CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation. Accumulation of poly-ubiquitinated Hsp90 client proteins

Journal of Biological Chemistry

Volumn 278, Issue 31, 2003, Pages 28490-28500

  Doong, Howard ^a   Rizzo, Kathryn ^a   Fang, Shengyun ^b   Kulpa, Vyta ^a   Weissman, Allan M ^b   Kohn, Elise C ^a  

^a Laboratory of Pathology   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; PROTEINS; TUMORS;

GELDANAMYCIN;

BIOCHEMISTRY;

CHAPERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; GELDANAMYCIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 70; PHOSPHOPROTEIN; PROTEIN BAG3; PROTEIN CAIR1; PROTEIN KINASE B; RAF PROTEIN; RAF1 PROTEIN; S6 KINASE; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACETYLCYSTEINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BENZOQUINONES; BREAST NEOPLASMS; CARRIER PROTEINS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; GENE DELETION; GENE EXPRESSION; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOSORBENT TECHNIQUES; LACTAMS, MACROCYCLIC; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; QUINONES; TRANSFECTION; TUMOR CELLS, CULTURED; UBIQUITIN;

EID: 0042208135     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209682200     Document Type: Article

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