vol.281 , pp. 35931-35941
    • Sai, J.1    Walker, G.2    Wikswo, J.3    Richmond, A.4
  • 48
    • 12744280743 scopus 로고    scopus 로고
    • An autoregulatory circuit for longrange self-organization in Dictyostelium cell populations
    • Sawai, S., Thomason, P. A. and Cox, E. C. (2005). An autoregulatory circuit for longrange self-organization in Dictyostelium cell populations. Nature 433, 323-326.
    • (2005) Nature , vol.433 , pp. 323-326
    • Sawai, S.1    Thomason, P.A.2    Cox, E.C.3
  • 49
    • 39749162982 scopus 로고    scopus 로고
    • High-throughput analysis of spatio-temporal dynamics in Dictyostelium
    • Sawai, S., Guan, X. J., Kuspa, A. and Cox, E. C. (2007). High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol. 8, R144.
    • (2007) Genome Biol. , vol.8
    • Sawai, S.1    Guan, X.J.2    Kuspa, A.3    Cox, E.C.4
  • 50
    • 0026065341 scopus 로고
    • Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum
    • Saxe, C. L., 3rd, Johnson, R., Devreotes, P. N. and Kimmel, A. R. (1991). Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum. Dev. Genet. 12, 6-13.
    • (1991) Dev. Genet. , vol.12 , pp. 6-13
    • Saxe, C.L.1    Johnson, R.2    Devreotes, P.N.3    Kimmel, A.R.4
  • 51
    • 78751519240 scopus 로고    scopus 로고
    • Evolutionary crossroads in developmental biology: Dictyostelium discoideum
    • Schaap, P. (2011). Evolutionary crossroads in developmental biology: Dictyostelium discoideum. Development 138, 387-396.
    • (2011) Development , vol.138 , pp. 387-396
    • Schaap, P.1
  • 53
    • 80052038573 scopus 로고    scopus 로고
    • b-Arrestin-mediated receptor trafficking and signal transduction
    • Shenoy, S. K. and Lefkowitz, R. J. (2011). b-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol. Sci. 32, 521-533.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 54
    • 80052359992 scopus 로고    scopus 로고
    • Emerging paradigms of barrestin-dependent seven transmembrane receptor signaling
    • Shukla, A. K., Xiao, K. and Lefkowitz, R. J. (2011). Emerging paradigms of barrestin-dependent seven transmembrane receptor signaling. Trends Biochem. Sci. 36, 457-469.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 457-469
    • Shukla, A.K.1    Xiao, K.2    Lefkowitz, R.J.3
  • 55
    • 0024366979 scopus 로고
    • Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia
    • Siegert, F. and Weijer, C. (1989). Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia. J. Cell Sci. 93, 325-335.
    • (1989) J. Cell Sci. , vol.93 , pp. 325-335
    • Siegert, F.1    Weijer, C.2
  • 56
    • 69949186370 scopus 로고    scopus 로고
    • How a cell crawls and the role of cortical myosin II
    • Soll, D. R., Wessels, D., Kuhl, S. and Lusche, D. F. (2009). How a cell crawls and the role of cortical myosin II. Eukaryot. Cell 8, 1381-1396.
    • (2009) Eukaryot. Cell , vol.8 , pp. 1381-1396
    • Soll, D.R.1    Wessels, D.2    Kuhl, S.3    Lusche, D.F.4
  • 58
    • 77952911072 scopus 로고    scopus 로고
    • Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
    • Swaney, K. F., Huang, C. H. and Devreotes, P. N. (2010). Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu. Rev. Biophys 39, 265-289.
    • (2010) Annu. Rev. Biophys , vol.39 , pp. 265-289
    • Swaney, K.F.1    Huang, C.H.2    Devreotes, P.N.3
  • 61
    • 0022575305 scopus 로고
    • The specificity of the cAMP receptor mediating activation of adenylate cyclase in Dictyostelium discoideum
    • Theibert, A., Palmisano, M., Jastorff, B. and Devreotes, P. (1986). The specificity of the cAMP receptor mediating activation of adenylate cyclase in Dictyostelium discoideum. Dev. Biol. 114, 529-533.
    • (1986) Dev. Biol. , vol.114 , pp. 529-533
    • Theibert, A.1    Palmisano, M.2    Jastorff, B.3    Devreotes, P.4
  • 62
    • 0019465923 scopus 로고
    • Adenosine 39,59-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution-fluorography
    • Tomchik, K. J. and Devreotes, P. N. (1981). Adenosine 39,59-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution-fluorography. Science 212, 443-446.
    • (1981) Science , vol.212 , pp. 443-446
    • Tomchik, K.J.1    Devreotes, P.N.2
  • 63
    • 33745253131 scopus 로고    scopus 로고
    • Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the downregulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells
    • Ueda, Y., Neel, N. F., Schutyser, E., Raman, D. and Richmond, A. (2006). Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the downregulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells. Cancer Res. 66, 5665-5675.
