Periodic Signaling Controlled by an Oscillatory Circuit That Includes Protein Kinases ERK2 and PKA

Science

Volumn 304, Issue 5672, 2004, Pages 875-878

  Maeda, Mineko ^a   Lu, Sijie ^a   Shaulsky, Gad ^a   Miyazaki, Yuji ^a   Kuwayama, Hidekazu ^a   Tanaka, Yoshimasa ^a   Kuspa, Adam ^a   Loomis, William F ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

NETWORKS (CIRCUITS); OSCILLATIONS; PHOSPHATES; PROTEINS;

CHEMOTACTIC SIGNALING; SELF-REGULATING SYSTEMS;

BIOTECHNOLOGY;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

PROTEIN;

ARTICLE; CHEMOTAXIS; DEVELOPMENTAL STAGE; DICTYOSTELIUM DISCOIDEUM; ENZYME ACTIVATION; NONHUMAN; PERIODICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; COMPUTER SIMULATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DICTYOSTELIUM; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTOZOAN PROTEINS; RECEPTORS, CYCLIC AMP; SIGNAL TRANSDUCTION;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM;

EID: 2442526725     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094647     Document Type: Article

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26. We thank S. Payne and W.-J. Rappel for assistance with the circuit simulations and M. Behrens for discussions. D. Ikeno made contributions to these studies. Supported by NIH grants GM62350 (W.F.L) and GMS2359 (A.K.), an NSF Biocomplexity Grant, and Ministry of Education, Science and Culture of Japan grants 12640633 and 13024248 (M.M.).