    • (2006) Cancer Res. , vol.66 , pp. 5665-5675
    • Ueda, Y.1    Neel, N.F.2    Schutyser, E.3    Raman, D.4    Richmond, A.5
  • 64
    • 0023644914 scopus 로고
    • Down-regulation of cell surface cyclic AMP receptors and desensitization of cyclic AMP-stimulated adenylate cyclase by cyclic AMP in Dictyostelium discoideum
    • Van Haastert, P. J. (1987a). Down-regulation of cell surface cyclic AMP receptors and desensitization of cyclic AMP-stimulated adenylate cyclase by cyclic AMP in Dictyostelium discoideum. Kinetics and concentration dependence. J. Biol. Chem. 262, 7700-7704.
    • (1987) Kinetics and concentration dependence. J. Biol. Chem. , vol.262 , pp. 7700-7704
    • Van Haastert, P.J.1
  • 65
    • 0023600209 scopus 로고
    • Differential effects of temperature on cAMP-induced excitation, adaptation, and deadaptation of adenylate and guanylate cyclase in Dictyostelium discoideum
    • Van Haastert, P. J. (1987b). Differential effects of temperature on cAMP-induced excitation, adaptation, and deadaptation of adenylate and guanylate cyclase in Dictyostelium discoideum. J. Cell Biol. 105, 2301-2306.
    • (1987) J. Cell Biol. , vol.105 , pp. 2301-2306
    • Van Haastert, P.J.1
  • 66
    • 0024279294 scopus 로고
    • Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum
    • Vaughan, R. A. and Devreotes, P. N. (1988). Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum. J. Biol. Chem. 263, 14538-14543.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14538-14543
    • Vaughan, R.A.1    Devreotes, P.N.2
  • 67
    • 1642506294 scopus 로고    scopus 로고
    • GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to GCSF in vivo
    • Vroon, A., Heijnen, C. J., Raatgever, R., Touw, I. P., Ploemacher, R. E., Premont, R. T. and Kavelaars, A. (2004). GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to GCSF in vivo. J. Leukoc. Biol. 75, 698-704.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 698-704
    • Vroon, A.1    Heijnen, C.J.2    Raatgever, R.3    Touw, I.P.4    Ploemacher, R.E.5    Premont, R.T.6    Kavelaars, A.7
  • 68
    • 33845412884 scopus 로고    scopus 로고
    • GRKs and arrestins: regulators of migration and inflammation
    • Vroon, A., Heijnen, C. J. and Kavelaars, A. (2006). GRKs and arrestins: regulators of migration and inflammation. J. Leukoc. Biol. 80, 1214-1221.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 1214-1221
    • Vroon, A.1    Heijnen, C.J.2    Kavelaars, A.3
  • 69
  • 70
    • 12844268483 scopus 로고    scopus 로고
    • Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium
    • Xu, X., Meier-Schellersheim, M., Jiao, X., Nelson, L. E. and Jin, T. (2005). Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol. Biol. Cell 16, 676-688.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 676-688
    • Xu, X.1    Meier-Schellersheim, M.2    Jiao, X.3    Nelson, L.E.4    Jin, T.5
  • 71
    • 33750129594 scopus 로고    scopus 로고
    • Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells
    • Xu, X., Brzostowski, J. A. and Jin, T. (2006). Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells. Methods Mol. Biol. 346, 281-296.
    • (2006) Methods Mol. Biol. , vol.346 , pp. 281-296
    • Xu, X.1    Brzostowski, J.A.2    Jin, T.3
  • 73
    • 0037590640 scopus 로고    scopus 로고
    • Constitutively active protein kinase A disrupts motility and chemotaxis in Dictyostelium discoideum
    • Zhang, H., Heid, P. J., Wessels, D., Daniels, K. J., Pham, T., Loomis, W. F. and Soll, D. R. (2003). Constitutively active protein kinase A disrupts motility and chemotaxis in Dictyostelium discoideum. Eukaryot. Cell 2, 62-75.
    • (2003) Eukaryot. Cell , vol.2 , pp. 62-75
    • Zhang, H.1    Heid, P.J.2    Wessels, D.3    Daniels, K.J.4    Pham, T.5    Loomis, W.F.6    Soll, D.R.7
  • 74
    • 67649856866 scopus 로고    scopus 로고
    • Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
    • Zidar, D. A., Violin, J. D., Whalen, E. J. and Lefkowitz, R. J. (2009). Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 106, 9649-9654.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9649-9654
    • Zidar, D.A.1    Violin, J.D.2    Whalen, E.J.3    Lefkowitz, R.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.